DK540986A - 2-substitueret-(2-substitueret amino)-n-arylalkyl-3-(indol-3-yl)propanamider, fremgangsmaade til deres fremstilling samt deres anvendelse - Google Patents
2-substitueret-(2-substitueret amino)-n-arylalkyl-3-(indol-3-yl)propanamider, fremgangsmaade til deres fremstilling samt deres anvendelseInfo
- Publication number
- DK540986A DK540986A DK540986A DK540986A DK540986A DK 540986 A DK540986 A DK 540986A DK 540986 A DK540986 A DK 540986A DK 540986 A DK540986 A DK 540986A DK 540986 A DK540986 A DK 540986A
- Authority
- DK
- Denmark
- Prior art keywords
- substituted
- propanamides
- indol
- arylalkyl
- procedures
- Prior art date
Links
- -1 AMINO Chemical class 0.000 title 2
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79806885A | 1985-11-14 | 1985-11-14 | |
US79806885 | 1985-11-14 | ||
US06/912,731 US4757151A (en) | 1985-11-14 | 1986-09-30 | 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl] |
US91273186 | 1986-09-30 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK540986D0 DK540986D0 (da) | 1986-11-12 |
DK540986A true DK540986A (da) | 1987-05-15 |
DK168006B1 DK168006B1 (da) | 1994-01-17 |
Family
ID=27121955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK540986A DK168006B1 (da) | 1985-11-14 | 1986-11-12 | 2- og n-substituerede-3-oeindol-3-ylaapropanamider, samt farmaceutiske praeparater indeholdende saadanne |
Country Status (8)
Country | Link |
---|---|
US (1) | US4757151A (da) |
EP (1) | EP0224151B1 (da) |
AU (1) | AU582921B2 (da) |
CA (1) | CA1274350A (da) |
DE (1) | DE3677335D1 (da) |
DK (1) | DK168006B1 (da) |
ES (1) | ES2032376T3 (da) |
GR (1) | GR3001413T3 (da) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1326108C (en) * | 1988-04-12 | 1994-01-11 | Sun Hyuk Kim | Cck antagonists |
US5010089A (en) * | 1988-08-12 | 1991-04-23 | Biomeasure, Inc. | CCK antagonists and their use in treating gastrointestinal disorders |
US5278316A (en) * | 1989-06-29 | 1994-01-11 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives |
US5631281A (en) * | 1989-06-29 | 1997-05-20 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives |
US5580896A (en) * | 1989-06-29 | 1996-12-03 | Warner-Lambert Company | Treatment of pain and colorectal cancer with dipeptoids of α-substituted Trp-Phe derivatives |
NZ234264A (en) * | 1989-06-29 | 1993-05-26 | Warner Lambert Co | N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions |
EP0547178A4 (en) * | 1990-08-31 | 1994-07-06 | Warner Lambert Co | Novel cholecystokinin antagonists, their preparation and therapeutic use |
CA2088980C (en) * | 1990-08-31 | 2002-04-16 | David C. Horwell | Pro-drugs for cck antagonists |
US5244905A (en) * | 1990-08-31 | 1993-09-14 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl polyhydro-β-carboline-phenylalanine- and phenethylamine derivatives |
US5264419A (en) * | 1990-08-31 | 1993-11-23 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives |
US5340825A (en) * | 1990-08-31 | 1994-08-23 | Warner-Lambert Company | Pro drugs for CCK antagonists |
US5593967A (en) * | 1990-08-31 | 1997-01-14 | Warner-Lambert Company | Cholecystokinin antagonists, their preparation and therapeutic use |
US5244915A (en) * | 1990-08-31 | 1993-09-14 | Warner-Lambert Company | Amico acid derivatives cyclized at the c-terminal |
EP0720601B1 (en) * | 1993-08-10 | 2000-10-25 | James Black Foundation Limited | Gastrin and cck receptor ligands |
US6869957B1 (en) | 1993-11-17 | 2005-03-22 | Eli Lilly And Company | Non-peptide tachykinin receptor antagonists |
US6403577B1 (en) | 1993-11-17 | 2002-06-11 | Eli Lilly And Company | Hexamethyleneiminyl tachykinin receptor antagonists |
US5554644A (en) * | 1994-06-08 | 1996-09-10 | Warner-Lambert Company | Tachykinin (NK2) antagonists |
MX9709875A (es) * | 1995-06-06 | 1998-03-31 | Pfizer | N-(indol-2-carbonil)-glicinamidas substituidas y derivados como inhibidores de glicogeno fosforilasa, composiciones que las contienen y uso de las mismas. |
HUP0000838A3 (en) | 1997-04-15 | 2001-04-28 | Csir | Extract containing steroid-glucosid, process for its isolation and synthesis, pharmaceutical composition containing it having appetite suppressant activity |
GB2355657B (en) | 1999-10-27 | 2004-07-28 | Phytopharm Plc | Inhibitors Of Gastric Acid Secretion |
GB2363985B (en) | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
US6277877B1 (en) | 2000-08-15 | 2001-08-21 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors |
AU2002213125B2 (en) * | 2000-10-11 | 2007-11-22 | Applied Biosystems, Llc. | Fluorescent nucleobase conjugates having anionic linkers |
KR101492351B1 (ko) * | 2010-09-22 | 2015-02-10 | 미쓰이가가쿠 아그로 가부시키가이샤 | 함불소 카바메이트기를 가지는 아미노산 아미드 유도체의 제조방법, 그 제조 중간체, 및 에틸렌디아민 유도체의 제조방법 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3899592A (en) * | 1968-04-08 | 1975-08-12 | Lilly Co Eli | Sweetening agent |
US3676458A (en) * | 1970-06-11 | 1972-07-11 | Lilly Co Eli | (indolymethyl) malonate compound |
CA1044142A (en) * | 1975-07-04 | 1978-12-12 | John N. Mcarthur | Anti-inflammatory dipeptide |
US3965260A (en) * | 1975-07-07 | 1976-06-22 | John N. McArthur | Anti-inflammatory dipeptide |
US4256641A (en) * | 1976-06-22 | 1981-03-17 | Hoffmann-La Roche Inc. | Novel syntheses of tryptophans |
US4073795A (en) * | 1976-06-22 | 1978-02-14 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
US4137404A (en) * | 1977-12-20 | 1979-01-30 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
US4198501A (en) * | 1977-12-20 | 1980-04-15 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
DE2901667A1 (de) * | 1979-01-17 | 1980-07-31 | Troponwerke Gmbh & Co Kg | Pharmazeutische verwendung von dipeptiden |
DE2904512A1 (de) * | 1979-02-07 | 1980-08-28 | Troponwerke Gmbh & Co Kg | Dehydropeptide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4316847A (en) * | 1979-07-30 | 1982-02-23 | Hoffmann-La Roche Inc. | Pyrroles and pyrrolidines |
US4623729A (en) * | 1982-07-22 | 1986-11-18 | E. R. Squibb & Sons, Inc. | Acylalkylaminocarbonyl substituted amino and imino acid compounds |
US4482567A (en) * | 1982-10-07 | 1984-11-13 | Research Foundation For Mental Hygiene, Inc. | N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics |
JPS6028988A (ja) * | 1983-06-29 | 1985-02-14 | Ajinomoto Co Inc | ペプチドの製造方法 |
EP0166355A2 (en) * | 1984-06-26 | 1986-01-02 | Merck & Co. Inc. | Substituted aminophenyl compounds and acylaminophenyl compounds and pharmaceutical compositions containing them |
-
1986
- 1986-09-30 US US06/912,731 patent/US4757151A/en not_active Expired - Fee Related
- 1986-11-12 AU AU65073/86A patent/AU582921B2/en not_active Ceased
- 1986-11-12 DK DK540986A patent/DK168006B1/da not_active IP Right Cessation
- 1986-11-14 EP EP86115859A patent/EP0224151B1/en not_active Expired - Lifetime
- 1986-11-14 CA CA000522979A patent/CA1274350A/en not_active Expired - Fee Related
- 1986-11-14 ES ES198686115859T patent/ES2032376T3/es not_active Expired - Lifetime
- 1986-11-14 DE DE8686115859T patent/DE3677335D1/de not_active Expired - Fee Related
-
1991
- 1991-01-31 GR GR91400097T patent/GR3001413T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU6507386A (en) | 1987-05-21 |
GR3001413T3 (en) | 1992-09-25 |
AU582921B2 (en) | 1989-04-13 |
DK540986D0 (da) | 1986-11-12 |
EP0224151A2 (en) | 1987-06-03 |
ES2032376T3 (es) | 1993-02-16 |
EP0224151A3 (en) | 1989-02-22 |
DK168006B1 (da) | 1994-01-17 |
EP0224151B1 (en) | 1991-01-30 |
US4757151A (en) | 1988-07-12 |
DE3677335D1 (de) | 1991-03-07 |
CA1274350A (en) | 1990-09-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |