RU2404992C2 - Ангиопоэтин-2-специфические связывающие агенты - Google Patents

Ангиопоэтин-2-специфические связывающие агенты Download PDF

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Publication number
RU2404992C2
RU2404992C2 RU2007118670/13A RU2007118670A RU2404992C2 RU 2404992 C2 RU2404992 C2 RU 2404992C2 RU 2007118670/13 A RU2007118670/13 A RU 2007118670/13A RU 2007118670 A RU2007118670 A RU 2007118670A RU 2404992 C2 RU2404992 C2 RU 2404992C2
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RU
Russia
Prior art keywords
seq
antibody
ang
specific binding
antibodies
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RU2007118670/13A
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English (en)
Russian (ru)
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RU2007118670A (ru
Inventor
Джонатон Дэниел ОЛИНЕР (US)
Джонатон Дэниел ОЛИНЕР
Кевин ГРЭХЕМ (US)
Кевин ГРЭХЕМ
Original Assignee
Эмджен Инк.
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Priority claimed from US10/982,440 external-priority patent/US7658924B2/en
Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of RU2007118670A publication Critical patent/RU2007118670A/ru
Application granted granted Critical
Publication of RU2404992C2 publication Critical patent/RU2404992C2/ru

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2007118670/13A 2004-10-19 2005-10-19 Ангиопоэтин-2-специфические связывающие агенты RU2404992C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62016104P 2004-10-19 2004-10-19
US60/620,161 2004-10-19
US10/982,440 2004-11-04
US10/982,440 US7658924B2 (en) 2001-10-11 2004-11-04 Angiopoietin-2 specific binding agents

Related Child Applications (1)

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RU2010132956/10A Division RU2010132956A (ru) 2004-10-19 2010-08-05 Ангиопоэтин-2-специфические связывающие агенты

Publications (2)

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RU2007118670A RU2007118670A (ru) 2008-12-27
RU2404992C2 true RU2404992C2 (ru) 2010-11-27

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RU2007118670/13A RU2404992C2 (ru) 2004-10-19 2005-10-19 Ангиопоэтин-2-специфические связывающие агенты
RU2010132956/10A RU2010132956A (ru) 2004-10-19 2010-08-05 Ангиопоэтин-2-специфические связывающие агенты

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RU2010132956/10A RU2010132956A (ru) 2004-10-19 2010-08-05 Ангиопоэтин-2-специфические связывающие агенты

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JP (2) JP2008520188A (enrdf_load_stackoverflow)
CN (1) CN101495513B (enrdf_load_stackoverflow)
BR (1) BRPI0518209A (enrdf_load_stackoverflow)
EA (1) EA011866B1 (enrdf_load_stackoverflow)
IL (1) IL182279A0 (enrdf_load_stackoverflow)
MA (1) MA29015B1 (enrdf_load_stackoverflow)
MX (1) MX2007004247A (enrdf_load_stackoverflow)
RU (2) RU2404992C2 (enrdf_load_stackoverflow)
SG (1) SG156668A1 (enrdf_load_stackoverflow)
ZA (1) ZA200704020B (enrdf_load_stackoverflow)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA022546B1 (ru) * 2011-09-28 2016-01-29 Федеральное Государственное Бюджетное Учреждение Науки Институт Биоорганической Химии Им. Академиков М.М. Шемякина И Ю.А. Овчинникова Российской Академии Наук Способ торможения роста карциномы эрлиха у лабораторного животного
RU2658601C2 (ru) * 2013-05-14 2018-06-21 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Биомаркер для прогнозирования и оценки чувствительности субъектов с раком эндометрия к соединениям ленватиниба
US10259791B2 (en) 2014-08-28 2019-04-16 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
US11090386B2 (en) 2015-02-25 2021-08-17 Eisai R&D Management Co., Ltd. Method for suppressing bitterness of quinoline derivative
US11369623B2 (en) 2015-06-16 2022-06-28 Prism Pharma Co., Ltd. Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor
US11547705B2 (en) 2015-03-04 2023-01-10 Merck Sharp & Dohme Llc Combination of a PD-1 antagonist and a VEGF-R/FGFR/RET tyrosine kinase inhibitor for treating cancer
US12220398B2 (en) 2015-08-20 2025-02-11 Eisai R&D Management Co., Ltd. Tumor therapeutic agent
US12226409B2 (en) 2017-05-16 2025-02-18 Eisai R&D Management Co., Ltd. Treatment of hepatocellular carcinoma
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA011866B1 (ru) * 2004-10-19 2009-06-30 Амджен Инк. Агенты, специфически связывающие ангиопоэтин-2
JO3182B1 (ar) * 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
JP2014532053A (ja) * 2011-09-30 2014-12-04 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 治療用ペプチド
NZ627859A (en) * 2012-01-23 2015-09-25 Regeneron Pharma Stabilized formulations containing anti-ang2 antibodies
WO2014100834A1 (en) * 2012-12-21 2014-06-26 The Regents Of The University Of California Methods and compositions for treatment of cyanide and hydrogen sulfide toxicity
AR100270A1 (es) * 2014-05-19 2016-09-21 Lilly Co Eli Anticuerpos ang2
CN106512006A (zh) * 2016-07-25 2017-03-22 广州道瑞医药科技有限公司 Angpt2分泌抑制剂在制备用于治疗血管瘤的药物中的应用
CN106075448A (zh) * 2016-07-25 2016-11-09 广州道瑞医药科技有限公司 Angpt2抑制剂在制备用于治疗血管瘤的药物中的应用
CN109096368B (zh) * 2018-09-30 2021-07-20 华南理工大学 一种同时具有抗氧化和护肝活性的多肽及编码该多肽的基因与其制备方法和应用
EP3932946A4 (en) * 2019-02-25 2023-03-22 Pharmabcine Inc. ANTI-ANG2 ANTIBODIES AND ITS USE
CN112126671B (zh) * 2020-08-18 2021-08-31 中山大学附属第五医院 无乳链球菌Streptococus agalactiae治疗子宫内膜异位症的应用
CN116265487B (zh) * 2021-12-16 2025-01-10 三优生物医药(上海)有限公司 抗ang2-vegf双特异性抗体及其用途

Citations (3)

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Publication number Priority date Publication date Assignee Title
US6524583B1 (en) * 1999-04-28 2003-02-25 Board Of Regents, The University Of Texas System Antibody methods for selectively inhibiting VEGF
WO2003030833A2 (en) * 2001-10-11 2003-04-17 Amgen Inc. Angiopoietin-2 specific binding agents
RU2003100502A (ru) * 2000-06-23 2004-06-27 Шеринг Акциенгезельшафт Комбинации и композиции, которые оказывают воздействие на функцию систем vegf/ рецептор vegf и ангиопоэтин/рецептор tie (ii), и их применение

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EP1165115B1 (en) * 1999-03-26 2003-05-28 Regeneron Pharmaceuticals, Inc. Modulation of vascular permeability by mean of tie2 receptor activators
EE200200706A (et) * 2000-06-23 2004-06-15 Schering Aktiengesellschaft VEGF-i/VEGF-retseptori ja angiopoetiini/Tie-retseptori funktsiooni mõjustavad kombinatsioonid ja kompositsioonid ning nende kasutamine (II)
US7205275B2 (en) * 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
ATE536868T1 (de) * 2001-10-12 2011-12-15 Monosolrx Llc Einheitliche filme als schnell auflösende verabreichungsformen enthaltend geschmacksmaskiereden stoff
EA011866B1 (ru) * 2004-10-19 2009-06-30 Амджен Инк. Агенты, специфически связывающие ангиопоэтин-2

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524583B1 (en) * 1999-04-28 2003-02-25 Board Of Regents, The University Of Texas System Antibody methods for selectively inhibiting VEGF
RU2003100502A (ru) * 2000-06-23 2004-06-27 Шеринг Акциенгезельшафт Комбинации и композиции, которые оказывают воздействие на функцию систем vegf/ рецептор vegf и ангиопоэтин/рецептор tie (ii), и их применение
WO2003030833A2 (en) * 2001-10-11 2003-04-17 Amgen Inc. Angiopoietin-2 specific binding agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Pakula et al. "Genetic analysis of protein stability and function", Annu Rev Genet., 1989; 23, реферат. *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA022546B1 (ru) * 2011-09-28 2016-01-29 Федеральное Государственное Бюджетное Учреждение Науки Институт Биоорганической Химии Им. Академиков М.М. Шемякина И Ю.А. Овчинникова Российской Академии Наук Способ торможения роста карциномы эрлиха у лабораторного животного
RU2658601C2 (ru) * 2013-05-14 2018-06-21 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Биомаркер для прогнозирования и оценки чувствительности субъектов с раком эндометрия к соединениям ленватиниба
US10517861B2 (en) 2013-05-14 2019-12-31 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
US11186547B2 (en) 2014-08-28 2021-11-30 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
US10259791B2 (en) 2014-08-28 2019-04-16 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
US10407393B2 (en) 2014-08-28 2019-09-10 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
US10822307B2 (en) 2014-08-28 2020-11-03 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
US11090386B2 (en) 2015-02-25 2021-08-17 Eisai R&D Management Co., Ltd. Method for suppressing bitterness of quinoline derivative
US11547705B2 (en) 2015-03-04 2023-01-10 Merck Sharp & Dohme Llc Combination of a PD-1 antagonist and a VEGF-R/FGFR/RET tyrosine kinase inhibitor for treating cancer
US12083112B2 (en) 2015-03-04 2024-09-10 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
US11369623B2 (en) 2015-06-16 2022-06-28 Prism Pharma Co., Ltd. Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor
US12220398B2 (en) 2015-08-20 2025-02-11 Eisai R&D Management Co., Ltd. Tumor therapeutic agent
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition
US12226409B2 (en) 2017-05-16 2025-02-18 Eisai R&D Management Co., Ltd. Treatment of hepatocellular carcinoma

Also Published As

Publication number Publication date
MA29015B1 (fr) 2007-11-01
IL182279A0 (en) 2007-07-24
EA200700876A1 (ru) 2007-10-26
SG156668A1 (en) 2009-11-26
JP2011207882A (ja) 2011-10-20
CN101495513A (zh) 2009-07-29
CN101495513B (zh) 2014-08-06
EA011866B1 (ru) 2009-06-30
ZA200704020B (en) 2008-06-25
RU2007118670A (ru) 2008-12-27
RU2010132956A (ru) 2012-02-10
BRPI0518209A (pt) 2008-11-04
JP2008520188A (ja) 2008-06-19
MX2007004247A (es) 2007-06-12

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Effective date: 20151020