EA017510B1 - Ингибиторы mpo для лечения множественной системной атрофии - Google Patents
Ингибиторы mpo для лечения множественной системной атрофии Download PDFInfo
- Publication number
- EA017510B1 EA017510B1 EA201000202A EA201000202A EA017510B1 EA 017510 B1 EA017510 B1 EA 017510B1 EA 201000202 A EA201000202 A EA 201000202A EA 201000202 A EA201000202 A EA 201000202A EA 017510 B1 EA017510 B1 EA 017510B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- mpo
- mice
- pharmaceutically acceptable
- treatment
- salts
- Prior art date
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- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
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| US95752507P | 2007-08-23 | 2007-08-23 | |
| US95752307P | 2007-08-23 | 2007-08-23 | |
| PCT/SE2008/050950 WO2009025618A1 (en) | 2007-08-23 | 2008-08-22 | Mipo inhibitors for the treatment of huntington's disease and multiple system atrophy |
Publications (2)
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| EA201000202A1 EA201000202A1 (ru) | 2010-10-29 |
| EA017510B1 true EA017510B1 (ru) | 2013-01-30 |
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| EA201000202A EA017510B1 (ru) | 2007-08-23 | 2008-08-22 | Ингибиторы mpo для лечения множественной системной атрофии |
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| SI (1) | SI2200616T1 (OSRAM) |
| WO (1) | WO2009025618A1 (OSRAM) |
| ZA (1) | ZA201000848B (OSRAM) |
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| AR039385A1 (es) * | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
| MY140748A (en) * | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| TW200806667A (en) * | 2006-04-13 | 2008-02-01 | Astrazeneca Ab | New compounds |
| TW200804383A (en) * | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| US20090054468A1 (en) * | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Use 938 |
| EP2627178B1 (en) | 2010-10-11 | 2018-05-02 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as crth2 antagonists |
| EP2776405A1 (en) | 2011-11-11 | 2014-09-17 | Pfizer Inc | 2-thiopyrimidinones |
| WO2013144088A1 (en) * | 2012-03-29 | 2013-10-03 | Basf Se | N-substituted hetero-bicyclic compounds and derivatives for combating animal pests ii |
| US9616063B2 (en) * | 2014-12-01 | 2017-04-11 | Astrazeneca Ab | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase |
| MX382097B (es) | 2015-05-05 | 2025-03-13 | Pfizer | 1-(2-aminoetil)-6-(2-(2-hidroxietoxi)-5-metilfenil)-2-tioxo-2,3-dihidropirimidin-4(1h)-ona, y el uso del mismo para tratar afecciones cardiovasculares. |
| CN111182898B (zh) * | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| KR102705858B1 (ko) * | 2017-07-17 | 2024-09-10 | 아스트라제네카 아베 | 의약에서의 사용을 위한 mpo 억제제 |
| US20240067651A1 (en) * | 2019-10-10 | 2024-02-29 | Biohaven Therapeutics Ltd. | Prodrugs of myeloperoxidase inhibitors |
| KR20220149709A (ko) * | 2020-03-05 | 2022-11-08 | 바이오하벤 테라퓨틱스 리미티드 | 골수 세포형과산화효소 저해제를 사용한 근위축성 측삭 경화증의 치료 방법 |
| IL297857A (en) * | 2020-05-06 | 2023-01-01 | Biohaven Therapeutics Ltd | Process for the preparation of verdiperstat |
| CN115403584B (zh) * | 2021-05-26 | 2024-04-02 | 长春金赛药业有限责任公司 | 2-硫代-2,3-二氢嘧啶-4-酮衍生物、药物组合物及其制备方法和应用 |
| TW202426450A (zh) | 2022-08-18 | 2024-07-01 | 瑞典商阿斯特捷利康公司 | 髓過氧化物酶抑制劑 |
| WO2024047094A1 (en) * | 2022-08-31 | 2024-03-07 | Astrazeneca Ab | Pharmaceutical formulation |
| EP4624473A1 (en) * | 2022-12-09 | 2025-10-01 | Shenzhen Salubris Pharmaceuticals Co., Ltd. | Pyrrolo[3,2-d]pyrimidin-4-one derivative, and preparation method therefor and medical use thereof |
| WO2024163892A1 (en) * | 2023-02-02 | 2024-08-08 | University Of Virginia Patent Foundation | Myeloperoxidase (mpo) inhibition as a treatment target for delayed cerebral injury (dci) in aneurysmal subarachnoid hemorrhage (sah) |
| WO2025172474A1 (en) | 2024-02-15 | 2025-08-21 | Astrazeneca Ab | Inhibitors of myeloperoxidase |
| WO2025190901A1 (en) | 2024-03-13 | 2025-09-18 | Institut National de la Santé et de la Recherche Médicale | Use of myeloperoxidase (mpo) inhibitors for promoting cd8+ t cell responses |
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| US20090054468A1 (en) * | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Use 938 |
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2008
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- 2008-08-22 WO PCT/SE2008/050950 patent/WO2009025618A1/en not_active Ceased
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- 2011-02-23 US US13/033,220 patent/US20110207755A1/en not_active Abandoned
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