EA011123B1 - Производные эстрогена в качестве ингибиторов стероидной сульфатазы - Google Patents

Производные эстрогена в качестве ингибиторов стероидной сульфатазы Download PDF

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Publication number
EA011123B1
EA011123B1 EA200501426A EA200501426A EA011123B1 EA 011123 B1 EA011123 B1 EA 011123B1 EA 200501426 A EA200501426 A EA 200501426A EA 200501426 A EA200501426 A EA 200501426A EA 011123 B1 EA011123 B1 EA 011123B1
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EA
Eurasian Patent Office
Prior art keywords
group
alkyl
compound according
hydrogen atom
compound
Prior art date
Application number
EA200501426A
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English (en)
Russian (ru)
Other versions
EA200501426A1 (ru
Inventor
Маттью Лис
Алан Пурохит
Майкл Джон Рид
Саймон Пол Ньюман
Суриндер Кумар Чандер
Фабрис Журден
Барри Виктор Ллойд Поттер
Original Assignee
Стерикс Лимитед
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Priority claimed from GB0306717A external-priority patent/GB0306717D0/en
Priority claimed from GB0315885A external-priority patent/GB0315885D0/en
Application filed by Стерикс Лимитед filed Critical Стерикс Лимитед
Publication of EA200501426A1 publication Critical patent/EA200501426A1/ru
Publication of EA011123B1 publication Critical patent/EA011123B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
EA200501426A 2003-03-24 2004-02-20 Производные эстрогена в качестве ингибиторов стероидной сульфатазы EA011123B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0306717A GB0306717D0 (en) 2003-03-24 2003-03-24 Compound
GB0315885A GB0315885D0 (en) 2003-07-07 2003-07-07 Compound
PCT/GB2004/000705 WO2004085459A1 (en) 2003-03-24 2004-02-20 Oestrogen derivatives as inhibitors of steroid sulphatase

Publications (2)

Publication Number Publication Date
EA200501426A1 EA200501426A1 (ru) 2006-06-30
EA011123B1 true EA011123B1 (ru) 2008-12-30

Family

ID=33099976

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501426A EA011123B1 (ru) 2003-03-24 2004-02-20 Производные эстрогена в качестве ингибиторов стероидной сульфатазы

Country Status (14)

Country Link
US (1) US7893284B2 (https=)
EP (1) EP1608671B1 (https=)
JP (1) JP4719144B2 (https=)
AT (1) ATE454395T1 (https=)
AU (1) AU2004224053B2 (https=)
BR (1) BRPI0408703A (https=)
CA (1) CA2520142C (https=)
DE (1) DE602004024966D1 (https=)
DK (1) DK1608671T3 (https=)
EA (1) EA011123B1 (https=)
ES (1) ES2339450T3 (https=)
MX (1) MXPA05010339A (https=)
PL (1) PL378577A1 (https=)
WO (1) WO2004085459A1 (https=)

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US8288367B2 (en) 2006-11-30 2012-10-16 Solvay Pharmaceuticals Gmbh Substituted estratriene derivatives as 17BETA HSD inhibitors
WO2008090517A2 (en) * 2007-01-26 2008-07-31 Piramal Life Sciences Limited Enriched plant extract, compound, and methods for the treatment of proliferative disorders
EP2149371A1 (en) 2008-07-28 2010-02-03 PregLem S.A. Use of steroid sulfatase inhibitors for the treatment of preterm labor
EP2334686B1 (en) 2008-08-28 2019-02-27 President and Fellows of Harvard College Cortistatin analogues and syntheses therof
WO2010123545A2 (en) * 2009-04-22 2010-10-28 President And Fellows Of Harvard College Angiogenesis inhibitors
WO2012116290A2 (en) * 2011-02-25 2012-08-30 Washington University Neuroactive 17(20)-z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
CN119192266A (zh) 2011-10-14 2024-12-27 萨奇治疗股份有限公司 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途
MX365644B (es) 2012-12-18 2019-06-10 Univ Washington Esteroides neuroactivos sustituidos con 19-alcoxi-17, profarmacos de los mismos, y metodos de tratamiento usando los mismos.
US9512170B2 (en) 2013-03-01 2016-12-06 Washington University Neuroactive 13, 17-substituted steroids as modulators for GABA type-A receptors
US9365502B2 (en) 2013-03-11 2016-06-14 Washington University Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors
US9562026B2 (en) 2013-03-14 2017-02-07 Washington University Neuroactive substituted cyclopent[a]anthracenes as modulators for GABA type-A receptors
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
WO2014169831A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
ES2807264T3 (es) 2013-04-17 2021-02-22 Sage Therapeutics Inc Esteroides neuroactivos 19-nor para métodos de tratamiento
JP6470258B2 (ja) 2013-04-17 2019-02-13 セージ セラピューティクス， インコーポレイテッド １９−ノルｃ３，３−ジ置換ｃ２１−ｎ−ピラゾリルステロイドおよびその使用方法
WO2015010054A2 (en) 2013-07-19 2015-01-22 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
ES2848823T3 (es) 2013-08-23 2021-08-12 Sage Therapeutics Inc Esteroides neuroactivos, composiciones y usos de los mismos
SG11201605178WA (en) 2013-12-24 2016-07-28 Harvard College Cortistatin analogues and syntheses and uses thereof
WO2015195962A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US10577390B2 (en) 2014-10-16 2020-03-03 Sage Therapeutics, Inc. Compositions and methods for treating CNS disorders
ME03809B (me) 2014-10-16 2021-04-20 Sage Therapeutics Inc KOMPOZICIJE I POSTUPCI ZA LEČENJE POREMEĆAJA CNS-a
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
WO2016123056A1 (en) 2015-01-26 2016-08-04 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP4155314A1 (en) 2015-02-20 2023-03-29 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
WO2016182932A1 (en) 2015-05-08 2016-11-17 President And Fellows Of Harvard College Cortistatin analogues, syntheses, and uses thereof
WO2017004411A1 (en) 2015-07-01 2017-01-05 President And Fellows Of Harvard College Cortistatin analogues and syntheses and uses thereof
AU2017283878A1 (en) * 2016-06-15 2019-01-03 Sony Corporation Information processing device, observation system, observation method, and program
MA45599A (fr) 2016-07-11 2019-05-15 Sage Therapeutics Inc Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
US20190233465A1 (en) 2016-07-11 2019-08-01 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use
CR20240234A (es) 2019-05-31 2024-07-09 Sage Therapeutics Inc ESTEROIDES NEUROACTIVOS Y COMPOSICIONES DE ESTOS (Divisional 2021-629)

Citations (7)

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WO1999027936A1 (en) * 1997-12-04 1999-06-10 Sterix Limited Steroid 3-o-sulphamate derivatives as inhibitors of oestrone sulphatase
WO1999033858A2 (en) * 1997-12-24 1999-07-08 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
WO1999064013A1 (en) * 1998-06-10 1999-12-16 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-o-sulphamate for inhibition of estrone sulphatase
WO2000043408A2 (en) * 1999-01-25 2000-07-27 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
WO2000066095A2 (en) * 1999-04-30 2000-11-09 Sterix Limited Use of estrone derivatives as antitumour agents
WO2002016392A1 (en) * 2000-08-18 2002-02-28 Sterix Limited Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
EP1284272A1 (en) * 2000-04-24 2003-02-19 Kyowa Hakko Kogyo Co., Ltd. Estra-1,3,5(10)-triene derivatives

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DE19723794A1 (de) * 1997-06-06 1998-12-10 Jenapharm Gmbh Nichtestrogene Derivate des Estradiols mit antioxidativer Aktivität
CN100338088C (zh) * 2000-05-11 2007-09-19 医学与化学研究所 2－取代的孕－1,3,5(10)－三烯和胆－1,3,5(10)－三烯衍生物及其生物活性
WO2002016395A1 (en) * 2000-08-18 2002-02-28 The Board Of Trustees Of The University Of Illinois Prodrugs of betulinic acid derivatives for the treatment of cancer and hiv
WO2002062347A1 (en) 2001-02-05 2002-08-15 Oncology Sciences Corporation Method and composition of novel compounds for the therapy and targeting of the primary modalities of cancer cell proliferation and homeostasis
GB0421106D0 (en) * 2004-09-22 2004-10-27 Sterix Ltd Compound

Patent Citations (7)

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Publication number Priority date Publication date Assignee Title
WO1999027936A1 (en) * 1997-12-04 1999-06-10 Sterix Limited Steroid 3-o-sulphamate derivatives as inhibitors of oestrone sulphatase
WO1999033858A2 (en) * 1997-12-24 1999-07-08 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
WO1999064013A1 (en) * 1998-06-10 1999-12-16 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-o-sulphamate for inhibition of estrone sulphatase
WO2000043408A2 (en) * 1999-01-25 2000-07-27 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
WO2000066095A2 (en) * 1999-04-30 2000-11-09 Sterix Limited Use of estrone derivatives as antitumour agents
EP1284272A1 (en) * 2000-04-24 2003-02-19 Kyowa Hakko Kogyo Co., Ltd. Estra-1,3,5(10)-triene derivatives
WO2002016392A1 (en) * 2000-08-18 2002-02-28 Sterix Limited Oestrogen-17-sulphamates as inhibitors of steroid sulphatase

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BOIVIN R.P. ET AL.: "Structure-Activity Relationship of 17alpha-Derivatives of Estradiol as Inhibitors of Steroid Sulfatase" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, 2000, pages 4465-4478, XP002232869 ISSN: 0022-2623 the whole document *
MACCARTHY-MORROGH L. ET AL.: "DIFFERENTIAL EFFECTS OF ESTRONE AND ESTRONE-3-O-SULFAMATE DERIVATIVES ON MITOTIC ARREST, APOPTOSIS AND MICROTUBULE ASSEMBLY IN HUMAN BREAST CANCER CELLS" CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 60, no. 19, 1 October 2000 (2000-10-01), pages 5441-5450, XP001031282 ISSN: 0008-5472 the whole document *

Also Published As

Publication number Publication date
JP2006521335A (ja) 2006-09-21
US7893284B2 (en) 2011-02-22
US20060094696A1 (en) 2006-05-04
EP1608671A1 (en) 2005-12-28
ES2339450T3 (es) 2010-05-20
DE602004024966D1 (de) 2010-02-25
EA200501426A1 (ru) 2006-06-30
DK1608671T3 (da) 2010-05-10
CA2520142C (en) 2011-01-04
BRPI0408703A (pt) 2006-03-07
CA2520142A1 (en) 2004-10-07
AU2004224053A1 (en) 2004-10-07
HK1082258A1 (en) 2006-06-02
JP4719144B2 (ja) 2011-07-06
AU2004224053B2 (en) 2011-06-09
EP1608671B1 (en) 2010-01-06
PL378577A1 (pl) 2006-05-02
MXPA05010339A (es) 2005-12-14
WO2004085459A1 (en) 2004-10-07
ATE454395T1 (de) 2010-01-15

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU