RU2257221C1 - Helminthicide species - Google Patents

Abstract

FIELD: medicine, helminthology, chemical-pharmaceutical industry.

SUBSTANCE: invention relates to the creature of medicinal species used for treatment of helminthism of different etiology. Invention proposes the helminthicide species comprising dried fennel seeds, clove fruits, thyme herb, common wormwood herb, tansy flowers, walnut leaves, tumeric roots, valerian roots and licorice roots in the following ratio, mas. p. p.: fennel seeds, 0.8-1.2; clove fruits, 0.4-0.8; thyme herb, 0.4-0.8; common wormwood herb, 0.8-1.2; tansy flowers, 0.8-1.2; walnut leaves, 0.8-1.2; tumeric roots, 0.4-0.6; valerian roots, 0.24-0.36, and licorice roots, 0.4-0.6. Helmithicide species is used as a powder or a powder placed into a capsule. The species elicits high activity in treatment of different parasitic diseases, such as ascariasis, enterobiasis, lamblialis, infection with flat helminthes and this species shows normalizing effect on functional activity of gastroenteric tract.

EFFECT: valuable medicinal properties of species.

4 cl, 4 ex

Description

The invention relates to medicine, namely to pharmacotherapy, and can be used as a medicine for helminthiases of various etiologies.

It is known that to get rid of helminths, in particular, in the treatment of ascariasis, anthelmintic drugs of the synthetic series are used: piperazine, naphthamone, decaris, etc. (Mashkovsky M.D. Medicines, M., Medicine, 1986, part II, p. 372). These drugs can have a negative side effect in the form of nausea, abdominal pain, headaches. In case of an overdose, for example, piperazine, muscle weakness, tremor are possible. Contraindications to the use of these drugs are organic diseases of the central nervous system and impaired liver function.

Another group of medicines consists of preparations based on plant materials. So, an anthelmintic drug is known, including medicinal verbena (see T.L. Pilat and other Kazakhstani register of biologically active food additives. Almaty, Leovit, 2000, p.150).

An analogue of the proposed invention is a drug collection consisting of dried bearberry leaves and dried rose hips with a ratio of components, parts by weight 1: 5. The collection is effective in the treatment of giardiasis and opisthorchiasis (patent RU 2148410, 2000). The disadvantage of this collection is that it is not very effective in the treatment of ascariasis, enterobiasis, and also from tapeworms.

The closest analogue of the proposed invention is an anthelmintic agent, which includes walnuts, pumpkin seeds, citrus wormwood, cloves and garlic as active components (see T.L. Pilat and other Kazakhstani register of biologically active food additives. Almaty, Leovit, 2000 city, p.204). However, this collection has strongly pronounced astringent properties, which may prevent the removal of worms with metabolic products, in addition, it is ineffective in giardiasis.

The objective of the present invention was to eliminate the noted drawbacks and the creation of an anthelmintic agent based on plant materials, which is highly active in the treatment of various parasitic diseases, such as ascariasis, enterobiasis, giardiasis, infection with flat worms, and has a normalizing effect on the gastrointestinal tract.

The problem is solved in that the anthelmintic collection based on plant materials is characterized by the fact that it contains dried fennel seeds, clove fruits, thyme grass, wormwood grass, tansy flowers, walnut leaf, turmeric root, valerian root and licorice root in the following ratio mass parts:

fennel seeds 0.8-1.2

cloves 0.4-0.6

thyme herb 0.4-0.6

wormwood grass 0.8-1.2

tansy flowers 0.8-1.2

walnut leaf 0.8-1.2

turmeric root 0.4-0.6

valerian root 0.24-0.36

licorice root 0.4-0.6

The proposed anthelmintic collection is preferably intended for the treatment of ascariasis, enterobiasis and giardiasis. It is also effective in cestotases (dwarf, bovine, pork tapeworm, wide ribbon). Preferably, it is used in the form of a powder that can be placed in capsules. It is possible to manufacture tablets based on this collection. It can also be used in the form of infusion or decoction.

The following is a characteristic of the proposed collection of plants. Fennel vulgaris (Foeniculum vulgare) is a powerful biennial or perennial plant of the umbelliferous family, the fruits of which are aromatic oblong two-seeded seeds and have a sweet, slightly spicy taste. Fruits contain up to 6% of essential oil, up to 12% of fatty oil, as well as proteins, sugar and other components. Fennel fruits have anthelmintic (anthelmintic), diuretic and antibacterial effects, and improve digestion.

Clove tree (Syzygium aromaticum) is a perennial tropical plant of the myrtle family. Flower buds (fruits) are collected unopened, they contain up to 20% of essential oil, consisting of 96% of eugenol, vanillin and other compounds. Clove has a strong, peculiar aroma and spicy taste, it is used to improve digestion, and also as an antiseptic.

Thyme (Thymus) is a genus of the plants of the Labaceae family, its leaves contain essential oils, mainly thymol, some tannins, bitterness and flavoids. Thyme has antihelminthic (anthelmintic), disinfectant and analgesic effects.

Bitter Wormwood (Artemisia absinthium) is a perennial herb of the family Asteraceae, its leaves contain bitter glycosides (absintin, anabsintin), essential oil, vitamin C, a small amount of tannins and a number of other substances. Wormwood enhances the secretion of gastric juice, bile and the contents of the pancreas, stimulates digestion, eliminates spasm of the colon, has anti-inflammatory and anthelmintic effects.

Common tansy (Tanacetum vulgare) is a perennial herbaceous plant of the family Asteraceae. Medicinal raw materials are flowers collected in baskets. Tansy contains essential oil, flavonoids, alkaloids, the bitter substance tanacetin, organic acids, including ascorbic, tannins and carotene. It has a choleretic, anti-inflammatory, antiseptic, anthelmintic and astringent effect.

Walnut (Juelans regia) is a tree of the walnut family. Medicinal raw materials in the proposed collection are leaves that contain many biologically active compounds: aldehydes, essential oils, alkaloids, vitamins C, PP, carotene, phenolcarboxylic acids, tannins, coumarins, flavonoids, anthocyanins, quinones and aromatic hydrocarbons. Walnut leaves have a bactericidal, anti-inflammatory, antihelminthic and general strengthening effect.

Turmeric (Curcuma longa) is an herbaceous plant in the ginger family. The raw material of the plant is the root of the plant, which contains essential oil, bitterness, curcumin and starch. The root has a strong antioxidant, anti-inflammatory and choleretic effect.

Valerian officinalis (Valeriana officinalis) is a perennial herbaceous plant of the Valerian family. Medicinal raw materials are biennial rhizomes with roots, which contain essential oil, isovalerianic acid, glycosides, traces of alkaloids, tannins, tarry substances, saponins and organic acids - formic, acetic, malic, palmitic and others. Valerian roots have a calming effect on the nervous system, relieve spasm of the coronary vessels, stomach and intestines, and also aid digestion.

Licorice smooth (Glucyrrhiza glabra) - An herbaceous plant in the legume family. Medicinal raw materials are roots and underground shoots that contain glycyrrhizin, sterols and flavoids and exhibit a laxative and bactericidal effect, regulate the water-salt balance. The sweet taste of licorice root improves the taste of other components included in the proposed collection, while accelerating their absorption in the intestines and enhanced medicinal effect.

Each of the components of the drug collection is approved for use by the pharmacopoeia.

The plants included in the collection are harvested, preferably in August - early September at the full moon. It is most preferable to collect plants 3-5 hours after a thunderstorm. The collected raw materials are dried in a darkened room at a temperature of no higher than 35 ° C. Then, the dried collection is crushed and ground into powder. The powder can be placed in a capsule soluble in the stomach and intestines.

In the proposed collection, the qualitative and quantitative composition of plant raw materials is selected experimentally in such a way as to ensure the possibility of a detrimental effect on a wide range of parasites while improving the gastrointestinal microflora, improving peristalsis and reducing flatulence. The concentration ranges of the ingredients indicated in the claims are optimal for achieving the above technical result. At the same time, plants that, when used individually, do not exhibit anthelmintic activity, in this collection enhance the action of the main anthelmintic preparations (tansy flowers, walnut leaves, fennel fruits and thyme herbs). Turmeric root, thyme grass and valerian root have strong detoxifying properties, increase mucus secretion, relieve intestinal cramps, thereby contributing to the successful elimination of destroyed parasites, and reduce the body's intoxication resulting from the death of helminths.

Unexpectedly, an additional effect was discovered - the anti-candidiasis effect of the proposed collection, while candida is destroyed in the oral cavity, stomach, intestines and genitals.

Preferably, the collection is applied as follows. The day before the start of its administration and during the entire period of treatment, patients stop consuming sweets, yeast dough products, and wheat flour in the evenings. The collection is used in a dry (powder) form, 1 teaspoon (tsp) (5 g) adults and children over the age of 10 years and 1/3 tsp. children under 10 years of age 40 minutes before meals 3 times a day (morning, afternoon and evening). Do not drink with water. You can roll a powdery collection into a loaf and, if swallowed, drink one or two sips of strong green tea or bite 1 tsp. jam from young fruits of walnut. The collection is consumed for 14 days, then they take a break for 3 days and continue taking the collection for 7 days. If during defecation there is an exit of parasites or their fragments, continue to use the collection for another 14 days.

Every third day of taking the fee after a gentle dinner (for example, cabbage salad), a laxative is used in the form of magnesia or castor oil (per 1 kg of weight 1 g of castor oil). Instead of a laxative, it is possible to wash the intestines with enemas (2-3 times during the course of treatment).

The present invention is illustrated by the following examples of the use of the proposed collection in the treatment of volunteers.

Example 1

Patient N., 45 years old. She complained of abdominal pain, fatigue during the day, memory impairment, as well as the condition of hair and nails. The diagnosis of ascariasis is confirmed by laboratory analysis of feces in which ascaris eggs were found.

The treatment was prescribed according to the above scheme. In preparing the collection, the dried ingredients were used in the following ratio: fennel seed - 80 g (0.8 parts by weight), clove fruits - 40 g (0.4 parts by weight), thyme grass - 40 g (0.4 parts by weight) h.), wormwood herb - 80 g (0.8 parts by weight), tansy flowers - 80 g (0.8 parts by weight), walnut leaf - 80 g (0.8 parts by weight) , turmeric root - 40 g (0.4 parts by weight), valerian root - 24 g (0.24 parts by weight) and licorice root - 40 g (0.4 parts by weight). The ingredients were mixed, crushed and triturated.

On the 4th day of treatment, half-decomposed roundworms were found in the feces. After a day's fasting and taking castor oil, more than twenty roundworms ranging in size from 10 to 15 cm emerged. Treatment lasted for a month until all the symptoms that the patient contacted disappeared.

Example 2

Patient M., 53 years old, applied for persistent headaches, overweight, and defecation disorders (1 time in 3 days). After diagnosis, giardiasis was confirmed, as well as enterobiosis.

The treatment was prescribed according to the above scheme. In preparing the collection, the dried ingredients were used in the following ratio: fennel seed - 100 g (1 parts by weight), clove fruits - 50 g (0.5 parts by weight), thyme grass - 50 g (0.5 parts by weight) .), wormwood grass - 100 g (1 part by weight), tansy flowers - 100 g (1 part by weight), walnut leaf - 100 g (1 part by weight), turmeric root - 50 g (0 5 parts by weight), valerian root - 30 g (0.3 parts by weight) and licorice root - 50 g (0.5 parts by weight). The ingredients were mixed, crushed and triturated.

On the 2nd day of treatment, many pinworms were found in the feces. On day 3, a decrease in headaches was noted. On the 10th day after the liver tubub, headaches disappeared, defecation returned to normal. Treatment continued for a month until complete cure for giardiasis of the liver and intestines.

Example 3

Patient N., 17 years old, came for pains from the back on the right and painful bloating.

The treatment was prescribed according to the above scheme. In preparing the collection, the dried ingredients were used in the following ratio: fennel seed - 120 g (1.2 parts by weight), clove fruits - 60 g (0.6 parts by weight), thyme herb - 60 g (0.6 parts by weight) hours), wormwood grass - 120 g (1.2 parts by weight), tansy flowers - 120 g (1.2 parts by weight), walnut leaf - 120 g (1.2 parts by weight) , turmeric root - 60 g (0.6 parts by weight), valerian root - 36 g (0.36 parts by weight) and licorice root - 60 g (0.6 parts by weight). The ingredients were mixed, crushed and triturated.

On the 2nd day of taking the collection, bloating intensified, defecation was impaired, after using castor oil and soft manipulations with the stomach according to the Ogulov method, defecation began. Over the next 10 hours, about 90 ascaris individuals of various sizes came out. Worms also appeared in the next week. The pain and bloating disappeared.

Example 4

Patient J., 25 years old, complaints of decreased appetite, nausea, stool disturbance, weight loss, troubled sleep. Diagnosis: candidiasis and cestotasis (dwarf tapeworm infection).

Treatment with anthelmintic collection was prescribed, the composition of which is shown in Example 2. One week after the collection was started, candidiasis of the oral cavity and genitals was cured, and dwarf tapeworm left on the 10th day after taking the laxative. The symptoms treated by the patient disappeared.

The presented examples indicate the high efficiency of the proposed anthelmintic collection.

Claims (4)

1. Anthelmintic collection based on plant materials, characterized in that it contains dried fennel seeds, cloves, thyme grass, wormwood grass, tansy flowers, walnut leaf, turmeric root, valerian root and licorice root in the following ratio, wt.h .: Fennel Seeds 0.8-1.2 Cloves 0.4-0.8 Thyme herb 0.4-0.8 Wormwood Grass 0.8-1.2 Tansy flowers 0.8-1.2 Walnut Leaf 0.8-1.2 Turmeric root 0.4-0.6 Valerian root 0.24-0.36 Licorice root 0.4-0.6 2. Anthelmintic collection according to claim 1, characterized in that it is intended for the treatment of ascariasis, enterobiasis, giardiasis and cestosis. 3. Anthelmintic collection according to claim 1, characterized in that it is used in powder form. 4. Anthelmintic collection according to claim 1, characterized in that it is used in the form of a powder placed in a capsule.