NZ584135A - Mpo inhibitors for the treatment of huntington's disease and multiple system atrophy - Google Patents
Mpo inhibitors for the treatment of huntington's disease and multiple system atrophyInfo
- Publication number
- NZ584135A NZ584135A NZ584135A NZ58413508A NZ584135A NZ 584135 A NZ584135 A NZ 584135A NZ 584135 A NZ584135 A NZ 584135A NZ 58413508 A NZ58413508 A NZ 58413508A NZ 584135 A NZ584135 A NZ 584135A
- Authority
- NZ
- New Zealand
- Prior art keywords
- thioxo
- tetrahydro
- methyl
- msa
- mpo
- Prior art date
Links
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95752307P | 2007-08-23 | 2007-08-23 | |
| US95752507P | 2007-08-23 | 2007-08-23 | |
| PCT/SE2008/050950 WO2009025618A1 (en) | 2007-08-23 | 2008-08-22 | Mipo inhibitors for the treatment of huntington's disease and multiple system atrophy |
Publications (1)
| Publication Number | Publication Date |
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| NZ584135A true NZ584135A (en) | 2012-04-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ584135A NZ584135A (en) | 2007-08-23 | 2008-08-22 | Mpo inhibitors for the treatment of huntington's disease and multiple system atrophy |
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| EP (1) | EP2200616B1 (OSRAM) |
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| KR (1) | KR101588464B1 (OSRAM) |
| CN (4) | CN113633641A (OSRAM) |
| AU (1) | AU2008289653B2 (OSRAM) |
| BR (1) | BRPI0815681A2 (OSRAM) |
| CA (1) | CA2698205C (OSRAM) |
| CY (1) | CY1113714T1 (OSRAM) |
| DK (1) | DK2200616T3 (OSRAM) |
| EA (1) | EA017510B1 (OSRAM) |
| ES (1) | ES2399846T3 (OSRAM) |
| HR (1) | HRP20130139T1 (OSRAM) |
| IL (2) | IL203738A (OSRAM) |
| ME (1) | ME01510B (OSRAM) |
| MX (1) | MX2010001983A (OSRAM) |
| MY (1) | MY155633A (OSRAM) |
| NZ (1) | NZ584135A (OSRAM) |
| PH (1) | PH12014501180A1 (OSRAM) |
| PL (1) | PL2200616T3 (OSRAM) |
| PT (1) | PT2200616E (OSRAM) |
| RS (1) | RS52665B (OSRAM) |
| SI (1) | SI2200616T1 (OSRAM) |
| WO (1) | WO2009025618A1 (OSRAM) |
| ZA (1) | ZA201000848B (OSRAM) |
Families Citing this family (22)
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| AR039385A1 (es) * | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
| MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| UY30267A1 (es) * | 2006-04-13 | 2007-11-30 | Astrazeneca Ab | Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones |
| TW200804383A (en) * | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| US20090054468A1 (en) * | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Use 938 |
| US8927559B2 (en) | 2010-10-11 | 2015-01-06 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as CRTH2 antagonists |
| CN103917529B (zh) | 2011-11-11 | 2016-08-17 | 辉瑞大药厂 | 2-硫代嘧啶酮类 |
| EP2831076B1 (en) * | 2012-03-29 | 2016-05-25 | Basf Se | N-substituted hetero-bicyclic compounds and derivatives for combating animal pests ii |
| US9616063B2 (en) | 2014-12-01 | 2017-04-11 | Astrazeneca Ab | 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase |
| MA42035A (fr) | 2015-05-05 | 2018-03-14 | Pfizer | 2-thiopyrimidinones |
| BR112019027717A2 (pt) * | 2017-06-28 | 2020-07-28 | Ptc Therapeutics, Inc. | métodos para tratar a doença de huntington |
| US11246870B2 (en) * | 2017-07-17 | 2022-02-15 | Astrazenca Ab | MPO inhibitors for use in medicine |
| KR20220080133A (ko) | 2019-10-10 | 2022-06-14 | 바이오하벤 테라퓨틱스 리미티드 | 골수퍼옥시다제 저해제의 전구약물 |
| KR20220149709A (ko) * | 2020-03-05 | 2022-11-08 | 바이오하벤 테라퓨틱스 리미티드 | 골수 세포형과산화효소 저해제를 사용한 근위축성 측삭 경화증의 치료 방법 |
| KR20230007453A (ko) * | 2020-05-06 | 2023-01-12 | 바이오하벤 테라퓨틱스 리미티드 | 베르디퍼스타트의 제조 과정 |
| CN115403584B (zh) * | 2021-05-26 | 2024-04-02 | 长春金赛药业有限责任公司 | 2-硫代-2,3-二氢嘧啶-4-酮衍生物、药物组合物及其制备方法和应用 |
| TW202426450A (zh) | 2022-08-18 | 2024-07-01 | 瑞典商阿斯特捷利康公司 | 髓過氧化物酶抑制劑 |
| CA3266275A1 (en) * | 2022-08-31 | 2024-03-07 | Astrazeneca Ab | PHARMACEUTICAL FORMULATION |
| CN120265633A (zh) * | 2022-12-09 | 2025-07-04 | 深圳信立泰药业股份有限公司 | 一种吡咯并[3,2-d]嘧啶-4-酮类衍生物及其制备方法和医药用途 |
| WO2024163892A1 (en) * | 2023-02-02 | 2024-08-08 | University Of Virginia Patent Foundation | Myeloperoxidase (mpo) inhibition as a treatment target for delayed cerebral injury (dci) in aneurysmal subarachnoid hemorrhage (sah) |
| WO2025172474A1 (en) | 2024-02-15 | 2025-08-21 | Astrazeneca Ab | Inhibitors of myeloperoxidase |
| WO2025190901A1 (en) | 2024-03-13 | 2025-09-18 | Institut National de la Santé et de la Recherche Médicale | Use of myeloperoxidase (mpo) inhibitors for promoting cd8+ t cell responses |
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| WO1999012546A1 (en) * | 1997-09-05 | 1999-03-18 | Kyowa Hakko Kogyo Co., Ltd. | Remedial agent for neural degeneration |
| GB0100623D0 (en) * | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds IV |
| GB0100620D0 (en) * | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical cokpounds V |
| KR20150080013A (ko) * | 2002-01-28 | 2015-07-08 | 교와 핫꼬 기린 가부시키가이샤 | 운동성 질환에 걸린 환자의 치료용 조성물 |
| AR039385A1 (es) * | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
| SE0302756D0 (sv) * | 2003-10-17 | 2003-10-17 | Astrazeneca Ab | Novel Compounds |
| MY140748A (en) * | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| UY30267A1 (es) * | 2006-04-13 | 2007-11-30 | Astrazeneca Ab | Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones |
| WO2007142577A1 (en) * | 2006-06-05 | 2007-12-13 | Astrazeneca Ab | Pyrrolo[3,2-d]pyrimidin-4-one derivative as myeloperoxidase inhibitor |
| AR066936A1 (es) * | 2007-06-13 | 2009-09-23 | Astrazeneca Ab | 3 - (2r - tetrahidrofuril - metil) - 2 - tioxantina. composiciones farmaceuticas. |
| US20090054468A1 (en) * | 2007-08-23 | 2009-02-26 | Astrazeneca Ab | New Use 938 |
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- 2008-08-22 CA CA2698205A patent/CA2698205C/en not_active Expired - Fee Related
- 2008-08-22 ME MEP-2013-49A patent/ME01510B/me unknown
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- 2008-08-22 EA EA201000202A patent/EA017510B1/ru not_active IP Right Cessation
- 2008-08-22 SI SI200830893T patent/SI2200616T1/sl unknown
- 2008-08-22 MY MYPI2010000753A patent/MY155633A/en unknown
- 2008-08-22 CN CN202110874748.4A patent/CN113633641A/zh active Pending
- 2008-08-22 AU AU2008289653A patent/AU2008289653B2/en not_active Ceased
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- 2008-08-22 PL PL08794174T patent/PL2200616T3/pl unknown
- 2008-08-22 CN CN200880111701A patent/CN101873857A/zh active Pending
- 2008-08-22 CN CN201610055826.7A patent/CN105687199A/zh active Pending
- 2008-08-22 HR HRP20130139AT patent/HRP20130139T1/hr unknown
- 2008-08-22 JP JP2010521817A patent/JP5247804B2/ja active Active
- 2008-08-22 DK DK08794174.6T patent/DK2200616T3/da active
- 2008-08-22 BR BRPI0815681-6A2A patent/BRPI0815681A2/pt not_active IP Right Cessation
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- 2008-08-22 WO PCT/SE2008/050950 patent/WO2009025618A1/en not_active Ceased
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2010
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- 2010-02-04 ZA ZA2010/00848A patent/ZA201000848B/en unknown
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2011
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2012
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2013
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- 2013-11-08 US US14/075,790 patent/US20140221400A1/en not_active Abandoned
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2014
- 2014-05-26 PH PH12014501180A patent/PH12014501180A1/en unknown
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2015
- 2015-07-23 IL IL240130A patent/IL240130A0/en unknown
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2018
- 2018-08-30 US US16/117,020 patent/US10772890B2/en active Active
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2020
- 2020-09-13 US US17/019,276 patent/US20200405724A1/en active Pending
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