DK477685A - Peptidsubstituerede heterocycliske forbindelser og anvendelse deraf som immunostimulerende eller antiinfektive forbindelser samt farmaceutiske praeparater - Google Patents
Peptidsubstituerede heterocycliske forbindelser og anvendelse deraf som immunostimulerende eller antiinfektive forbindelser samt farmaceutiske praeparater Download PDFInfo
- Publication number
- DK477685A DK477685A DK477685A DK477685A DK477685A DK 477685 A DK477685 A DK 477685A DK 477685 A DK477685 A DK 477685A DK 477685 A DK477685 A DK 477685A DK 477685 A DK477685 A DK 477685A
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- peptime
- immunostimulating
- pharmaceutical preparations
- substituted heterocyclic
- Prior art date
Links
- 230000002924 anti-infective effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000003308 immunostimulating effect Effects 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/662,668 US4619915A (en) | 1984-10-19 | 1984-10-19 | Peptide-substituted heterocyclic immunostimulants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK477685D0 DK477685D0 (da) | 1985-10-18 |
| DK477685A true DK477685A (da) | 1986-04-20 |
Family
ID=24658673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK477685A DK477685A (da) | 1984-10-19 | 1985-10-18 | Peptidsubstituerede heterocycliske forbindelser og anvendelse deraf som immunostimulerende eller antiinfektive forbindelser samt farmaceutiske praeparater |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4619915A (no) |
| EP (1) | EP0178845A3 (no) |
| JP (1) | JPS61100564A (no) |
| KR (1) | KR870000810B1 (no) |
| CN (1) | CN85107088A (no) |
| AU (1) | AU554078B2 (no) |
| CA (1) | CA1277099C (no) |
| CS (1) | CS252832B2 (no) |
| DD (1) | DD240546A5 (no) |
| DK (1) | DK477685A (no) |
| EG (1) | EG17820A (no) |
| ES (1) | ES8702433A1 (no) |
| FI (1) | FI854074L (no) |
| GR (1) | GR852526B (no) |
| HU (1) | HU200783B (no) |
| IL (1) | IL76706A0 (no) |
| NO (1) | NO167923C (no) |
| NZ (1) | NZ213877A (no) |
| PH (1) | PH21389A (no) |
| PT (1) | PT81319B (no) |
| ZA (1) | ZA858017B (no) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU201094B (en) * | 1986-01-23 | 1990-09-28 | Pfizer | Process for producing immunostimulant acyltripeptides and pharmaceutical compositions comprising same as active ingredient |
| US5079366A (en) * | 1987-04-07 | 1992-01-07 | University Of Florida | Quarternary pyridinium salts |
| US4888427A (en) * | 1987-04-07 | 1989-12-19 | University Of Florida | Amino acids containing dihydropyridine ring systems for site-specific delivery of peptides to the brain |
| US4874608A (en) * | 1987-04-27 | 1989-10-17 | Imreg, Inc. | Therapeutic method for treating malignancies |
| WO1999012572A1 (en) | 1997-09-10 | 1999-03-18 | University Of Florida | Compounds and method for the prevention and treatment of diabetic retinopathy |
| US6451974B1 (en) | 1999-03-17 | 2002-09-17 | Novo Nordisk A/S | Method of acylating peptides and novel acylating agents |
| US7273921B2 (en) * | 2002-09-25 | 2007-09-25 | Novo Nordisk A/S | Method for producing acylated peptides |
| UA84146C2 (ru) * | 2003-05-21 | 2008-09-25 | Прозидион Лимитед | Амиды пирролопиридин-2-карбоновой кислоты как ингибиторы гликогенфосфорилазы, способ их получения, фармацевтическая композиция и их применение как терапевтических агентов для лечения заболеваний |
| US7405210B2 (en) | 2003-05-21 | 2008-07-29 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase |
| US7869746B2 (en) | 2006-03-10 | 2011-01-11 | Ricoh Company, Ltd. | Image forming device, powder supply device, and powder storage unit including a gas supplying unit |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4322341A (en) * | 1980-05-13 | 1982-03-30 | Fujisawa Pharmaceutical Co | Peptide, process for preparation thereof and use thereof |
| GR81332B (no) * | 1980-12-01 | 1984-12-11 | Fujisawa Pharmaceutical Co | |
| GR77929B (no) * | 1981-01-29 | 1984-09-25 | Fujisawa Pharmaceutical Co |
-
1984
- 1984-10-19 US US06/662,668 patent/US4619915A/en not_active Expired - Fee Related
-
1985
- 1985-09-23 CN CN198585107088A patent/CN85107088A/zh active Pending
- 1985-10-10 EP EP85307237A patent/EP0178845A3/en not_active Withdrawn
- 1985-10-14 IL IL76706A patent/IL76706A0/xx not_active IP Right Cessation
- 1985-10-16 CS CS857386A patent/CS252832B2/cs not_active IP Right Cessation
- 1985-10-17 PT PT81319A patent/PT81319B/pt not_active IP Right Cessation
- 1985-10-17 NZ NZ213877A patent/NZ213877A/xx unknown
- 1985-10-17 CA CA000493180A patent/CA1277099C/en not_active Expired - Fee Related
- 1985-10-17 ES ES547976A patent/ES8702433A1/es not_active Expired
- 1985-10-18 ZA ZA858017A patent/ZA858017B/xx unknown
- 1985-10-18 AU AU48851/85A patent/AU554078B2/en not_active Ceased
- 1985-10-18 FI FI854074A patent/FI854074L/fi not_active Application Discontinuation
- 1985-10-18 NO NO854162A patent/NO167923C/no unknown
- 1985-10-18 KR KR1019850007688A patent/KR870000810B1/ko not_active IP Right Cessation
- 1985-10-18 GR GR852526A patent/GR852526B/el unknown
- 1985-10-18 DD DD85281877A patent/DD240546A5/de not_active IP Right Cessation
- 1985-10-18 DK DK477685A patent/DK477685A/da not_active Application Discontinuation
- 1985-10-18 HU HU854034A patent/HU200783B/hu not_active IP Right Cessation
- 1985-10-18 JP JP60233167A patent/JPS61100564A/ja active Pending
- 1985-10-20 EG EG666/85A patent/EG17820A/xx active
- 1985-10-21 PH PH32956A patent/PH21389A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4619915A (en) | 1986-10-28 |
| NZ213877A (en) | 1988-10-28 |
| NO167923C (no) | 1991-12-27 |
| JPS61100564A (ja) | 1986-05-19 |
| FI854074L (fi) | 1986-04-20 |
| NO167923B (no) | 1991-09-16 |
| CS252832B2 (en) | 1987-10-15 |
| DK477685D0 (da) | 1985-10-18 |
| PT81319B (pt) | 1987-11-30 |
| KR860003272A (ko) | 1986-05-21 |
| NO854162L (no) | 1986-04-21 |
| KR870000810B1 (ko) | 1987-04-20 |
| HU200783B (en) | 1990-08-28 |
| CS738685A2 (en) | 1987-02-12 |
| CA1277099C (en) | 1990-11-27 |
| EG17820A (en) | 1991-03-30 |
| FI854074A0 (fi) | 1985-10-18 |
| PT81319A (en) | 1985-11-01 |
| EP0178845A3 (en) | 1987-07-29 |
| HUT38656A (en) | 1986-06-30 |
| CN85107088A (zh) | 1986-06-10 |
| ES8702433A1 (es) | 1986-12-16 |
| ZA858017B (en) | 1987-05-27 |
| IL76706A0 (en) | 1986-02-28 |
| DD240546A5 (de) | 1986-11-05 |
| AU4885185A (en) | 1986-05-01 |
| GR852526B (no) | 1986-02-19 |
| AU554078B2 (en) | 1986-08-07 |
| ES547976A0 (es) | 1986-12-16 |
| EP0178845A2 (en) | 1986-04-23 |
| PH21389A (en) | 1987-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |