DK92688A - Polypeptid, dna og anvendelse deraf - Google Patents

Polypeptid, dna og anvendelse deraf

Info

Publication number
DK92688A
DK92688A DK092688A DK92688A DK92688A DK 92688 A DK92688 A DK 92688A DK 092688 A DK092688 A DK 092688A DK 92688 A DK92688 A DK 92688A DK 92688 A DK92688 A DK 92688A
Authority
DK
Denmark
Prior art keywords
activity
mutein
fibroblast growth
polypeptid
dna
Prior art date
Application number
DK092688A
Other languages
English (en)
Other versions
DK92688D0 (da
DK173269B1 (da
Inventor
Masaharu Senoo
Tsutomu Kurokawa
Koichi Igarashi
Reiko Sasada
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DK92688D0 publication Critical patent/DK92688D0/da
Publication of DK92688A publication Critical patent/DK92688A/da
Application granted granted Critical
Publication of DK173269B1 publication Critical patent/DK173269B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • C07K14/503Fibroblast growth factor [FGF] basic FGF [bFGF]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/55IL-2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK198800926A 1987-02-24 1988-02-23 Mutein af basisk fibroblastvækstfaktor, rekombinant DNA kodende for dette og transformant indeholdende nævnte DNA samt frem DK173269B1 (da)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
JP4221887 1987-02-24
JP4221887 1987-02-24
JP4344487 1987-02-25
JP4344487 1987-02-25
JP8197787 1987-04-02
JP8197787 1987-04-02
JP14751187 1987-06-12
JP14751187 1987-06-12
JP20151087 1987-08-11
JP20151087 1987-08-11
JP29028387 1987-11-17
JP29028387 1987-11-17
JP1626088 1988-01-26
JP63016260A JP2526965B2 (ja) 1987-02-24 1988-01-26 ムテイン,dnaおよびその用途

Publications (3)

Publication Number Publication Date
DK92688D0 DK92688D0 (da) 1988-02-23
DK92688A true DK92688A (da) 1988-08-25
DK173269B1 DK173269B1 (da) 2000-05-29

Family

ID=27563743

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198800926A DK173269B1 (da) 1987-02-24 1988-02-23 Mutein af basisk fibroblastvækstfaktor, rekombinant DNA kodende for dette og transformant indeholdende nævnte DNA samt frem

Country Status (14)

Country Link
EP (1) EP0281822B1 (da)
JP (1) JP2526965B2 (da)
KR (1) KR960013574B1 (da)
CN (1) CN1031893C (da)
AT (1) ATE108829T1 (da)
AU (1) AU613564B2 (da)
CS (1) CS407691A3 (da)
DE (1) DE3850690T2 (da)
DK (1) DK173269B1 (da)
ES (1) ES2056842T3 (da)
FI (1) FI96316C (da)
IE (1) IE64299B1 (da)
IL (1) IL85473A (da)
NO (1) NO180305C (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852177A (en) * 1987-02-24 1998-12-22 Takeda Chemical Industries, Ltd. Basic fibroblast growth factor (bFGF) muteins
WO1988010269A1 (en) * 1987-06-18 1988-12-29 Monash University Growth factors
AU611614B2 (en) * 1987-06-18 1991-06-13 Monash University Growth factors
GB8821795D0 (en) * 1988-09-16 1988-10-19 Erba Carlo Spa New derivatives of human/bovine basic fibroplast growth factor
US5352589A (en) * 1988-09-16 1994-10-04 Farmitalia Carlo Erba S.R.L. Deletion mutant of basic fibroblast growth factor and production thereof
US5120715A (en) * 1988-12-12 1992-06-09 Takeda Chemical Industries, Ltd. Method for purifying fibroblast growth factor protein
US5464943A (en) * 1989-04-26 1995-11-07 Takeda Chemical Industries, Ltd. DNA encoding glycosylated FGF and production thereof
CA2015313A1 (en) * 1989-04-26 1990-10-26 Masaharu Senoo Glycosylated fgf and production thereof
CA2020654A1 (en) * 1989-07-07 1991-01-08 Yohko Akiyama Stabilized fgf composition and production thereof
WO1991009954A1 (en) * 1989-12-27 1991-07-11 Resnick Michael A Novel system for isolating and producing new genes, gene products and dna sequences
CA2069872A1 (en) 1989-12-28 1991-06-29 Yoshio Kozai Monoclonal antibody, hybridomas, their production and use
JPH047617A (ja) * 1990-04-26 1992-01-13 Canon Inc 電子機器
US5612211A (en) * 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
US5206354A (en) * 1990-11-23 1993-04-27 American Cyanamid Company Dna sequence encoding active fragment of fibroblast growth factor, hbf-2
CA2056142A1 (en) 1990-11-27 1992-05-28 Hirotomo Masuya Pyridopyridazine compounds and their use
DE69211723T2 (de) * 1991-02-15 1996-10-31 Takeda Chemical Industries Ltd Mit einem Zellwachstumsfaktor bewirkte Anregung von Wachstum im Knocheninneren
ATE138102T1 (de) * 1991-02-19 1996-06-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von cysteinfreien peptiden
US5492894A (en) * 1991-03-21 1996-02-20 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
TW209174B (da) 1991-04-19 1993-07-11 Takeda Pharm Industry Co Ltd
JP3303211B2 (ja) * 1991-04-26 2002-07-15 武田薬品工業株式会社 bFGFムテインおよびその製造法
US5461029A (en) * 1992-04-24 1995-10-24 American Cyanamid Company Method of treating herpes viral infections using HBNF and MK proteins
US6805865B1 (en) * 1993-05-27 2004-10-19 Entremed, Inc. Compositions and methods for treating cancer and hyperproliferative disorders
JPH07114789B2 (ja) * 1993-08-26 1995-12-13 工業技術院長 上肢動作補助機構
ATE299181T1 (de) * 1993-09-24 2005-07-15 Wyeth Corp Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren
JP2562413B2 (ja) * 1993-11-04 1996-12-11 株式会社東京機械製作所 版胴における刷版装着装置
IT1269321B (it) * 1994-04-15 1997-03-26 Eniricerche Spa Mutanti stabili della d-n- -carbamilasi
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
SI1541674T1 (sl) 2002-06-18 2011-04-29 Eisai R&D Man Co Ltd Primarno kultivirani adipociti za gensko terapijo
AU2007227256B2 (en) 2006-03-20 2012-10-04 Entremed, Inc. Disease modifying anti-arthritic activity of 2-methoxyestradiol
CN102690782A (zh) * 2012-06-14 2012-09-26 安徽农业大学 一种成纤维细胞培养液
KR101610861B1 (ko) * 2014-07-28 2016-04-11 (주)케어젠 골분화 촉진능 및 치주인대섬유모세포 활성 촉진능을 갖는 펩타이드 및 이의 용도
CN105924532A (zh) * 2016-06-08 2016-09-07 盘古基因生物工程(南京)股份有限公司 一种可溶性碱性成纤维细胞生长因子融合蛋白表达载体及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56026B1 (en) * 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
US4956455A (en) * 1984-03-05 1990-09-11 The Salk Institute For Biological Studies Bovine fibroblast growth factor
EP0593065B1 (en) * 1985-09-12 2002-08-21 Scios Inc. Recombinant fibroblast growth factors
EP0298723A1 (en) * 1987-07-07 1989-01-11 California Biotechnology, Inc. Recombinant fibroblast growth factors
KR890701607A (ko) * 1987-11-24 1989-12-21 원본미기재 섬유아세포 성장 인자의 유사체

Also Published As

Publication number Publication date
CN1031893C (zh) 1996-05-29
JPH02193A (ja) 1990-01-05
FI880845A0 (fi) 1988-02-23
ATE108829T1 (de) 1994-08-15
AU613564B2 (en) 1991-08-01
CN88100913A (zh) 1988-09-07
NO180305B (no) 1996-12-16
KR960013574B1 (en) 1996-10-09
NO180305C (no) 1997-03-26
CS407691A3 (en) 1992-06-17
JP2526965B2 (ja) 1996-08-21
AU1208588A (en) 1988-08-25
FI96316B (fi) 1996-02-29
FI96316C (fi) 1996-06-10
DE3850690T2 (de) 1995-01-05
NO880719D0 (no) 1988-02-18
EP0281822A2 (en) 1988-09-14
DE3850690D1 (de) 1994-08-25
EP0281822B1 (en) 1994-07-20
NO880719L (no) 1988-08-25
IL85473A (en) 1997-03-18
IE64299B1 (en) 1995-07-26
KR880010130A (ko) 1988-10-07
FI880845A (fi) 1988-08-25
IE880482L (en) 1988-08-24
ES2056842T3 (es) 1994-10-16
DK92688D0 (da) 1988-02-23
EP0281822A3 (en) 1990-03-21
DK173269B1 (da) 2000-05-29

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired