EA008480B1 - Выделенный полинуклеотид (варианты), содержащий его вектор и клетка-хозяин, кодируемый им полипептид рецептора nogo, уменьшающий опосредованное этим рецептором ингибирование роста аксонов (варианты), выделенное антитело и фармацевтическая композиция на их основе - Google Patents
Выделенный полинуклеотид (варианты), содержащий его вектор и клетка-хозяин, кодируемый им полипептид рецептора nogo, уменьшающий опосредованное этим рецептором ингибирование роста аксонов (варианты), выделенное антитело и фармацевтическая композиция на их основе Download PDFInfo
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- EA008480B1 EA008480B1 EA200200755A EA200200755A EA008480B1 EA 008480 B1 EA008480 B1 EA 008480B1 EA 200200755 A EA200200755 A EA 200200755A EA 200200755 A EA200200755 A EA 200200755A EA 008480 B1 EA008480 B1 EA 008480B1
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| WO1999066041A1 (en) | 1998-06-16 | 1999-12-23 | Human Genome Sciences, Inc. | 94 human secreted proteins |
| US7371836B2 (en) | 1998-03-27 | 2008-05-13 | Genentech, Inc. | PRO526 nucleic acids |
| US7723488B2 (en) | 1998-03-27 | 2010-05-25 | Genentech, Inc. | Monoclonal antibodies to secreted and transmembrane polypeptides |
| US20020072493A1 (en) * | 1998-05-19 | 2002-06-13 | Yeda Research And Development Co. Ltd. | Activated T cells, nervous system-specific antigens and their uses |
| US7034132B2 (en) | 2001-06-04 | 2006-04-25 | Anderson David W | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| PL356887A1 (en) * | 2000-01-12 | 2004-07-12 | Yale University | Nogo receptor-mediated blockade of axonal growth |
| US7119165B2 (en) | 2000-01-12 | 2006-10-10 | Yale University | Nogo receptor-mediated blockade of axonal growth |
| US20070026394A1 (en) * | 2000-02-11 | 2007-02-01 | Lawrence Blatt | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies |
| DE60141409D1 (de) | 2000-10-06 | 2010-04-08 | Biogen Idec Inc | Homologe des nogo rezeptors |
| GB0101312D0 (en) | 2001-01-18 | 2001-02-28 | Glaxo Group Ltd | Assay |
| GB0101313D0 (en) * | 2001-01-18 | 2001-02-28 | Glaxo Group Ltd | Assay |
| JP2005507246A (ja) * | 2001-08-27 | 2005-03-17 | ノバルティス アクチエンゲゼルシャフト | Ｎｏｇｏレセプターホモログおよびそれらの使用 |
| US7309485B2 (en) * | 2001-12-03 | 2007-12-18 | Children's Medical Center Corporation | Reducing myelin-mediated inhibition of axon regeneration |
| FR2841261B1 (fr) * | 2002-06-25 | 2004-08-27 | Univ Pasteur | Compositions et methodes pour detecter les pathologies affectant la transmission neuromusculaire |
| MXPA05001615A (es) * | 2002-08-10 | 2005-08-19 | Biogen Idec Inc | Antagonistas del nogo receptor. |
| EP1534736B1 (en) * | 2002-08-10 | 2010-06-02 | Yale University | Nogo receptor antagonists |
| GB0228832D0 (en) | 2002-12-10 | 2003-01-15 | Novartis Ag | Organic compound |
| JP2006526382A (ja) * | 2002-12-06 | 2006-11-24 | シンガポール ジェネラル ホスピタル ピーティーイー リミテッド | 中枢神経系の損傷 |
| US7842666B2 (en) * | 2002-12-20 | 2010-11-30 | Research Foundation Of City University Of New York | Inhibitors of myelin-associated glycoprotein (MAG) activity for regulating neural growth and regeneration |
| EP2248899B8 (en) | 2003-03-19 | 2015-07-15 | Biogen MA Inc. | NOGO receptor binding protein |
| US7541335B2 (en) * | 2003-04-04 | 2009-06-02 | University Of Rochester | Nogo-receptors and methods of use |
| AU2004231742A1 (en) * | 2003-04-16 | 2004-11-04 | Biogen Idec Ma Inc. | Nogo-receptor antagonists for the treatment of conditions involving amyloid plaques |
| CN101410130A (zh) * | 2003-05-15 | 2009-04-15 | 利兰·斯坦福青年大学托管委员会 | 新颖的免疫调节肽 |
| MXPA05012307A (es) * | 2003-05-16 | 2006-07-03 | Acorda Therapeutics Inc | Mutantes que degradan proteoglicanos para tratamiento del snc. |
| US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
| GB0321997D0 (en) * | 2003-09-19 | 2003-10-22 | Novartis Ag | Organic compound |
| US8912144B2 (en) * | 2003-12-16 | 2014-12-16 | Children's Medical Center Corporation | Method for treating stroke via administration of NEP1-40 and inosine |
| WO2005059515A2 (en) * | 2003-12-16 | 2005-06-30 | Children's Medical Center Corporation | Method for treating neurological disorders |
| EP2474317A1 (en) | 2004-06-24 | 2012-07-11 | Biogen Idec MA Inc. | Treatment of conditions involving demyelination |
| WO2006017673A2 (en) | 2004-08-03 | 2006-02-16 | Biogen Idec Ma Inc. | Taj in neuronal function |
| WO2006047049A2 (en) * | 2004-10-01 | 2006-05-04 | Yale University | Nogo-a polypeptide fragments, variant nogo receptor-1 polypeptides, and uses thereof |
| WO2006059959A1 (en) * | 2004-12-01 | 2006-06-08 | National University Of Singapore | Nogo a protein fragments as neuronal network-interacting peptides |
| EP1904091A4 (en) | 2005-07-07 | 2009-12-23 | Univ Yale | COMPOSITIONS AND METHODS FOR SUPPRESSING THE INHIBITION OF AXON GROWTH |
| WO2007008547A2 (en) | 2005-07-08 | 2007-01-18 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
| CA2623635C (en) | 2005-09-26 | 2013-04-02 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase abci mutants |
| WO2007089601A2 (en) | 2006-01-27 | 2007-08-09 | Biogen Idec Ma Inc. | Nogo receptor antagonists |
| EP2023735A4 (en) * | 2006-05-15 | 2011-05-25 | Biogen Idec Inc | USE OF ANTAGONISTS OF THE NOGO RECEPTOR 1 (NGR1) TO PROMOTE THE SURVIVAL OF OLIGODENDROCYTES |
| US8642040B2 (en) | 2006-07-24 | 2014-02-04 | Biogen Idec Ma Inc. | Methods for promoting myelination, neuronal survival and oligodendrocyte differentiation via administration of Sp35 or TrkA antagonists |
| CN105111310B (zh) | 2006-11-21 | 2019-07-26 | 雅培制药有限公司 | 抗nogo-66受体(ngr)的中和单克隆抗体及其用途 |
| US8992918B2 (en) | 2008-03-13 | 2015-03-31 | Yale University | Reactivation of axon growth and recovery in chronic spinal cord injury |
| US20090285803A1 (en) * | 2008-05-13 | 2009-11-19 | Jasvinder Atwal | ANTI-PirB ANTIBODIES |
| JP2011527572A (ja) | 2008-07-09 | 2011-11-04 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Ｌｉｎｇｏ抗体または断片を含む組成物 |
| JP2015518829A (ja) | 2012-05-14 | 2015-07-06 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | 運動ニューロンに関する状態の処置のためのｌｉｎｇｏ−２アンタゴニスト |
| CN104935294B (zh) * | 2014-03-20 | 2018-07-20 | 晶宏半导体股份有限公司 | 振荡器 |
| AU2016205197B2 (en) | 2015-01-08 | 2021-10-21 | Biogen Ma Inc. | LINGO-1 antagonists and uses for treatment of demyelinating disorders |
| CN109354605B (zh) * | 2015-07-17 | 2021-02-05 | 暨南大学 | 一种Nogo-A受体结合肽及其衍生物与应用 |
| CN113527462B (zh) * | 2020-04-22 | 2023-05-23 | 北京大学 | 一种具有镇痛作用的小分子肽及其特异性抗体 |
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