EA025840B1 - Производные пиразина в качестве агонистов каннабиноидного рецептора 2 - Google Patents

Производные пиразина в качестве агонистов каннабиноидного рецептора 2 Download PDF

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Publication number
EA025840B1
EA025840B1 EA201590827A EA201590827A EA025840B1 EA 025840 B1 EA025840 B1 EA 025840B1 EA 201590827 A EA201590827 A EA 201590827A EA 201590827 A EA201590827 A EA 201590827A EA 025840 B1 EA025840 B1 EA 025840B1
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EA
Eurasian Patent Office
Prior art keywords
difluoroazetidin
cyclopropylmethoxy
pyrazin
carboxylic acid
carbonyl
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Application number
EA201590827A
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English (en)
Russian (ru)
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EA201590827A1 (ru
Inventor
Баледи Дхурвасулу
Уве ГРЕТЕР
Маттиас НЕТТЕКОФЕН
Штефан Рёфер
Марк РОДЖЕРС-ЭВАНС
Танья ШУЛЬЦ-ГАШ
Original Assignee
Ф. Хоффманн-Ля Рош Аг
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Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of EA201590827A1 publication Critical patent/EA201590827A1/ru
Publication of EA025840B1 publication Critical patent/EA025840B1/ru

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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61P27/02—Ophthalmic agents
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA201590827A 2012-12-07 2013-12-04 Производные пиразина в качестве агонистов каннабиноидного рецептора 2 EA025840B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12196024 2012-12-07
PCT/EP2013/075444 WO2014086807A1 (en) 2012-12-07 2013-12-04 Novel pyrazine derivatives as cb2 receptor agonists

Publications (2)

Publication Number Publication Date
EA201590827A1 EA201590827A1 (ru) 2015-09-30
EA025840B1 true EA025840B1 (ru) 2017-02-28

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EA201590827A EA025840B1 (ru) 2012-12-07 2013-12-04 Производные пиразина в качестве агонистов каннабиноидного рецептора 2

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US (1) US9512141B2 (https=)
EP (1) EP2928882B1 (https=)
JP (1) JP6322646B2 (https=)
KR (1) KR20150092156A (https=)
CN (1) CN104837830B (https=)
AR (1) AR093804A1 (https=)
AU (1) AU2013354115B2 (https=)
BR (1) BR112015009603A2 (https=)
CA (1) CA2885418A1 (https=)
CL (1) CL2015001318A1 (https=)
CR (1) CR20150210A (https=)
CY (1) CY1118808T1 (https=)
DK (1) DK2928882T3 (https=)
EA (1) EA025840B1 (https=)
ES (1) ES2621958T3 (https=)
HR (1) HRP20170572T1 (https=)
HU (1) HUE030836T2 (https=)
IL (1) IL237982A (https=)
IN (1) IN2015DN03145A (https=)
LT (1) LT2928882T (https=)
MA (1) MA38217B1 (https=)
MX (1) MX2015006036A (https=)
PE (1) PE20151060A1 (https=)
PH (1) PH12015501072B1 (https=)
PL (1) PL2928882T3 (https=)
PT (1) PT2928882T (https=)
RS (1) RS55951B1 (https=)
SG (1) SG11201504011UA (https=)
SI (1) SI2928882T1 (https=)
TW (1) TW201427960A (https=)
UA (1) UA116894C2 (https=)
WO (1) WO2014086807A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014224784B2 (en) 2013-03-07 2018-03-08 F. Hoffmann-La Roche Ag Novel pyrazol derivatives
CN105121436B (zh) 2013-03-26 2018-07-27 豪夫迈·罗氏有限公司 新的吡啶衍生物
AU2014261585B2 (en) 2013-05-02 2018-03-08 F. Hoffmann-La Roche Ag Purine derivatives as CB2 receptor agonists
WO2014177527A1 (en) 2013-05-02 2014-11-06 F. Hoffmann-La Roche Ag Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists
JP6441356B2 (ja) 2013-09-06 2018-12-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規トリアゾロ［４，５−ｄ］ピリミジン誘導体
WO2015150440A1 (en) * 2014-04-04 2015-10-08 F. Hoffmann-La Roche Ag Pyridine-2-amides useful as cb2 agonists
EP3386951B1 (en) * 2015-12-09 2020-02-26 H. Hoffnabb-La Roche Ag Phenyl derivatives as cannabinoid receptor 2 agonists
AR112199A1 (es) 2017-06-20 2019-10-02 Hoffmann La Roche Derivados de piridina como agonistas inversos del receptor cannabinoide 2
JP7456948B2 (ja) 2018-06-27 2024-03-27 エフ． ホフマン－ラ ロシュ アーゲー 放射性標識カンナビノイド受容体２リガンド
EP3814337B1 (en) 2018-06-27 2025-05-14 F. Hoffmann-La Roche AG Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
CN112119068A (zh) 2018-06-27 2020-12-22 豪夫迈·罗氏有限公司 作为大麻素受体2的抑制剂的新型氮杂环丁烷-取代的吡啶和吡嗪化合物
PE20210368A1 (es) 2018-06-27 2021-02-26 Eth Zuerich Nuevos compuestos de piridina y pirazina como inhibidores del receptor cannabinoide 2
WO2022128050A1 (en) 2020-12-14 2022-06-23 Symrise Ag Medicament for fighting inflammation and pain

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008040649A2 (en) * 2006-10-04 2008-04-10 F. Hoffmann-La Roche Ag Pyrazine-2-carboxamide derivatives as cb2 receptor modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629346B2 (en) * 2006-06-19 2009-12-08 Hoffmann-La Roche Inc. Pyrazinecarboxamide derivatives as CB1 antagonists
WO2012031817A1 (en) 2010-09-09 2012-03-15 F. Hoffmann-La Roche Ag Determination of abca1 protein levels in cells
US9321727B2 (en) 2011-06-10 2016-04-26 Hoffmann-La Roche Inc. Pyridine derivatives as agonists of the CB2 receptor
US9403808B2 (en) * 2011-10-28 2016-08-02 Hoffmann-La Roche Inc. Pyrazine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008040649A2 (en) * 2006-10-04 2008-04-10 F. Hoffmann-La Roche Ag Pyrazine-2-carboxamide derivatives as cb2 receptor modulators

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CN104837830B (zh) 2018-07-20
UA116894C2 (uk) 2018-05-25
DK2928882T3 (en) 2017-02-20
AU2013354115B2 (en) 2017-10-05
CR20150210A (es) 2015-05-29
PT2928882T (pt) 2017-03-16
PL2928882T3 (pl) 2017-07-31
EP2928882B1 (en) 2017-01-18
CN104837830A (zh) 2015-08-12
MA38217A1 (fr) 2017-02-28
EA201590827A1 (ru) 2015-09-30
PH12015501072A1 (en) 2015-08-03
US20150299220A1 (en) 2015-10-22
SG11201504011UA (en) 2015-07-30
MA38217B1 (fr) 2017-11-30
HUE030836T2 (en) 2017-06-28
AR093804A1 (es) 2015-06-24
CY1118808T1 (el) 2018-01-10
US9512141B2 (en) 2016-12-06
JP6322646B2 (ja) 2018-05-09
CL2015001318A1 (es) 2015-10-02
IN2015DN03145A (https=) 2015-10-02
TW201427960A (zh) 2014-07-16
MX2015006036A (es) 2015-08-07
KR20150092156A (ko) 2015-08-12
JP2016505557A (ja) 2016-02-25
PH12015501072B1 (en) 2015-08-03
EP2928882A1 (en) 2015-10-14
ES2621958T3 (es) 2017-07-05
BR112015009603A2 (pt) 2017-07-04
LT2928882T (lt) 2017-03-27
PE20151060A1 (es) 2015-07-25
RS55951B1 (sr) 2017-09-29
HK1208030A1 (en) 2016-02-19
AU2013354115A1 (en) 2015-04-09
CA2885418A1 (en) 2014-06-12
IL237982A (en) 2017-06-29
WO2014086807A1 (en) 2014-06-12
SI2928882T1 (sl) 2017-05-31
HRP20170572T1 (hr) 2017-06-16

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU