DOP2022000010A - Inhibidores tricíclicos de kars dependientes de akr1c3 - Google Patents

Inhibidores tricíclicos de kars dependientes de akr1c3

Info

Publication number
DOP2022000010A
DOP2022000010A DO2022000010A DO2022000010A DOP2022000010A DO P2022000010 A DOP2022000010 A DO P2022000010A DO 2022000010 A DO2022000010 A DO 2022000010A DO 2022000010 A DO2022000010 A DO 2022000010A DO P2022000010 A DOP2022000010 A DO P2022000010A
Authority
DO
Dominican Republic
Prior art keywords
kars
akr1c3
dependent
tricyclic inhibitors
inhibitors
Prior art date
Application number
DO2022000010A
Other languages
English (en)
Inventor
Adair Chris
Chen Tracy
Ding Jian
Fryer Christy
Isome Yuko
Nakajima Katsumasa
Savage Nik
Sterling Twomey Ariel
LARRAUFIE Marie-Helene
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of DOP2022000010A publication Critical patent/DOP2022000010A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4747—Quinolines; Isoquinolines spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a nuevos compuestos tricíclicos que son inhibidores de KARS dependientes de AKR1C3, procesos para su preparación, composiciones farmacéuticas y medicamentos que los contienen, y a su uso en enfermedades y trastornos mediados por un inhibidor de KARS dependiente de AKR1C3.
DO2022000010A 2019-08-01 2022-01-20 Inhibidores tricíclicos de kars dependientes de akr1c3 DOP2022000010A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962881619P 2019-08-01 2019-08-01
US202063009513P 2020-04-14 2020-04-14
US202063033932P 2020-06-03 2020-06-03
PCT/IB2020/057285 WO2021005586A1 (en) 2019-08-01 2020-07-31 Tricyclic akr1c3 dependent kars inhibitors

Publications (1)

Publication Number Publication Date
DOP2022000010A true DOP2022000010A (es) 2022-03-15

Family

ID=71994691

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2022000010A DOP2022000010A (es) 2019-08-01 2022-01-20 Inhibidores tricíclicos de kars dependientes de akr1c3

Country Status (33)

Country Link
US (2) US11970497B2 (es)
EP (2) EP4013500B1 (es)
JP (1) JP7008161B2 (es)
KR (1) KR20220025845A (es)
CN (1) CN114206870B (es)
AU (1) AU2020309846B2 (es)
BR (1) BR112022001308A2 (es)
CA (1) CA3139940A1 (es)
CL (1) CL2022000201A1 (es)
CO (1) CO2022000370A2 (es)
CR (1) CR20220031A (es)
CU (1) CU24698B1 (es)
DK (1) DK4013500T3 (es)
DO (1) DOP2022000010A (es)
EC (1) ECSP22005621A (es)
ES (1) ES2969591T3 (es)
FI (1) FI4013500T3 (es)
HR (1) HRP20231734T1 (es)
HU (1) HUE064882T2 (es)
IL (1) IL287792A (es)
JO (1) JOP20220020A1 (es)
LT (1) LT4013500T (es)
MX (1) MX2022000961A (es)
PE (1) PE20220343A1 (es)
PL (1) PL4013500T3 (es)
PT (1) PT4013500T (es)
RS (1) RS65068B1 (es)
SA (1) SA522431533B1 (es)
SI (1) SI4013500T1 (es)
TW (1) TW202120507A (es)
UY (1) UY38806A (es)
WO (1) WO2021005586A1 (es)
ZA (1) ZA202108632B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220024403A (ko) 2019-06-14 2022-03-03 얀센 파마슈티카 엔.브이. 치환된 피라졸로-피라진 및 이들의 glun2b 수용체 조절제로서의 용도
UY38806A (es) 2019-08-01 2021-02-26 Novartis Ag Compuestos inhibidores tricíclicos de kars dependientes de akr1c3, composiciones y sus usos
US20240142453A1 (en) 2020-09-02 2024-05-02 Ascentawits Pharmaceuticals, Ltd. Akr1c3 detection method, and diagnostic kit for detecting akr1c3 and use thereof
CN113135878A (zh) * 2021-04-09 2021-07-20 新沂市凯美斯特医药科技有限公司 一种以呋喃为原料合成3-氨基甲基四氢呋喃的方法
MX2023013112A (es) * 2021-05-07 2024-02-09 Organon R&D Finland Ltd Nuevos compuestos heterociclicos, composiciones, procedimientos de preparacion y usos de los mismos.
CN115403579A (zh) * 2021-05-27 2022-11-29 上海拓界生物医药科技有限公司 一种新的螺环衍生物及其用途
CN118829436A (zh) 2022-03-15 2024-10-22 深圳艾欣达伟医药科技有限公司 治疗brca突变癌症患者的方法
CN118804755A (zh) * 2022-06-10 2024-10-18 深圳艾欣达伟医药科技有限公司 Akr1c3酶激活前药治疗癌症患者的方法
WO2024023641A1 (en) 2022-07-26 2024-02-01 Novartis Ag Methods of tricyclic akr1c3 dependent kars inhibitor dosing field of the invention
WO2024023659A1 (en) 2022-07-26 2024-02-01 Novartis Ag Pharmaceutical compositions of tricyclic akr1c3 dependent kars inhibitor and methods for making same
WO2024023666A1 (en) 2022-07-26 2024-02-01 Novartis Ag Crystalline forms of an akr1c3 dependent kars inhibitor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012630A1 (en) * 1999-08-13 2001-02-22 Sepracor Inc. Spirocyclic ligands for sigma receptors, and libraries and methods of use thereof
US20100048604A1 (en) * 2004-08-20 2010-02-25 Yee Dominic J Ligands for Aldoketoreductases
US8110578B2 (en) 2008-10-27 2012-02-07 Signal Pharmaceuticals, Llc Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
UY33779A (es) * 2010-12-10 2012-07-31 Boehringer Ingelheim Int ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas?
EP3078374B1 (en) * 2011-10-17 2019-06-19 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer
KR102398323B1 (ko) 2015-03-10 2022-05-16 아센타위츠 파마슈티컬즈 리미티드 Dna 알킬화제
US10167293B2 (en) * 2016-05-26 2019-01-01 Bayer Pharma Aktiengesellschaft [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
US20220033407A1 (en) * 2018-12-18 2022-02-03 Novartis Ag N-(pyridin-2-ylsulfonyl)cyclopropanecarboxamide Derivatives and their Use in the Treatment of Disease
UY38806A (es) 2019-08-01 2021-02-26 Novartis Ag Compuestos inhibidores tricíclicos de kars dependientes de akr1c3, composiciones y sus usos

Also Published As

Publication number Publication date
KR20220025845A (ko) 2022-03-03
EP4349839A2 (en) 2024-04-10
CU24698B1 (es) 2024-03-05
SA522431533B1 (ar) 2024-04-16
CO2022000370A2 (es) 2022-01-28
AU2020309846B2 (en) 2023-12-14
BR112022001308A2 (pt) 2022-05-17
JOP20220020A1 (ar) 2023-01-30
US20240262827A1 (en) 2024-08-08
ECSP22005621A (es) 2022-02-25
EP4349839A3 (en) 2024-10-02
CA3139940A1 (en) 2021-01-14
RS65068B1 (sr) 2024-02-29
DK4013500T3 (da) 2024-01-02
PT4013500T (pt) 2024-01-11
CN114206870B (zh) 2024-09-03
CL2022000201A1 (es) 2022-11-18
SI4013500T1 (sl) 2024-02-29
HUE064882T2 (hu) 2024-04-28
IL287792A (en) 2022-01-01
HRP20231734T1 (hr) 2024-03-15
AU2020309846A1 (en) 2022-01-06
LT4013500T (lt) 2024-01-25
JP2021527113A (ja) 2021-10-11
US20220315582A1 (en) 2022-10-06
UY38806A (es) 2021-02-26
EP4013500A1 (en) 2022-06-22
JP7008161B2 (ja) 2022-01-25
MX2022000961A (es) 2022-02-14
US11970497B2 (en) 2024-04-30
CR20220031A (es) 2022-02-09
FI4013500T3 (fi) 2024-01-19
ES2969591T3 (es) 2024-05-21
CU20220005A7 (es) 2022-09-08
EP4013500B1 (en) 2023-10-25
CN114206870A (zh) 2022-03-18
ZA202108632B (en) 2024-09-25
PL4013500T3 (pl) 2024-03-25
TW202120507A (zh) 2021-06-01
WO2021005586A1 (en) 2021-01-14
PE20220343A1 (es) 2022-03-14

Similar Documents

Publication Publication Date Title
CL2022000201A1 (es) Inhibidores tricíclicos de kars dependientes de akr1c3
NI202000078A (es) Compuestos heteroaril tetracíclicos
ECSP21004787A (es) Inhibidores de inflamasoma nlrp3
UY38001A (es) Compuestos que inhiben las proteínas ras mutantes g12c
ECSP21073246A (es) Compuestos tricíclicos condensados útiles como agentes anticancerígenos
DOP2018000062A (es) Piridinona dicaboxamidas para uso como inhibidores de bromodominio
BR112016028845A2 (pt) composto, composição farmacêutica e uso de um composto
CO2017007325A2 (es) 2,4 diamino-quinolina sustituida como nuevos agentes anti-cancerigenos
CU20140037A7 (es) Derivados de estra- 1,3,5(10), 16- tetraen- 3- carboximida, procedimientos para su preparación, preparados farmacéuticos que los contienen, así como su uso para la preparación de medicamentos
DOP2015000005A (es) Derivados de estra 1,3,5(10), 16 tetraeno 3 sustituidos, métodos para su preparación, preparaciones farmacéuticas que los contienen, así como su uso para la preparación de medicamentos
UY35344A (es) Oestra-1,3,5(10),16-tetraeno-3-carboxamidas
CL2018003121A1 (es) Inhibidores del potenciador del homólogo zeste 2.
CL2019001991A1 (es) Moduladores del receptor de estrógeno.
BR112017022158A2 (pt) compostos, composições farmacêuticas e uso de um composto
UY37729A (es) NUEVOS COMPUESTOS QUE INHIBEN LA ACTIVIDAD DE Nav1.7
UY36758A (es) Inhibidores del potenciador del homólogo zeste 2
CL2023001220A1 (es) Inhibidores de interleucina-17
CL2021000930A1 (es) Piridazinas novedosas
CO2018012020A2 (es) Derivados de piridinilo, composiciones farmacéuticas y sus usos como inhibidores aoc3
CL2021003228A1 (es) Compuestos tricíclicos y su uso
ECSP21010874A (es) Piridopirimidinas como inhibidores del receptor de histamina h4
UY38217A (es) Derivados de 1-imidazotiadiazol-2h-pirrol-5-ona