EA032261B1 - Способы получения твердых форм менахинолов - Google Patents

Способы получения твердых форм менахинолов Download PDF

Info

Publication number
EA032261B1
EA032261B1 EA201791845A EA201791845A EA032261B1 EA 032261 B1 EA032261 B1 EA 032261B1 EA 201791845 A EA201791845 A EA 201791845A EA 201791845 A EA201791845 A EA 201791845A EA 032261 B1 EA032261 B1 EA 032261B1
Authority
EA
Eurasian Patent Office
Prior art keywords
bacillus
vitamin
formula
menaquinol
temperature
Prior art date
Application number
EA201791845A
Other languages
English (en)
Russian (ru)
Other versions
EA201791845A1 (ru
Inventor
Давиде Бьянки
Симона Дали
Никколо Миралья
Антонелла Трентин
Федерика Кольцани
Франческа Боллини
Чезаре ПОНЦОНЕ
Original Assignee
Гносис С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гносис С.п.А. filed Critical Гносис С.п.А.
Publication of EA201791845A1 publication Critical patent/EA201791845A1/ru
Publication of EA032261B1 publication Critical patent/EA032261B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/06—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by conversion of non-aromatic six-membered rings or of such rings formed in situ into aromatic six-membered rings, e.g. by dehydrogenation
    • C07C37/07—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by conversion of non-aromatic six-membered rings or of such rings formed in situ into aromatic six-membered rings, e.g. by dehydrogenation with simultaneous reduction of C=O group in that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
    • C07C37/70—Purification; separation; Use of additives, e.g. for stabilisation by physical treatment
    • C07C37/84—Purification; separation; Use of additives, e.g. for stabilisation by physical treatment by crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/225—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/38—Pseudomonas
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA201791845A 2015-03-20 2016-03-18 Способы получения твердых форм менахинолов EA032261B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITUB20150528 2015-03-20
PCT/IB2016/051528 WO2016151447A1 (en) 2015-03-20 2016-03-18 Solid forms of menaquinols

Publications (2)

Publication Number Publication Date
EA201791845A1 EA201791845A1 (ru) 2018-02-28
EA032261B1 true EA032261B1 (ru) 2019-04-30

Family

ID=53284441

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791845A EA032261B1 (ru) 2015-03-20 2016-03-18 Способы получения твердых форм менахинолов

Country Status (15)

Country Link
US (1) US10563270B2 (enExample)
EP (1) EP3270902A1 (enExample)
JP (1) JP2018514507A (enExample)
KR (1) KR20170128333A (enExample)
CN (1) CN107428645A (enExample)
AU (1) AU2016238473B2 (enExample)
BR (1) BR112017019750A2 (enExample)
CA (1) CA2979997A1 (enExample)
EA (1) EA032261B1 (enExample)
GE (2) GEAP201914586A (enExample)
IL (1) IL254502B (enExample)
MX (1) MX2017011934A (enExample)
PH (1) PH12017501692A1 (enExample)
WO (1) WO2016151447A1 (enExample)
ZA (1) ZA201706282B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202012070YA (en) 2018-06-08 2021-01-28 Epizon Pharma Inc Methods and compositions for preventing or treating tissue calcification
MX2020013301A (es) 2018-06-08 2021-05-12 Epizon Pharma Inc Metodos y composiciones para prevenir o tratar calcifilaxis.
US10822295B2 (en) 2018-09-12 2020-11-03 Epizon Pharma, Inc. Menaquinol compositions and methods of treatment
EP4001421A1 (en) * 2020-11-16 2022-05-25 Endektovet Ltd Method for obtaining oil extract of menaquinone-7 from fermentation broth
CN112778092B (zh) * 2020-12-31 2023-03-24 玉溪健坤生物药业有限公司 一种还原型维生素k2的制备方法及其用途
CN115304464B (zh) * 2022-09-02 2023-03-14 新拓洋生物工程有限公司 一种维生素k2(35)的提取方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003137716A (ja) * 2001-10-30 2003-05-14 Eau De Faveur:Kk 皮膚の外用剤
JP2006083132A (ja) * 2004-09-17 2006-03-30 Kaneka Corp 還元型ビタミンkの製造方法
EP2060256A1 (en) * 2007-11-16 2009-05-20 Gnosis S.p.A. Pharmaceutical and nutraceutical compositions based on menaquinols

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI310029B (enExample) * 2001-07-13 2009-05-21 Kaneka Corp
TWI329510B (en) * 2001-10-10 2010-09-01 Kaneka Corp Method of stabilizing reduced coenzyme q10
CN103687495A (zh) * 2011-05-20 2014-03-26 弗里斯兰品牌有限公司 包含维生素k2的组合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003137716A (ja) * 2001-10-30 2003-05-14 Eau De Faveur:Kk 皮膚の外用剤
JP2006083132A (ja) * 2004-09-17 2006-03-30 Kaneka Corp 還元型ビタミンkの製造方法
EP2060256A1 (en) * 2007-11-16 2009-05-20 Gnosis S.p.A. Pharmaceutical and nutraceutical compositions based on menaquinols

Also Published As

Publication number Publication date
IL254502B (en) 2020-09-30
AU2016238473A1 (en) 2017-08-24
ZA201706282B (en) 2019-01-30
IL254502A0 (en) 2017-11-30
GEP20197040B (en) 2019-11-11
WO2016151447A1 (en) 2016-09-29
CN107428645A (zh) 2017-12-01
JP2018514507A (ja) 2018-06-07
US20180066326A1 (en) 2018-03-08
US10563270B2 (en) 2020-02-18
KR20170128333A (ko) 2017-11-22
AU2016238473B2 (en) 2020-03-12
PH12017501692A1 (en) 2018-03-19
BR112017019750A2 (en) 2018-05-29
GEAP201914586A (en) 2019-07-25
EP3270902A1 (en) 2018-01-24
MX2017011934A (es) 2018-02-09
EA201791845A1 (ru) 2018-02-28
CA2979997A1 (en) 2016-09-29

Similar Documents

Publication Publication Date Title
CA2835788C (en) Amorphous minocycline base and process for its preparation
AU2016238473B2 (en) Solid forms of menaquinols
JP2020055825A (ja) 多価不飽和ヒドロキシ脂肪酸の薬学的に許容される塩
JP2002253288A (ja) ホスファチドの製造と使用
CN101781345B (zh) 田蓟苷的制备方法
US20170283433A1 (en) Pharmaceutical formulations containing 3-(4-cinnamyl-l-piperazinyl) amino derivatives of 3-formylrifamycin sv and 3-formylrifamycin s and a process of their preparation
RU2411939C1 (ru) Способ получения 2,3,6,7-тетрагидроксинафтазарина
US8013175B2 (en) Method of refining episesamin
JP4095153B2 (ja) シアタン誘導体及びこれを有効成分とする神経成長因子産生誘導剤
CN110746419B (zh) 化合物及其制备方法和应用、药物
RU2515936C2 (ru) Высокочистый пентамицин
JP2792010B2 (ja) フタリド誘導体及びこれを有効成分とする子宮頚癌細胞の殺細胞剤
CN114773184A (zh) 一种从迷迭香中制备高纯度鼠尾草酸钠盐的方法
CN103467369A (zh) 尼莫地平杂质ⅰ的制备方法
JP6856223B2 (ja) ヒト毛乳頭細胞増殖用組成物
JP2001299289A (ja) リグナン類含有胡麻処理物の製造方法
WO2018074794A1 (ko) 신규한 퀘르세틴계 화합물
BG109099A (bg) Метод за получаване на силибинин
JPH0381225A (ja) 抗真菌剤
BE569202A (enExample)

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU