EA030410B1 - Замещенные конденсированные гетероциклы в качестве модуляторов gpr119 для лечения диабета, ожирения, дислипидемии и связанных нарушений - Google Patents
Замещенные конденсированные гетероциклы в качестве модуляторов gpr119 для лечения диабета, ожирения, дислипидемии и связанных нарушений Download PDFInfo
- Publication number
- EA030410B1 EA030410B1 EA201692008A EA201692008A EA030410B1 EA 030410 B1 EA030410 B1 EA 030410B1 EA 201692008 A EA201692008 A EA 201692008A EA 201692008 A EA201692008 A EA 201692008A EA 030410 B1 EA030410 B1 EA 030410B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- oxy
- pyridyl
- cyclopropylmethoxy
- oxopyrrolidin
- pyridin
- Prior art date
Links
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C07—ORGANIC CHEMISTRY
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- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (2)
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|---|---|---|---|
| EP14305494 | 2014-04-04 | ||
| PCT/EP2015/057414 WO2015150564A1 (en) | 2014-04-04 | 2015-04-02 | Substituted fused heterocycles as gpr119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders |
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| EA201692008A1 EA201692008A1 (ru) | 2017-02-28 |
| EA030410B1 true EA030410B1 (ru) | 2018-07-31 |
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| EA201692008A EA030410B1 (ru) | 2014-04-04 | 2015-04-02 | Замещенные конденсированные гетероциклы в качестве модуляторов gpr119 для лечения диабета, ожирения, дислипидемии и связанных нарушений |
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| AP2016009521A0 (en) | 2014-04-04 | 2016-10-31 | Lundbeck & Co As H | Halogenated quinazolin-thf-amines as pde1 inhibitors |
| TW201625605A (zh) | 2014-04-04 | 2016-07-16 | 賽諾菲公司 | 用於治療糖尿病、肥胖、血脂異常及相關病症之作為ｇｐｒ１１９調節劑的經取代之稠合雜環類 |
| TWI784968B (zh) | 2016-09-09 | 2022-12-01 | 丹麥商西蘭製藥公司 | 澱粉素類似物 |
| US10392366B2 (en) | 2017-02-21 | 2019-08-27 | Sanofi | Azetidine compounds as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders |
| WO2019043635A1 (en) | 2017-09-01 | 2019-03-07 | Richter Gedeon Nyrt. | COMPOUNDS INHIBITING THE ACTIVITY OF D-AMINO ACID OXIDASE |
| JP7265276B2 (ja) * | 2018-05-31 | 2023-04-26 | 華領医薬技術（上海）有限公司 | グルコキナーゼ活性化剤およびｓｇｌｔ－２阻害薬を含む医薬品の組合せ、組成物、配合剤、ならびにその調製方法および使用 |
| KR102131359B1 (ko) * | 2018-09-07 | 2020-07-07 | 오토텔릭바이오 주식회사 | 안정성이 향상된 의약 조성물 |
| EP3976053A4 (en) * | 2019-05-31 | 2022-11-23 | Avolynt | COMPOSITIONS AND METHODS OF TREATING A METABOLIC DISEASE |
| JP7502811B2 (ja) * | 2019-11-05 | 2024-06-19 | レスバーロジックス コーポレイション | Ｂｅｔブロモドメイン阻害物質およびナトリウム依存性グルコース輸送体２阻害物質の組み合わせで主要な心血管有害事象（ｍａｃｅ）を処置および／または予防する方法 |
| PH12022552277A1 (en) | 2020-02-28 | 2024-03-04 | Kallyope Inc | Gpr40 agonists |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| JP2023531726A (ja) | 2020-06-26 | 2023-07-25 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004110994A1 (en) * | 2003-06-18 | 2004-12-23 | Pfizer Products Inc. | Novel piperazinyl-aryloxy and piperazinyl-heteroaryloxy-n-aryl lactams |
| WO2007124254A2 (en) * | 2006-04-21 | 2007-11-01 | Eli Lilly And Company | Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| WO2011146335A1 (en) * | 2010-05-17 | 2011-11-24 | Array Biopharma Inc. | Piperidinyl-substituted lactams as gpr119 modulators |
| US20110306599A1 (en) * | 2009-11-25 | 2011-12-15 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010048149A2 (en) | 2008-10-20 | 2010-04-29 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
| AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
| JP2013537234A (ja) | 2010-09-17 | 2013-09-30 | アレイ バイオファーマ、インコーポレイテッド | Ｇｐｒ１１９モジュレーターとしてのピペリジニル置換ラクタム |
| CA2853784A1 (en) | 2011-11-11 | 2013-05-16 | Glaxosmithkline Llc | Treatment of blood lipid abnormalities and other conditions |
| TW201625605A (zh) | 2014-04-04 | 2016-07-16 | 賽諾菲公司 | 用於治療糖尿病、肥胖、血脂異常及相關病症之作為ｇｐｒ１１９調節劑的經取代之稠合雜環類 |
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2015
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- 2015-04-01 AR ARP150100989A patent/AR099936A1/es unknown
- 2015-04-02 CR CR20160460A patent/CR20160460A/es unknown
- 2015-04-02 SG SG11201606758SA patent/SG11201606758SA/en unknown
- 2015-04-02 PE PE2016001909A patent/PE20161378A1/es not_active Application Discontinuation
- 2015-04-02 KR KR1020167026911A patent/KR20160132885A/ko not_active Withdrawn
- 2015-04-02 EP EP15713528.6A patent/EP3126336B1/en active Active
- 2015-04-02 EA EA201692008A patent/EA030410B1/ru not_active IP Right Cessation
- 2015-04-02 MA MA39346A patent/MA39346B1/fr unknown
- 2015-04-02 MX MX2016013033A patent/MX2016013033A/es unknown
- 2015-04-02 WO PCT/EP2015/057414 patent/WO2015150564A1/en not_active Ceased
- 2015-04-02 AU AU2015239021A patent/AU2015239021A1/en not_active Abandoned
- 2015-04-02 CN CN201580017438.3A patent/CN106164073A/zh active Pending
- 2015-04-02 CA CA2942753A patent/CA2942753A1/en not_active Abandoned
- 2015-04-02 JP JP2016560725A patent/JP2017509679A/ja not_active Abandoned
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2016
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- 2016-08-15 PH PH12016501619A patent/PH12016501619A1/en unknown
- 2016-09-29 IL IL248129A patent/IL248129A0/en unknown
- 2016-09-30 CL CL2016002497A patent/CL2016002497A1/es unknown
- 2016-10-03 US US15/284,213 patent/US9758520B2/en not_active Expired - Fee Related
- 2016-10-04 EC ECIEPI201678779A patent/ECSP16078779A/es unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004110994A1 (en) * | 2003-06-18 | 2004-12-23 | Pfizer Products Inc. | Novel piperazinyl-aryloxy and piperazinyl-heteroaryloxy-n-aryl lactams |
| WO2007124254A2 (en) * | 2006-04-21 | 2007-11-01 | Eli Lilly And Company | Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| US20110306599A1 (en) * | 2009-11-25 | 2011-12-15 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
| WO2011146335A1 (en) * | 2010-05-17 | 2011-11-24 | Array Biopharma Inc. | Piperidinyl-substituted lactams as gpr119 modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201606758SA (en) | 2016-09-29 |
| JP2017509679A (ja) | 2017-04-06 |
| EP3126336A1 (en) | 2017-02-08 |
| ECSP16078779A (es) | 2017-02-24 |
| MX2016013033A (es) | 2017-01-09 |
| CA2942753A1 (en) | 2015-10-08 |
| AU2015239021A1 (en) | 2016-10-13 |
| CL2016002497A1 (es) | 2017-03-31 |
| KR20160132885A (ko) | 2016-11-21 |
| IL248129A0 (en) | 2016-11-30 |
| TW201625605A (zh) | 2016-07-16 |
| PE20161378A1 (es) | 2016-12-26 |
| EA201692008A1 (ru) | 2017-02-28 |
| PH12016501619A1 (en) | 2017-02-06 |
| US20170022198A1 (en) | 2017-01-26 |
| US9758520B2 (en) | 2017-09-12 |
| DOP2016000212A (es) | 2016-11-15 |
| CR20160460A (es) | 2017-02-21 |
| MA39346A1 (fr) | 2017-09-29 |
| CN106164073A (zh) | 2016-11-23 |
| MA39346B1 (fr) | 2019-03-29 |
| AR099936A1 (es) | 2016-08-31 |
| EP3126336B1 (en) | 2018-12-05 |
| WO2015150564A1 (en) | 2015-10-08 |
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