EA009935B1 - Новая синергетическая комбинация, включающая рофлумиласт и формотерол - Google Patents
Новая синергетическая комбинация, включающая рофлумиласт и формотерол Download PDFInfo
- Publication number
- EA009935B1 EA009935B1 EA200500774A EA200500774A EA009935B1 EA 009935 B1 EA009935 B1 EA 009935B1 EA 200500774 A EA200500774 A EA 200500774A EA 200500774 A EA200500774 A EA 200500774A EA 009935 B1 EA009935 B1 EA 009935B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- roflumilast
- formoterol
- pharmaceutically acceptable
- acceptable salt
- drug
- Prior art date
Links
- 229960002848 formoterol Drugs 0.000 title claims abstract description 49
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 title claims abstract description 49
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 229960002586 roflumilast Drugs 0.000 title claims abstract description 46
- 239000011885 synergistic combination Substances 0.000 title 1
- 238000011282 treatment Methods 0.000 claims abstract description 8
- 208000018569 Respiratory Tract disease Diseases 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims description 23
- 239000013543 active substance Substances 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 20
- 229940079593 drug Drugs 0.000 claims description 19
- 208000019693 Lung disease Diseases 0.000 claims description 13
- 239000002552 dosage form Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 9
- 208000024891 symptom Diseases 0.000 claims description 9
- 208000006673 asthma Diseases 0.000 claims description 6
- 206010006451 bronchitis Diseases 0.000 claims description 6
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 5
- 208000023504 respiratory system disease Diseases 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims description 3
- 210000002345 respiratory system Anatomy 0.000 claims description 3
- 206010052613 Allergic bronchitis Diseases 0.000 claims description 2
- 201000009961 allergic asthma Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 description 11
- 239000000546 pharmaceutical excipient Substances 0.000 description 9
- 239000000443 aerosol Substances 0.000 description 7
- 239000000556 agonist Substances 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 108010058846 Ovalbumin Proteins 0.000 description 5
- 229940092253 ovalbumin Drugs 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 210000003979 eosinophil Anatomy 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000003380 propellant Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 206010070834 Sensitisation Diseases 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229940124630 bronchodilator Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000011866 long-term treatment Methods 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000009325 pulmonary function Effects 0.000 description 2
- 230000008313 sensitization Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- SJJCQDRGABAVBB-UHFFFAOYSA-N 1-hydroxy-2-naphthoic acid Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CC=C21 SJJCQDRGABAVBB-UHFFFAOYSA-N 0.000 description 1
- YGTUPRIZNBMOFV-UHFFFAOYSA-N 2-(4-hydroxybenzoyl)benzoic acid Chemical compound OC(=O)C1=CC=CC=C1C(=O)C1=CC=C(O)C=C1 YGTUPRIZNBMOFV-UHFFFAOYSA-N 0.000 description 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 description 1
- WXHLLJAMBQLULT-UHFFFAOYSA-N 2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-n-(2-methyl-6-sulfanylphenyl)-1,3-thiazole-5-carboxamide;hydrate Chemical compound O.C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1S WXHLLJAMBQLULT-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 208000014181 Bronchial disease Diseases 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 206010014950 Eosinophilia Diseases 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 229940008126 aerosol Drugs 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001441 androstanes Chemical class 0.000 description 1
- 230000000603 anti-haemophilic effect Effects 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- -1 for example Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003580 lung surfactant Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000000668 oral spray Substances 0.000 description 1
- 229940041678 oral spray Drugs 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02026505 | 2002-11-27 | ||
| PCT/EP2003/013275 WO2004047829A1 (en) | 2002-11-27 | 2003-11-26 | New synergistic combination comprising roflumilast and formoterol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200500774A1 EA200500774A1 (ru) | 2005-12-29 |
| EA009935B1 true EA009935B1 (ru) | 2008-04-28 |
Family
ID=32338002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200500774A EA009935B1 (ru) | 2002-11-27 | 2003-11-26 | Новая синергетическая комбинация, включающая рофлумиласт и формотерол |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20060142308A1 (OSRAM) |
| EP (1) | EP1567139B1 (OSRAM) |
| JP (1) | JP2006508994A (OSRAM) |
| KR (1) | KR101071798B1 (OSRAM) |
| CN (1) | CN100346777C (OSRAM) |
| AT (1) | ATE399543T1 (OSRAM) |
| AU (1) | AU2003292120B2 (OSRAM) |
| BR (1) | BR0316451A (OSRAM) |
| CA (1) | CA2506962C (OSRAM) |
| CO (1) | CO5690570A2 (OSRAM) |
| CY (1) | CY1110369T1 (OSRAM) |
| DE (1) | DE60321953D1 (OSRAM) |
| DK (1) | DK1567139T3 (OSRAM) |
| EA (1) | EA009935B1 (OSRAM) |
| ES (1) | ES2309357T3 (OSRAM) |
| HR (1) | HRP20050579B1 (OSRAM) |
| IL (1) | IL168308A (OSRAM) |
| IS (1) | IS2575B (OSRAM) |
| MA (1) | MA27539A1 (OSRAM) |
| ME (1) | ME00489B (OSRAM) |
| MX (1) | MXPA05005437A (OSRAM) |
| NO (1) | NO334247B1 (OSRAM) |
| NZ (1) | NZ540659A (OSRAM) |
| PL (1) | PL216752B1 (OSRAM) |
| PT (1) | PT1567139E (OSRAM) |
| RS (1) | RS51081B (OSRAM) |
| SI (1) | SI1567139T1 (OSRAM) |
| TN (1) | TNSN05131A1 (OSRAM) |
| UA (1) | UA83018C2 (OSRAM) |
| WO (1) | WO2004047829A1 (OSRAM) |
| ZA (1) | ZA200503308B (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| MXPA04008070A (es) | 2003-03-10 | 2004-11-26 | Altana Pharma Ag | Novedoso proceso para la preparacion de roflumilasto. |
| US8663694B2 (en) * | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
| DE102005030733A1 (de) * | 2005-07-01 | 2007-01-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff |
| UA106422C2 (uk) * | 2006-07-05 | 2014-08-26 | Такеда Гмбх | КОМБІНОВАНЕ ЗАСТОСУВАННЯ ІНГІБІТОРА PDE4 ТА ІНГІБІТОРА HMG-CоA-РЕДУКТАЗИ ДЛЯ ПРОФІЛАКТИКИ АБО ЗЦІЛЮВАЛЬНОГО ЛІКУВАННЯ ЗАПАЛЬНОГО ЗАХВОРЮВАННЯ ЛЕГЕНІВ |
| WO2013077830A1 (en) * | 2011-11-25 | 2013-05-30 | Mahmut Bilgic | Synergistilly active combinations of roflumilast and carmoterol |
| US20130172303A1 (en) * | 2012-01-03 | 2013-07-04 | Forest Laboratories Holdings Ltd. | Roflumilast compositions for the treatment of copd |
| CN110403922A (zh) * | 2013-01-28 | 2019-11-05 | 理森制药股份公司 | 通过吸入罗氟司特n-氧化物治疗自身免疫、呼吸和/或炎性病症的方法 |
| CN104800214A (zh) * | 2014-01-27 | 2015-07-29 | 成都英诺新科技有限公司 | 一种罗氟司特吸入气雾剂复方及制备方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998035683A1 (en) * | 1997-02-17 | 1998-08-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Compositions for the treatment of ards or irds containing 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide and lung surfactant |
| WO2000067741A2 (en) * | 1999-05-10 | 2000-11-16 | Sepracor Inc. | (s,r) formoterol methods and compositions |
| WO2001013953A2 (en) * | 1999-08-21 | 2001-03-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Synergistic combination of pde inhibitors and beta 2 adrenoceptor agonist |
| US6288118B1 (en) * | 1998-08-26 | 2001-09-11 | Smithkline Beecham Corporation | Therapies for treating pulmonary diseases |
| WO2002066422A1 (en) * | 2001-02-14 | 2002-08-29 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
| WO2002076933A1 (en) * | 2001-03-22 | 2002-10-03 | Glaxo Group Limited | Formailide derivatives as beta2-adrenoreceptor agonists |
| WO2002088167A1 (en) * | 2001-04-30 | 2002-11-07 | Glaxo Group Limited | Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795564A (en) * | 1991-04-05 | 1998-08-18 | Sepracor, Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
| HU220041B (hu) * | 1993-07-02 | 2001-10-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Fluor-alkoxi-helyettesített benzamidszármazékok, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyászati készítmények |
| US6624181B1 (en) * | 1997-02-28 | 2003-09-23 | Altana Pharma Ag | Synergistic combination |
| EP0975347B1 (de) * | 1997-02-28 | 2008-02-20 | Nycomed GmbH | Synergistische kombination von pde-hemmern und adenylatcyclase-agonisten bzw. guanylcyclyse-agonisten |
-
2003
- 2003-11-26 CA CA2506962A patent/CA2506962C/en not_active Expired - Fee Related
- 2003-11-26 EA EA200500774A patent/EA009935B1/ru not_active IP Right Cessation
- 2003-11-26 NZ NZ540659A patent/NZ540659A/en not_active IP Right Cessation
- 2003-11-26 US US10/535,816 patent/US20060142308A1/en not_active Abandoned
- 2003-11-26 SI SI200331344T patent/SI1567139T1/sl unknown
- 2003-11-26 HR HRP20050579AA patent/HRP20050579B1/hr not_active IP Right Cessation
- 2003-11-26 EP EP03767663A patent/EP1567139B1/en not_active Expired - Lifetime
- 2003-11-26 KR KR1020057009210A patent/KR101071798B1/ko not_active Expired - Fee Related
- 2003-11-26 JP JP2004554480A patent/JP2006508994A/ja active Pending
- 2003-11-26 PT PT03767663T patent/PT1567139E/pt unknown
- 2003-11-26 MX MXPA05005437A patent/MXPA05005437A/es active IP Right Grant
- 2003-11-26 UA UAA200505966A patent/UA83018C2/uk unknown
- 2003-11-26 DK DK03767663T patent/DK1567139T3/da active
- 2003-11-26 ES ES03767663T patent/ES2309357T3/es not_active Expired - Lifetime
- 2003-11-26 AT AT03767663T patent/ATE399543T1/de active
- 2003-11-26 WO PCT/EP2003/013275 patent/WO2004047829A1/en not_active Ceased
- 2003-11-26 BR BR0316451-9A patent/BR0316451A/pt not_active IP Right Cessation
- 2003-11-26 RS YUP-2005/0382A patent/RS51081B/sr unknown
- 2003-11-26 ME MEP-2008-782A patent/ME00489B/me unknown
- 2003-11-26 PL PL377732A patent/PL216752B1/pl unknown
- 2003-11-26 CN CNB2003801037450A patent/CN100346777C/zh not_active Expired - Fee Related
- 2003-11-26 AU AU2003292120A patent/AU2003292120B2/en not_active Ceased
- 2003-11-26 DE DE60321953T patent/DE60321953D1/de not_active Expired - Lifetime
-
2005
- 2005-04-25 ZA ZA200503308A patent/ZA200503308B/en unknown
- 2005-05-01 IL IL168308A patent/IL168308A/en not_active IP Right Cessation
- 2005-05-10 TN TNP2005000131A patent/TNSN05131A1/en unknown
- 2005-06-16 MA MA28343A patent/MA27539A1/fr unknown
- 2005-06-17 NO NO20052999A patent/NO334247B1/no not_active IP Right Cessation
- 2005-06-20 IS IS7898A patent/IS2575B/is unknown
- 2005-06-27 CO CO05062787A patent/CO5690570A2/es not_active Application Discontinuation
-
2008
- 2008-09-17 CY CY20081101017T patent/CY1110369T1/el unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998035683A1 (en) * | 1997-02-17 | 1998-08-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Compositions for the treatment of ards or irds containing 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide and lung surfactant |
| US6288118B1 (en) * | 1998-08-26 | 2001-09-11 | Smithkline Beecham Corporation | Therapies for treating pulmonary diseases |
| WO2000067741A2 (en) * | 1999-05-10 | 2000-11-16 | Sepracor Inc. | (s,r) formoterol methods and compositions |
| WO2001013953A2 (en) * | 1999-08-21 | 2001-03-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Synergistic combination of pde inhibitors and beta 2 adrenoceptor agonist |
| WO2002066422A1 (en) * | 2001-02-14 | 2002-08-29 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
| WO2002076933A1 (en) * | 2001-03-22 | 2002-10-03 | Glaxo Group Limited | Formailide derivatives as beta2-adrenoreceptor agonists |
| WO2002088167A1 (en) * | 2001-04-30 | 2002-11-07 | Glaxo Group Limited | Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha |
Non-Patent Citations (3)
| Title |
|---|
| CAMPILLO N. ET AL.: "Novel bronchodilators in the treatment of asthma and COPD" EXPERT OPINION ON THERAPEUTIC PATENTS 2002 UNITED KINGDOM, vol. 12, no. 1, 2002, pages 53-63, XP002237401, ISSN: 1354-3776, page 55, right-hand column, line 56-page 56, right-hand column, paragraph 6, page 58, right-hand column-page 60, left-hand column, paragraph 2, figures 1, 4 * |
| MAESEN B. L. P. ET AL.: "EFFECTS OF FORMOTEROL IN APPARENTLY POORLY REVERSIBLE CHRONIC OBSTRUCTIVE PULMONARY DISEASE" EUROPEAN RESPIRATORY JOURNAL, MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, DK, vol. 13, no. 5, 1999, pages 1103-1108, XP001020413, ISSN: 0903-1936, abstract * |
| REID P.: "ROFLUMILAST", CURRENT OPINION IN INVESTIGATIONAL DRUGS, CURRENT DRUGS, LONDON, GB, vol. 3, no. 8, August 2002 (2002-08), pages 1165-1170, XP001119630, ISSN: 0967-8298, page 1165, page 1167, right-hand column, paragraph 4 * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL200923B1 (pl) | Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu | |
| SK82296A3 (en) | Use of mometasone fluroate for treating airway passage and lung diseases | |
| EP1661570A2 (en) | Compositions comprising ipatropium and xylometazoline for treatment of the common cold | |
| CN1235545A (zh) | 含有氯雷他定和减充血剂的用于治疗哮喘的组合物 | |
| BG107596A (bg) | Фармацевтичен състав на салметерол и флутиказон пропионат | |
| EA009935B1 (ru) | Новая синергетическая комбинация, включающая рофлумиласт и формотерол | |
| AU2003288169B8 (en) | Synergistic combination comprising roflumilast and (R,R) -formoterol | |
| WO2001012192A2 (en) | Pharmaceutical compositions comprising a-(2-aminoethyl)-benzothiazolone and disodium cromoglycate or nedocromil | |
| HK1081861B (en) | New synergistic combination comprising roflumilast and formoterol | |
| HK1081862B (en) | Synergistic combination comprising roflumilast and (r,r)-formoterol | |
| HK1067984B (en) | Compositions comprising ipatropium and xylometazoline for treatment of the common cold | |
| HK1092064A (en) | Compositions comprising ipatropium and xylometazoline for treatment of the common cold |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD1A | Registration of transfer to a eurasian application by order of succession in title | ||
| PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title | ||
| PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title | ||
| PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title | ||
| TC4A | Change in name of a patent proprietor in a eurasian patent | ||
| PC4A | Registration of transfer of a eurasian patent by assignment | ||
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |