EA032023B1 - Комбинация регорафениба и ацетилсалициловой кислоты для лечения рака - Google Patents

Комбинация регорафениба и ацетилсалициловой кислоты для лечения рака Download PDF

Info

Publication number
EA032023B1
EA032023B1 EA201500365A EA201500365A EA032023B1 EA 032023 B1 EA032023 B1 EA 032023B1 EA 201500365 A EA201500365 A EA 201500365A EA 201500365 A EA201500365 A EA 201500365A EA 032023 B1 EA032023 B1 EA 032023B1
Authority
EA
Eurasian Patent Office
Prior art keywords
ser
gly
thr
leu
gin
Prior art date
Application number
EA201500365A
Other languages
English (en)
Russian (ru)
Other versions
EA201500365A1 (ru
Inventor
Олаф Вебер
Карл Цигельбауер
Original Assignee
Байер Фарма Акциенгезельшафт
Байер Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46963566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA032023(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байер Фарма Акциенгезельшафт, Байер Аг filed Critical Байер Фарма Акциенгезельшафт
Publication of EA201500365A1 publication Critical patent/EA201500365A1/ru
Publication of EA032023B1 publication Critical patent/EA032023B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/612Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201500365A 2012-09-25 2013-09-23 Комбинация регорафениба и ацетилсалициловой кислоты для лечения рака EA032023B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12185852 2012-09-25
PCT/EP2013/069735 WO2014048881A1 (en) 2012-09-25 2013-09-23 Combination of regorafenib and acetylsalicylic acid for treating cancer

Publications (2)

Publication Number Publication Date
EA201500365A1 EA201500365A1 (ru) 2015-08-31
EA032023B1 true EA032023B1 (ru) 2019-03-29

Family

ID=46963566

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201500365A EA032023B1 (ru) 2012-09-25 2013-09-23 Комбинация регорафениба и ацетилсалициловой кислоты для лечения рака

Country Status (29)

Country Link
US (1) US10898500B2 (enExample)
EP (1) EP2900269B1 (enExample)
JP (1) JP6294888B2 (enExample)
KR (1) KR102210575B1 (enExample)
CN (1) CN104994876A (enExample)
AU (1) AU2013322854B2 (enExample)
BR (1) BR112015006686B1 (enExample)
CA (1) CA2885688C (enExample)
CL (1) CL2015000744A1 (enExample)
CY (1) CY1120939T1 (enExample)
DK (1) DK2900269T3 (enExample)
EA (1) EA032023B1 (enExample)
ES (1) ES2687985T3 (enExample)
HK (1) HK1214169A1 (enExample)
HR (1) HRP20181462T1 (enExample)
HU (1) HUE039878T2 (enExample)
IL (1) IL237690B (enExample)
LT (1) LT2900269T (enExample)
MX (1) MX357035B (enExample)
MY (1) MY183969A (enExample)
NZ (1) NZ705860A (enExample)
PH (1) PH12015500587A1 (enExample)
PL (1) PL2900269T3 (enExample)
PT (1) PT2900269T (enExample)
RS (1) RS57875B1 (enExample)
SG (2) SG11201501963RA (enExample)
SI (1) SI2900269T1 (enExample)
WO (1) WO2014048881A1 (enExample)
ZA (1) ZA201502840B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI633087B (zh) 2012-06-13 2018-08-21 赫孚孟拉羅股份公司 新穎二氮雜螺環烷及氮雜螺環烷
HRP20191937T1 (hr) 2012-09-25 2020-01-10 F. Hoffmann - La Roche Ag Derivati heksahidropirolo [3,4-c]pirola i srodni spojevi kao inhibitori autotaksina (atx) i kao inhibitori proizvodnje lizofosfatidne kiseline (lpa) za liječenje npr. bubrežnih bolesti
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
LT3074400T (lt) 2013-11-26 2018-02-12 F. Hoffmann-La Roche Ag Oktahidro-ciklobuta [1,2-c;3,4-c`]dipirolo dariniai kaip autotaksino inhibitoriai
EA037928B1 (ru) 2014-03-26 2021-06-08 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
PE20161223A1 (es) 2014-03-26 2016-11-12 Hoffmann La Roche Compuestos condensados de [1,4]diazepina como inhibidores de la produccion de autotaxina (atx) y acido lisofosfatidico (lpa)
CN104829523B (zh) * 2014-04-30 2017-10-31 药源药物化学(上海)有限公司 瑞戈非尼盐及其晶型、制备方法
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
MX377277B (es) 2015-09-04 2025-03-07 Hoffmann La Roche Derivados de fenoximetilo.
CN105267167A (zh) * 2015-09-11 2016-01-27 江苏嘉逸医药有限公司 一种瑞戈非尼口服固体药物组合物的制备方法
CA2991615A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
AU2016328535A1 (en) 2015-09-24 2017-11-09 F. Hoffmann-La Roche Ag Bicyclic compounds as ATX inhibitors
AU2016328365B2 (en) 2015-09-24 2020-04-23 F. Hoffmann-La Roche Ag New bicyclic compounds as dual ATX/CA inhibitors
EP3353178B1 (en) 2015-09-24 2021-07-14 F. Hoffmann-La Roche AG Bicyclic compounds as dual atx/ca inhibitors
DK3474858T3 (da) * 2016-06-28 2021-11-22 Asamedic As Tokomponentsammensætning omfattende acetylsalicylsyre
JP7090099B2 (ja) 2017-03-16 2022-06-23 エフ.ホフマン-ラ ロシュ アーゲー Atxインヒビターとしての新規二環式化合物
BR112019019017A2 (pt) 2017-03-16 2020-04-14 Hoffmann La Roche compostos heterocíclicos de utilidade como inibidores duplos de atx/ca
HUE066487T2 (hu) * 2017-06-02 2024-08-28 Bayer Healthcare Llc Regorafenib és nivolumab kombinációja rák kezelésére
EP3501522A1 (en) 2017-12-22 2019-06-26 Asamedic AS Compositions comprising acetylsalicylic acid and a phosphate salt
EP3501523A1 (en) 2017-12-22 2019-06-26 Asamedic AS Two-component compositions comprising acetyl salicylic acid and a carbonate salt
KR20210156389A (ko) 2020-06-17 2021-12-27 재단법인대구경북과학기술원 레고라페닙을 유효성분으로 포함하는 염증질환의 예방 또는 치료용 약학적 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040121004A1 (en) * 2002-12-20 2004-06-24 Rajneesh Taneja Dosage forms containing a PPI, NSAID, and buffer
US20050038080A1 (en) * 2003-07-23 2005-02-17 Stephen Boyer Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
WO2007054303A2 (en) * 2005-11-10 2007-05-18 Bayer Healthcare Ag Diaryl urea for treating diabetic neuropathy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620834B1 (en) * 1999-07-02 2003-09-16 Hisamitsu Pharmaceutical Co., Inc. Medicinal compositions for treating colorectal cancer
AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
GB201002530D0 (en) * 2010-02-15 2010-03-31 Univ Wolverhampton The Di-aspirin derivatives
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040121004A1 (en) * 2002-12-20 2004-06-24 Rajneesh Taneja Dosage forms containing a PPI, NSAID, and buffer
US20050038080A1 (en) * 2003-07-23 2005-02-17 Stephen Boyer Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
WO2007054303A2 (en) * 2005-11-10 2007-05-18 Bayer Healthcare Ag Diaryl urea for treating diabetic neuropathy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Axel Grothey ET AL.: "Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial for the CORRECT Study Group", vol. 381, no. 9863 26 January 2013 (2013-01-26), pages 303-312, XP055085767, England ISSN: 1474-547X, DOI: 10.1016/S0140-6736(12)61900-X Retrieved from the Internet: URL:http://www.sciencedirect.com/science/article/pii/S014067361261900X/pdfft?md5=e17489b174c639b82e7af7ee8d13a5a6&pid=1-s2.0-S014067361261900X-main.pdf [retrieved on 2013-10-29] the whole document *
Burn J. ET AL.: "Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial", vol. 378, no. 9809 17 December 2011 (2011-12-17), pages 2081-2087, XP055085755, DOI: 10.1016/S0140-6736(11)61049-0 Retrieved from the Internet: URL:http://www.sciencedirect.com/science/article/pii/S0140673611610490/pdfft?md5=19ba873b6a5e35d3b91007d03cd8334a&pid=1-s2.0-S0140673611610490-main.pdf [retrieved on 2013-10-29] the whole document *

Also Published As

Publication number Publication date
CY1120939T1 (el) 2019-12-11
IL237690B (en) 2019-07-31
EP2900269B1 (en) 2018-08-01
DK2900269T3 (en) 2018-10-01
JP6294888B2 (ja) 2018-03-14
PL2900269T3 (pl) 2019-02-28
IL237690A0 (en) 2015-05-31
WO2014048881A1 (en) 2014-04-03
SI2900269T1 (sl) 2018-10-30
LT2900269T (lt) 2018-11-12
NZ705860A (en) 2018-07-27
SG10201702356VA (en) 2017-04-27
US10898500B2 (en) 2021-01-26
MY183969A (en) 2021-03-17
EP2900269A1 (en) 2015-08-05
ZA201502840B (en) 2017-11-29
CA2885688C (en) 2021-03-02
BR112015006686B1 (pt) 2022-04-05
ES2687985T3 (es) 2018-10-30
HRP20181462T1 (hr) 2018-11-02
BR112015006686A2 (pt) 2019-08-27
US20150202214A1 (en) 2015-07-23
AU2013322854A1 (en) 2015-04-02
HUE039878T2 (hu) 2019-02-28
PH12015500587A1 (en) 2015-05-11
CN104994876A (zh) 2015-10-21
RS57875B1 (sr) 2018-12-31
CL2015000744A1 (es) 2016-01-08
CA2885688A1 (en) 2014-04-03
SG11201501963RA (en) 2015-04-29
HK1214169A1 (zh) 2016-07-22
JP2015529234A (ja) 2015-10-05
MX2015003728A (es) 2015-09-23
KR20150060869A (ko) 2015-06-03
PT2900269T (pt) 2018-10-22
EA201500365A1 (ru) 2015-08-31
MX357035B (es) 2018-06-25
AU2013322854B2 (en) 2018-07-19
KR102210575B1 (ko) 2021-02-02

Similar Documents

Publication Publication Date Title
EA032023B1 (ru) Комбинация регорафениба и ацетилсалициловой кислоты для лечения рака
TWI428322B (zh) 4-〔4-({〔4-氯-3-(三氟甲基)苯基〕胺甲醯基}胺基)-3-氟苯氧基〕-n-甲基吡啶-2-羧醯胺單水合物
AU2023282197B2 (en) Combination of regorafenib and PD-1/PD-L1(2) inhibitors for treating cancer
ES2291690T3 (es) Derivados de furopiridina para el tratamiento de trastornos hiperproliferativos.
RU2774838C2 (ru) Комбинация регорафениба и ингибиторов pd-1/pd-l1(2) для лечения рака
WO2021160708A1 (en) Combination of regorafenib and msln-ttc for treating cancer
HK40015063A (en) Combination of regorafenib and pd-1/pd-l1(2) inhibitors for treating cancer

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG TJ TM