EA028434B1 - Лечение рака ингибиторами tor киназы - Google Patents

Лечение рака ингибиторами tor киназы Download PDF

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Publication number
EA028434B1
EA028434B1 EA201491694A EA201491694A EA028434B1 EA 028434 B1 EA028434 B1 EA 028434B1 EA 201491694 A EA201491694 A EA 201491694A EA 201491694 A EA201491694 A EA 201491694A EA 028434 B1 EA028434 B1 EA 028434B1
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EA
Eurasian Patent Office
Prior art keywords
overexpression
patient
twenty
stereoisomer
ethyl
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EA201491694A
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English (en)
Russian (ru)
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EA201491694A1 (ru
Inventor
Шуйчань Сюй
Кристен Мей Хедж
Original Assignee
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
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Publication of EA201491694A1 publication Critical patent/EA201491694A1/ru
Publication of EA028434B1 publication Critical patent/EA028434B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EA201491694A 2012-03-15 2013-03-14 Лечение рака ингибиторами tor киназы EA028434B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261611370P 2012-03-15 2012-03-15
US201261715329P 2012-10-18 2012-10-18
PCT/US2013/031202 WO2013138556A1 (en) 2012-03-15 2013-03-14 Treatment of cancer with tor kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201491694A1 EA201491694A1 (ru) 2015-06-30
EA028434B1 true EA028434B1 (ru) 2017-11-30

Family

ID=47998542

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491694A EA028434B1 (ru) 2012-03-15 2013-03-14 Лечение рака ингибиторами tor киназы

Country Status (20)

Country Link
US (1) US20130245029A1 (https=)
EP (1) EP2825168B1 (https=)
JP (2) JP2015516375A (https=)
KR (3) KR102057358B1 (https=)
CN (2) CN107137402A (https=)
AU (1) AU2013203156C1 (https=)
BR (1) BR112014022697A2 (https=)
CA (1) CA2867349A1 (https=)
EA (1) EA028434B1 (https=)
ES (1) ES2677908T3 (https=)
IL (2) IL234640B (https=)
MX (1) MX360877B (https=)
MY (1) MY182650A (https=)
NI (1) NI201400109A (https=)
NZ (1) NZ628421A (https=)
PH (2) PH12014502048B1 (https=)
SG (1) SG11201405706TA (https=)
TW (2) TWI664968B (https=)
WO (1) WO2013138556A1 (https=)
ZA (1) ZA201406709B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
PE20151995A1 (es) 2013-01-16 2016-01-13 Signal Pharm Llc Compuestos sustituidos de pirrolopirimidina, composiciones de los mismos, y metodos de tratamiento con los mismos
CN105377299B (zh) 2013-04-17 2018-06-12 西格诺药品有限公司 用于治疗前列腺癌的包含二氢吡嗪并-吡嗪化合物和雄激素受体拮抗剂的组合疗法
CA2908742C (en) 2013-04-17 2021-06-01 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer
WO2014172436A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
US9505764B2 (en) 2013-04-17 2016-11-29 Signal Pharmaceuticals, Llc Treatment of cancer with dihydropyrazino-pyrazines
CA2909579A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer
US9630966B2 (en) 2013-04-17 2017-04-25 Signal Pharmaceuticals, Llc Treatment of cancer with dihydropyrazino-pyrazines
CA2909629C (en) 2013-04-17 2022-12-13 Signal Pharmaceuticals, Llc Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
NZ629486A (en) 2013-05-29 2017-11-24 Signal Pharm Llc Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
US9512129B2 (en) 2014-04-16 2016-12-06 Signal Pharmaceuticals, Llc Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
ES2823756T3 (es) 2014-04-16 2021-05-10 Signal Pharm Llc Métodos para tratar el cáncer usando terapia de combinación de inhibidores de quinasa TOR
WO2015160882A1 (en) 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc SOLID FORMS COMPRISING 7-(6-(2-HYDROXYPROPAN-2YL) PYRIDIN-3-YL)-1-(TRANS)-4-METHOXYCYCLOHEXYL)-3, 4-DIHYDROPYRAZINO[2,3-b] PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
NZ629796A (en) 2014-07-14 2015-12-24 Signal Pharm Llc Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
WO2016010886A1 (en) 2014-07-14 2016-01-21 Signal Pharmaceuticals, Llc Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
JP6883653B2 (ja) 2016-12-20 2021-06-09 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ アミノ−トリアゾロピリジン化合物および癌の治療におけるその使用
TWI787284B (zh) 2017-06-22 2022-12-21 美商西建公司 以b型肝炎病毒感染表徵之肝細胞癌之治療
BR202019004173Y1 (pt) 2018-03-01 2024-02-20 Essilor International Dispositivo óptico
CN216310444U (zh) 2018-03-01 2022-04-15 依视路国际公司 镜片元件
CN113493471B (zh) * 2020-04-03 2024-06-11 山东轩竹医药科技有限公司 杂芳环类激酶抑制剂

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008051493A2 (en) * 2006-10-19 2008-05-02 Signal Pharmaceuticals, Llc Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
WO2008051494A1 (en) * 2006-10-19 2008-05-02 Signal Pharmaceuticals, Llc Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors
WO2010062571A1 (en) * 2008-10-27 2010-06-03 Signal Pharmaceuticals, Llc Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway
WO2011133668A2 (en) * 2010-04-20 2011-10-27 President And Fellows Of Harvard College Methods and compositions for the treatment of cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201500511TA (en) 2009-10-26 2015-03-30 Signal Pharm Llc Methods Of Synthesis And Purification Of Heteroaryl Compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008051493A2 (en) * 2006-10-19 2008-05-02 Signal Pharmaceuticals, Llc Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
WO2008051494A1 (en) * 2006-10-19 2008-05-02 Signal Pharmaceuticals, Llc Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors
WO2010062571A1 (en) * 2008-10-27 2010-06-03 Signal Pharmaceuticals, Llc Mtor kinase inhibitors for oncology indications and diseases associated with the mtor/p13k/akt pathway
WO2011133668A2 (en) * 2010-04-20 2011-10-27 President And Fellows Of Harvard College Methods and compositions for the treatment of cancer

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
ANA S. MARTINS, ET AL.: "Insulin-Like Growth Factor IReceptor Pathway Inhibition byADW742, Alone or in Combinationwith Imatinib,Doxorubicin, orVincristine, Is a Novel Therapeutic Approach in EwingTumor", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH., US, vol. 12, no. 11, 1 June 2006 (2006-06-01), US, pages 3532 - 3540, XP002551195, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-05-1778 *
BALAMUTH, N.J. ; WOMER, R.B.: "Ewing's sarcoma", THE LANCET ONCOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 11, no. 2, 1 February 2010 (2010-02-01), AMSTERDAM, NL, pages 184 - 192, XP026884321, ISSN: 1470-2045, DOI: 10.1016/S1470-2045(09)70286-4 *
DANCEY JANET E; MONZON JOSE: "Ridaforolimus: a promising drug in the treatment of soft-tissue sarcoma and other malignancies", FUTURE ONCOLOGY, UK, vol. 7, no. 7, 1 July 2011 (2011-07-01), UK, pages 827 - 839, XP009169333, ISSN: 1744-8301, DOI: 10.2217/fon.11.57 *
LORI BERK; MONICA M. MITA; JEFF KREISBERG; CAMILLE L. BEDROSIAN; ANTHONY W. TOLCHER; TIM CLACKSON; VICTOR M. RIVERA: "Analysis of the pharmacodynamic activity of the mTOR inhibitor ridaforolimus (AP23573, MK-8669) in a phase 1 clinical trial", CANCER CHEMOTHERAPY AND PHARMACOLOGY, SPRINGER, BERLIN, DE, vol. 69, no. 5, 10 January 2012 (2012-01-10), Berlin, DE, pages 1369 - 1377, XP035047366, ISSN: 1432-0843, DOI: 10.1007/s00280-011-1813-7 *
MARK AGULNIK: "New developments in mammalian target of rapamycin inhibitors for the treatment of sarcoma", CANCER, ¬JOHN WILEY & SONS| :, vol. 118, no. 6, 15 March 2012 (2012-03-15), pages 1486 - 1497, XP055061618, ISSN: 0008543X, DOI: 10.1002/cncr.26361 *
MITA M M, MITA A C, CHU Q S, ROWINSKY E K, FETTERLY G J, GOLDSTON M, PATNAIK A, MATHEWS L, RICART A D, MAYS T, KNOWLES H, RIVERA V: "Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies.", JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, USA, vol. 26, no. 3, 20 January 2008 (2008-01-20), USA, pages 361 - 367, XP002696908, ISSN: 1527-7755, DOI: 10.1200/JCO.2007.12.0345 *
OIKAWA T: "ETS TRANSCRIPTION FACTORS: POSSIBLE TARGETS FOR CANCER THERAPY", CANCER SCIENCE, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 95, no. 08, 1 August 2004 (2004-08-01), JP, pages 626 - 633, XP009039358, ISSN: 1347-9032, DOI: 10.1111/j.1349-7006.2004.tb03320.x *
P. C. HOLLENHORST, M. W. FERRIS, M. A. HULL, H. CHAE, S. KIM, B. J. GRAVES: "Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells", GENES & DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, vol. 25, no. 20, 15 October 2011 (2011-10-15), pages 2147 - 2157, XP055061642, ISSN: 08909369, DOI: 10.1101/gad.17546311 *
R. M. SQUILLACE, D. MILLER, M. COOKSON, S. D. WARDWELL, L. MORAN, D. CLAPHAM, F. WANG, T. CLACKSON, V. M. RIVERA: "Antitumor Activity of Ridaforolimus and Potential Cell-Cycle Determinants of Sensitivity in Sarcoma and Endometrial Cancer Models", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, INC., vol. 10, no. 10, 1 October 2011 (2011-10-01), pages 1959 - 1968, XP055061614, ISSN: 15357163, DOI: 10.1158/1535-7163.MCT-11-0273 *
SILVIA MATEO-LOZANO, OSCAR M TIRADO AND VICENTE NOTARIO: "Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation.", ONCOGENE, vol. 22, no. 58, 18 December 2003 (2003-12-18), pages 9282 - 9287, XP002665931, ISSN: 0950-9232, DOI: 10.1038/SJ.ONC.1207081 *
VINCENZI BRUNO; NAPOLITANO ANDREA; D'ONOFRIO LORETTA; FREZZA ANNA MARIA; SILLETTA MARIANNA; VENDITTI OLGA; SANTINI DANIELE; TONINI: "Targeted therapy in sarcomas: mammalian target of rapamycin inhibitors from bench to bedside", EXPERT OPINION ON INVESTIGATIONAL DRUGS, INFORMA HEALTHCARE, UNITED KINGDOM, vol. 20, no. 12, 1 December 2011 (2011-12-01), United Kingdom, pages 1685 - 1705, XP009169335, ISSN: 1744-7658, DOI: 10.1517/13543784.2011.628984 *
VIVEK SUBBIAH, AUNG NAING, ROBERT E. BROWN, HELEN CHEN, LAURENCE DOYLE, PATRICIA LORUSSO, ROBERT BENJAMIN, PETE ANDERSON, RAZELLE : "Targeted Morphoproteomic Profiling of Ewing's Sarcoma Treated with Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors: Response/Resistance Signatures", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, vol. 6, no. 4, 1 January 2011 (2011-01-01), pages e18424 - e18424, XP055061616, ISSN: 19326203, DOI: 10.1371/journal.pone.0018424 *

Also Published As

Publication number Publication date
TWI664968B (zh) 2019-07-11
PH12018502234A1 (en) 2019-08-14
TW201343167A (zh) 2013-11-01
MX2014011117A (es) 2015-04-08
JP2018065820A (ja) 2018-04-26
IL234640A0 (en) 2014-11-30
JP6470821B2 (ja) 2019-02-13
AU2013203156A1 (en) 2013-10-03
KR20200034818A (ko) 2020-03-31
JP2015516375A (ja) 2015-06-11
IL274318A (en) 2020-06-30
MY182650A (en) 2021-01-27
US20130245029A1 (en) 2013-09-19
HK1201755A1 (en) 2015-09-11
KR20190058673A (ko) 2019-05-29
NI201400109A (es) 2015-01-15
AU2013203156B2 (en) 2015-12-10
BR112014022697A2 (pt) 2020-06-30
TWI600428B (zh) 2017-10-01
CN104302295A (zh) 2015-01-21
CA2867349A1 (en) 2013-09-19
IL234640B (en) 2020-05-31
NZ628421A (en) 2016-04-29
ES2677908T3 (es) 2018-08-07
AU2013203156C1 (en) 2016-02-18
MX360877B (es) 2018-11-21
PH12018502234B1 (en) 2021-07-23
TW201733586A (zh) 2017-10-01
KR20140138929A (ko) 2014-12-04
WO2013138556A1 (en) 2013-09-19
ZA201406709B (en) 2016-07-27
EA201491694A1 (ru) 2015-06-30
SG11201405706TA (en) 2014-10-30
PH12014502048A1 (en) 2014-12-10
PH12014502048B1 (en) 2020-10-28
CN107137402A (zh) 2017-09-08
EP2825168A1 (en) 2015-01-21
CN104302295B (zh) 2017-06-20
KR102057358B1 (ko) 2019-12-18
EP2825168B1 (en) 2018-05-09

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