EA008433B1 - Производные инсулина длительного действия и способы их использования - Google Patents
Производные инсулина длительного действия и способы их использования Download PDFInfo
- Publication number
- EA008433B1 EA008433B1 EA200600305A EA200600305A EA008433B1 EA 008433 B1 EA008433 B1 EA 008433B1 EA 200600305 A EA200600305 A EA 200600305A EA 200600305 A EA200600305 A EA 200600305A EA 008433 B1 EA008433 B1 EA 008433B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- insulin
- conjugate
- diabetes
- type
- example iii
- Prior art date
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Classifications
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
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- Chemical & Material Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
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| US55658504P | 2004-03-25 | 2004-03-25 | |
| PCT/CA2004/001409 WO2005012346A1 (en) | 2003-07-25 | 2004-07-26 | Long lasting insulin derivatives and methods thereof |
Publications (2)
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| EA200600305A1 EA200600305A1 (ru) | 2006-06-30 |
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| US6514500B1 (en) | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| PT1180121E (pt) * | 1999-05-17 | 2004-03-31 | Conjuchem Inc | Peptidos insulinotropicos de longa duracao |
| US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
| DK1360202T3 (da) | 2001-02-16 | 2008-09-22 | Conjuchem Biotechnologies Inc | Langvarigt glucagon-lignende peptid 2 (GLP-2) til behandling af gastrointestinale sygdomme og lidelser |
| TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
| ES2435522T3 (es) | 2005-02-02 | 2013-12-20 | Novo Nordisk A/S | Derivados de insulina |
| AU2007247109B2 (en) * | 2006-05-09 | 2012-03-15 | Novo Nordisk A/S | Insulin derivative |
| CN101541830A (zh) | 2006-09-22 | 2009-09-23 | 诺沃-诺迪斯克有限公司 | 蛋白酶抗性的胰岛素类似物 |
| EP2114437A2 (en) | 2006-10-16 | 2009-11-11 | ConjuChem Biotechnologies Inc. | Modified corticotropin releasing factor peptides and uses thereof |
| WO2008132224A2 (en) | 2007-04-30 | 2008-11-06 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
| CN101970477B (zh) | 2008-03-14 | 2014-12-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定的胰岛素类似物 |
| HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| EP2262539B1 (en) | 2008-04-01 | 2015-07-15 | Novo Nordisk A/S | Insulin albumin conjugates |
| WO2010088286A1 (en) * | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
| EP2836508B1 (en) | 2012-04-11 | 2016-06-29 | Novo Nordisk A/S | Insulin formulations |
| MX349035B (es) | 2012-05-17 | 2017-07-07 | Extend Biosciences Inc | Portadores para el suministro mejorado de farmaco. |
| CA2926701A1 (en) | 2013-10-07 | 2015-04-16 | Novo Nordisk A/S | Novel derivative of an insulin analogue |
| MY186251A (en) | 2014-01-20 | 2021-06-30 | Hanmi Pharm Ind Co Ltd | Long-acting insulin and use thereof |
| AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
| TWI684458B (zh) | 2014-05-30 | 2020-02-11 | 南韓商韓美藥品股份有限公司 | 包含胰島素及ｇｌｐ-１/昇糖素雙重促效劑之治療糖尿病之組成物 |
| KR20160001391A (ko) * | 2014-06-27 | 2016-01-06 | 한미약품 주식회사 | 신규한 지속형 인슐린 아날로그 결합체 및 이의 용도 |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| CN107531762A (zh) * | 2015-05-07 | 2018-01-02 | 科德克希思公司 | 青霉素g酰化酶 |
| UY36870A (es) | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
| AU2017332408B2 (en) | 2016-09-23 | 2022-02-10 | Hanmi Pharm. Co., Ltd. | Insulin analogs with reduced affinity to insulin receptor and use thereof |
| ES2886837T3 (es) | 2016-12-16 | 2021-12-21 | Novo Nordisk As | Composiciones farmacéuticas que contienen insulina |
| WO2018174668A2 (ko) | 2017-03-23 | 2018-09-27 | 한미약품 주식회사 | 인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도 |
| CN113773400B (zh) * | 2020-06-09 | 2023-08-18 | 宁波鲲鹏生物科技有限公司 | 一种门冬胰岛素衍生物及其应用 |
| CN113855678A (zh) * | 2021-09-08 | 2021-12-31 | 武汉生命奥义生物科技有限公司 | 一种用于辅助治疗二型糖尿病的组合物 |
| US12233115B2 (en) | 2022-09-30 | 2025-02-25 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
| CN115894719B (zh) * | 2022-11-24 | 2023-10-20 | 武汉禾元生物科技股份有限公司 | 一种人血清白蛋白胰岛素偶联物及其制备方法 |
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| US3868356A (en) * | 1971-01-28 | 1975-02-25 | Nat Res Dev | N-Acylated, O-substituted insulin derivatives |
| US3868357A (en) * | 1971-01-28 | 1975-02-25 | Nat Res Dev | Alkanedioic acid derivatives of insulin |
| WO1995005187A1 (en) * | 1993-08-13 | 1995-02-23 | United Medical & Dental Schools Of Guy's And St Thomas' Hospitals | Hepatoselective pharmaceutical actives |
| CA2334859A1 (en) * | 1998-06-12 | 1999-12-23 | Kings College London | Insulin analogue |
| CA2363712A1 (en) * | 1999-05-17 | 2000-11-23 | Conjuchem Inc. | Long lasting insulinotropic peptides |
| US6323311B1 (en) * | 1999-09-22 | 2001-11-27 | University Of Utah Research Foundation | Synthesis of insulin derivatives |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3509120A (en) * | 1966-12-28 | 1970-04-28 | Squibb & Sons Inc | N-terminal mono- and diaminoacyl-insulin |
| JPS5272284A (en) * | 1975-12-12 | 1977-06-16 | Dainippon Pharmaceutical Co | Enzymeeimmunoassay reagent |
| CA1196863A (en) * | 1983-06-08 | 1985-11-19 | Mattheus F.A. Goosen | Slow release injectable insulin composition |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| US5514646A (en) * | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| US5612034A (en) * | 1990-10-03 | 1997-03-18 | Redcell, Inc. | Super-globuling for in vivo extended lifetimes |
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-
2004
- 2004-07-26 SI SI200431199T patent/SI1648933T1/sl unknown
- 2004-07-26 CA CA2526957A patent/CA2526957C/en not_active Expired - Fee Related
- 2004-07-26 AU AU2004261319A patent/AU2004261319B2/en not_active Ceased
- 2004-07-26 EP EP04801809A patent/EP1648933B1/en not_active Revoked
- 2004-07-26 BR BRPI0412252-6A patent/BRPI0412252A/pt not_active IP Right Cessation
- 2004-07-26 JP JP2006521357A patent/JP2007520441A/ja active Pending
- 2004-07-26 EP EP09159269A patent/EP2085406A1/en not_active Withdrawn
- 2004-07-26 WO PCT/CA2004/001409 patent/WO2005012346A1/en not_active Ceased
- 2004-07-26 PL PL04801809T patent/PL1648933T3/pl unknown
- 2004-07-26 DK DK04801809T patent/DK1648933T3/da active
- 2004-07-26 ES ES04801809T patent/ES2328579T3/es not_active Expired - Lifetime
- 2004-07-26 AT AT04801809T patent/ATE433994T1/de active
- 2004-07-26 DE DE602004021603T patent/DE602004021603D1/de not_active Expired - Lifetime
- 2004-07-26 US US10/565,900 patent/US20060241019A1/en not_active Abandoned
- 2004-07-26 EA EA200600305A patent/EA008433B1/ru not_active IP Right Cessation
-
2006
- 2006-02-23 NO NO20060888A patent/NO20060888L/no not_active Application Discontinuation
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2011
- 2011-03-22 AU AU2011201278A patent/AU2011201278A1/en not_active Abandoned
- 2011-08-26 JP JP2011184958A patent/JP2012062311A/ja active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2526957A1 (en) | 2005-02-10 |
| EP2085406A1 (en) | 2009-08-05 |
| JP2012062311A (ja) | 2012-03-29 |
| AU2004261319B2 (en) | 2010-12-23 |
| CA2526957C (en) | 2011-07-12 |
| DK1648933T3 (da) | 2009-09-07 |
| EP1648933A1 (en) | 2006-04-26 |
| ATE433994T1 (de) | 2009-07-15 |
| HK1091843A1 (en) | 2007-01-26 |
| NO20060888L (no) | 2006-04-25 |
| BRPI0412252A (pt) | 2006-09-19 |
| AU2004261319A1 (en) | 2005-02-10 |
| WO2005012346A1 (en) | 2005-02-10 |
| EP1648933B1 (en) | 2009-06-17 |
| ES2328579T3 (es) | 2009-11-16 |
| DE602004021603D1 (de) | 2009-07-30 |
| JP2007520441A (ja) | 2007-07-26 |
| PL1648933T3 (pl) | 2010-01-29 |
| AU2011201278A1 (en) | 2011-04-07 |
| EA200600305A1 (ru) | 2006-06-30 |
| SI1648933T1 (sl) | 2010-01-29 |
| US20060241019A1 (en) | 2006-10-26 |
| EP1648933A4 (en) | 2007-02-28 |
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