DE3677335D1 - 2-substituierte (2-substituierte amino)-n-aralkyl-3-(indol-3-yl)-propanamide. - Google Patents
2-substituierte (2-substituierte amino)-n-aralkyl-3-(indol-3-yl)-propanamide.Info
- Publication number
- DE3677335D1 DE3677335D1 DE8686115859T DE3677335T DE3677335D1 DE 3677335 D1 DE3677335 D1 DE 3677335D1 DE 8686115859 T DE8686115859 T DE 8686115859T DE 3677335 T DE3677335 T DE 3677335T DE 3677335 D1 DE3677335 D1 DE 3677335D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- propanamides
- indol
- aralkyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- -1 AMINO Chemical class 0.000 title 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79806885A | 1985-11-14 | 1985-11-14 | |
US06/912,731 US4757151A (en) | 1985-11-14 | 1986-09-30 | 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl] |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3677335D1 true DE3677335D1 (de) | 1991-03-07 |
Family
ID=27121955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686115859T Expired - Fee Related DE3677335D1 (de) | 1985-11-14 | 1986-11-14 | 2-substituierte (2-substituierte amino)-n-aralkyl-3-(indol-3-yl)-propanamide. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4757151A (de) |
EP (1) | EP0224151B1 (de) |
AU (1) | AU582921B2 (de) |
CA (1) | CA1274350A (de) |
DE (1) | DE3677335D1 (de) |
DK (1) | DK168006B1 (de) |
ES (1) | ES2032376T3 (de) |
GR (1) | GR3001413T3 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1326108C (en) * | 1988-04-12 | 1994-01-11 | Sun Hyuk Kim | Cck antagonists |
US5010089A (en) * | 1988-08-12 | 1991-04-23 | Biomeasure, Inc. | CCK antagonists and their use in treating gastrointestinal disorders |
US5631281A (en) * | 1989-06-29 | 1997-05-20 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives |
NZ234264A (en) * | 1989-06-29 | 1993-05-26 | Warner Lambert Co | N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions |
US5278316A (en) * | 1989-06-29 | 1994-01-11 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives |
US5580896A (en) * | 1989-06-29 | 1996-12-03 | Warner-Lambert Company | Treatment of pain and colorectal cancer with dipeptoids of α-substituted Trp-Phe derivatives |
US5340825A (en) * | 1990-08-31 | 1994-08-23 | Warner-Lambert Company | Pro drugs for CCK antagonists |
US5264419A (en) * | 1990-08-31 | 1993-11-23 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives |
US5244915A (en) * | 1990-08-31 | 1993-09-14 | Warner-Lambert Company | Amico acid derivatives cyclized at the c-terminal |
NZ239595A (en) * | 1990-08-31 | 1994-06-27 | Warner Lambert Co | Cholecystokinin antagonistic compounds ; pharmaceutical compositions and use thereof |
NZ239591A (en) * | 1990-08-31 | 1994-07-26 | Warner Lambert Co | Tryptophan derivatives and pharmaceutical compositions |
US5593967A (en) * | 1990-08-31 | 1997-01-14 | Warner-Lambert Company | Cholecystokinin antagonists, their preparation and therapeutic use |
US5244905A (en) * | 1990-08-31 | 1993-09-14 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl polyhydro-β-carboline-phenylalanine- and phenethylamine derivatives |
CA2167154A1 (en) * | 1993-08-10 | 1995-02-16 | Sarkis Barret Kalindjian | Gastrin and cck receptor ligands |
US6869957B1 (en) | 1993-11-17 | 2005-03-22 | Eli Lilly And Company | Non-peptide tachykinin receptor antagonists |
US6403577B1 (en) | 1993-11-17 | 2002-06-11 | Eli Lilly And Company | Hexamethyleneiminyl tachykinin receptor antagonists |
US5554644A (en) * | 1994-06-08 | 1996-09-10 | Warner-Lambert Company | Tachykinin (NK2) antagonists |
DE69523182T2 (de) * | 1995-06-06 | 2002-02-07 | Pfizer | Substituierte n-(indol-2-carbonyl)-glycinamide und derivate als glycogen phosphorylase inhibitoren |
ATE502041T1 (de) | 1997-04-15 | 2011-04-15 | Csir | Nicht-therapeutische methode zur appetitunterdrückung |
GB2396815B (en) | 1999-10-27 | 2004-09-08 | Phytopharm Plc | A composition comprising a pregnenone derivative and an NSAID |
GB2363985B (en) | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
US6277877B1 (en) | 2000-08-15 | 2001-08-21 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors |
ATE431355T1 (de) * | 2000-10-11 | 2009-05-15 | Applera Corp | Fluoreszierende nukleobasekonjugate mit anionische linker |
CN103124722B (zh) * | 2010-09-22 | 2014-11-12 | 三井化学Agro株式会社 | 具有含氟氨基甲酸酯基的氨基酸酰胺衍生物的制造方法、其制造中间体、及乙二胺衍生物的制造方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3899592A (en) * | 1968-04-08 | 1975-08-12 | Lilly Co Eli | Sweetening agent |
US3676458A (en) * | 1970-06-11 | 1972-07-11 | Lilly Co Eli | (indolymethyl) malonate compound |
CA1044142A (en) * | 1975-07-04 | 1978-12-12 | John N. Mcarthur | Anti-inflammatory dipeptide |
US3965260A (en) * | 1975-07-07 | 1976-06-22 | John N. McArthur | Anti-inflammatory dipeptide |
US4073795A (en) * | 1976-06-22 | 1978-02-14 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
US4256641A (en) * | 1976-06-22 | 1981-03-17 | Hoffmann-La Roche Inc. | Novel syntheses of tryptophans |
US4198501A (en) * | 1977-12-20 | 1980-04-15 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
US4137404A (en) * | 1977-12-20 | 1979-01-30 | Hoffmann-La Roche Inc. | Synthesis of tryptophans |
DE2901667A1 (de) * | 1979-01-17 | 1980-07-31 | Troponwerke Gmbh & Co Kg | Pharmazeutische verwendung von dipeptiden |
DE2904512A1 (de) * | 1979-02-07 | 1980-08-28 | Troponwerke Gmbh & Co Kg | Dehydropeptide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4316847A (en) * | 1979-07-30 | 1982-02-23 | Hoffmann-La Roche Inc. | Pyrroles and pyrrolidines |
US4623729A (en) * | 1982-07-22 | 1986-11-18 | E. R. Squibb & Sons, Inc. | Acylalkylaminocarbonyl substituted amino and imino acid compounds |
US4482567A (en) * | 1982-10-07 | 1984-11-13 | Research Foundation For Mental Hygiene, Inc. | N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics |
JPS6028988A (ja) * | 1983-06-29 | 1985-02-14 | Ajinomoto Co Inc | ペプチドの製造方法 |
EP0166355A2 (de) * | 1984-06-26 | 1986-01-02 | Merck & Co. Inc. | Substituierte Aminophenyl- und Acylaminophenyl-Verbindungen und deren pharmazeutische Zusammensetzungen |
-
1986
- 1986-09-30 US US06/912,731 patent/US4757151A/en not_active Expired - Fee Related
- 1986-11-12 DK DK540986A patent/DK168006B1/da not_active IP Right Cessation
- 1986-11-12 AU AU65073/86A patent/AU582921B2/en not_active Ceased
- 1986-11-14 DE DE8686115859T patent/DE3677335D1/de not_active Expired - Fee Related
- 1986-11-14 ES ES198686115859T patent/ES2032376T3/es not_active Expired - Lifetime
- 1986-11-14 EP EP86115859A patent/EP0224151B1/de not_active Expired - Lifetime
- 1986-11-14 CA CA000522979A patent/CA1274350A/en not_active Expired - Fee Related
-
1991
- 1991-01-31 GR GR91400097T patent/GR3001413T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0224151A2 (de) | 1987-06-03 |
DK540986A (da) | 1987-05-15 |
EP0224151B1 (de) | 1991-01-30 |
DK168006B1 (da) | 1994-01-17 |
AU6507386A (en) | 1987-05-21 |
CA1274350A (en) | 1990-09-18 |
ES2032376T3 (es) | 1993-02-16 |
AU582921B2 (en) | 1989-04-13 |
DK540986D0 (da) | 1986-11-12 |
US4757151A (en) | 1988-07-12 |
EP0224151A3 (en) | 1989-02-22 |
GR3001413T3 (en) | 1992-09-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |