EA025107B1 - Способ диагностирования болезни альцгеймера, нейродегенерации при синдроме дауна или легкого когнитивного нарушения у субъекта (варианты) и набор для осуществления способа - Google Patents

Способ диагностирования болезни альцгеймера, нейродегенерации при синдроме дауна или легкого когнитивного нарушения у субъекта (варианты) и набор для осуществления способа Download PDF

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EA025107B1
EA025107B1 EA201100253A EA201100253A EA025107B1 EA 025107 B1 EA025107 B1 EA 025107B1 EA 201100253 A EA201100253 A EA 201100253A EA 201100253 A EA201100253 A EA 201100253A EA 025107 B1 EA025107 B1 EA 025107B1
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amount
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zeg
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EA201100253A
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EA201100253A1 (ru
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Ханс-Ульрих Демут
Штефан Шиллинг
Мартин Клайншмидт
Йенс-Ульрих Рафельд
Астрид Келен
Моник Борнак
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Пробиодруг Аг
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Publication of EA201100253A1 publication Critical patent/EA201100253A1/ru
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/521—Chemokines
    • G01N2333/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1or LDCF-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91045—Acyltransferases (2.3)
    • G01N2333/91074—Aminoacyltransferases (general) (2.3.2)
    • G01N2333/9108—Aminoacyltransferases (general) (2.3.2) with definite EC number (2.3.2.-)
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
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    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/38—Pediatrics
    • G01N2800/385—Congenital anomalies
    • G01N2800/387—Down syndrome; Trisomy 18; Trisomy 13

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  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • General Physics & Mathematics (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201100253A 2008-07-31 2009-07-31 Способ диагностирования болезни альцгеймера, нейродегенерации при синдроме дауна или легкого когнитивного нарушения у субъекта (варианты) и набор для осуществления способа EA025107B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8515408P 2008-07-31 2008-07-31
PCT/EP2009/059951 WO2010012828A2 (en) 2008-07-31 2009-07-31 Glutaminyl cyclase as a diagnostic / prognostic indicator for neurodegenerative diseases

Publications (2)

Publication Number Publication Date
EA201100253A1 EA201100253A1 (ru) 2011-10-31
EA025107B1 true EA025107B1 (ru) 2016-11-30

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EA201100253A EA025107B1 (ru) 2008-07-31 2009-07-31 Способ диагностирования болезни альцгеймера, нейродегенерации при синдроме дауна или легкого когнитивного нарушения у субъекта (варианты) и набор для осуществления способа

Country Status (15)

Country Link
US (3) US20100028918A1 (https=)
EP (1) EP2329274B1 (https=)
JP (1) JP5677297B2 (https=)
KR (1) KR101682728B1 (https=)
CN (2) CN103983787A (https=)
AU (1) AU2009275869B2 (https=)
BR (1) BRPI0916601B1 (https=)
CA (1) CA2731933A1 (https=)
EA (1) EA025107B1 (https=)
IL (1) IL210266A (https=)
MX (1) MX2011001093A (https=)
NZ (1) NZ590658A (https=)
SG (1) SG193148A1 (https=)
WO (1) WO2010012828A2 (https=)
ZA (1) ZA201100177B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011101433A1 (en) * 2010-02-18 2011-08-25 Probiodrug Ag Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and screening methods for inhibitors of glutaminyl cyclase
SG194770A1 (en) 2011-05-27 2013-12-30 Probiodrug Ag Radiolabelled glutaminyl cyclase inhibitors
JP2018501482A (ja) 2014-12-19 2018-01-18 プロビオドルグ エージー ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法
CN104946680A (zh) * 2015-06-11 2015-09-30 深圳大学 用于表达qc的重组载体及其制备方法、引物、基因工程菌
KR102362919B1 (ko) * 2016-07-08 2022-02-16 아지노모토 가부시키가이샤 경도 인지 장해 또는 알츠하이머형 인지증의 평가 방법
KR102858457B1 (ko) * 2023-06-07 2025-09-11 계명대학교 산학협력단 Ccl8 단백질 또는 이를 코딩하는 유전자를 유효성분으로 포함하는 퇴행성 뇌질환 진단용 바이오마커 조성물

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20070191366A1 (en) * 2003-05-05 2007-08-16 Torsten Hoffmann Use of effectors of glutaminyl and glutamate cyclases
WO2008034891A2 (en) * 2006-09-21 2008-03-27 Probiodrug Ag Novel genes related to glutaminyl cyclase

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JP4374316B2 (ja) * 1993-01-25 2009-12-02 武田薬品工業株式会社 β−アミロイドまたはその誘導体に対する抗体およびその用途
JP3590468B2 (ja) * 1996-01-22 2004-11-17 財団法人 東京都医学研究機構 アルツハイマー病診断薬
WO2004013172A2 (en) * 2002-07-24 2004-02-12 Innogenetics N.V. Fragments of beta-amyloid as targets for vaccination against alzheimer disease
CN1784220B (zh) * 2003-05-05 2011-08-03 前体生物药物股份公司 谷氨酰胺酰基和谷氨酸环化酶效应物的应用
BRPI0415409A (pt) * 2003-10-15 2006-12-05 Probiodrug Ag uso de efetuadores de ciclases de glutaminila e glutamato
US20060094064A1 (en) * 2003-11-19 2006-05-04 Sandip Ray Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids
CA2554809C (en) * 2004-02-05 2014-04-29 Probiodrug Ag Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
US7592467B2 (en) * 2005-04-11 2009-09-22 Probiodrug Ag Inhibitors of prolyl endopeptidase
EP1865326B1 (en) * 2006-06-08 2011-09-07 FU Berlin Assay for the diagnosis of Alzheimer's Disease based on the determination of the ratio of secretase Aß cleavage products
WO2008087197A1 (en) * 2007-01-19 2008-07-24 Probiodrug Ag In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070191366A1 (en) * 2003-05-05 2007-08-16 Torsten Hoffmann Use of effectors of glutaminyl and glutamate cyclases
WO2008034891A2 (en) * 2006-09-21 2008-03-27 Probiodrug Ag Novel genes related to glutaminyl cyclase

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CYNIS HOLGER ET AL: "Amyloidogenic processing of amyloid precursor protein: Evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 47, no. 28, 1 July 2008 (2008-07-01), US, pages 7405 - 7413, XP002568788, ISSN: 0006-2960, DOI: 10.1021/BI800250P *
CYNIS, H. ; SCHILLING, S. ; BODNAR, M. ; HOFFMANN, T. ; HEISER, U. ; SAIDO, T.C. ; DEMUTH, H.U.: "Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS & PROTEOMICS, ELSEVIER, NETHERLANDS, vol. 1764, no. 10, 1 October 2006 (2006-10-01), Netherlands, pages 1618 - 1625, XP025123183, ISSN: 1570-9639, DOI: 10.1016/j.bbapap.2006.08.003 *
GONTSAROVA ANASTASSIA, ET AL: "Glutaminyl cyclase activity is a characteristic feature of human cerebrospinal fluid", CLINICA CHIMICA ACTA, ELSEVIER BV, AMSTERDAM, NL, vol. 389, no. 1-2, 1 March 2008 (2008-03-01), AMSTERDAM, NL, pages 152 - 159, XP002559604, ISSN: 0009-8981, DOI: 10.1016/j.cca.2007.12.010 *
GÜNTERT A, ET AL: "High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain.", NEUROSCIENCE, NEW YORK, NY, US, vol. 143, no. 2, 1 December 2006 (2006-12-01), US, pages 461 - 475, XP002568789, ISSN: 0306-4522, DOI: 10.1016/J.NEUROSCIENCE.2006.08.027 *
SCHILLING STEPHAN, ET AL: "Glutaminyl cyclase inhibition attenuates pyroglutamate A beta and Alzheimer's disease-like pathology", NATURE MEDICINE., NATURE PUBLISHING GROUP, NEW YORK, NY., US, vol. 14, no. 10, 1 October 2008 (2008-10-01), US, pages 1106 - 1111, XP002559603, ISSN: 1078-8956, DOI: 10.1038/nm.1872 *

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Publication number Publication date
CN102112880A (zh) 2011-06-29
EP2329274B1 (en) 2015-12-02
IL210266A (en) 2016-04-21
ZA201100177B (en) 2012-02-29
CN102112880B (zh) 2014-06-25
US20150247180A1 (en) 2015-09-03
BRPI0916601B1 (pt) 2021-05-25
HK1155813A1 (en) 2012-05-25
WO2010012828A2 (en) 2010-02-04
JP5677297B2 (ja) 2015-02-25
SG193148A1 (en) 2013-09-30
BRPI0916601A2 (pt) 2015-11-10
US20170097365A1 (en) 2017-04-06
MX2011001093A (es) 2011-03-15
CN103983787A (zh) 2014-08-13
AU2009275869A1 (en) 2010-02-04
EP2329274A2 (en) 2011-06-08
EA201100253A1 (ru) 2011-10-31
WO2010012828A3 (en) 2010-05-06
KR20110049781A (ko) 2011-05-12
IL210266A0 (en) 2011-03-31
JP2011529571A (ja) 2011-12-08
KR101682728B1 (ko) 2016-12-05
AU2009275869B2 (en) 2015-05-21
CA2731933A1 (en) 2010-02-04
NZ590658A (en) 2012-07-27
US20100028918A1 (en) 2010-02-04

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