EA017879B1 - Улучшенное определение экспрессии mage-a - Google Patents

Улучшенное определение экспрессии mage-a Download PDF

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Publication number
EA017879B1
EA017879B1 EA201000334A EA201000334A EA017879B1 EA 017879 B1 EA017879 B1 EA 017879B1 EA 201000334 A EA201000334 A EA 201000334A EA 201000334 A EA201000334 A EA 201000334A EA 017879 B1 EA017879 B1 EA 017879B1
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Eurasian Patent Office
Prior art keywords
gene
mace
primer
primers
protein
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EA201000334A
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English (en)
Russian (ru)
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EA201000334A1 (ru
Inventor
Илзе Влассенброэк
Катя Бьеро
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Онкометилом Сайенсиз Са
Глаксосмитклайн Байолоджикалс С.А.
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Publication of EA201000334A1 publication Critical patent/EA201000334A1/ru
Publication of EA017879B1 publication Critical patent/EA017879B1/ru

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001184Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001186MAGE
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2525/00Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30Oligonucleotides characterised by their secondary structure
    • C12Q2525/301Hairpin oligonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2561/00Nucleic acid detection characterised by assay method
    • C12Q2561/113Real time assay
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    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/10Detection mode being characterised by the assay principle
    • C12Q2565/101Interaction between at least two labels
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201000334A 2007-09-17 2008-09-17 Улучшенное определение экспрессии mage-a EA017879B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96012807P 2007-09-17 2007-09-17
PCT/GB2008/003142 WO2009037438A1 (en) 2007-09-17 2008-09-17 Improved detection of mage-a expression

Publications (2)

Publication Number Publication Date
EA201000334A1 EA201000334A1 (ru) 2011-02-28
EA017879B1 true EA017879B1 (ru) 2013-03-29

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EA201000334A EA017879B1 (ru) 2007-09-17 2008-09-17 Улучшенное определение экспрессии mage-a

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EP (2) EP2201131B8 (enExample)
JP (1) JP5406839B2 (enExample)
KR (1) KR20100085917A (enExample)
CN (1) CN101932723B (enExample)
AU (1) AU2008300397A1 (enExample)
BR (1) BRPI0817008A2 (enExample)
CA (2) CA2699853A1 (enExample)
CO (1) CO6260156A2 (enExample)
CR (1) CR11504A (enExample)
DO (1) DOP2010000076A (enExample)
EA (1) EA017879B1 (enExample)
IL (1) IL204525A0 (enExample)
MA (1) MA31753B1 (enExample)
MX (1) MX2010002965A (enExample)
NZ (2) NZ596545A (enExample)
WO (2) WO2009037441A1 (enExample)
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CN102251033B (zh) * 2011-07-05 2013-03-20 北京大学人民医院 基于mage-a3基因辅助诊断多发性骨髓瘤患者的定量检测试剂盒
US20140213471A1 (en) 2013-01-24 2014-07-31 California Institute Of Technology Chromophore-based characterization and detection methods
CA2902916C (en) * 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
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CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
CN105100961B (zh) * 2015-07-23 2018-03-13 华为技术有限公司 视频缩略图生成方法及生成装置
US11685955B2 (en) 2016-05-16 2023-06-27 Dimo Dietrich Method for predicting response of patients with malignant diseases to immunotherapy
DE102016005947B3 (de) * 2016-05-16 2017-06-08 Dimo Dietrich Verfahren zur Abschätzung der Prognose und zur Prädiktion des Ansprechens auf eine Immuntherapie von Patienten mit malignen Erkrankungen
US10294518B2 (en) 2016-09-16 2019-05-21 Fluxion Biosciences, Inc. Methods and systems for ultra-sensitive detection of genomic alterations
US20200010907A1 (en) 2017-03-17 2020-01-09 Mdxhealth Sa Mgmt epigenetic deep-sequencing assay
US20180271710A1 (en) * 2017-03-22 2018-09-27 Bragi GmbH Wireless earpiece for tinnitus therapy
WO2018237327A1 (en) * 2017-06-22 2018-12-27 Triact Therapeutics, Inc. Methods of treating glioblastoma
US11628144B2 (en) 2017-09-29 2023-04-18 Triact Therapeutics, Inc. Iniparib formulations and uses thereof
US11441182B2 (en) * 2018-08-08 2022-09-13 Virginia Commonwealth University Multiplexed and recyclable single-molecule sensors for quantitative analysis of nucleic-acid biomarkers
CN109540856B (zh) * 2018-11-08 2022-01-28 南京师范大学 一种基于荧光共振能量转移检测不同亚型乳腺癌细胞的试剂
CN111551978B (zh) * 2020-05-08 2022-09-27 中国辐射防护研究院 一种放射性土壤样品采样过程不确定度的评定方法
WO2023108145A1 (en) * 2021-12-10 2023-06-15 Nuprobe Usa, Inc. Universal probes for amplification and detection of nucleic acids
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Publication number Publication date
NZ596545A (en) 2013-05-31
CA2699853A1 (en) 2009-03-26
KR20100085917A (ko) 2010-07-29
US20160032368A1 (en) 2016-02-04
WO2009037441A1 (en) 2009-03-26
US9050280B2 (en) 2015-06-09
CR11504A (es) 2011-05-10
EA201000334A1 (ru) 2011-02-28
IL204525A0 (en) 2010-11-30
ZA201001878B (en) 2011-05-25
EP2201131B8 (en) 2014-12-10
MX2010002965A (es) 2010-09-14
US8481700B2 (en) 2013-07-09
JP2010538633A (ja) 2010-12-16
CN101932723A (zh) 2010-12-29
DOP2010000076A (es) 2010-08-15
EP2201131B1 (en) 2014-11-05
CN101932723B (zh) 2014-09-10
EP2201131A1 (en) 2010-06-30
US20110287416A1 (en) 2011-11-24
US20130302363A1 (en) 2013-11-14
WO2009037438A1 (en) 2009-03-26
EP2198045A1 (en) 2010-06-23
CO6260156A2 (es) 2011-03-22
JP5406839B2 (ja) 2014-02-05
WO2009037438A8 (en) 2010-04-15
MA31753B1 (fr) 2010-10-01
CA2699856C (en) 2019-08-20
NZ583796A (en) 2011-12-22
US10053724B2 (en) 2018-08-21
AU2008300397A1 (en) 2009-03-26
US20100280105A1 (en) 2010-11-04
BRPI0817008A2 (pt) 2017-05-16
CA2699856A1 (en) 2009-03-26

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