DK655088A - N-(biphenyl-2-ylmethyl)-3-hydroxyglutaramidsyre-forbindelser, farmaceutiske praeparater indeholdende disse og deres anvendelse til fremstilling af hypocholesterolaemiske laegemidler - Google Patents
N-(biphenyl-2-ylmethyl)-3-hydroxyglutaramidsyre-forbindelser, farmaceutiske praeparater indeholdende disse og deres anvendelse til fremstilling af hypocholesterolaemiske laegemidlerInfo
- Publication number
- DK655088A DK655088A DK655088A DK655088A DK655088A DK 655088 A DK655088 A DK 655088A DK 655088 A DK655088 A DK 655088A DK 655088 A DK655088 A DK 655088A DK 655088 A DK655088 A DK 655088A
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen
- alkyl
- compound
- benzyl
- methyl
- Prior art date
Links
- BUTNYNOHMFKCLP-UHFFFAOYSA-N 3-hydroxy-5-oxo-5-[(2-phenylphenyl)methylamino]pentanoic acid Chemical class C1(=CC=CC=C1C1=CC=CC=C1)CNC(=O)CC(CC(=O)O)O BUTNYNOHMFKCLP-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000000871 hypocholesterolemic effect Effects 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 229940127226 anticholesterol agent Drugs 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- -1 isobenzofuran-3(1H)-on-1-yl Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/89—Benzo [c] furans; Hydrogenated benzo [c] furans with two oxygen atoms directly attached in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1987/003140 WO1989004821A1 (en) | 1987-11-25 | 1987-11-25 | N-(biphenylmethyl)-3-hydroxyglutaramic acid and derivatives as hypocholesterolemic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK655088D0 DK655088D0 (da) | 1988-11-24 |
| DK655088A true DK655088A (da) | 1989-07-18 |
Family
ID=22202689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK655088A DK655088A (da) | 1987-11-25 | 1988-11-24 | N-(biphenyl-2-ylmethyl)-3-hydroxyglutaramidsyre-forbindelser, farmaceutiske praeparater indeholdende disse og deres anvendelse til fremstilling af hypocholesterolaemiske laegemidler |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5169976A (pt) |
| EP (1) | EP0318181B1 (pt) |
| JP (1) | JPH0676361B2 (pt) |
| AT (1) | ATE90667T1 (pt) |
| DE (1) | DE3881836T2 (pt) |
| DK (1) | DK655088A (pt) |
| ES (1) | ES2054828T3 (pt) |
| IE (1) | IE62445B1 (pt) |
| PT (1) | PT89054B (pt) |
| WO (1) | WO1989004821A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5238908A (en) * | 1989-08-31 | 1993-08-24 | Rohm And Haas Company | Herbicidal glutaramic acids and derivatives |
| US5217996A (en) * | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
| US5686152A (en) * | 1995-08-03 | 1997-11-11 | Johnson; Linda F. | Metal initiated nucleation of diamond |
| CN104610262B (zh) * | 2013-11-01 | 2017-06-06 | 上海医药工业研究院 | 联苯类化合物、中间体、制备方法、药物组合物及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3341528A (en) * | 1963-11-07 | 1967-09-12 | Warner Lambert Pharmaceutical | Substituted benzoquinolines |
| JPS53147073A (en) * | 1977-05-24 | 1978-12-21 | Sankyo Co Ltd | Mevalonolactone derivatives |
| US4459422A (en) * | 1979-08-17 | 1984-07-10 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
| US4375475A (en) * | 1979-08-17 | 1983-03-01 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
| NZ194557A (en) * | 1979-08-17 | 1984-09-28 | Merck & Co Inc | Substituted pyranone derivatives;dihydroxy acids therefrom;pharmaceutical compositions |
| US4603145A (en) * | 1983-05-06 | 1986-07-29 | American Cyanamid Company | Antiatherosclerotic diphenyl alkanamides |
| US4772626A (en) * | 1986-01-31 | 1988-09-20 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4855321A (en) * | 1986-01-31 | 1989-08-08 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4678806A (en) * | 1986-09-02 | 1987-07-07 | Merck & Co., Inc. | Prodrugs of antihypercholesterolemic compounds |
-
1987
- 1987-11-25 US US07/487,948 patent/US5169976A/en not_active Expired - Lifetime
- 1987-11-25 WO PCT/US1987/003140 patent/WO1989004821A1/en unknown
-
1988
- 1988-11-10 DE DE88310582T patent/DE3881836T2/de not_active Expired - Fee Related
- 1988-11-10 EP EP88310582A patent/EP0318181B1/en not_active Expired - Lifetime
- 1988-11-10 ES ES88310582T patent/ES2054828T3/es not_active Expired - Lifetime
- 1988-11-10 AT AT88310582T patent/ATE90667T1/de not_active IP Right Cessation
- 1988-11-22 JP JP63295919A patent/JPH0676361B2/ja not_active Expired - Lifetime
- 1988-11-23 PT PT89054A patent/PT89054B/pt not_active IP Right Cessation
- 1988-11-24 DK DK655088A patent/DK655088A/da not_active Application Discontinuation
- 1988-11-24 IE IE352488A patent/IE62445B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01165562A (ja) | 1989-06-29 |
| DE3881836T2 (de) | 1993-10-14 |
| EP0318181A2 (en) | 1989-05-31 |
| ES2054828T3 (es) | 1994-08-16 |
| DE3881836D1 (de) | 1993-07-22 |
| WO1989004821A1 (en) | 1989-06-01 |
| US5169976A (en) | 1992-12-08 |
| DK655088D0 (da) | 1988-11-24 |
| PT89054A (pt) | 1988-12-01 |
| IE62445B1 (en) | 1995-02-08 |
| ATE90667T1 (de) | 1993-07-15 |
| IE883524L (en) | 1989-05-25 |
| PT89054B (pt) | 1993-03-31 |
| EP0318181A3 (en) | 1990-08-01 |
| EP0318181B1 (en) | 1993-06-16 |
| JPH0676361B2 (ja) | 1994-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |