EA031798B1 - Применение ифенпродила для лечения диабета - Google Patents

Применение ифенпродила для лечения диабета Download PDF

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Publication number
EA031798B1
EA031798B1 EA201590849A EA201590849A EA031798B1 EA 031798 B1 EA031798 B1 EA 031798B1 EA 201590849 A EA201590849 A EA 201590849A EA 201590849 A EA201590849 A EA 201590849A EA 031798 B1 EA031798 B1 EA 031798B1
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EA
Eurasian Patent Office
Prior art keywords
ifenprodil
glucose
metformin
diabetes
use according
Prior art date
Application number
EA201590849A
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English (en)
Russian (ru)
Other versions
EA201590849A1 (ru
Inventor
Даниель Коэн
Илья Чумаков
Сергей Набирошкин
Родольф Аж
Original Assignee
Фарнекст
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Publication of EA201590849A1 publication Critical patent/EA201590849A1/ru
Publication of EA031798B1 publication Critical patent/EA031798B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EA201590849A 2012-10-30 2013-10-30 Применение ифенпродила для лечения диабета EA031798B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261720156P 2012-10-30 2012-10-30
EP12306354.7A EP2727587A1 (en) 2012-10-30 2012-10-30 Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
PCT/EP2013/072728 WO2014068007A1 (en) 2012-10-30 2013-10-30 Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level

Publications (2)

Publication Number Publication Date
EA201590849A1 EA201590849A1 (ru) 2015-11-30
EA031798B1 true EA031798B1 (ru) 2019-02-28

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EA201590849A EA031798B1 (ru) 2012-10-30 2013-10-30 Применение ифенпродила для лечения диабета

Country Status (17)

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US (2) US10092554B2 (OSRAM)
EP (3) EP2727587A1 (OSRAM)
JP (2) JP6387010B2 (OSRAM)
KR (1) KR20150081323A (OSRAM)
CN (2) CN110141663A (OSRAM)
AU (2) AU2013340826B2 (OSRAM)
BR (1) BR112015009702A2 (OSRAM)
CA (1) CA2888576C (OSRAM)
EA (1) EA031798B1 (OSRAM)
ES (2) ES2870028T3 (OSRAM)
HK (1) HK1214168A1 (OSRAM)
IL (1) IL238283A0 (OSRAM)
MX (1) MX2015005368A (OSRAM)
NZ (1) NZ707139A (OSRAM)
SG (2) SG10201801695XA (OSRAM)
WO (1) WO2014068007A1 (OSRAM)
ZA (1) ZA201503110B (OSRAM)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2819664T (pt) * 2012-03-01 2017-08-24 Pharnext Novas composições para tratar esclerose lateral amiotrófica
WO2014036528A2 (en) 2012-08-31 2014-03-06 Ixchel Pharma, Llc Agents useful for treating obesity, diabetes and related disorders
US9171343B1 (en) 2012-09-11 2015-10-27 Aseko, Inc. Means and method for improved glycemic control for diabetic patients
US9897565B1 (en) 2012-09-11 2018-02-20 Aseko, Inc. System and method for optimizing insulin dosages for diabetic subjects
JP6540505B2 (ja) * 2013-03-29 2019-07-10 国立大学法人 熊本大学 ２型糖尿病治療剤
ES2959444T3 (es) 2013-04-04 2024-02-26 Boehringer Ingelheim Vetmedica Gmbh Tratamiento de trastornos metabólicos en animales equinos
WO2015063140A1 (en) 2013-10-30 2015-05-07 Pharnext Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
AU2014364999B2 (en) 2013-12-17 2019-12-12 Boehringer Ingelheim Vetmedica Gmbh Treatment of metabolic disorders in feline animals
EP3096765B1 (en) 2014-01-23 2018-12-05 Boehringer Ingelheim Vetmedica GmbH Treatment of metabolic disorders in canine animals
US9898585B2 (en) 2014-01-31 2018-02-20 Aseko, Inc. Method and system for insulin management
US9486580B2 (en) 2014-01-31 2016-11-08 Aseko, Inc. Insulin management
AU2015217796B2 (en) 2014-02-11 2020-04-30 Pharnext Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders
KR20250096885A (ko) 2014-04-01 2025-06-27 베링거잉겔하임베트메디카게엠베하 말과 동물에서 대사 장애의 치료
US9839644B2 (en) 2014-09-09 2017-12-12 ARKAY Therapeutics, LLC Formulations and methods for treatment of metabolic syndrome
HUE068152T2 (hu) 2014-09-25 2024-12-28 Boehringer Ingelheim Vetmedica Gmbh SGLT2-gátlók és dopamin agonisták kombinációs kezelése anyagcserezavarok megelõzésére lófélékben
AU2015339576B2 (en) 2014-10-27 2020-02-06 Glytec, Llc Subcutaneous outpatient management
US11081226B2 (en) 2014-10-27 2021-08-03 Aseko, Inc. Method and controller for administering recommended insulin dosages to a patient
CN104434952B (zh) * 2014-12-08 2017-10-24 成都恒瑞制药有限公司 一种治疗糖尿病的药物组合物及其制备方法
CN105055413A (zh) * 2015-07-23 2015-11-18 上海市第六人民医院 一种小檗碱和瑞格列奈的药物组合物
EP3337402B1 (en) 2015-08-20 2026-01-07 Glytec, LLC Diabetes management therapy advisor
EP3341024B1 (en) 2015-08-27 2024-10-09 Boehringer Ingelheim Vetmedica GmbH Liquid pharmaceutical compositions comprising sglt-2 inhibitors
US12359209B2 (en) 2018-04-17 2025-07-15 The Johns Hopkins Unversity Recombinant therapeutic interventions for cancer
US10918700B2 (en) * 2019-04-12 2021-02-16 Sdg, Inc. Lipid-based nanoparticles and use of same in optimized insulin dosing regimens
US12396983B2 (en) * 2020-02-07 2025-08-26 Neuroventi Composition comprising rilmenidine compound as active ingredient for treatment of fragile X syndrome or related developmental disability
US20240009292A1 (en) * 2020-10-01 2024-01-11 The Johns Hopkins University Bcg based vaccine compositions and methods of use thereof
CN112294827B (zh) * 2020-11-12 2021-12-24 四川大学华西医院 5-胆甾烯 -3β-醇硫酸酯盐的用途
KR102543789B1 (ko) * 2021-03-08 2023-06-20 주식회사 온코크로스 토르세미드 및 크로몰린을 포함하는 대사질환 예방 또는 치료용 조성물
CN114786683B (zh) 2021-04-09 2024-01-12 北京大学 一种siRNA、药物组合物以及使用其治疗糖尿病的方法
WO2022225984A1 (en) * 2021-04-19 2022-10-27 Spruce Health Sciences Inc. Nutritional supplement for regulating blood sugar
KR20250038064A (ko) 2023-09-11 2025-03-19 김강숙 산양삼을 함유하는 김부각의 제조 방법 및 그 방법에 의해 제조된 김부각

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030162754A1 (en) * 2001-12-17 2003-08-28 Tufts University Use of GABA and GABAB agonists
WO2004011003A1 (en) * 2002-07-25 2004-02-05 Pharmacia Italia S.P.A. Nicergoline, mmdl and mdl for the treatment of neurodegenerative disorders of the retina and optic nerve
US20050025714A1 (en) * 1997-10-01 2005-02-03 Novadel Pharma, Inc. Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders
GB2432526A (en) * 2005-11-24 2007-05-30 Arakis Ltd Use of ifenprodil for the treatment of ophthalmic diseases
EP1884513A1 (en) * 2005-05-23 2008-02-06 Japan Tobacco, Inc. Pyrazole compound and therapeutic agent for diabetes comprising the same
US20080213362A1 (en) * 2007-02-02 2008-09-04 Lawrence Solomon Compositions and methods using torsemide
WO2008141189A1 (en) * 2007-05-09 2008-11-20 Elixir Pharmaceuticals, Inc. Ghrelin modulating compounds and combinations thereof
WO2014013025A1 (en) * 2012-07-18 2014-01-23 Pharnext Baclofen and acamprosate based therapy of macular degeneration disorders

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2314719A1 (fr) * 1975-04-11 1977-01-14 Roussel Uclaf Nouveau medicament notamment diuretique
IT1157365B (it) * 1977-10-24 1987-02-11 Sandoz Ag Medicamenti per trattare l'obesita' o ridurre il peso del corpo
US5019591A (en) * 1989-02-17 1991-05-28 Pennsylvania Research Corporation Method for treating retinopathy and other small vessel disorders associated with diabetes
JPH059114A (ja) * 1990-08-29 1993-01-19 Takeda Chem Ind Ltd 糖尿病性合併症の予防・治療剤
JP4821037B2 (ja) 2000-08-25 2011-11-24 富士通株式会社 ラマン増幅を用いた光増幅器およびラマン励起光源
ATE362757T1 (de) * 2001-01-26 2007-06-15 Schering Corp Kombinationen eines hemmers der sterolabsorption und eines kardiovaskulären wirkstoffes zur behandlung von kardiovaskulären indikationen
JP2005519918A (ja) * 2002-01-30 2005-07-07 ファルマシア・コーポレーション 病因性状態を予防または治療するためのアルドステロン受容体拮抗剤およびα−アドレナリン作用変調剤の組み合わせ治療
WO2005089741A2 (en) * 2004-03-17 2005-09-29 Sosei R&D Ltd. The treatment of inflammatory disorders and pain using beta-aminoalcohols
AU2006245717B8 (en) * 2005-05-10 2010-10-14 Laboratoires Fournier S.A. Novel use of liver X receptor agonists
EP1829534A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome
WO2007098939A1 (en) * 2006-02-28 2007-09-07 Laboratorios Del Dr. Esteve, S.A. Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome
CL2008000683A1 (es) * 2007-03-09 2008-08-01 Indigene Pharmaceuticals Inc Composicion farmaceutica que comprende metformina r-(+) lipoato y un inhibidor de la enzima de conversion de angiotensina (ace); formulacion de dosis unitaria; y uso en el tratamiento de la diabetes.
US20090054473A1 (en) * 2007-08-22 2009-02-26 Gilead Colorado, Inc. Therapy for complications of diabetes
US20110046076A1 (en) * 2009-02-13 2011-02-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
UA113165C2 (xx) * 2011-03-01 2016-12-26 Застосування комбінації баклофену і акампросату для лікування неврологічних захворювань та композиція, яка містить баклофен і акампросат
AU2012312266A1 (en) * 2011-09-21 2013-05-02 Gilead Sciences, Inc. Sodium channel blockers reduce glucagon secretion

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050025714A1 (en) * 1997-10-01 2005-02-03 Novadel Pharma, Inc. Buccal, polar and non-polar spray or capsule containing drugs for treating metabolic disorders
US20030162754A1 (en) * 2001-12-17 2003-08-28 Tufts University Use of GABA and GABAB agonists
WO2004011003A1 (en) * 2002-07-25 2004-02-05 Pharmacia Italia S.P.A. Nicergoline, mmdl and mdl for the treatment of neurodegenerative disorders of the retina and optic nerve
EP1884513A1 (en) * 2005-05-23 2008-02-06 Japan Tobacco, Inc. Pyrazole compound and therapeutic agent for diabetes comprising the same
GB2432526A (en) * 2005-11-24 2007-05-30 Arakis Ltd Use of ifenprodil for the treatment of ophthalmic diseases
US20080213362A1 (en) * 2007-02-02 2008-09-04 Lawrence Solomon Compositions and methods using torsemide
WO2008141189A1 (en) * 2007-05-09 2008-11-20 Elixir Pharmaceuticals, Inc. Ghrelin modulating compounds and combinations thereof
WO2014013025A1 (en) * 2012-07-18 2014-01-23 Pharnext Baclofen and acamprosate based therapy of macular degeneration disorders

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
"Metformin/Repaglinide (PrandiMet) for type 2 diabetes.", THE MEDICAL LETTER ON DRUGS AND THERAPEUTICS, USA, vol. 51, no. 1313, 1 June 2009 (2009-06-01), USA, pages 41 - 43, XP009177448, ISSN: 1523-2859 *
ANGHINAH R; OLIVEIRA A S B; GABBAL A A: "Effect of baclofen on pain in diabetic neuropathy [4]", MUSCLE AND NERVEMUSCLE, vol. 17, no. 8, 1 August 1994 (1994-08-01), pages 958 - 959, XP009177368, ISSN: 0148-639X *
BEALES P E, ET AL.: "BACLOFEN, A GAMMA-AMINOBUTYRIC ACID-B RECEPTOR AGONIST, DELAYS DIABETES ONSETIN THE NON-OBESE DIABETIC MOUSE", ACTA DIABETOLOGICA., SPRINGER INTERNATIONAL, BERLIN., DE, vol. 32, no. 01, 1 March 1995 (1995-03-01), DE, pages 53 - 56, XP001095343, ISSN: 0940-5429, DOI: 10.1007/BF00581047 *
CRINQUETTE J-F; COLOMBEL J-F; MAY J P; CHANTRE M; CLAERBOUT J-F; BONVARLET F; BONVARLET P: "A DIFFUSE FORM OF DUCTAL ECTASIA OF THE PANCREAS", GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE, PARIS, FR, vol. 12, no. 11, 1 January 1988 (1988-01-01), FR, pages 866 - 867, XP009175923, ISSN: 0399-8320 *
DUNN C. J., PETERS D. H.: "A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC USE IN NON-INSULIN-DEPENDENT DIABETES MELLITUS.", DRUGS, ADIS INTERNATIONAL LTD., NZ, vol. 49., no. 05., 1 May 1995 (1995-05-01), NZ, pages 721 - 749., XP000921043, ISSN: 0012-6667, DOI: 10.2165/00003495-199549050-00007 *
FREYRIA J: "Clinical trial with an antiischemic drug in atherosclerotic and diabetic arteriopathies = Essai de la thérapeutique anti-ischémique dans le traitement des artériopathies de surchage", GAZETTE MEDICALE DE FRANCE., PARIS., FR, vol. 82, no. 16, 1 January 1975 (1975-01-01), FR, pages 1989 - 1990, 1993-1996, XP009175880, ISSN: 0016-5557 *
GOMEZ R, ET AL.: "GABA AGONISTS DIFFERENTIALLY MODIFY BLOOD GLUCOSE LEVELS OF DIABETIC RATS", JAPANESE JOURNAL OF PHARMACOLOGY., THE JAPANESE PHARMACOLOGICAL SOCIETY, KYOTO, JP, vol. 80, no. 04, 1 August 1999 (1999-08-01), KYOTO, JP, pages 327 - 331, XP001095576, ISSN: 0021-5198, DOI: 10.1254/jjp.80.327 *
HOLLENBERG N K; MICKIEWICZ C: "HYPERKALEMIA IN DIABETES MELLITUS EFFECT OF A TRIAMTERENE HYDROCHLOROTHIAZIDE COMBINATION", ARCHIVES OF INTERNAL MEDICINE., AMERICAN MEDICAL ASSOCIATION, US, vol. 149, no. 6, 1 June 1989 (1989-06-01), US, pages 1327 - 1330, XP009177371, ISSN: 0003-9926, DOI: 10.1001/archinte.149.6.1327 *
LANGEVIN J. ET AL.: "Etude du tartrate d' ifenprodil dans le traitement des accidents vasculaires c�r�braux aigus", OUEST MEDICAL., EXPANSION SCIENTIFIQUE FRANCAISE, PARIS., FR, vol. 29., 20 May 1976 (1976-05-20), FR, pages 853/854., XP002088157, ISSN: 0048-2366 *
LEHNERT H; SCHMITZ H; BEYER J; WILMBUSSE H; PIESCHE L: "Controlled clinical trial investigating the influence of torasemide and furosemide on carbohydrate metabolism in patients with cardiac failure and concomitant type II diabetes", INTERNATIONAL CONGRESS SERIES., EXCERPTA MEDICA, AMSTERDAM., NL, 1 January 1993 (1993-01-01), NL, pages 271 - 274, XP009177369, ISSN: 0531-5131 *
SABBAH A: "PHARMACOLOGICAL BIOLOGICAL AND CLINICAL EFFECTS OF A NEW ANTI ASTHMATIC FENSPIRIDE", PHARMACOLOGIST, vol. 11, no. 2, 1 January 1969 (1969-01-01), pages 266, XP009177442, ISSN: 0031-7004 *
SALEM H; SHEMANO I; BEILER J M; ORZECHOWSKI R; HITCHENS J T; CLEMENTE E: "FENSPIRIDE A NONSYMPATHOMIMETIC BRONCHO DILATOR WITH ANTI ALLERGIC ACTIVITY", ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, vol. 193, no. 1, 1 January 1971 (1971-01-01), pages 111 - 123, XP009177441, ISSN: 0003-9780 *
SEITZ RUEDIGER J; BLANK BETTINA; KIWIT JUERGEN C W; BENECKE REINER: "Stiff-person syndrome with anti-glutamic acid decarboxylase autoantibodies: Complete remission of symptoms after intrathecal baclofen administration", JOURNAL OF NEUROLOGY - ZEITSCHRIFT FUER NEUROLOGIE, SPRINGER VERLAG, BERLIN., DE, vol. 242, no. 10, 1 October 1995 (1995-10-01), DE, pages 618 - 622, XP009177376, ISSN: 0340-5354, DOI: 10.1007/BF00866910 *
WALKER B R; CAPUZZI D M; ALEXANDER F; FAMILIAR R G; HOPPE R C: "HYPERKALEMIA AFTER TRIAMTERENE IN DIABETIC PATIENTS", CLINICAL PHARMACOLOGY AND THERAPEUTICS, NATURE PUBLISHING GROUP, US, vol. 13, no. 5, part 1, 1 January 1972 (1972-01-01), US, pages 643 - 651, XP009168825, ISSN: 0009-9236, DOI: 10.1002/cpt1972135part1643 *
WEICHENHAIN B, KOOTEN VAN H-J, STANDL E: "HYPERTENSION AND INSULIN RESISTANCE GLYCAEMIA AND INSULINAEMIA IN OVERWEIGHT HYPERTENSIVE PATIENTS", DRUGS, ADIS INTERNATIONAL LTD., NZ, vol. 46, no. SUPPL. 02, 1 January 1993 (1993-01-01), NZ, pages 183 - 188, XP001097733, ISSN: 0012-6667, DOI: 10.2165/00003495-199300462-00028 *
YAMASHITA S; NUMOTO T; TAKENAGA K; SHIMIZU K; YAMAURA T; UMEHARA N; OBA M; AOYAMA M; NOGUCHI K; ET AL: "GENERAL PHARMACOLOGICAL ACTIVITIES OF N-2 METHYL-3-CHLOROPHENYL ANTHRANILIC-ACID GEA-6414", IGAKKAI ZASSHI -JOURNAL OF MEDICAL SOCIETY OF TOHO UNIVERSITY, TOHO DAIGAKU IGAKUBU IGAKKAI, TOKYO, JP, vol. 28, no. 4, 1 January 1981 (1981-01-01), JP, pages 685 - 697, XP009177377, ISSN: 0040-8670 *
Yamashita Y.: "EFFECT OF 2-(4-BENZYL-PIPERIDIN)-1-(4-HYDROXYPHENYL)-1-PROPANOL ON BLOOD GLUCOSE CONCENTRATION", 15 December 1979 (1979-12-15), XP055099599, Retrieved from the Internet: URL:http://ac.els-cdn.com/0006295279903915/1-s2.0-0006295279903915-main.pdf?_tid=bac 12656-8a5b-11e3-a971-00000aab0f6b&acdnat=1391161413_84a229c13ef1d04933704cceb9fledb9 [retrieved on 2014-01-31], the whole document, in particular, page 3503, column 1, paragraph 2 *

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