EA020455B1 - Бис(дигидрофосфатная) соль 6-{2-[1-(6-метил-3-пиридазинил)-4-пиперидинил]этокси}-3-этокси-1,2-бензизоксазола (1:2), способ ее получения и ее применение в композиции и способе лечения или предотвращения пикорнавирусных инфекций - Google Patents
Бис(дигидрофосфатная) соль 6-{2-[1-(6-метил-3-пиридазинил)-4-пиперидинил]этокси}-3-этокси-1,2-бензизоксазола (1:2), способ ее получения и ее применение в композиции и способе лечения или предотвращения пикорнавирусных инфекций Download PDFInfo
- Publication number
- EA020455B1 EA020455B1 EA201001835A EA201001835A EA020455B1 EA 020455 B1 EA020455 B1 EA 020455B1 EA 201001835 A EA201001835 A EA 201001835A EA 201001835 A EA201001835 A EA 201001835A EA 020455 B1 EA020455 B1 EA 020455B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- salt
- bis
- ethoxy
- dihydrogen phosphate
- piperidinyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5634108P | 2008-05-27 | 2008-05-27 | |
| PCT/AU2009/000663 WO2009143571A1 (en) | 2008-05-27 | 2009-05-27 | Antiviral salts |
Publications (2)
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| EA201001835A1 EA201001835A1 (ru) | 2011-06-30 |
| EA020455B1 true EA020455B1 (ru) | 2014-11-28 |
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| EA201001835A EA020455B1 (ru) | 2008-05-27 | 2009-05-27 | Бис(дигидрофосфатная) соль 6-{2-[1-(6-метил-3-пиридазинил)-4-пиперидинил]этокси}-3-этокси-1,2-бензизоксазола (1:2), способ ее получения и ее применение в композиции и способе лечения или предотвращения пикорнавирусных инфекций |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8580791B2 (https=) |
| EP (1) | EP2297141B1 (https=) |
| JP (1) | JP5469662B2 (https=) |
| KR (1) | KR20110019759A (https=) |
| CN (1) | CN102046621B (https=) |
| AU (1) | AU2009253738B2 (https=) |
| BR (1) | BRPI0912038A2 (https=) |
| CA (1) | CA2725618C (https=) |
| CO (1) | CO6280534A2 (https=) |
| EA (1) | EA020455B1 (https=) |
| MX (1) | MX2010013019A (https=) |
| NZ (1) | NZ590286A (https=) |
| WO (1) | WO2009143571A1 (https=) |
| ZA (1) | ZA201009284B (https=) |
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| NZ603040A (en) * | 2010-04-15 | 2015-03-27 | Biota Scient Management | Compound for treatment of respiratory condition or disease |
| EP2585067B1 (en) | 2010-06-25 | 2017-08-09 | Biota Scientific Management Pty Ltd | Compound for the treatment of enteroviruses |
| CN102617462B (zh) * | 2012-02-28 | 2014-02-12 | 南京大学 | 特异性抑制肌肉微小核糖核酸的化合物及其合成方法和应用 |
| EA201692549A1 (ru) * | 2014-06-20 | 2017-08-31 | Эвайраджен Терепьютикс, Инк. | Безводная кристаллическая форма свободного основания 6-{2-[1-(6-метил-3-пиридазинил)-4-пиперидинил]этокси}-3-этокси-1,2-бензизоксазола |
| US20250281519A1 (en) * | 2021-05-05 | 2025-09-11 | Emory University | Nucleotide and nucleoside therapeutic compositions, combinations and uses related thereto |
| WO2024192151A2 (en) * | 2023-03-13 | 2024-09-19 | Altesa BioSciences, Inc. | Method of dosing vapendavir to treat enterovirus infections |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002050045A1 (en) * | 2000-12-18 | 2002-06-27 | Biota Scientific Management Pty Ltd | Antiviral agents |
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| IT1170387B (it) | 1982-06-07 | 1987-06-03 | Glaxo Group Ltd | Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono |
| GB2162522B (en) | 1984-08-01 | 1988-02-24 | Glaxo Group Ltd | An indole derivative |
| GB9026998D0 (en) | 1990-12-12 | 1991-01-30 | Glaxo Group Ltd | Medicaments |
| US5514778A (en) * | 1993-07-01 | 1996-05-07 | Eli Lilly And Company | Anti-picornaviral agents |
| US5693661A (en) * | 1995-06-07 | 1997-12-02 | Eli Lilly And Company | Anti-viral compounds |
| US5545653A (en) * | 1995-06-07 | 1996-08-13 | Eli Lilly And Company | Anti-viral compounds |
| US5891874A (en) * | 1996-06-05 | 1999-04-06 | Eli Lilly And Company | Anti-viral compound |
| US5821242A (en) * | 1996-06-06 | 1998-10-13 | Eli Lilly And Company | Anti-viral compounds |
| AU6031898A (en) * | 1997-01-22 | 1998-08-07 | Eli Lilly And Company | Anti-viral compounds |
| CA2293508A1 (en) * | 1997-06-04 | 1998-12-10 | Louis Nickolaus Jungheim | Anti-viral compounds |
| CZ289425B6 (cs) * | 1998-05-20 | 2002-01-16 | Eli Lilly And Company | Imidazo[1,2-a] pyridinové sloučeniny, jejich pouľití a farmaceutický přípravek s jejich obsahem |
| US6358971B1 (en) * | 1998-05-20 | 2002-03-19 | Eli Lilly And Company | Anti-viral compounds |
-
2009
- 2009-05-27 CA CA2725618A patent/CA2725618C/en not_active Expired - Fee Related
- 2009-05-27 AU AU2009253738A patent/AU2009253738B2/en not_active Ceased
- 2009-05-27 EA EA201001835A patent/EA020455B1/ru not_active IP Right Cessation
- 2009-05-27 US US12/994,633 patent/US8580791B2/en active Active
- 2009-05-27 NZ NZ590286A patent/NZ590286A/en not_active IP Right Cessation
- 2009-05-27 CN CN200980120191.2A patent/CN102046621B/zh not_active Expired - Fee Related
- 2009-05-27 EP EP09753335.0A patent/EP2297141B1/en not_active Not-in-force
- 2009-05-27 JP JP2011510782A patent/JP5469662B2/ja not_active Expired - Fee Related
- 2009-05-27 WO PCT/AU2009/000663 patent/WO2009143571A1/en not_active Ceased
- 2009-05-27 BR BRPI0912038A patent/BRPI0912038A2/pt not_active IP Right Cessation
- 2009-05-27 KR KR1020107029303A patent/KR20110019759A/ko not_active Ceased
- 2009-05-27 MX MX2010013019A patent/MX2010013019A/es active IP Right Grant
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2010
- 2010-11-25 CO CO10148308A patent/CO6280534A2/es not_active Application Discontinuation
- 2010-12-23 ZA ZA2010/09284A patent/ZA201009284B/en unknown
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2013
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002050045A1 (en) * | 2000-12-18 | 2002-06-27 | Biota Scientific Management Pty Ltd | Antiviral agents |
Non-Patent Citations (2)
| Title |
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| Chemical Abstracts Accession No. 137:63249 & CAS Registry Fife RN 439085-51-5 See abstract, page 3 compound 35 of table 3, page 24 line 10-28 and page 25 line 19-27 * |
| GENNARO A. R (editor) "Remington: The Science and Practice of Pharmacy" Volume II, 19Edition, A. Mack Publishing Company, 1995, USA. pp 843-1934 See page 1457, table 2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2297141A4 (en) | 2012-04-25 |
| JP2011520991A (ja) | 2011-07-21 |
| CN102046621B (zh) | 2014-11-12 |
| CN102046621A (zh) | 2011-05-04 |
| ZA201009284B (en) | 2012-06-27 |
| CA2725618C (en) | 2016-04-12 |
| AU2009253738A1 (en) | 2009-12-03 |
| EA201001835A1 (ru) | 2011-06-30 |
| US9206171B2 (en) | 2015-12-08 |
| NZ590286A (en) | 2011-08-26 |
| EP2297141B1 (en) | 2015-10-21 |
| BRPI0912038A2 (pt) | 2017-06-20 |
| WO2009143571A1 (en) | 2009-12-03 |
| KR20110019759A (ko) | 2011-02-28 |
| AU2009253738B2 (en) | 2012-12-13 |
| JP5469662B2 (ja) | 2014-04-16 |
| US20140179710A1 (en) | 2014-06-26 |
| US20110144118A1 (en) | 2011-06-16 |
| CO6280534A2 (es) | 2011-05-20 |
| MX2010013019A (es) | 2011-03-21 |
| EP2297141A1 (en) | 2011-03-23 |
| CA2725618A1 (en) | 2009-12-03 |
| US8580791B2 (en) | 2013-11-12 |
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