EA032023B1 - Комбинация регорафениба и ацетилсалициловой кислоты для лечения рака - Google Patents

Комбинация регорафениба и ацетилсалициловой кислоты для лечения рака Download PDF

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Publication number
EA032023B1
EA032023B1 EA201500365A EA201500365A EA032023B1 EA 032023 B1 EA032023 B1 EA 032023B1 EA 201500365 A EA201500365 A EA 201500365A EA 201500365 A EA201500365 A EA 201500365A EA 032023 B1 EA032023 B1 EA 032023B1
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EA
Eurasian Patent Office
Prior art keywords
ser
gly
thr
leu
gin
Prior art date
Application number
EA201500365A
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English (en)
Russian (ru)
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EA201500365A1 (ru
Inventor
Олаф Вебер
Карл Цигельбауер
Original Assignee
Байер Фарма Акциенгезельшафт
Байер Аг
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46963566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA032023(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байер Фарма Акциенгезельшафт, Байер Аг filed Critical Байер Фарма Акциенгезельшафт
Publication of EA201500365A1 publication Critical patent/EA201500365A1/ru
Publication of EA032023B1 publication Critical patent/EA032023B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201500365A 2012-09-25 2013-09-23 Комбинация регорафениба и ацетилсалициловой кислоты для лечения рака EA032023B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12185852 2012-09-25
PCT/EP2013/069735 WO2014048881A1 (en) 2012-09-25 2013-09-23 Combination of regorafenib and acetylsalicylic acid for treating cancer

Publications (2)

Publication Number Publication Date
EA201500365A1 EA201500365A1 (ru) 2015-08-31
EA032023B1 true EA032023B1 (ru) 2019-03-29

Family

ID=46963566

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201500365A EA032023B1 (ru) 2012-09-25 2013-09-23 Комбинация регорафениба и ацетилсалициловой кислоты для лечения рака

Country Status (29)

Country Link
US (1) US10898500B2 (enExample)
EP (1) EP2900269B1 (enExample)
JP (1) JP6294888B2 (enExample)
KR (1) KR102210575B1 (enExample)
CN (1) CN104994876A (enExample)
AU (1) AU2013322854B2 (enExample)
BR (1) BR112015006686B1 (enExample)
CA (1) CA2885688C (enExample)
CL (1) CL2015000744A1 (enExample)
CY (1) CY1120939T1 (enExample)
DK (1) DK2900269T3 (enExample)
EA (1) EA032023B1 (enExample)
ES (1) ES2687985T3 (enExample)
HK (1) HK1214169A1 (enExample)
HR (1) HRP20181462T1 (enExample)
HU (1) HUE039878T2 (enExample)
IL (1) IL237690B (enExample)
LT (1) LT2900269T (enExample)
MX (1) MX357035B (enExample)
MY (1) MY183969A (enExample)
NZ (1) NZ705860A (enExample)
PH (1) PH12015500587A1 (enExample)
PL (1) PL2900269T3 (enExample)
PT (1) PT2900269T (enExample)
RS (1) RS57875B1 (enExample)
SG (2) SG10201702356VA (enExample)
SI (1) SI2900269T1 (enExample)
WO (1) WO2014048881A1 (enExample)
ZA (1) ZA201502840B (enExample)

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SI2861566T1 (sl) 2012-06-13 2017-03-31 F. Hoffmann-La Roche Ag Novi diazaspirocikloalkan in azaspirocikloalkan
PL2900669T3 (pl) 2012-09-25 2020-01-31 F. Hoffmann-La Roche Ag Pochodne heksahydropirolo[3,4-C]pirolu i związki pokrewne jako inhibitory autotaksyny (ATX) oraz inhibitory produkcji kwasu lizofosfatydowego (LPA) do leczenia np. chorób nerek
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
AU2014356583B2 (en) 2013-11-26 2019-02-28 F. Hoffmann-La Roche Ag New octahydro-cyclobuta (1,2-c;3,4-c')dipyrrol-2-yl
CR20160418A (es) 2014-03-26 2016-11-07 Hoffmann La Roche Nuevos compuestos biciclicos de 7 eslabones
MA50635A (fr) 2014-03-26 2020-08-12 Hoffmann La Roche Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique
CN104829523B (zh) * 2014-04-30 2017-10-31 药源药物化学(上海)有限公司 瑞戈非尼盐及其晶型、制备方法
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
EP3344619B1 (en) 2015-09-04 2020-10-28 H. Hoffnabb-La Roche Ag Phenoxymethyl derivatives
CN105267167A (zh) * 2015-09-11 2016-01-27 江苏嘉逸医药有限公司 一种瑞戈非尼口服固体药物组合物的制备方法
MA42918A (fr) 2015-09-24 2018-08-01 Hoffmann La Roche Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
BR112018006080A2 (pt) 2015-09-24 2018-10-09 F. Hoffmann-La Roche Ag novos compostos bicíclicos como inibidores de dupla ação de atx/ca
AU2016328437A1 (en) 2015-09-24 2018-01-25 F. Hoffmann-La Roche Ag Bicyclic compounds as ATX inhibitors
WO2017050747A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
LT3474858T (lt) * 2016-06-28 2021-12-27 Asamedic As Dviejų komponentų kompozicija, apimanti acetilsalicilo rūgštį
EP3596060B1 (en) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG New bicyclic compounds as atx inhibitors
RU2019132254A (ru) 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
PT3630112T (pt) * 2017-06-02 2024-04-23 Bayer Healthcare Llc Combinação de regorafenib e nivolumab para tratamento de cancro
EP3501522A1 (en) 2017-12-22 2019-06-26 Asamedic AS Compositions comprising acetylsalicylic acid and a phosphate salt
EP3501523A1 (en) 2017-12-22 2019-06-26 Asamedic AS Two-component compositions comprising acetyl salicylic acid and a carbonate salt
KR20210156389A (ko) 2020-06-17 2021-12-27 재단법인대구경북과학기술원 레고라페닙을 유효성분으로 포함하는 염증질환의 예방 또는 치료용 약학적 조성물

Citations (3)

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US20040121004A1 (en) * 2002-12-20 2004-06-24 Rajneesh Taneja Dosage forms containing a PPI, NSAID, and buffer
US20050038080A1 (en) * 2003-07-23 2005-02-17 Stephen Boyer Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
WO2007054303A2 (en) * 2005-11-10 2007-05-18 Bayer Healthcare Ag Diaryl urea for treating diabetic neuropathy

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WO2001002014A1 (en) * 1999-07-02 2001-01-11 Hisamitsu Pharmaceutical Co., Inc. Medicinal compositions for treating colorectal cancer
AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
GB201002530D0 (en) * 2010-02-15 2010-03-31 Univ Wolverhampton The Di-aspirin derivatives
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US20040121004A1 (en) * 2002-12-20 2004-06-24 Rajneesh Taneja Dosage forms containing a PPI, NSAID, and buffer
US20050038080A1 (en) * 2003-07-23 2005-02-17 Stephen Boyer Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
WO2007054303A2 (en) * 2005-11-10 2007-05-18 Bayer Healthcare Ag Diaryl urea for treating diabetic neuropathy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Axel Grothey ET AL.: "Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial for the CORRECT Study Group", vol. 381, no. 9863 26 January 2013 (2013-01-26), pages 303-312, XP055085767, England ISSN: 1474-547X, DOI: 10.1016/S0140-6736(12)61900-X Retrieved from the Internet: URL:http://www.sciencedirect.com/science/article/pii/S014067361261900X/pdfft?md5=e17489b174c639b82e7af7ee8d13a5a6&pid=1-s2.0-S014067361261900X-main.pdf [retrieved on 2013-10-29] the whole document *
Burn J. ET AL.: "Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial", vol. 378, no. 9809 17 December 2011 (2011-12-17), pages 2081-2087, XP055085755, DOI: 10.1016/S0140-6736(11)61049-0 Retrieved from the Internet: URL:http://www.sciencedirect.com/science/article/pii/S0140673611610490/pdfft?md5=19ba873b6a5e35d3b91007d03cd8334a&pid=1-s2.0-S0140673611610490-main.pdf [retrieved on 2013-10-29] the whole document *

Also Published As

Publication number Publication date
HK1214169A1 (zh) 2016-07-22
EP2900269A1 (en) 2015-08-05
US20150202214A1 (en) 2015-07-23
AU2013322854A1 (en) 2015-04-02
PH12015500587A1 (en) 2015-05-11
HUE039878T2 (hu) 2019-02-28
KR102210575B1 (ko) 2021-02-02
WO2014048881A1 (en) 2014-04-03
ZA201502840B (en) 2017-11-29
MY183969A (en) 2021-03-17
EP2900269B1 (en) 2018-08-01
US10898500B2 (en) 2021-01-26
BR112015006686A2 (pt) 2019-08-27
AU2013322854B2 (en) 2018-07-19
CL2015000744A1 (es) 2016-01-08
SI2900269T1 (sl) 2018-10-30
CY1120939T1 (el) 2019-12-11
MX2015003728A (es) 2015-09-23
IL237690A0 (en) 2015-05-31
PL2900269T3 (pl) 2019-02-28
CA2885688C (en) 2021-03-02
CA2885688A1 (en) 2014-04-03
ES2687985T3 (es) 2018-10-30
HRP20181462T1 (hr) 2018-11-02
JP6294888B2 (ja) 2018-03-14
SG11201501963RA (en) 2015-04-29
SG10201702356VA (en) 2017-04-27
CN104994876A (zh) 2015-10-21
DK2900269T3 (en) 2018-10-01
KR20150060869A (ko) 2015-06-03
BR112015006686B1 (pt) 2022-04-05
MX357035B (es) 2018-06-25
JP2015529234A (ja) 2015-10-05
EA201500365A1 (ru) 2015-08-31
PT2900269T (pt) 2018-10-22
LT2900269T (lt) 2018-11-12
RS57875B1 (sr) 2018-12-31
NZ705860A (en) 2018-07-27
IL237690B (en) 2019-07-31

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