EA031522B1 - Биоразлагаемая композиция для доставки лекарственного средства (варианты) и способ получения биоразлагаемой композиции (варианты) - Google Patents

Биоразлагаемая композиция для доставки лекарственного средства (варианты) и способ получения биоразлагаемой композиции (варианты) Download PDF

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Publication number
EA031522B1
EA031522B1 EA201492172A EA201492172A EA031522B1 EA 031522 B1 EA031522 B1 EA 031522B1 EA 201492172 A EA201492172 A EA 201492172A EA 201492172 A EA201492172 A EA 201492172A EA 031522 B1 EA031522 B1 EA 031522B1
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EA
Eurasian Patent Office
Prior art keywords
biodegradable
poly
composition
lactic acid
active principle
Prior art date
Application number
EA201492172A
Other languages
English (en)
Russian (ru)
Other versions
EA201492172A1 (ru
Inventor
Жорж Годриол
Кристоф Роберже
Original Assignee
Мединселл
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Application filed by Мединселл filed Critical Мединселл
Publication of EA201492172A1 publication Critical patent/EA201492172A1/ru
Publication of EA031522B1 publication Critical patent/EA031522B1/ru

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201492172A 2012-06-27 2013-06-27 Биоразлагаемая композиция для доставки лекарственного средства (варианты) и способ получения биоразлагаемой композиции (варианты) EA031522B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261665192P 2012-06-27 2012-06-27
PCT/IB2013/001547 WO2014001904A1 (en) 2012-06-27 2013-06-27 Biodegradable drug delivery for hydrophobic compositions

Publications (2)

Publication Number Publication Date
EA201492172A1 EA201492172A1 (ru) 2015-09-30
EA031522B1 true EA031522B1 (ru) 2019-01-31

Family

ID=49117888

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201492172A EA031522B1 (ru) 2012-06-27 2013-06-27 Биоразлагаемая композиция для доставки лекарственного средства (варианты) и способ получения биоразлагаемой композиции (варианты)

Country Status (23)

Country Link
US (5) US20150150987A1 (enExample)
EP (1) EP2866837B1 (enExample)
JP (1) JP6134788B2 (enExample)
KR (1) KR102189442B1 (enExample)
CN (1) CN104582733B (enExample)
AU (1) AU2013282891B2 (enExample)
BR (1) BR112014031773B1 (enExample)
CA (1) CA2877083C (enExample)
CL (1) CL2014003531A1 (enExample)
CO (1) CO7160098A2 (enExample)
CR (1) CR20140581A (enExample)
CU (1) CU24287B1 (enExample)
EA (1) EA031522B1 (enExample)
ES (1) ES2938586T3 (enExample)
IL (1) IL236472B (enExample)
IN (1) IN2014DN11063A (enExample)
MA (1) MA37809B1 (enExample)
MX (1) MX353280B (enExample)
SG (1) SG11201408658PA (enExample)
TN (1) TN2014000520A1 (enExample)
UA (1) UA113549C2 (enExample)
WO (2) WO2014001905A1 (enExample)
ZA (1) ZA201409291B (enExample)

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CA2856520C (en) 2011-11-23 2021-04-06 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
UA119324C2 (uk) * 2013-04-02 2019-06-10 Теміс Медікер Лімітед Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні
AU2014306759B2 (en) 2013-08-12 2018-04-26 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
WO2015095391A1 (en) 2013-12-17 2015-06-25 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
WO2015110915A2 (en) * 2014-01-27 2015-07-30 Medincell Retro-inverso analogs of spadin display increased antidepressant effects
AR100562A1 (es) 2014-05-22 2016-10-12 Therapeuticsmd Inc Composición farmacéutica de estradiol y progesterona para terapia de reemplazo hormonal
WO2016010771A1 (en) 2014-07-17 2016-01-21 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
US20170290846A1 (en) * 2014-09-30 2017-10-12 University Of Tennessee Research Foundation In situ gelling form for long-acting drug delivery
CA2964628A1 (en) 2014-10-20 2016-04-28 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
FR3027522B1 (fr) 2014-10-27 2016-12-09 I Ceram Composition poreuse chargee en principe actif
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
FI3377041T3 (fi) * 2015-11-16 2023-11-30 Medincell S A Menetelmä farmaseuttisesti aktiivisten pääainesosien morselloimiseksi ja/tai kohdentamiseksi synoviaalikudokseen
AU2017239645A1 (en) 2016-04-01 2018-10-18 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
WO2018081138A1 (en) * 2016-10-24 2018-05-03 Yale University Biodegradable contraceptive implants
JP2020511483A (ja) 2017-03-20 2020-04-16 テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーTeva Pharmaceuticals International GmbH 徐放性オランザピン製剤
MX2020000618A (es) * 2017-07-17 2020-09-28 Medincell Composicion farmaceutica.
GB2568526A (en) 2017-11-20 2019-05-22 Rebio Tech Oy Composition
CN108078911A (zh) * 2017-12-08 2018-05-29 复旦大学 用于动物避孕的热致水凝胶缓释兽药注射剂及其制备方法
US12252556B2 (en) 2018-08-22 2025-03-18 Bacainn Biotherapeutics, Ltd. Cyclosporine compositions and methods of use
GB201900258D0 (en) 2019-01-08 2019-02-27 Medincell Pharmaceutical composition
EP4027973B8 (en) * 2019-09-13 2025-12-17 Medincell S.A. Drug delivery formulations
CN111700876A (zh) * 2020-03-12 2020-09-25 上海市肿瘤研究所 一种治疗系统性红斑狼疮的载药递送给药系统及其制备方法
CN116847827A (zh) 2020-12-16 2023-10-03 美蒂森股份公司 用于预防性治疗SARS-CoV-2病毒(COVID-19)的方法和组合物
FI20215186A1 (en) 2021-02-19 2022-08-20 Rebio Tech Oy Compositions for ophthalmic treatment
EP4308077A1 (en) 2021-03-17 2024-01-24 MedinCell S.A. Long acting injectable formulation comprising risperidone and biodegradable polymers
JP2024516264A (ja) * 2021-04-30 2024-04-12 メディンセル エスアー 新規製剤
WO2025081046A1 (en) * 2023-10-11 2025-04-17 The Brigham And Women's Hospital, Inc. Ultra-high drug loading injectable drug suspension of hydrophobic drugs for long-term drug delivery

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WO1993000070A1 (en) * 1991-06-28 1993-01-07 Endorecherche Inc. Controlled release systems and low dose androgens
WO1993024154A1 (en) * 1992-06-03 1993-12-09 Fuisz Technologies, Ltd. Biodegradable controlled release melt-spun delivery system
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US6350812B1 (en) * 1995-11-29 2002-02-26 Centre National De La Recherche Scientifique (Cnrs) Hydrogels containing triblock copolymers, and preparation and use thereof
WO2002045689A1 (en) * 2000-12-07 2002-06-13 Samyang Corporation Compositions for sustained delivery of hydrophobic drugs and process for the preparation thereof
US6592899B2 (en) * 2001-10-03 2003-07-15 Macromed Incorporated PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
US20050112170A1 (en) * 2003-11-20 2005-05-26 Hossainy Syed F. Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same
WO2007019439A2 (en) * 2005-08-04 2007-02-15 Angiotech International Ag Block copolymer compositions and uses thereof
WO2009129509A2 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Methods and compositions for treating post-operative pain comprising a local anesthetic
CN101810560A (zh) * 2009-02-20 2010-08-25 北京大学 环孢a聚合物胶束组合物
EP2359860A2 (en) * 2008-11-21 2011-08-24 Samyang Corporation Polymer micelle composition for treatment of resistant cancer cells
WO2012090070A2 (en) * 2010-12-29 2012-07-05 Medincell Biodegradable drug delivery compositions

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US4745160A (en) * 1984-06-26 1988-05-17 Imperial Chemical Industries Plc Biodegradable amphipathic copolymers
WO1993000070A1 (en) * 1991-06-28 1993-01-07 Endorecherche Inc. Controlled release systems and low dose androgens
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WO1997010849A1 (en) * 1995-09-21 1997-03-27 Sam Yang Co., Ltd. Copolymeric micelle drug composition and method for the preparation thereof
US6350812B1 (en) * 1995-11-29 2002-02-26 Centre National De La Recherche Scientifique (Cnrs) Hydrogels containing triblock copolymers, and preparation and use thereof
WO2002045689A1 (en) * 2000-12-07 2002-06-13 Samyang Corporation Compositions for sustained delivery of hydrophobic drugs and process for the preparation thereof
US6592899B2 (en) * 2001-10-03 2003-07-15 Macromed Incorporated PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water
US20050112170A1 (en) * 2003-11-20 2005-05-26 Hossainy Syed F. Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same
WO2007019439A2 (en) * 2005-08-04 2007-02-15 Angiotech International Ag Block copolymer compositions and uses thereof
WO2009129509A2 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Methods and compositions for treating post-operative pain comprising a local anesthetic
EP2359860A2 (en) * 2008-11-21 2011-08-24 Samyang Corporation Polymer micelle composition for treatment of resistant cancer cells
CN101810560A (zh) * 2009-02-20 2010-08-25 北京大学 环孢a聚合物胶束组合物
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Publication number Publication date
AU2013282891A1 (en) 2015-01-22
CU24287B1 (es) 2017-12-08
ZA201409291B (en) 2017-05-31
CU20140148A7 (es) 2015-03-30
CR20140581A (es) 2015-02-06
US20190160171A1 (en) 2019-05-30
MX2014015902A (es) 2015-07-17
IN2014DN11063A (enExample) 2015-09-25
US20200085958A1 (en) 2020-03-19
CL2014003531A1 (es) 2015-08-28
AU2013282891B2 (en) 2018-04-12
JP2015522001A (ja) 2015-08-03
US20220354956A1 (en) 2022-11-10
CN104582733A (zh) 2015-04-29
BR112014031773A2 (pt) 2017-06-27
MA37809A1 (fr) 2017-07-31
BR112014031773B1 (pt) 2020-10-13
KR20150027265A (ko) 2015-03-11
US20150150987A1 (en) 2015-06-04
UA113549C2 (xx) 2017-02-10
AU2013282891A2 (en) 2015-02-05
ES2938586T3 (es) 2023-04-12
SG11201408658PA (en) 2015-02-27
CA2877083A1 (en) 2014-01-02
EA201492172A1 (ru) 2015-09-30
EP2866837A1 (en) 2015-05-06
IL236472A0 (en) 2015-02-26
WO2014001904A1 (en) 2014-01-03
KR102189442B1 (ko) 2020-12-11
IL236472B (en) 2020-02-27
CA2877083C (en) 2020-10-06
US20210008216A1 (en) 2021-01-14
WO2014001905A1 (en) 2014-01-03
MA37809B1 (fr) 2018-12-31
JP6134788B2 (ja) 2017-05-24
CN104582733B (zh) 2017-07-04
HK1208374A1 (en) 2016-03-04
TN2014000520A1 (en) 2016-03-30
EP2866837B1 (en) 2022-12-14
MX353280B (es) 2018-01-05
CO7160098A2 (es) 2015-01-15

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