EA018259B1 - Замещенные хиназолины - Google Patents

Замещенные хиназолины Download PDF

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Publication number
EA018259B1
EA018259B1 EA200900740A EA200900740A EA018259B1 EA 018259 B1 EA018259 B1 EA 018259B1 EA 200900740 A EA200900740 A EA 200900740A EA 200900740 A EA200900740 A EA 200900740A EA 018259 B1 EA018259 B1 EA 018259B1
Authority
EA
Eurasian Patent Office
Prior art keywords
anagrelide
pharmaceutically acceptable
compound
compounds
group
Prior art date
Application number
EA200900740A
Other languages
English (en)
Russian (ru)
Other versions
EA200900740A1 (ru
Inventor
Ричард Франклин
Бернард Голдинг
Original Assignee
ШАЙЕ ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ШАЙЕ ЭлЭлСи filed Critical ШАЙЕ ЭлЭлСи
Publication of EA200900740A1 publication Critical patent/EA200900740A1/ru
Publication of EA018259B1 publication Critical patent/EA018259B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EA200900740A 2006-11-28 2007-11-19 Замещенные хиназолины EA018259B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0623750.7A GB0623750D0 (en) 2006-11-28 2006-11-28 Substituted quinazolines
PCT/GB2007/050697 WO2008065444A2 (fr) 2006-11-28 2007-11-19 Quinazolines substituées

Publications (2)

Publication Number Publication Date
EA200900740A1 EA200900740A1 (ru) 2010-02-26
EA018259B1 true EA018259B1 (ru) 2013-06-28

Family

ID=37671460

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900740A EA018259B1 (ru) 2006-11-28 2007-11-19 Замещенные хиназолины

Country Status (14)

Country Link
EP (1) EP2099802A2 (fr)
JP (1) JP2010511030A (fr)
KR (1) KR20090094268A (fr)
CN (1) CN101558071B (fr)
AR (1) AR064002A1 (fr)
AU (1) AU2007327047B2 (fr)
BR (1) BRPI0719570A2 (fr)
CA (1) CA2670123A1 (fr)
EA (1) EA018259B1 (fr)
GB (1) GB0623750D0 (fr)
IL (1) IL198809A0 (fr)
MX (1) MX2009005579A (fr)
TW (1) TW200838537A (fr)
WO (1) WO2008065444A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB2460915B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
GB0822970D0 (en) 2008-12-17 2009-01-21 Shire Llc Process for the preparation of anagrelide and analogues
GB201004495D0 (en) 2010-03-18 2010-05-05 Shire Llc Subtituted quinazolines
GB201017783D0 (en) 2010-10-21 2010-12-01 Shire Llc Process for the preparation of anagrelide and analogues thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0021338A1 (fr) * 1979-06-20 1981-01-07 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés de la quinazoline et préparations pharmaceutiques
US4256748A (en) * 1977-07-25 1981-03-17 Hoffmann-La Roche Inc. Imidazo[2,1-b]quinazolin-2(3H)-ones and pharmaceutical compositions for treatment and prophylaxis of cardiac insufficiency and cardiac failure
WO2006017822A2 (fr) * 2004-08-04 2006-02-16 Shire Holdings Ag Derives de quinazoline, utilisation de ces derniers dans le traitement de la thrombocythemie

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA803535B (en) * 1979-06-20 1981-06-24 Hoffmann La Roche Novel quinazoline derivatives and pharmaceutical preparations
DK1589973T4 (da) * 2003-01-23 2013-04-08 Shire Biopharmaceuticals Holdings Ireland Ltd Formulering og fremgangsmåder til behandling af thrombocytæmi
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256748A (en) * 1977-07-25 1981-03-17 Hoffmann-La Roche Inc. Imidazo[2,1-b]quinazolin-2(3H)-ones and pharmaceutical compositions for treatment and prophylaxis of cardiac insufficiency and cardiac failure
EP0021338A1 (fr) * 1979-06-20 1981-01-07 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés de la quinazoline et préparations pharmaceutiques
WO2006017822A2 (fr) * 2004-08-04 2006-02-16 Shire Holdings Ag Derives de quinazoline, utilisation de ces derniers dans le traitement de la thrombocythemie

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIENZLE F. ET AL.: "1,5-DIHYDROIMIDAZOQUINAZOLINONES AS BLOOD PLATELET AGGREGATION INHIBITORS", CHIMIE THERAPEUTIQUE, EDITIONS DIMEO, ARCUEIL, FR, vol. 17, no. 6, 1 January 1982 (1982-01-01), pages 547-556, XP009059097, ISSN: 0009-4374, page 549, tab. I; compounds 44, 48, 66 *
VENUTI M.С. ET AL.: "INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASE. 2. STRUCTURAL VARIATIONS OF N-CYCLOHEXYL-N-METHYL-4- not (1,2,3,5-TETRAHYDRO-2-OXOIMIDAZO not 2,1-B 3/4 QUINAZOLIN-7-YL)-OXY 3/4 BUTYRAMIDE (RS-82856)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, vol. 30, no. 2, 1 January 1987 (1987-01-01), pages 303-318, XP000941985, ISSN: 0022-2623, Scheme XIV, page 307, compounds 75A, 83, 84, 85, page 310-page 311, tab. vi *

Also Published As

Publication number Publication date
BRPI0719570A2 (pt) 2013-12-10
CN101558071A (zh) 2009-10-14
CA2670123A1 (fr) 2008-06-05
WO2008065444A2 (fr) 2008-06-05
CN101558071B (zh) 2013-04-24
IL198809A0 (en) 2010-02-17
EP2099802A2 (fr) 2009-09-16
MX2009005579A (es) 2009-08-12
AU2007327047B2 (en) 2012-08-30
EA200900740A1 (ru) 2010-02-26
GB0623750D0 (en) 2007-01-10
WO2008065444B1 (fr) 2008-10-09
AU2007327047A1 (en) 2008-06-05
WO2008065444A3 (fr) 2008-07-31
AR064002A1 (es) 2009-03-04
JP2010511030A (ja) 2010-04-08
TW200838537A (en) 2008-10-01
KR20090094268A (ko) 2009-09-04

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU