EA027269B1 - Извлечение карбоновой кислоты из ее магниевых солей путем осаждения с применением хлористо-водородной кислоты, пригодное для выделения продукта реакции из ферментативного бульона - Google Patents
Извлечение карбоновой кислоты из ее магниевых солей путем осаждения с применением хлористо-водородной кислоты, пригодное для выделения продукта реакции из ферментативного бульона Download PDFInfo
- Publication number
- EA027269B1 EA027269B1 EA201490408A EA201490408A EA027269B1 EA 027269 B1 EA027269 B1 EA 027269B1 EA 201490408 A EA201490408 A EA 201490408A EA 201490408 A EA201490408 A EA 201490408A EA 027269 B1 EA027269 B1 EA 027269B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- solution
- succinic acid
- magnesium
- magnesium succinate
- precipitation
- Prior art date
Links
- 238000001556 precipitation Methods 0.000 title claims abstract description 87
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title claims abstract description 26
- 238000000855 fermentation Methods 0.000 title claims description 51
- 230000004151 fermentation Effects 0.000 title claims description 51
- 159000000003 magnesium salts Chemical class 0.000 title abstract description 5
- 238000011084 recovery Methods 0.000 title description 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title 1
- 238000010626 work up procedure Methods 0.000 title 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 241
- 239000000243 solution Substances 0.000 claims abstract description 143
- 239000001384 succinic acid Substances 0.000 claims abstract description 114
- OKUCEQDKBKYEJY-UHFFFAOYSA-N tert-butyl 3-(methylamino)pyrrolidine-1-carboxylate Chemical compound CNC1CCN(C(=O)OC(C)(C)C)C1 OKUCEQDKBKYEJY-UHFFFAOYSA-N 0.000 claims abstract description 88
- 238000000034 method Methods 0.000 claims abstract description 66
- 239000002244 precipitate Substances 0.000 claims abstract description 34
- 238000005979 thermal decomposition reaction Methods 0.000 claims abstract description 30
- 239000007864 aqueous solution Substances 0.000 claims abstract description 18
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims abstract description 17
- 239000007900 aqueous suspension Substances 0.000 claims abstract description 14
- 239000000395 magnesium oxide Substances 0.000 claims abstract description 13
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 13
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims abstract description 11
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims abstract description 10
- 239000002028 Biomass Substances 0.000 claims abstract description 5
- 230000020477 pH reduction Effects 0.000 claims description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 34
- 101000581326 Homo sapiens Mediator of DNA damage checkpoint protein 1 Proteins 0.000 claims description 25
- 102100027643 Mediator of DNA damage checkpoint protein 1 Human genes 0.000 claims description 25
- 239000000725 suspension Substances 0.000 claims description 21
- 238000001816 cooling Methods 0.000 claims description 15
- 239000011777 magnesium Substances 0.000 claims description 13
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 11
- 229910052749 magnesium Inorganic materials 0.000 claims description 11
- 239000007787 solid Substances 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 230000008021 deposition Effects 0.000 claims description 7
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 7
- 239000000347 magnesium hydroxide Substances 0.000 claims description 7
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 7
- 230000003472 neutralizing effect Effects 0.000 claims description 7
- 239000007921 spray Substances 0.000 claims description 5
- 238000000746 purification Methods 0.000 claims description 4
- 239000007789 gas Substances 0.000 claims description 3
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 238000000151 deposition Methods 0.000 claims 4
- 238000000926 separation method Methods 0.000 abstract description 10
- 229910001629 magnesium chloride Inorganic materials 0.000 abstract description 7
- 230000001376 precipitating effect Effects 0.000 abstract description 2
- 150000003839 salts Chemical class 0.000 description 22
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 20
- 230000008569 process Effects 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 11
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 11
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 11
- 238000001704 evaporation Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 230000008020 evaporation Effects 0.000 description 9
- 238000005185 salting out Methods 0.000 description 8
- 230000008901 benefit Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000002425 crystallisation Methods 0.000 description 5
- 230000008025 crystallization Effects 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 230000006911 nucleation Effects 0.000 description 5
- 238000010899 nucleation Methods 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 238000005260 corrosion Methods 0.000 description 4
- 230000007797 corrosion Effects 0.000 description 4
- 230000002255 enzymatic effect Effects 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- 239000012296 anti-solvent Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 102100039121 Histone-lysine N-methyltransferase MECOM Human genes 0.000 description 2
- 101001033728 Homo sapiens Histone-lysine N-methyltransferase MECOM Proteins 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000003916 acid precipitation Methods 0.000 description 2
- 239000002535 acidifier Substances 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
- 239000000920 calcium hydroxide Substances 0.000 description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229910017604 nitric acid Inorganic materials 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- -1 M§§0 4 Chemical class 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- PBUBJNYXWIDFMU-UHFFFAOYSA-L calcium;butanedioate Chemical compound [Ca+2].[O-]C(=O)CCC([O-])=O PBUBJNYXWIDFMU-UHFFFAOYSA-L 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000011141 high resolution liquid chromatography Methods 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- QWDJLDTYWNBUKE-UHFFFAOYSA-L magnesium bicarbonate Chemical compound [Mg+2].OC([O-])=O.OC([O-])=O QWDJLDTYWNBUKE-UHFFFAOYSA-L 0.000 description 1
- 239000002370 magnesium bicarbonate Substances 0.000 description 1
- 229910000022 magnesium bicarbonate Inorganic materials 0.000 description 1
- 235000014824 magnesium bicarbonate Nutrition 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 238000009283 thermal hydrolysis Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B7/00—Halogens; Halogen acids
- C01B7/01—Chlorine; Hydrogen chloride
- C01B7/03—Preparation from chlorides
- C01B7/035—Preparation of hydrogen chloride from chlorides
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F5/00—Compounds of magnesium
- C01F5/02—Magnesia
- C01F5/06—Magnesia by thermal decomposition of magnesium compounds
- C01F5/10—Magnesia by thermal decomposition of magnesium compounds by thermal decomposition of magnesium chloride with water vapour
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F5/00—Compounds of magnesium
- C01F5/26—Magnesium halides
- C01F5/30—Chlorides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Geology (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11177633 | 2011-08-16 | ||
| US201161524353P | 2011-08-17 | 2011-08-17 | |
| PCT/NL2012/050572 WO2013025105A1 (en) | 2011-08-16 | 2012-08-16 | Recovery of carboxylic acid from their magnesium salts by precipitation using hydrochloric acid, useful for fermentation broth work-up |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201490408A1 EA201490408A1 (ru) | 2014-07-30 |
| EA027269B1 true EA027269B1 (ru) | 2017-07-31 |
Family
ID=50279087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201490408A EA027269B1 (ru) | 2011-08-16 | 2012-08-16 | Извлечение карбоновой кислоты из ее магниевых солей путем осаждения с применением хлористо-водородной кислоты, пригодное для выделения продукта реакции из ферментативного бульона |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9376364B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2744745B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6146922B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101991705B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103813977A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012295625B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014003379A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2843696C (cg-RX-API-DMAC7.html) |
| EA (1) | EA027269B1 (cg-RX-API-DMAC7.html) |
| IN (1) | IN2014CN01924A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2744745T3 (cg-RX-API-DMAC7.html) |
| UA (1) | UA112991C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013025105A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201401748B (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012032999B1 (pt) | 2010-06-26 | 2022-11-29 | Virdia, Llc | Hidrolisado lignocelulósico e métodos de hidrólise ácida e desacidificação para gerar misturas de açúcar a partir de lignocelulose |
| IL206678A0 (en) | 2010-06-28 | 2010-12-30 | Hcl Cleantech Ltd | A method for the production of fermentable sugars |
| US9512495B2 (en) | 2011-04-07 | 2016-12-06 | Virdia, Inc. | Lignocellulose conversion processes and products |
| BR112014003074A2 (pt) | 2011-08-16 | 2017-02-21 | Purac Biochem Bv | recuperação de ácido carboxílico a partir de seus sais de magnésio através de precipitação usando ácido clorídrico, útil para trabalho de caldo de fermentação |
| MY179474A (en) * | 2011-08-16 | 2020-11-07 | Purac Biochem Bv | Recovery of carboxylic acid from their magnesium salts by precipitation using hydrochloric acid, useful for fermentation broth work-up |
| GB2535435B (en) | 2012-05-03 | 2016-12-07 | Virdia Inc | Methods for treating lignocellulosic materials |
| EP2821368A1 (en) * | 2013-07-03 | 2015-01-07 | PURAC Biochem BV | Method for processing magnesium chloride solutions |
| CN112226466A (zh) | 2015-01-07 | 2021-01-15 | 威尔迪亚公司 | 萃取和转化半纤维素糖的方法 |
| CN114410850A (zh) * | 2015-05-27 | 2022-04-29 | 威尔迪亚有限责任公司 | 用于处理木质纤维素材料的综合方法 |
| EP3118185A1 (en) | 2015-07-14 | 2017-01-18 | PURAC Biochem BV | Method for manufacturing succinic acid |
| EP3124434A1 (en) * | 2015-07-31 | 2017-02-01 | PURAC Biochem BV | Method for providing a succinic acid solution |
| US10850990B2 (en) * | 2016-01-19 | 2020-12-01 | Purac Biochem Bv | Method for processing magnesium chloride solutions and method for manufacturing carboxylic acids |
| MY192175A (en) | 2016-06-29 | 2022-08-04 | Valinge Innovation Ab | Method and device for inserting a tongue |
| CN114906812B (zh) * | 2022-06-01 | 2023-06-23 | 湖南吴赣药业有限公司 | 一种有机混酸分离纯化方法 |
| WO2024097329A1 (en) | 2022-11-02 | 2024-05-10 | Amalgamated Research Llc | Smb separator for organic acid purification using a strong acid cation resin |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000001378A1 (en) * | 1998-06-30 | 2000-01-13 | Karl William Baumgart | Methods and compositions for treatment of disorders associated with chlamydial and similar bacterial infection |
| US20060276674A1 (en) * | 2003-09-30 | 2006-12-07 | Ajinomoto Co., Inc. | Method for purifying succinic acid from fermentation broth |
| KR20100122773A (ko) * | 2009-05-13 | 2010-11-23 | 삼성석유화학(주) | 발효액으로부터 숙신산을 분리 및 정제하는 방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ117394A (cg-RX-API-DMAC7.html) | 1954-12-08 | |||
| GB9102393D0 (en) | 1991-02-05 | 1991-03-20 | Ici Plc | Production of terephthalic acid |
| IL126264A0 (en) | 1998-09-17 | 1999-05-09 | Tami Inst For Research & Dev L | Process for preparing lactic acid |
| US6670505B1 (en) | 2000-03-07 | 2003-12-30 | Eastman Chemical Company | Process for the recovery of organic acids from aqueous solutions |
| US6660505B2 (en) | 2000-06-22 | 2003-12-09 | Cognis Corporation | Isolation of carboxylic acids from fermentation broth |
| JP2009079057A (ja) * | 2005-04-22 | 2009-04-16 | Mitsubishi Chemicals Corp | ポリエステル及びその製造方法 |
| US20080223519A1 (en) | 2006-12-06 | 2008-09-18 | Locko George A | Polyamide polyols and polyurethanes, methods for making and using, and products made therefrom |
| FR2925068B1 (fr) * | 2007-12-13 | 2010-01-08 | Roquette Freres | Procedes de production d'acide succinique |
| CN101550079B (zh) * | 2009-05-12 | 2010-10-27 | 安徽丰原发酵技术工程研究有限公司 | 一种连续制备丁二酸的方法 |
| US8431372B2 (en) * | 2009-06-19 | 2013-04-30 | Mbi International | Fermentation method using a magnesium compound containing oxygen |
| CN101748161B (zh) | 2010-01-19 | 2012-06-06 | 南京工业大学 | 一种厌氧发酵纯化丁二酸的工艺 |
| BR112014003074A2 (pt) | 2011-08-16 | 2017-02-21 | Purac Biochem Bv | recuperação de ácido carboxílico a partir de seus sais de magnésio através de precipitação usando ácido clorídrico, útil para trabalho de caldo de fermentação |
-
2012
- 2012-08-16 UA UAA201402003A patent/UA112991C2/uk unknown
- 2012-08-16 IN IN1924CHN2014 patent/IN2014CN01924A/en unknown
- 2012-08-16 CN CN201280045958.1A patent/CN103813977A/zh active Pending
- 2012-08-16 BR BR112014003379A patent/BR112014003379A2/pt not_active IP Right Cessation
- 2012-08-16 US US14/238,666 patent/US9376364B2/en not_active Expired - Fee Related
- 2012-08-16 AU AU2012295625A patent/AU2012295625B2/en not_active Ceased
- 2012-08-16 CA CA2843696A patent/CA2843696C/en active Active
- 2012-08-16 WO PCT/NL2012/050572 patent/WO2013025105A1/en not_active Ceased
- 2012-08-16 PL PL12750876T patent/PL2744745T3/pl unknown
- 2012-08-16 KR KR1020147006790A patent/KR101991705B1/ko not_active Expired - Fee Related
- 2012-08-16 EA EA201490408A patent/EA027269B1/ru not_active IP Right Cessation
- 2012-08-16 JP JP2014525958A patent/JP6146922B2/ja not_active Expired - Fee Related
- 2012-08-16 EP EP12750876.0A patent/EP2744745B1/en active Active
-
2014
- 2014-03-10 ZA ZA2014/01748A patent/ZA201401748B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000001378A1 (en) * | 1998-06-30 | 2000-01-13 | Karl William Baumgart | Methods and compositions for treatment of disorders associated with chlamydial and similar bacterial infection |
| US20060276674A1 (en) * | 2003-09-30 | 2006-12-07 | Ajinomoto Co., Inc. | Method for purifying succinic acid from fermentation broth |
| KR20100122773A (ko) * | 2009-05-13 | 2010-11-23 | 삼성석유화학(주) | 발효액으로부터 숙신산을 분리 및 정제하는 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201401748B (en) | 2015-01-28 |
| IN2014CN01924A (cg-RX-API-DMAC7.html) | 2015-05-29 |
| JP6146922B2 (ja) | 2017-06-14 |
| US20140200365A1 (en) | 2014-07-17 |
| EP2744745A1 (en) | 2014-06-25 |
| CN103813977A (zh) | 2014-05-21 |
| EA201490408A1 (ru) | 2014-07-30 |
| AU2012295625A1 (en) | 2014-03-20 |
| JP2014524254A (ja) | 2014-09-22 |
| UA112991C2 (uk) | 2016-11-25 |
| KR101991705B1 (ko) | 2019-06-21 |
| KR20140064870A (ko) | 2014-05-28 |
| PL2744745T3 (pl) | 2020-05-18 |
| CA2843696C (en) | 2019-09-24 |
| CA2843696A1 (en) | 2013-02-21 |
| WO2013025105A8 (en) | 2014-04-10 |
| WO2013025105A1 (en) | 2013-02-21 |
| AU2012295625B2 (en) | 2016-05-12 |
| BR112014003379A2 (pt) | 2017-03-01 |
| EP2744745B1 (en) | 2019-10-30 |
| US9376364B2 (en) | 2016-06-28 |
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