EA011866B1 - Агенты, специфически связывающие ангиопоэтин-2 - Google Patents

Агенты, специфически связывающие ангиопоэтин-2 Download PDF

Info

Publication number
EA011866B1
EA011866B1 EA200700876A EA200700876A EA011866B1 EA 011866 B1 EA011866 B1 EA 011866B1 EA 200700876 A EA200700876 A EA 200700876A EA 200700876 A EA200700876 A EA 200700876A EA 011866 B1 EA011866 B1 EA 011866B1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
absent
antibodies
amino acid
specific binding
Prior art date
Application number
EA200700876A
Other languages
English (en)
Russian (ru)
Other versions
EA200700876A1 (ru
Inventor
Джонатон Даниел Олайнер
Кевин Грэхэм
Original Assignee
Амджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/982,440 external-priority patent/US7658924B2/en
Application filed by Амджен Инк. filed Critical Амджен Инк.
Publication of EA200700876A1 publication Critical patent/EA200700876A1/ru
Publication of EA011866B1 publication Critical patent/EA011866B1/ru

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA200700876A 2004-10-19 2005-10-19 Агенты, специфически связывающие ангиопоэтин-2 EA011866B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62016104P 2004-10-19 2004-10-19
US10/982,440 US7658924B2 (en) 2001-10-11 2004-11-04 Angiopoietin-2 specific binding agents
PCT/US2005/037911 WO2006045049A1 (en) 2004-10-19 2005-10-19 Angiopoietin-2 specific binding agents

Publications (2)

Publication Number Publication Date
EA200700876A1 EA200700876A1 (ru) 2007-10-26
EA011866B1 true EA011866B1 (ru) 2009-06-30

Family

ID=39608222

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700876A EA011866B1 (ru) 2004-10-19 2005-10-19 Агенты, специфически связывающие ангиопоэтин-2

Country Status (10)

Country Link
JP (2) JP2008520188A (https=)
CN (1) CN101495513B (https=)
BR (1) BRPI0518209A (https=)
EA (1) EA011866B1 (https=)
IL (1) IL182279A0 (https=)
MA (1) MA29015B1 (https=)
MX (1) MX2007004247A (https=)
RU (2) RU2404992C2 (https=)
SG (1) SG156668A1 (https=)
ZA (1) ZA200704020B (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0518209A (pt) * 2004-10-19 2008-11-04 Amgen Inc agentes de ligação especìficos à angiopoietina-2
JO3182B1 (ar) * 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
MY162940A (en) 2009-08-19 2017-07-31 Eisai R&D Man Co Ltd Quinoline derivative-containing pharmaceutical composition
EA022546B1 (ru) * 2011-09-28 2016-01-29 Федеральное Государственное Бюджетное Учреждение Науки Институт Биоорганической Химии Им. Академиков М.М. Шемякина И Ю.А. Овчинникова Российской Академии Наук Способ торможения роста карциномы эрлиха у лабораторного животного
HUE034044T2 (en) * 2011-09-30 2018-01-29 Dana Farber Cancer Inst Inc Therapeutic peptides
KR102063028B1 (ko) * 2012-01-23 2020-01-07 리제너론 파아마슈티컬스, 인크. 항-ang2 항체를 함유하는 안정화된 제형
WO2014100834A1 (en) * 2012-12-21 2014-06-26 The Regents Of The University Of California Methods and compositions for treatment of cyanide and hydrogen sulfide toxicity
NZ714049A (en) * 2013-05-14 2020-05-29 Eisai R&D Man Co Ltd Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
AR100270A1 (es) * 2014-05-19 2016-09-21 Lilly Co Eli Anticuerpos ang2
PT3524595T (pt) 2014-08-28 2022-09-19 Eisai R&D Man Co Ltd Derivado de quinolina altamente puro e método para produção do mesmo
LT3263106T (lt) 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. Chinolino darinių kartumo sumažinimo būdas
KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
MX373231B (es) 2015-06-16 2020-05-08 Eisai R&D Man Co Ltd Agente anticancerigeno.
US12220398B2 (en) 2015-08-20 2025-02-11 Eisai R&D Management Co., Ltd. Tumor therapeutic agent
CN106075448A (zh) * 2016-07-25 2016-11-09 广州道瑞医药科技有限公司 Angpt2抑制剂在制备用于治疗血管瘤的药物中的应用
CN106512006A (zh) * 2016-07-25 2017-03-22 广州道瑞医药科技有限公司 Angpt2分泌抑制剂在制备用于治疗血管瘤的药物中的应用
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition
RU2019134940A (ru) 2017-05-16 2021-06-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Лечение гепатоцеллюлярной карциномы
CN109096368B (zh) * 2018-09-30 2021-07-20 华南理工大学 一种同时具有抗氧化和护肝活性的多肽及编码该多肽的基因与其制备方法和应用
US20220204603A1 (en) * 2019-02-25 2022-06-30 Pharmabcine Inc. Anti-ang2 antibody and use thereof
CN112126671B (zh) * 2020-08-18 2021-08-31 中山大学附属第五医院 无乳链球菌Streptococus agalactiae治疗子宫内膜异位症的应用
CN116265487B (zh) * 2021-12-16 2025-01-10 三优生物医药(上海)有限公司 抗ang2-vegf双特异性抗体及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057901A1 (en) * 1999-03-26 2000-10-05 Regeneron Pharmaceuticals, Inc. Modulation of vascular permeability by means of tie2 receptor activators
WO2003030883A1 (en) * 2001-10-12 2003-04-17 Kosmos Pharma Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20030236193A1 (en) * 2001-10-11 2003-12-25 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342219B1 (en) * 1999-04-28 2002-01-29 Board Of Regents, The University Of Texas System Antibody compositions for selectively inhibiting VEGF
AU784231B2 (en) * 2000-06-23 2006-02-23 Schering Aktiengesellschaft Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/tie receptor function and their use (II)
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
BRPI0518209A (pt) * 2004-10-19 2008-11-04 Amgen Inc agentes de ligação especìficos à angiopoietina-2

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057901A1 (en) * 1999-03-26 2000-10-05 Regeneron Pharmaceuticals, Inc. Modulation of vascular permeability by means of tie2 receptor activators
US20030236193A1 (en) * 2001-10-11 2003-12-25 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
WO2003030883A1 (en) * 2001-10-12 2003-04-17 Kosmos Pharma Uniform films for rapid dissolve dosage form incorporating taste-masking compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAI M. ET AL.: "Single chain Fv antibody against angiopoietin-2 inhibits VEGF-induced endothelial cell proliferation and migration in vitro". BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 309, no. 4, 3 October, 2003 (2003-10-03), pages 946-951, XP004455833, ISSN: 0006-291X *
OLINER J. ET AL.: "Suppression of angiogenesis and tumor growth by selective Inhibition of angiopoietin-2". CANCER CELL, XX, US, vol. 6, no. 5, November 2004 (2004-11), pages 507-516, XP002348738, ISSN: 1535-6108, the whole document *

Also Published As

Publication number Publication date
MX2007004247A (es) 2007-06-12
JP2011207882A (ja) 2011-10-20
CN101495513A (zh) 2009-07-29
ZA200704020B (en) 2008-06-25
CN101495513B (zh) 2014-08-06
SG156668A1 (en) 2009-11-26
IL182279A0 (en) 2007-07-24
MA29015B1 (fr) 2007-11-01
RU2010132956A (ru) 2012-02-10
RU2007118670A (ru) 2008-12-27
EA200700876A1 (ru) 2007-10-26
JP2008520188A (ja) 2008-06-19
BRPI0518209A (pt) 2008-11-04
RU2404992C2 (ru) 2010-11-27

Similar Documents

Publication Publication Date Title
EA011866B1 (ru) Агенты, специфически связывающие ангиопоэтин-2
JP4705022B2 (ja) ヒトアンジオポエチン−2の特異的結合物質を用いた炎症性疾患の治療方法
ES2439221T3 (es) Agentes de unión específicos de angiopoyetina-2
ES2402918T3 (es) Agentes de unión específicos de angiopoietina-2 humana
TWI476206B (zh) 對肝細胞生長因子具專一性之結合劑
JP5908972B2 (ja) 新規な抗原結合タンパク質
TWI398448B (zh) 多胜肽及抗體
JP2014040428A (ja) アンジオポエチン−2特異的結合物質
EA022308B1 (ru) Антитела, направленные против ангиопоэтина-1 и ангиопоэтина-2, и их применение
US20060051366A1 (en) Use of soluble CD26 as inhibitor of angiogenesis and inflammation
HK1136836A (en) Angiopoietin-2 specific binding agents
BRPI0216042B1 (pt) Polipeptídeo capaz de se ligar a ANG-2, vetor de expressão, célula hospedeira, composição farmacêutica, e, uso dos referidos polipeptídeos.
HK1103094A (en) Methods of treatment of inflammatory diseases using specific binding agents of human angiopoietin-2
HK1103093A (en) Methods of treatment of inflammatory diseases using specific binding agents of human angiopoietin-2
HK1103092A (en) Methods of treatment of inflammatory diseases using specific binding agents of human angiopoietin-2

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU