EA028017B1 - Method for producing an agent having anti-inflammatory activity from vegetable raw material - Google Patents

Abstract

The invention is related to pharmacy, in particular, to a method for producing an agent having anti-inflammatory activity, namely, common licorice syrup, from vegetable raw material. The objective of the method according to the invention is higher yield of the extractive substance and subsequent use of common licorice in combination with widely used kinds of vegetable raw materials, production of an agent having anti-inflammatory activity. Proposed are preparations based on common licorice syrup suitable for use by children and people for whom ethanol tinctures are contraindicated. The syrup is prepared using aqueous extract of common licorice at room temperature, without heating, with addition of fruit-berry extracts and/or condensed juices and/or extracts of medicinal plants. The anti-inflammatory preparations produced are non-toxic and easily absorbed.

Description

The invention relates to pharmacy and relates to a method for producing funds from plant materials, namely, licorice syrups with anti-inflammatory activity.

Inflammation, as a general biological reaction to various pathogenic irritants, lies at the heart of a myriad group of diseases and often leads to disability and disability of the population. The use of synthetic drugs with an anti-inflammatory effect is accompanied by the development of pronounced adverse reactions and complications.

The disadvantages of the tools used and the increasing requirements of modern therapy actualize the search for new, effective and low-toxic antiflogistics among medicinal plants that could have a complex effect, provide a prolonged effect with a minimum of side effects and the possibility of long-term use.

A known method of obtaining a thick extract of licorice, purified water, with a ratio of raw materials: water 1: 5 at a temperature of 70-80 ° C, vigorous stirring for 5-6 hours (ΑΖ patent No. 20090055, 2009).

The disadvantage of this method is the complexity of the technology for obtaining the final product, namely the elevated temperature and reaction time.

A known method of obtaining the extract from medicinal raw materials, where the extraction is carried out for 2 days using 0.5% ammonium hydroxide, then precipitated with 96% ethanol, filtered, the resulting liquid extract is concentrated by evaporation (ΑΖ patent No. P960014, 1994).

The disadvantage is the presence of ethanol and the use of a large amount of irritating reagent - ammonium hydroxide.

The closest is a method of obtaining a medicinal syrup based on a thick extract of licorice naked with the addition of a liquid extract of hawthorn obtained with a water-alcohol extractant and sugar syrup (ΑΖ Patent No. 20090056, 2009).

A disadvantage of the known syrup is the presence of ethyl alcohol in the final product, which limits its use (children, pregnant women, etc.).

The objective of the proposed method is to increase the yield of extractives with the subsequent use of licorice extract in combination with widespread types of plant materials, obtaining funds with anti-inflammatory activity.

The problem is achieved by the fact that the method includes grinding the roots and rhizomes of licorice naked up to 3 mm, extraction with purified water during heating and constant stirring, followed by filtration, mixing with syrup, where according to the invention the licorice roots are extracted with bare purified room temperature water at a ratio of 1 : 5-7 during the day, then a fresh portion of the crushed licorice roots is immersed in the resulting infusion and left for a day, the liquid part is drained and the licorice roots are well outlived, after of the resulting extract was filtered, concentrated, and then condensed licorice extract-administered rafida sugar syrup or its substitute, is further added fruity berry extract or condensed juice and / or aqueous extract of medicinal plants at a ratio of 1: 6-7; according to the invention, pomegranate juice and / or hawthorn extract and / or sea buckthorn extract and / or barberry extract and / or rosehip extract and / or blueberry juice and / or grape juice and / or juice are taken as fruit and berry syrup currants and / or gooseberry juice and / or raspberry and / or strawberry juice and / or blackberry juice and / or dogwood juice and / or pear juice and / or medlar juice and / or juniper extract; according to the invention, calendula and / or horsetail extract of field and / or motherwort and / or chamomile and / or thyme and / or elecampane roots and / or elderberry and / or marshmallow roots are taken as medicinal plants and / or peppermint, and / or nettle, and / or lemon balm, and / or St. John's wort, and / or string, and / or valerian, and / or immortelle, and / or Echinacea, and / or plantain, and / or clover , and / or anise, and / or hops, and / or Tribulus terrestris, and / or Golden root, and / or parsley.

The essence of the alleged invention is the creation of preparations based on the extract of licorice, suitable for use by children and people who are contraindicated in tinctures on ethanol.

Methods for the isolation of active (biologically active) substances from plant materials, in particular medicinal plants, by extraction of both aboveground and underground parts of these plants are widely known in the pharmaceutical, cosmetic, food, and medical industries.

Plants serve as an important source of active compositions and compounds used in medicine. New plants, new compounds from plants, or even modifications of compounds found in plants, are of great interest to phytomedicine.

The methods used in the extraction of components from plants are of great importance not only in terms of the yield of the obtained compounds, but also in the chemical nature of those compounds that can actually be obtained. It is promising to create antibacterial herbal preparations with additional therapeutic properties: detoxifying, antipyretic, anti-inflammatory, expectorant, antispasmodic, anti-allergic, which will allow a comprehensive approach to solving the problem, to provide relief of the symptoms of the infection process, especially in mild and moderate forms.

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The pharmacological properties of licorice are determined by its chemical composition.

The expectorant properties of licorice are associated with the content of glycyrrhizin in the roots of the plant, it has a cortisone-like effect, similar to steroid hormones, it enhances the cortical layer of the adrenal glands, stimulates the activity of the ciliary epithelium in the trachea and bronchi, and also enhances the secretory function of the mucous membranes of the upper respiratory tract.

In addition, licorice root and its extracts have an antispasmodic and wound healing effect on smooth muscles, as they contain flavone compounds, among which the most active are liquivirozide and liquivirton.

Galenic licorice root preparations are widely used in medical practice as an expectorant, enveloping and softening cough remedy for diseases of the upper respiratory tract, mainly in the presence of poorly separated, thick and viscous secretions, as well as with far-reaching inflammatory manifestations, especially in children and individuals advanced age.

Licorice root is also prescribed for peptic ulcer of the stomach and duodenum, in chronic inflammatory conditions of the gastrointestinal tract, especially with increased acidity of the gastric juice.

The therapeutic efficacy of licorice root is quite high (especially its therapeutic enveloping properties) and diverse. In this regard, for a narrower, but more effective use of the therapeutic effect of the plant, we have created compositions based on thick licorice root syrup with juice or extracts based on berries, fruits and medicinal plants. The syrup was prepared in a standard way on refined sugar or its substitute at the rate of 95 parts of sugar syrup and 5 parts of a thick extract of licorice root.

Fruit and berry juices or their extracts, as well as extracts of medicinal plants, contain a large amount of vitamins and other biologically active substances that soften the sugary taste of licorice, the syrup acquires the color and smell of that berry, fruit or extract of medicinal plants on the basis of which the extract is prepared .

Purified water (FS22619-97) is obtained by distillation on a DE4 brand apparatus.

When using the ratio of purified water to crushed licorice roots above the claimed limit, the amount of biologically active substances recovered decreases, and below it leads to an increase in the yield of ballast substances.

When using the ratio of fruit and berry juice or extract or extract of medicinal plants to the crushed licorice roots above the claimed limit leads to fermentation, and below to sugaring.

The proposed anti-inflammatory agent based on the roots and rhizomes of licorice with berry syrups is prepared as follows.

Condensed fruit and berry juice, or an aqueous extract, or an aqueous extract of medicinal plants, is preliminarily prepared. Then, sugar syrup is prepared from refined sugar or its substitute at a ratio of 36:64 parts of water and refined sugar, boiled until boiling, foam is collected, then cooled to room temperature.

Shredded licorice roots are placed in the flask and poured with purified water at room temperature within the claimed limits, closed with a ground lid. The flask is placed for 24 hours in a dark room, sometimes shaken. Then, on the second day, a new portion of licorice root is poured over and kept for another 24 hours in a dark room. After this, the licorice root infusion is drained and the licorice roots are squeezed out well, the saturated infusion obtained is filtered and concentrated (until the moisture content is not more than 25%). The prepared infusion of refined sugar syrup or its substitute is introduced into the obtained infusion. Then, extracts or condensed fruit-berry juice or extracts of medicinal plants are introduced into the finished licorice syrup, and fruits, berries or medicinal plants are taken in equal amounts. The obtained biologically active licorice syrup is used as a preparation for various diseases.

The alleged invention is illustrated by the following examples.

Cholagogue.

Example 1

Take 100 g of crushed licorice roots and place in a flask with a ground stopper, pour 500 ml (ratio of licorice roots to purified will 1: 5) with purified water at room temperature and left for 24 hours in a dark room, shake several times during this time . After that, 100 g of a fresh portion of crushed licorice is poured into the same flask, closed with a ground stopper and left for another 24 hours. Then the liquid part is poured into another container, and the soaked roots of licorice are carefully squeezed out and the resulting liquid is added to the container with the first liquid. Then the resulting extract is filtered and concentrated in a water bath until the moisture content is not more than 25%. Then, a pre-prepared standard saccharaffinade syrup is introduced into the resulting condensed extract. An extract of a mixture based on barberry, grapes and calendula taken in a ratio of 1: 1: 1 is introduced into the obtained licorice syrup, with a ratio of licorice syrup to a mixture of extract 1: 6. The resulting product is sweet-sour, pleasant smell, dark brown.

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Example 2

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. The extract is the same.

Example 3

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 7. The ratio of licorice syrup to the mixture of extract 1: 7. The extract is the same.

Diuretics

Example 4

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 5. The ratio of licorice syrup to the mixture of extract 1: 6. As an extract, take an extract of juniper and horsetail with the juices of grapes, gooseberries, strawberries, blackberries, lingonberries in a ratio of 1: 1: 1: 1: 1: 1: 1: 1. Sweet and sour taste. Yellowish greenish color. Bouquet of berry smell.

Example 5

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. The extract is the same.

Example 6

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 7. The ratio of licorice syrup to the mixture of extract 1: 7. As an extract, take the extract of the fruits of juniper, horsetail and parsley in a ratio of 1: 1: 1.

Heart remedy.

Example 7

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 5. The ratio of licorice syrup to the mixture of extract 1: 6. As extracts, extract of hawthorn and motherwort in a ratio of 1: 1 are taken. The taste is sweetish-bitter, the smell is dominated by licorice, naked, brown-red.

Example 8

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. The extract is the same.

Example 9

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 7. The ratio of licorice syrup to the mixture of extract 1: 7. The extract is the same.

Multivitamin.

Example 10

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 5. The ratio of licorice syrup to the mixture of extract 1: 6. As an extract, take the condensed juices of sea buckthorn, raspberries, rose hips, currants, taken in a ratio of 1: 1: 1: 1. Pleasant sweet and sour taste of a mixture of berries, the smell of berries, reddish yellow.

Example 11

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. As an extract, take the condensed juices of sea buckthorn, blueberries, currants in a ratio of 1: 1: 1. Pleasant sweet and sour taste and smell of a mixture of berries, reddish yellow.

Example 12

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 7. The ratio of licorice syrup to the mixture of extract 1: 7. Condensed pomegranate juice is taken as an extract. Pleasant sweet and sour taste and smell of pomegranate, dark red.

Antidiarrheal agent.

Example 13

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 5. The ratio of licorice syrup to the mixture of extract 1: 6. As an extract, take condensed juices of pear, dogwood, medlar and chamomile extract, taken in equal quantities. Pleasant sweet and sour taste and smell of juices, yellowish.

Example 14

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. The extract is the same.

Example 15

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 7. The ratio of licorice syrup to the mixture of extract 1: 7. The extract is the same.

Antitussive

Example 16

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. Concentrated extracts are taken as an extract.

- 3 028017 in equal amounts: thyme grass, elecampane roots, rose hips, elderberry flowers, marshmallow roots. The taste is slightly bitter, the color is red-brown, the smell is grassy.

Example 17

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. The extract is the same.

Example 18

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 7. The ratio of licorice syrup to the mixture of extract 1: 7. The extract is the same.

Sedative

Example 19

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. As an extract, take a condensed extract of a mixture of medicinal plants, taken in equal amounts: lemon balm, hypericum, motherwort, valerian, peppermint. The taste is slightly bitter, the smell is mostly mint, the color is greenish-yellow.

Example 20

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. The extract is the same.

Example 21

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 7. The ratio of licorice syrup to the mixture of extract 1: 7. The extract is the same.

Antiallergic agent.

Example 22

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. As an extract, a mixture of medicinal plants of a series of nettles and nettles and condensed juice of tut in equal quantities are taken. The color is yellowish-greenish, the taste is sweet-bitter, the smell is grassy.

Example 23

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. The extract is the same.

Example 24

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 7. The ratio of licorice syrup to the mixture of extract 1: 7. The extract is the same.

Immunostimulating agent.

Example 25

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. As an extract, take a mixture of medicinal plants in equal amounts: echinacea, golden root, rosehip. The color is yellow-brown, the taste is sweetish, the smell is spicy.

Example 26

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. The extract is the same.

Example 27

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 7. The ratio of licorice syrup to the mixture of extract 1: 7. The extract is the same.

Stomachic.

Example 28

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. Medicinal plants in equal amounts are taken as extract: peppermint, clover, plantain. The color is greenish yellow, the taste is bitter-sweet, the smell is mint.

Example 29

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. The extract is the same.

Example 30

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. The extract is the same.

Antisclerotic.

Example 31

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. Medicinal plants in equal amounts are taken as an extract: creeping anchor, hawthorn, rosehip, clover, immortelle. The color is brown - 4 028017 yellow, the taste is bitter-sweet, the smell is grassy.

Example 32

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. The extract is the same.

Example 33

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 7. The ratio of licorice syrup to the mixture of extract 1: 7. The extract is the same.

Antihypertensive, antispasmodic.

Example 34

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. Medicinal plants in equal amounts are taken as extract: peppermint, anise, hawthorn, hops. The color is brown-yellow, the taste is bitter-sweet, the smell is mint.

Example 35

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 6. The ratio of licorice syrup to the mixture of extract 1: 6.5. The extract is the same.

Example 36

Carried out analogously to example 1. The ratio of the roots of licorice naked to purified water 1: 7. The ratio of licorice syrup to the mixture of extract 1: 7. The extract is the same.

Thus, non-toxic, easily digestible anti-inflammatory drugs are proposed.

Claims (3)

CLAIM 1. The method of obtaining funds from plant materials with anti-inflammatory activity, including grinding the roots and rhizomes of licorice bare to a particle size of 3 mm, carrying out the extraction of particles by infusing them in purified water at room temperature at a ratio of 1: 5-7 during the day, adding fresh portions of the particles and re-infusion during the day, separating the obtained extract with the addition of liquid squeezed from the soaked particles into it, filtering and thickening the extract, introducing into it a solution of sugar-raffi nada or its substitute with obtaining syrup and mixing the syrup with an extract or condensed juice prepared from fruit-profitable raw materials and / or aqueous extract of medicinal plants at a ratio of syrup: fruit-extract, and / or juice, and / or extract of medicinal plants 1: 6- 7 2. The method according to claim 1, in which as the fruit and berry raw materials use pomegranate juice, and / or hawthorn extract, and / or sea buckthorn extract, and / or barberry extract, and / or rosehip extract, and / or blueberry juice, and / or grape juice, and / or currant juice, and / or gooseberry juice, and / or raspberry juice, and / or strawberry juice, and / or blackberry juice, and / or cornel juice, and / or pear juice, and / or medlar juice, and / or juniper extract. 3. The method according to claim 1, in which the extract of calendula, and / or horsetail, and / or motherwort, and / or chamomile, and / or thyme herb, and / or deviacila root, and / or elderberry flowers, and / or althea roots, and / or peppermint, and / or nettle, and / or lemon balm, and / or hypericum, and / or succession, and / or valerian, and / or immortelle, and / or echinacea, and / or plantain, and / or clover, and / or anise, and / or hops, and / or yakortsev creeping, and / or golden root, and / or parsley ordinary.