EA011866B1 - Агенты, специфически связывающие ангиопоэтин-2 - Google Patents

Агенты, специфически связывающие ангиопоэтин-2 Download PDF

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Publication number
EA011866B1
EA011866B1 EA200700876A EA200700876A EA011866B1 EA 011866 B1 EA011866 B1 EA 011866B1 EA 200700876 A EA200700876 A EA 200700876A EA 200700876 A EA200700876 A EA 200700876A EA 011866 B1 EA011866 B1 EA 011866B1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
absent
antibodies
amino acid
specific binding
Prior art date
Application number
EA200700876A
Other languages
English (en)
Russian (ru)
Other versions
EA200700876A1 (ru
Inventor
Джонатон Даниел Олайнер
Кевин Грэхэм
Original Assignee
Амджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/982,440 external-priority patent/US7658924B2/en
Application filed by Амджен Инк. filed Critical Амджен Инк.
Publication of EA200700876A1 publication Critical patent/EA200700876A1/ru
Publication of EA011866B1 publication Critical patent/EA011866B1/ru

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA200700876A 2004-10-19 2005-10-19 Агенты, специфически связывающие ангиопоэтин-2 EA011866B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62016104P 2004-10-19 2004-10-19
US10/982,440 US7658924B2 (en) 2001-10-11 2004-11-04 Angiopoietin-2 specific binding agents
PCT/US2005/037911 WO2006045049A1 (en) 2004-10-19 2005-10-19 Angiopoietin-2 specific binding agents

Publications (2)

Publication Number Publication Date
EA200700876A1 EA200700876A1 (ru) 2007-10-26
EA011866B1 true EA011866B1 (ru) 2009-06-30

Family

ID=39608222

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700876A EA011866B1 (ru) 2004-10-19 2005-10-19 Агенты, специфически связывающие ангиопоэтин-2

Country Status (10)

Country Link
JP (2) JP2008520188A (enrdf_load_stackoverflow)
CN (1) CN101495513B (enrdf_load_stackoverflow)
BR (1) BRPI0518209A (enrdf_load_stackoverflow)
EA (1) EA011866B1 (enrdf_load_stackoverflow)
IL (1) IL182279A0 (enrdf_load_stackoverflow)
MA (1) MA29015B1 (enrdf_load_stackoverflow)
MX (1) MX2007004247A (enrdf_load_stackoverflow)
RU (2) RU2404992C2 (enrdf_load_stackoverflow)
SG (1) SG156668A1 (enrdf_load_stackoverflow)
ZA (1) ZA200704020B (enrdf_load_stackoverflow)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA011866B1 (ru) * 2004-10-19 2009-06-30 Амджен Инк. Агенты, специфически связывающие ангиопоэтин-2
JO3182B1 (ar) * 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
EA022546B1 (ru) * 2011-09-28 2016-01-29 Федеральное Государственное Бюджетное Учреждение Науки Институт Биоорганической Химии Им. Академиков М.М. Шемякина И Ю.А. Овчинникова Российской Академии Наук Способ торможения роста карциномы эрлиха у лабораторного животного
JP2014532053A (ja) * 2011-09-30 2014-12-04 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 治療用ペプチド
NZ627859A (en) * 2012-01-23 2015-09-25 Regeneron Pharma Stabilized formulations containing anti-ang2 antibodies
WO2014100834A1 (en) * 2012-12-21 2014-06-26 The Regents Of The University Of California Methods and compositions for treatment of cyanide and hydrogen sulfide toxicity
CN105264380B (zh) 2013-05-14 2017-09-05 卫材R&D管理有限公司 用于预测和评价子宫内膜癌受试者对乐伐替尼化合物响应性的生物标志
AR100270A1 (es) * 2014-05-19 2016-09-21 Lilly Co Eli Anticuerpos ang2
AU2015309862C1 (en) 2014-08-28 2020-10-15 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
DK3263106T3 (da) 2015-02-25 2024-01-08 Eisai R&D Man Co Ltd Fremgangsmåde til undertrykkelse af bitterhed af quinolinderivat
KR20240064733A (ko) 2015-03-04 2024-05-13 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
BR112017027227B1 (pt) 2015-06-16 2023-12-12 Eisai R&D Management Co., Ltd Agente anti-câncer
MX381976B (es) 2015-08-20 2025-03-13 Eisai R&D Man Co Ltd Agente terapéutico contra tumores.
CN106512006A (zh) * 2016-07-25 2017-03-22 广州道瑞医药科技有限公司 Angpt2分泌抑制剂在制备用于治疗血管瘤的药物中的应用
CN106075448A (zh) * 2016-07-25 2016-11-09 广州道瑞医药科技有限公司 Angpt2抑制剂在制备用于治疗血管瘤的药物中的应用
ES2971448T3 (es) 2017-02-08 2024-06-05 Eisai R&D Man Co Ltd Composición farmacéutica para el tratamiento de tumores
SG11201910100PA (en) 2017-05-16 2019-11-28 Eisai R&D Man Co Ltd Treatment of hepatocellular carcinoma
CN109096368B (zh) * 2018-09-30 2021-07-20 华南理工大学 一种同时具有抗氧化和护肝活性的多肽及编码该多肽的基因与其制备方法和应用
EP3932946A4 (en) * 2019-02-25 2023-03-22 Pharmabcine Inc. ANTI-ANG2 ANTIBODIES AND ITS USE
CN112126671B (zh) * 2020-08-18 2021-08-31 中山大学附属第五医院 无乳链球菌Streptococus agalactiae治疗子宫内膜异位症的应用
CN116265487B (zh) * 2021-12-16 2025-01-10 三优生物医药(上海)有限公司 抗ang2-vegf双特异性抗体及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057901A1 (en) * 1999-03-26 2000-10-05 Regeneron Pharmaceuticals, Inc. Modulation of vascular permeability by means of tie2 receptor activators
WO2003030883A1 (en) * 2001-10-12 2003-04-17 Kosmos Pharma Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20030236193A1 (en) * 2001-10-11 2003-12-25 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
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WO2000064946A2 (en) * 1999-04-28 2000-11-02 Board Of Regents, The University Of Texas System Compositions and methods for cancer treatment by selectively inhibiting vegf
EE200200706A (et) * 2000-06-23 2004-06-15 Schering Aktiengesellschaft VEGF-i/VEGF-retseptori ja angiopoetiini/Tie-retseptori funktsiooni mõjustavad kombinatsioonid ja kompositsioonid ning nende kasutamine (II)
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
EA011866B1 (ru) * 2004-10-19 2009-06-30 Амджен Инк. Агенты, специфически связывающие ангиопоэтин-2

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057901A1 (en) * 1999-03-26 2000-10-05 Regeneron Pharmaceuticals, Inc. Modulation of vascular permeability by means of tie2 receptor activators
US20030236193A1 (en) * 2001-10-11 2003-12-25 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
WO2003030883A1 (en) * 2001-10-12 2003-04-17 Kosmos Pharma Uniform films for rapid dissolve dosage form incorporating taste-masking compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAI M. ET AL.: "Single chain Fv antibody against angiopoietin-2 inhibits VEGF-induced endothelial cell proliferation and migration in vitro". BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 309, no. 4, 3 October, 2003 (2003-10-03), pages 946-951, XP004455833, ISSN: 0006-291X *
OLINER J. ET AL.: "Suppression of angiogenesis and tumor growth by selective Inhibition of angiopoietin-2". CANCER CELL, XX, US, vol. 6, no. 5, November 2004 (2004-11), pages 507-516, XP002348738, ISSN: 1535-6108, the whole document *

Also Published As

Publication number Publication date
MA29015B1 (fr) 2007-11-01
IL182279A0 (en) 2007-07-24
EA200700876A1 (ru) 2007-10-26
SG156668A1 (en) 2009-11-26
JP2011207882A (ja) 2011-10-20
CN101495513A (zh) 2009-07-29
CN101495513B (zh) 2014-08-06
RU2404992C2 (ru) 2010-11-27
ZA200704020B (en) 2008-06-25
RU2007118670A (ru) 2008-12-27
RU2010132956A (ru) 2012-02-10
BRPI0518209A (pt) 2008-11-04
JP2008520188A (ja) 2008-06-19
MX2007004247A (es) 2007-06-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU