DK447786A - Fremgangsmaade til udvinding af insulin-forloebere fra reaktionsblandingen, der fremkommer ved foldning af insulin-forloebere ud fra de tilsvarende s-sulfonater - Google Patents

Fremgangsmaade til udvinding af insulin-forloebere fra reaktionsblandingen, der fremkommer ved foldning af insulin-forloebere ud fra de tilsvarende s-sulfonater Download PDF

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Publication number
DK447786A
DK447786A DK447786A DK447786A DK447786A DK 447786 A DK447786 A DK 447786A DK 447786 A DK447786 A DK 447786A DK 447786 A DK447786 A DK 447786A DK 447786 A DK447786 A DK 447786A
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DK
Denmark
Prior art keywords
insulin
chain
pct
reaction mixture
folding
Prior art date
Application number
DK447786A
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English (en)
Other versions
DK447786D0 (da
DK172712B1 (da
Inventor
Ulrich Grau
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK447786A publication Critical patent/DK447786A/da
Publication of DK447786D0 publication Critical patent/DK447786D0/da
Application granted granted Critical
Publication of DK172712B1 publication Critical patent/DK172712B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/625—Extraction from natural sources
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
DK198604477A 1985-01-19 1986-09-18 Fremgangsmåde til udvinding af insulin-forløbere fra reaktionsblandinger, der fremkommer ved foldning af insulin-forløbere DK172712B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19853501641 DE3501641A1 (de) 1985-01-19 1985-01-19 Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
DE3501641 1985-01-19
PCT/EP1986/000008 WO1986004335A1 (en) 1985-01-19 1986-01-11 Process for the preparation of insulin precursors contained in reaction mixtures resulting from the preparation of insulin precurssors by plaiting respective s-sulphonates
EP8600008 1986-01-11

Publications (3)

Publication Number Publication Date
DK447786A true DK447786A (da) 1986-09-18
DK447786D0 DK447786D0 (da) 1986-09-18
DK172712B1 DK172712B1 (da) 1999-06-14

Family

ID=6260194

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198604477A DK172712B1 (da) 1985-01-19 1986-09-18 Fremgangsmåde til udvinding af insulin-forløbere fra reaktionsblandinger, der fremkommer ved foldning af insulin-forløbere

Country Status (9)

Country Link
US (1) US4801684A (da)
EP (1) EP0245267B1 (da)
JP (1) JPS62501501A (da)
AT (1) ATE58741T1 (da)
AU (1) AU579710B2 (da)
DE (2) DE3501641A1 (da)
DK (1) DK172712B1 (da)
HU (1) HU200611B (da)
WO (1) WO1986004335A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
US5492936A (en) * 1990-11-30 1996-02-20 Allergan, Inc. Bimodal molecular weight hyaluronate formulations and methods for using same
ES2097426T3 (es) * 1992-12-02 1997-04-01 Hoechst Ag Procedimiento para la obtencion de proinsulina con puentes de cistina correctamente unidos.
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
DE19735711C2 (de) * 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
KR100253916B1 (ko) * 1997-12-29 2000-05-01 김충환 사람 인슐린 전구체의 제조방법
WO2002067969A2 (en) 2001-02-21 2002-09-06 Medtronic Minimed, Inc. Stabilized insulin formulations
WO2012152439A1 (en) 2011-05-10 2012-11-15 Glucometrix Ag Comprehensive buffer system for renaturing human proinsulin or proinsulin derivatives
KR20170036643A (ko) * 2015-09-24 2017-04-03 한미약품 주식회사 인슐린의 제조 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2428412A1 (de) * 1974-06-12 1976-01-15 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
DE2923787A1 (de) * 1979-06-12 1980-12-18 Max Planck Gesellschaft Verfahren zur selektiven bildung von disulfidbruecken in polypeptiden und die dabei erhaltenen produkte als wirkstoffe enthaltende arzneimittel
RO81951B (ro) * 1980-03-27 1984-02-28 Eli Lilly And Company Procedeu de preparare a unui precursor de insulina
NZ196610A (en) * 1980-03-27 1984-03-16 Lilly Co Eli Preparation of insulin or insulin analog
PH16156A (en) * 1980-03-27 1983-07-18 Lilly Co Eli Process for producing an insulin precursor
US4421685A (en) * 1980-03-27 1983-12-20 Eli Lilly And Company Process for producing an insulin
US4430266A (en) * 1980-11-28 1984-02-07 Eli Lilly And Company Process for producing an insulin precursor
US4654324A (en) * 1981-08-27 1987-03-31 Eli Lilly And Company Human proinsulin pharmaceutical formulations
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus

Also Published As

Publication number Publication date
WO1986004335A1 (en) 1986-07-31
HUT46041A (en) 1988-09-28
ATE58741T1 (de) 1990-12-15
EP0245267A1 (de) 1987-11-19
DE3501641A1 (de) 1986-07-24
AU5356886A (en) 1986-08-13
AU579710B2 (en) 1988-12-08
DK447786D0 (da) 1986-09-18
EP0245267B1 (de) 1990-11-28
DE3675936D1 (de) 1991-01-10
US4801684A (en) 1989-01-31
HU200611B (en) 1990-07-28
DK172712B1 (da) 1999-06-14
JPS62501501A (ja) 1987-06-18

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired