DK494287A - Recombinat dna-teknik og anvendelse deraf til fremstilling af human tumornekrose-faktor - Google Patents

Recombinat dna-teknik og anvendelse deraf til fremstilling af human tumornekrose-faktor

Info

Publication number
DK494287A
DK494287A DK494287A DK494287A DK494287A DK 494287 A DK494287 A DK 494287A DK 494287 A DK494287 A DK 494287A DK 494287 A DK494287 A DK 494287A DK 494287 A DK494287 A DK 494287A
Authority
DK
Denmark
Prior art keywords
dna technology
human tumor
tumor cancer
cancer factor
manufacturing human
Prior art date
Application number
DK494287A
Other languages
Danish (da)
English (en)
Other versions
DK494287D0 (da
Inventor
Kotikanyad Sreekrishna
Motohiro Fuke
Rica Helayne Potenz
Original Assignee
Phillips Petroleum Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phillips Petroleum Co filed Critical Phillips Petroleum Co
Publication of DK494287D0 publication Critical patent/DK494287D0/da
Publication of DK494287A publication Critical patent/DK494287A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK494287A 1986-09-22 1987-09-21 Recombinat dna-teknik og anvendelse deraf til fremstilling af human tumornekrose-faktor DK494287A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/909,528 US5002876A (en) 1986-09-22 1986-09-22 Yeast production of human tumor necrosis factor

Publications (2)

Publication Number Publication Date
DK494287D0 DK494287D0 (da) 1987-09-21
DK494287A true DK494287A (da) 1988-03-23

Family

ID=25427386

Family Applications (1)

Application Number Title Priority Date Filing Date
DK494287A DK494287A (da) 1986-09-22 1987-09-21 Recombinat dna-teknik og anvendelse deraf til fremstilling af human tumornekrose-faktor

Country Status (8)

Country Link
US (1) US5002876A (xx)
EP (1) EP0263311A3 (xx)
JP (1) JPS63164891A (xx)
AU (1) AU601768B2 (xx)
DK (1) DK494287A (xx)
IE (1) IE872368L (xx)
IL (1) IL83899A0 (xx)
NO (1) NO873927L (xx)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2217325B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene for tumour necrosis factor alpha.
CA2000101A1 (en) * 1988-12-22 1990-06-22 Mary E. Digan Pichia pastoris glyceraldehyde-3-phosphate dehydrogenase gene
JPH05184352A (ja) * 1990-01-16 1993-07-27 Centro De Ing Genetica Y Biotecnol ピヒア パストリス（Ｐｉｃｈｉａ ｐａｓｔｏｒｉｓ）酵母中での異種遺伝子の発現方法、発現ベクターおよび形質転換微生物
US5187775A (en) * 1990-03-15 1993-02-16 Dnastar, Inc. Computer representation of nucleotide and protein sequences
US6197548B1 (en) 1990-04-02 2001-03-06 Medeva Pharma Limited Transformed Pichia expressing the pertactin antigen
US5653974A (en) * 1990-10-18 1997-08-05 Board Of Regents,The University Of Texas System Preparation and characterization of liposomal formulations of tumor necrosis factor
US5268273A (en) * 1990-12-14 1993-12-07 Phillips Petroleum Company Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same
WO1992013951A1 (en) * 1991-02-04 1992-08-20 The Salk Institute Biotechnology/Industrial Associates, Inc. Production of human serum albumin in methylotrophic yeast cells
DE69232666T2 (de) * 1991-04-01 2003-03-20 Merck & Co., Inc. Gene, die die proteolytische aktivitaet von pichia beeinflussen und deren verwendung
JP2960295B2 (ja) 1993-11-01 1999-10-06 三菱電機株式会社 カートリッジ交換機構
US5945275A (en) * 1994-10-18 1999-08-31 Corvas International, Inc. Nematode-extracted anticoagulant protein
CA2202351A1 (en) * 1994-10-18 1996-04-25 George Phillip Vlasuk Nematode-extracted serine protease inhibitors and anticoagulant proteins
US5866542A (en) * 1994-10-18 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5863894A (en) * 1995-06-05 1999-01-26 Corvas International, Inc. Nematode-extracted anticoagulant protein
US5866543A (en) * 1995-06-05 1999-02-02 Corvas International, Inc. Nematode-extracted anticoagulant protein
EP0788546B9 (en) 1994-10-18 2007-06-13 Dendreon Corporation Nematode-extracted serine protease inhibitors and anticoagulant proteins
CA2253937A1 (en) * 1996-05-10 1997-11-20 Phylomed Corporation Methods for oxidizing disulfide bonds using ozone
MX9605082A (es) 1996-10-24 1998-04-30 Univ Autonoma De Nuevo Leon Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano.
US6617171B2 (en) * 1998-02-27 2003-09-09 The General Hospital Corporation Methods for diagnosing and treating autoimmune disease
US6720174B1 (en) 1999-01-28 2004-04-13 Novozymes A/S Phytases
US6599710B1 (en) 1999-03-10 2003-07-29 The General Hospital Corporation Treatment of autoimmune disease
US6258559B1 (en) * 1999-03-22 2001-07-10 Zymogenetics, Inc. Method for producing proteins in transformed Pichia
US7259253B2 (en) * 1999-05-14 2007-08-21 Quark Biotech, Inc. Genes associated with mechanical stress, expression products therefrom, and uses thereof
CN1324941A (zh) * 2000-05-19 2001-12-05 上海博德基因开发有限公司 一种新的多肽——人半乳糖激酶11和编码这种多肽的多核苷酸
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
DK1522590T3 (da) 2000-06-28 2009-12-21 Glycofi Inc Fremgangsmåde til fremstilling af modificerede glykoproteiner
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
US7863020B2 (en) * 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
US7449308B2 (en) * 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US7625756B2 (en) 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
US6645739B2 (en) 2001-07-26 2003-11-11 Phoenix Pharmacologies, Inc. Yeast expression systems, methods of producing polypeptides in yeast, and compositions relating to same
US7582313B2 (en) * 2002-06-27 2009-09-01 The General Hospital Corporation Methods of organ regeneration using Hox 11-expressing pluripotent cells
US7628988B2 (en) 2002-06-27 2009-12-08 The General Hospital Corporation Methods and compositions for treating type 1 diabetes
WO2004045376A2 (en) * 2002-11-15 2004-06-03 The General Hospital Corporation Screening methods to identify treatments for autoimmune disease
ES2347239T3 (es) * 2002-12-02 2010-10-27 Amgen Fremont Inc. Anticuerpos dirigidos al factor de necrosis tumoral y usos de los mismos.
US7118901B2 (en) * 2002-12-18 2006-10-10 Roche Diagnostics Operations, Inc. Recombinant bovine pancreatic desoxyribonuclease I with high specific activity
ATE387494T1 (de) * 2002-12-20 2008-03-15 Hoffmann La Roche Hitzelabile desoxyribonuklease i-varianten
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
EP1460425A1 (en) * 2003-03-17 2004-09-22 Boehringer Mannheim Gmbh Deglycosylated enzymes for conjugates
ES2337684T3 (es) * 2003-12-05 2010-04-28 F. Hoffmann-La Roche Ag Carboxipeptidasa b recombinante y su purificacion.
US20080102054A1 (en) * 2005-01-18 2008-05-01 Faustman Denise L Compositions Containing Agm Cells And Methods Of Use Thereof
MY146082A (en) * 2005-09-14 2012-06-29 Sanofi Aventis Deutschland Cleavage of precursors of insulins by a variant of trypsin
CA2641828A1 (en) 2005-12-20 2007-07-05 University Of Central Florida Research Foundation Isolated mcpip and methods of use
EP3936137A1 (en) 2013-02-07 2022-01-12 The General Hospital Corporation Methods for expansion or depletion of t-regulatory cells
WO2015080943A1 (en) 2013-11-26 2015-06-04 Yale University Novel cell-penetrating compositions and methods using same
HRP20231392T1 (hr) 2015-05-15 2024-04-26 The General Hospital Corporation Antagonistička protutijela na superobitelj receptora za faktor tumorske nekroze
EP3355914B1 (en) 2015-09-29 2024-03-06 The General Hospital Corporation A composition comprising bcg for reducing cholesterol.
CN116715767A (zh) 2016-05-13 2023-09-08 综合医院公司 拮抗性抗肿瘤坏死因子受体超家族抗体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599311A (en) * 1982-08-13 1986-07-08 Kawasaki Glenn H Glycolytic promotersfor regulated protein expression: protease inhibitor
US4661454A (en) * 1983-02-28 1987-04-28 Collaborative Research, Inc. GAL1 yeast promoter linked to non galactokinase gene
NZ207926A (en) * 1983-04-25 1988-04-29 Genentech Inc Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
JPS60260522A (ja) * 1984-06-07 1985-12-23 Asahi Chem Ind Co Ltd 遺伝子組換体が生産する生理活性物質の安定化法
GR851626B (xx) * 1984-07-05 1985-11-26 Genentech Inc
US4677064A (en) * 1984-11-09 1987-06-30 Cetus Corporation Human tumor necrosis factor
US4677063A (en) * 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast

Also Published As

Publication number Publication date
EP0263311A3 (en) 1989-03-22
NO873927D0 (no) 1987-09-18
AU7865087A (en) 1988-05-19
EP0263311A2 (en) 1988-04-13
DK494287D0 (da) 1987-09-21
JPS63164891A (ja) 1988-07-08
US5002876A (en) 1991-03-26
AU601768B2 (en) 1990-09-20
IL83899A0 (en) 1988-02-29
IE872368L (en) 1988-03-22
NO873927L (no) 1988-03-23

Similar Documents

Publication Publication Date Title
DK494287A (da) Recombinat dna-teknik og anvendelse deraf til fremstilling af human tumornekrose-faktor
DK550386A (da) Engangsble og fremgangsmaade til fremstilling deraf.
GB2158829B (en) Human tumor necrosis factor and dna therefor
DK166087D0 (da) Proteiner og fremgangsmaade til fremstilling deraf
DK551187D0 (da) Terapeutisk praeparat og dettes fremstilling
DK260687A (da) Immunoglobulin-konjugater og fremgangsmaade til fremstilling deraf
DK279886A (da) Human tumornekrosefaktor
DK412787D0 (da) Medicinsk-kirurgisk pose og dennes fremstilling
DK554485D0 (da) Geltandplejemiddel og fremgangsmaade til fremstilling deraf
DK533387D0 (da) Indretning til fiskeopdraet og fremgangsmaade til fremstilling heraf
DK220487A (da) Aeuniversel organomineralsk og biostimulerende goedningsmiddel og fremgangsmaade til fremstilling af sammeae
DK182986D0 (da) 5-pyrimidincarboxamider og behandling af leukaemi og tumorer dermed
KR890700358A (ko) 인체 종양관련 항원
DK413187D0 (da) Semicarbazoner og thiosemicarbazoner
DK203087D0 (da) Proteiner og fremgangsmaade til fremstilling deraf
DK154283D0 (da) Produkter og metoder til behandling af cancer
DK143488A (da) Laegemiddel til behandling af cancer
DK362987D0 (da) Hexahydroarylquinolizin og fremgangsmaade til fremstilling deraf
ES1005896Y (es) Bigudi
DK434388A (da) Fremgangsmaade og anlaeg til informationssoegning
KR870013007U (ko) 화장용 문신기구
DK452087A (da) 3-brom-2,6-dimethoxybenzamider, deres fremstilling og anvendelse
FR2607003B1 (fr) Carte cutanee homeopathique
DK629586D0 (da) Fremgangsmaade og anlaeg til behandling eller undersaegelse af slagtekroppe
DK227087D0 (da) Urtepotte og underskaal

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment