EA009872B1 - АНТИ-Aβ АНТИТЕЛА - Google Patents

АНТИ-Aβ АНТИТЕЛА Download PDF

Info

Publication number
EA009872B1
EA009872B1 EA200601545A EA200601545A EA009872B1 EA 009872 B1 EA009872 B1 EA 009872B1 EA 200601545 A EA200601545 A EA 200601545A EA 200601545 A EA200601545 A EA 200601545A EA 009872 B1 EA009872 B1 EA 009872B1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
peptide
cells
antibodies
secretase
Prior art date
Application number
EA200601545A
Other languages
English (en)
Russian (ru)
Other versions
EA200601545A1 (ru
Inventor
Рональд Брэдли Дематтос
Ума Кучибхотла
Си-Чиун Ян
Дон Б. Макклур
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200601545A1 publication Critical patent/EA200601545A1/ru
Publication of EA009872B1 publication Critical patent/EA009872B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
EA200601545A 2004-02-23 2005-02-17 АНТИ-Aβ АНТИТЕЛА EA009872B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54676404P 2004-02-23 2004-02-23
PCT/US2005/005198 WO2005082939A2 (en) 2004-02-23 2005-02-17 Anti-abeta antibody

Publications (2)

Publication Number Publication Date
EA200601545A1 EA200601545A1 (ru) 2007-02-27
EA009872B1 true EA009872B1 (ru) 2008-04-28

Family

ID=34910810

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601545A EA009872B1 (ru) 2004-02-23 2005-02-17 АНТИ-Aβ АНТИТЕЛА

Country Status (20)

Country Link
US (1) US20070190046A1 (https=)
EP (1) EP1720909B1 (https=)
JP (1) JP4851348B2 (https=)
KR (2) KR100889430B1 (https=)
CN (1) CN1922209B (https=)
AT (1) ATE534667T1 (https=)
AU (1) AU2005217596B2 (https=)
BR (1) BRPI0507856A (https=)
CA (1) CA2556436C (https=)
CY (1) CY1112162T1 (https=)
DK (1) DK1720909T3 (https=)
EA (1) EA009872B1 (https=)
ES (1) ES2375627T3 (https=)
IL (1) IL177611A (https=)
NO (1) NO20064239L (https=)
PL (1) PL1720909T3 (https=)
PT (1) PT1720909E (https=)
SI (1) SI1720909T1 (https=)
UA (1) UA93181C2 (https=)
WO (1) WO2005082939A2 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
HRP20140240T4 (hr) 2005-11-30 2017-02-24 Abbvie Inc. Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba
EP1959996A2 (en) 2005-12-12 2008-08-27 AC Immune S.A. Monoclonal antibody
EP2046833B9 (en) 2006-07-14 2014-02-19 AC Immune S.A. Humanized antibody against amyloid beta
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
HRP20140049T1 (hr) 2007-01-05 2014-02-28 University Of Zürich Anti beta-amiloid antitijela i njihova upotreba
WO2008081008A1 (en) 2007-01-05 2008-07-10 University Of Zurich Method of providing disease-specific binding molecules and targets
TW200844110A (en) 2007-01-11 2008-11-16 Univ Marburg Philipps Diagnosis and treatment of alzheimer's disease and other neurodementing diseases
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8048420B2 (en) * 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
BRPI0818623A2 (pt) * 2007-10-05 2017-05-23 Ac Immune Sa composição farmacêutica, e, métodos para reduzir a carga da placa na camada de célula de gânglio retinal de um animal, para reduzir a quantidade de placas na camada de célula de gânglio retinal de um animal, para diminuir a quantidade total de amilóide-beta solúvel na camada de célula de gânglio retinal de um animal, para prevenir, tratar e/ou aliviar os efeitos de uma doença ocular associada com anormalidades patológicas/mudanças no tecido do sistema visual, para monitorar doença ocular residual mínima associada com anormalidades patológicas/mudanças nos tecidos do sistema visual, para predizer responsividade de um paciente, e para reter ou diminuir a pressão ocular nos olhos de um animal
AU2008311367B2 (en) 2007-10-05 2014-11-13 Ac Immune S.A. Use of anti-amyloid beta antibody in ocular diseases
AU2009319864A1 (en) 2008-11-25 2011-07-14 Biogen Idec Ma Inc. Use of DR6 and P75 antagonists to promote survival of cells of the nervous system
CN102317316B (zh) 2008-12-19 2014-08-13 帕尼玛制药股份公司 人抗α突触核蛋白自身抗体
US20110110942A1 (en) 2009-11-12 2011-05-12 Genentech, Inc. Method of promoting dendritic spine density
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
EP2598882B1 (en) 2010-07-30 2017-07-26 AC Immune S.A. Safe and functional humanized antibodies for use in treating an amyloidosis
PL3042917T3 (pl) * 2010-08-12 2018-07-31 Eli Lilly And Company Przeciwciała przeciwko peptydowi beta amyloidu N3pGlu i ich zastosowanie
EP3533803B1 (en) 2010-08-14 2021-10-27 AbbVie Inc. Anti-amyloid-beta antibodies
SI2723379T1 (sl) 2011-06-23 2019-03-29 Biogen International Neuroscience Gmbh Molekule, ki se vežejo ma anti alfa-sinuklein
US20150209406A1 (en) 2012-09-07 2015-07-30 Massachusetts Eye And Ear Infirmary Methods and compositions for regenerating hair cells and/or supporting cells
US20150209367A1 (en) 2012-09-07 2015-07-30 Massachusetts Eye & Ear Infirmary Treating Hearing Loss
CN120904322A (zh) 2013-09-13 2025-11-07 豪夫迈·罗氏有限公司 包含纯化的重组多肽的方法和组合物
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
JP6840774B2 (ja) 2016-05-16 2021-03-10 ザ ジェネラル ホスピタル コーポレイション 肺上皮エンジニアリングにおけるヒト気道幹細胞
US20210355138A1 (en) * 2016-08-11 2021-11-18 Eli Lilly And Company Aminothiazinies and their use as bace1 inhibitors
CN118370815A (zh) 2017-08-22 2024-07-23 渤健马萨诸塞州股份有限公司 含有抗β淀粉样蛋白抗体的药物组合物
TWI843040B (zh) 2021-01-11 2024-05-21 美商美國禮來大藥廠 抗N3pGlu類澱粉β抗體及其用途
WO2022251048A1 (en) 2021-05-24 2022-12-01 Eli Lilly And Company Anti-amyloid beta antibodies and uses thereof
CA3243602A1 (en) 2022-02-03 2023-08-10 Eli Lilly And Company Regional Tau Imaging for the Diagnosis and Treatment of Alzheimer's Disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002046237A2 (en) * 2000-12-06 2002-06-13 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
WO2002088306A2 (en) * 2001-04-30 2002-11-07 Eli Lilly And Company Humanized antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0001232A3 (en) 1996-12-23 2001-02-28 Elan Pharmaceuticals Inc San F Cycloalkyl, lactam, lactone derivatives and their thio analogues inhibiting betha-amyloid peptide release and/or its synthesis and pharmaceutical compositions containing the compounds
US6518011B1 (en) * 1999-01-13 2003-02-11 Bristol-Myers Squibb Company Method for screening compounds to identify beta-amyloid production modulators
DE1257584T1 (de) * 2000-02-24 2003-05-28 Lilly Co Eli Humanisierte antikörper, die amyloid beta peptid demarkieren
JP2003530437A (ja) * 2000-04-13 2003-10-14 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ Ａβ４２低下物質

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002046237A2 (en) * 2000-12-06 2002-06-13 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
WO2002088306A2 (en) * 2001-04-30 2002-11-07 Eli Lilly And Company Humanized antibodies

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BARNES L. M. ET AL.: "Advances in animal cell recombinant protein production: GS-NSO expression system", CYTOTECHNOLOGY, vol. 32, no. 2, February 2000 (2000-02), pages 109-123, XP002301322, ISSN: 0920-9069, the whole document *
CHAUHAN NEELIMA B. ET AL.: "Intracerebroventricular passive immunization with anti-Abeta antibody 1n Tg2576", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 74, no. 1, 1 October 2003 (2003-10-01), pages 142-147, XP002339442, ISSN: 0360-4012, abstract, page 143, right-hand column, last paragraph - page 144, left-hand column, paragraph 1 *
MILLER DAVID L. ET AL.: "Humoral immune response to fibrillar beta-amyloid peptide", BIOCHEMISTRY, vol. 42, no. 40, 14 October 2003 (2003-10-14), pages 11682-11692, XP002339443, ISSN: 0006-2960, page 11683, right-hand column, paragraph 2 - paragraph 3 *
YOO E. M. ET AL.: "Myeloma expression systems", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V..AMSTERDAM, NL, vol. 261, no. 1-2, 1 March 2002 (2002-03-01), pages 1-20, XP004341264, ISSN: 0022-1759, abstract, page 3, left-hand column, line 1 - line 13 table 1, page 13, right-hand column, last paragraph *

Also Published As

Publication number Publication date
CN1922209B (zh) 2012-09-05
AU2005217596A1 (en) 2005-09-09
CA2556436A1 (en) 2005-09-09
KR20060126785A (ko) 2006-12-08
PT1720909E (pt) 2011-12-23
US20070190046A1 (en) 2007-08-16
DK1720909T3 (da) 2012-01-30
JP2008500279A (ja) 2008-01-10
JP4851348B2 (ja) 2012-01-11
CY1112162T1 (el) 2015-12-09
EP1720909A2 (en) 2006-11-15
WO2005082939A2 (en) 2005-09-09
EA200601545A1 (ru) 2007-02-27
WO2005082939A3 (en) 2005-10-27
KR20090005410A (ko) 2009-01-13
IL177611A (en) 2013-05-30
CA2556436C (en) 2014-04-01
EP1720909B1 (en) 2011-11-23
KR100889430B1 (ko) 2009-03-23
ES2375627T3 (es) 2012-03-02
AU2005217596B2 (en) 2012-01-19
PL1720909T3 (pl) 2012-04-30
SI1720909T1 (sl) 2012-01-31
NO20064239L (no) 2006-11-20
UA93181C2 (ru) 2011-01-25
ATE534667T1 (de) 2011-12-15
CN1922209A (zh) 2007-02-28
IL177611A0 (en) 2006-12-10
BRPI0507856A (pt) 2007-07-10

Similar Documents

Publication Publication Date Title
EA009872B1 (ru) АНТИ-Aβ АНТИТЕЛА
JP4540132B2 (ja) Ｉｌ−６レセプター抗体を含んでなる筋蛋白分解抑制剤
JP2023116817A (ja) 抗体製剤および方法
Madri et al. Isolation and tissue localization of type AB2 collagen from normal lung parenchyma
KR20250061718A (ko) 항-인플루엔자 b 바이러스 항체, 인플루엔자 b 바이러스의 검출용 시약 및 키트
EA012162B1 (ru) Способ рефолдинга рекомбинантных антител
EA032054B1 (ru) Моноклональное антитело или его антигенсвязывающий фрагмент, его применения, клеточная линия гибридомы для его получения, фармацевтическая композиция, содержащая моноклональное антитело или его антигенсвязывающий фрагмент, способ диагностики in vitro амилоид-ассоциированного заболевания и набор для его осуществления
WO2025180021A1 (zh) 一种抗人与鼠TfR的抗体或其抗原结合片段及其用途
DE60128452T2 (de) Monoklonale antikörper gegen den menschlichen ldl-rezeptor, deren herstellung und verwendung
Richter et al. A study of two types of ferritin from rat hepatomas
Salant et al. Altered glomerular permeability induced by F (ab′) 2 and Fab′ antibodies to rat renal tubular epithelial antigen
EP0131834B1 (en) Monoclonal antibody having specificity to only one type of an isozyme of human cardiac myosin heavy chain
AU603053B2 (en) Novel lymphokine, monoclonal antibody specific to the lymphokine, and their production and uses
DE69229230T2 (de) Antikörpertest zur erkennung von alkoholikern und zur überwachung der alkoholaufnahme
Natorio et al. Role of dipeptidyl peptidase IV (gp 108) in passive Heymann nephritis. Use of dipeptidyl peptidase IV-deficient rats
JPH08510446A (ja) 組換え骨形成タンパク質を生成するための方法および組成物
JP2779193B2 (ja) 抗ヒト組織因子モノクローナル抗体
US20030186335A1 (en) Monoclonal antibodies, hybridomas, cell isolation method, isolated cells and immunological diagnostic method
JP2643040B2 (ja) モノクローナル抗体
MXPA06009560A (en) Anti-abeta antibody
JPH0560359B2 (https=)
JPH013199A (ja) モノクロ−ナル抗体
TW202140555A (zh) 失智症之預防或治療劑
JPH01171495A (ja) モノクローナル抗体及びそれを用いる定量法
WO1989001947A1 (fr) Proteine derivee d'un corps vivant

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU