EA026510B1 - Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей - Google Patents

Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей Download PDF

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Publication number
EA026510B1
EA026510B1 EA201201385A EA201201385A EA026510B1 EA 026510 B1 EA026510 B1 EA 026510B1 EA 201201385 A EA201201385 A EA 201201385A EA 201201385 A EA201201385 A EA 201201385A EA 026510 B1 EA026510 B1 EA 026510B1
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EA
Eurasian Patent Office
Prior art keywords
group
optionally substituted
heteroaromatic
aromatic
formula
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Application number
EA201201385A
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English (en)
Russian (ru)
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EA201201385A1 (ru
Inventor
Жан-Люк Рено
Никола Паннетье
Жан-Пьер Лекув
Люсиль Вейссе-Людо
Соллен Мулен
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Ле Лаборатуар Сервье
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Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA201201385A1 publication Critical patent/EA201201385A1/ru
Publication of EA026510B1 publication Critical patent/EA026510B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2282—Unsaturated compounds used as ligands
    • B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2235/00—Indexing scheme associated with group B01J35/00, related to the analysis techniques used to determine the catalysts form or properties
    • B01J2235/05—Nuclear magnetic resonance [NMR]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201201385A 2011-12-20 2012-11-09 Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей EA026510B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1103933A FR2984319B1 (fr) 2011-12-20 2011-12-20 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (2)

Publication Number Publication Date
EA201201385A1 EA201201385A1 (ru) 2013-06-28
EA026510B1 true EA026510B1 (ru) 2017-04-28

Family

ID=47115640

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201201385A EA026510B1 (ru) 2011-12-20 2012-11-09 Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей

Country Status (34)

Country Link
US (1) US8513410B2 (https=)
EP (1) EP2607353B1 (https=)
JP (1) JP5670406B2 (https=)
KR (1) KR101470879B1 (https=)
CN (1) CN103172566B (https=)
AR (1) AR088678A1 (https=)
AU (1) AU2012244188B2 (https=)
BR (1) BR102012028614A2 (https=)
CA (1) CA2795741C (https=)
CL (1) CL2012003136A1 (https=)
CY (1) CY1115682T1 (https=)
DK (1) DK2607353T3 (https=)
EA (1) EA026510B1 (https=)
ES (1) ES2525032T3 (https=)
FR (1) FR2984319B1 (https=)
GE (1) GEP20156350B (https=)
HR (1) HRP20141023T1 (https=)
JO (1) JO3031B1 (https=)
MA (1) MA34276B1 (https=)
MD (1) MD4336C1 (https=)
MX (1) MX2012012938A (https=)
MY (1) MY170662A (https=)
PE (1) PE20131097A1 (https=)
PL (1) PL2607353T3 (https=)
PT (1) PT2607353E (https=)
RS (1) RS53541B1 (https=)
SA (1) SA112330994B1 (https=)
SG (1) SG191471A1 (https=)
SI (1) SI2607353T1 (https=)
TW (1) TWI440627B (https=)
UA (1) UA111329C2 (https=)
UY (1) UY34423A (https=)
WO (1) WO2013093220A1 (https=)
ZA (1) ZA201208160B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN105669554A (zh) * 2016-02-22 2016-06-15 徐建立 一种盐酸伊伐布雷定杂质及其制备方法和应用
FR3071833B1 (fr) * 2017-09-29 2020-01-03 Universite Paris-Sud Nouveau procede de synthese d'amines tertiaires dissymetriques

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA007745B1 (ru) * 2004-04-13 2006-12-29 Ле Лаборатуар Сервье Способ получения ивабрадина
WO2008065681A2 (en) * 2006-11-30 2008-06-05 Cadila Healthcare Limited Process for preparation of ivabradine hydrochloride
WO2008146308A2 (en) * 2007-05-30 2008-12-04 Ind-Swift Laboratories Limited Process for the preparation of ivabradine hydrochloride and polymorph thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
US6225487B1 (en) * 1998-04-17 2001-05-01 Symyx Technologies, Inc. Ancillary ligands and metal complexes, catalysts and compositions using same and methods of testing
US6521793B1 (en) * 1998-10-08 2003-02-18 Symyx Technologies, Inc. Catalyst ligands, catalytic metal complexes and processes using same
EP1595888A1 (en) * 2004-05-11 2005-11-16 Degussa AG Cycloolefin phosphine ligands and their use in catalysis
US7857994B2 (en) 2007-05-30 2010-12-28 GE Lighting Solutions, LLC Green emitting phosphors and blends thereof
FR2920773B1 (fr) 2007-09-11 2009-10-23 Servier Lab Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2933975B1 (fr) * 2008-07-17 2011-02-18 Servier Lab Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
FR2940287B1 (fr) * 2008-12-24 2010-12-24 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2941695B1 (fr) * 2009-02-04 2011-02-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA007745B1 (ru) * 2004-04-13 2006-12-29 Ле Лаборатуар Сервье Способ получения ивабрадина
WO2008065681A2 (en) * 2006-11-30 2008-06-05 Cadila Healthcare Limited Process for preparation of ivabradine hydrochloride
WO2008146308A2 (en) * 2007-05-30 2008-12-04 Ind-Swift Laboratories Limited Process for the preparation of ivabradine hydrochloride and polymorph thereof

Also Published As

Publication number Publication date
EP2607353A1 (fr) 2013-06-26
CA2795741A1 (fr) 2013-06-20
RS53541B1 (sr) 2015-02-27
UA111329C2 (uk) 2016-04-25
ZA201208160B (en) 2013-06-26
PL2607353T3 (pl) 2015-01-30
JP5670406B2 (ja) 2015-02-18
DK2607353T3 (en) 2014-12-08
JP2013129650A (ja) 2013-07-04
EP2607353B1 (fr) 2014-08-27
MX2012012938A (es) 2013-06-19
UY34423A (es) 2013-07-31
MY170662A (en) 2019-08-26
SA112330994B1 (ar) 2015-08-03
TWI440627B (zh) 2014-06-11
SI2607353T1 (sl) 2014-12-31
CN103172566A (zh) 2013-06-26
AR088678A1 (es) 2014-06-25
CY1115682T1 (el) 2017-01-25
ES2525032T3 (es) 2014-12-16
CN103172566B (zh) 2015-11-18
NZ603483A (en) 2014-02-28
KR20130071350A (ko) 2013-06-28
GEP20156350B (en) 2015-08-25
HK1186733A1 (zh) 2014-03-21
BR102012028614A2 (pt) 2014-12-16
MD4336C1 (ro) 2015-10-31
US8513410B2 (en) 2013-08-20
KR101470879B1 (ko) 2014-12-09
MA34276B1 (fr) 2013-06-01
TW201326132A (zh) 2013-07-01
JO3031B1 (ar) 2016-09-05
AU2012244188B2 (en) 2015-07-30
FR2984319A1 (fr) 2013-06-21
PE20131097A1 (es) 2013-10-12
EA201201385A1 (ru) 2013-06-28
MD4336B1 (ro) 2015-03-31
PT2607353E (pt) 2014-10-10
AU2012244188A1 (en) 2013-07-04
WO2013093220A1 (fr) 2013-06-27
CL2012003136A1 (es) 2014-08-01
FR2984319B1 (fr) 2013-12-27
HRP20141023T1 (hr) 2014-12-05
US20130158256A1 (en) 2013-06-20
SG191471A1 (en) 2013-07-31
CA2795741C (fr) 2015-09-08

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU