EA017985B1 - Способы определения устойчивости рака к ингибиторам гистондеацетилазы - Google Patents

Способы определения устойчивости рака к ингибиторам гистондеацетилазы Download PDF

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EA017985B1
EA017985B1 EA200900927A EA200900927A EA017985B1 EA 017985 B1 EA017985 B1 EA 017985B1 EA 200900927 A EA200900927 A EA 200900927A EA 200900927 A EA200900927 A EA 200900927A EA 017985 B1 EA017985 B1 EA 017985B1
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Eurasian Patent Office
Prior art keywords
cancer
expression
biomarker genes
expression levels
inhibitor
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EA200900927A
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English (en)
Russian (ru)
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EA200900927A1 (ru
Inventor
Джозеф Дж. Багги
Срирам Баласубраманиан
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Фармасайкликс, Инк.
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Publication of EA200900927A1 publication Critical patent/EA200900927A1/ru
Publication of EA017985B1 publication Critical patent/EA017985B1/ru

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EA200900927A 2007-01-30 2008-01-30 Способы определения устойчивости рака к ингибиторам гистондеацетилазы EA017985B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88731807P 2007-01-30 2007-01-30
US91185507P 2007-04-13 2007-04-13
PCT/US2008/052540 WO2008095050A1 (en) 2007-01-30 2008-01-30 Methods for determining cancer resistance to histone deacetylase inhibitors

Publications (2)

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EA200900927A1 EA200900927A1 (ru) 2010-04-30
EA017985B1 true EA017985B1 (ru) 2013-04-30

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EA200900927A EA017985B1 (ru) 2007-01-30 2008-01-30 Способы определения устойчивости рака к ингибиторам гистондеацетилазы
EA201201640A EA201201640A1 (ru) 2007-01-30 2008-01-30 Способы определения устойчивости рака к ингибиторам гистондеацетилазы

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EA201201640A EA201201640A1 (ru) 2007-01-30 2008-01-30 Способы определения устойчивости рака к ингибиторам гистондеацетилазы

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US (3) US7838234B2 (https=)
EP (2) EP2993473A1 (https=)
JP (2) JP5670055B2 (https=)
KR (1) KR101483805B1 (https=)
CN (1) CN101657217B (https=)
AU (2) AU2008210421B2 (https=)
CA (1) CA2677000A1 (https=)
EA (2) EA017985B1 (https=)
NZ (1) NZ579048A (https=)
WO (1) WO2008095050A1 (https=)

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