DK401575A - Cis-decahydroisoquinolin-analgetika og fremgangsmade til deres fremstilling - Google Patents

Cis-decahydroisoquinolin-analgetika og fremgangsmade til deres fremstilling

Info

Publication number
DK401575A
DK401575A DK401575A DK401575A DK401575A DK 401575 A DK401575 A DK 401575A DK 401575 A DK401575 A DK 401575A DK 401575 A DK401575 A DK 401575A DK 401575 A DK401575 A DK 401575A
Authority
DK
Denmark
Prior art keywords
analgetics
decahydroisoquinoline
cis
procedures
preparation
Prior art date
Application number
DK401575A
Other languages
Danish (da)
English (en)
Inventor
W C Ripka
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of DK401575A publication Critical patent/DK401575A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK401575A 1974-09-09 1975-09-08 Cis-decahydroisoquinolin-analgetika og fremgangsmade til deres fremstilling DK401575A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50430274A 1974-09-09 1974-09-09
US59946175A 1975-08-01 1975-08-01

Publications (1)

Publication Number Publication Date
DK401575A true DK401575A (da) 1976-03-10

Family

ID=27054787

Family Applications (1)

Application Number Title Priority Date Filing Date
DK401575A DK401575A (da) 1974-09-09 1975-09-08 Cis-decahydroisoquinolin-analgetika og fremgangsmade til deres fremstilling

Country Status (19)

Country Link
US (1) US4150135A (xx)
JP (1) JPS5154572A (xx)
AR (1) AR208562A1 (xx)
AU (1) AU503631B2 (xx)
BE (1) BE833212A (xx)
DD (1) DD123190A5 (xx)
DE (1) DE2539907A1 (xx)
DK (1) DK401575A (xx)
ES (2) ES440830A1 (xx)
FI (1) FI752516A (xx)
FR (2) FR2283681A1 (xx)
GB (1) GB1484431A (xx)
IE (1) IE41898B1 (xx)
IL (1) IL48061A (xx)
LU (1) LU73348A1 (xx)
NL (1) NL7510617A (xx)
NO (1) NO753062L (xx)
SE (1) SE7509022L (xx)
SU (1) SU682126A3 (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK152732B (da) * 1977-04-04 1988-05-02 Hoffmann La Roche Fremgangsmaade til fremstilling af imidazodiazepinderivater

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419517A (en) * 1973-06-01 1983-12-06 E. I. Du Pont De Nemours & Co. 4a-Aryl-trans-decahydroisoquinolines
US4219652A (en) * 1975-09-30 1980-08-26 Eli Lilly And Company N-Methyl and N-phenethyl-cis-decahydroisoquinolines
US4301290A (en) * 1975-12-16 1981-11-17 Sandoz Ltd. Organic compounds
DE2636684C3 (de) * 1976-08-14 1980-06-19 Merck Patent Gmbh, 6100 Darmstadt Phenylcyclohexanderivate und ihre Verwendung in flüssigkristallinen Dielektrika
DE2702598C2 (de) * 1977-01-22 1984-10-25 Merck Patent Gmbh, 6100 Darmstadt Cyclohexylcyclohexane und diese enthaltende Dielektrika
US4289882A (en) 1978-04-26 1981-09-15 The United States Of America As Represented By The Department Of Health & Human Services 4A-Aryl-decahydroisoquinolines
JPS57122041A (en) * 1981-01-21 1982-07-29 Suntory Ltd Phenylclohexane derivative
US4349677A (en) * 1981-11-09 1982-09-14 Morton-Norwich Products, Inc. 3,4-Dihydro-3,4-isoquinolinedione 4-oxime
US4537963A (en) * 1981-12-28 1985-08-27 E. I. Du Pont De Nemours And Company Intermediates for octahydrobenzofuro[3,2-E]isoquinolines
US4579952A (en) * 1981-12-28 1986-04-01 E. I. Du Pont De Nemours And Company Intermediates for octahydrobenzofuro[3,2-e]isoquinolines
US4421916A (en) * 1981-12-28 1983-12-20 E. I. Du Pont De Nemours & Co. Intermediates for octahydrobenzofuro[3,2-e]isoquinolines
IT1307327B1 (it) * 1995-09-12 2001-10-30 Smithkline Beecham Spa Derivati idroisochinolinici sostituiti
CN105473554B (zh) 2013-07-10 2019-08-13 沃泰克斯药物股份有限公司 作为离子通道调节剂的稠合的哌啶酰胺类

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2740788A (en) * 1956-04-03 J-hydroxy-n-propargyl-morphinanes
DE1670694B2 (de) 1966-05-05 1976-07-22 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von tetrahydroisochinolinen
US3546227A (en) * 1966-12-01 1970-12-08 Sandoz Ag 2,3-dihydro-1h-benz(d,e)isoquinoline carboxamidines
US3666763A (en) * 1970-01-06 1972-05-30 Hoffmann La Roche 4-phenyl isoquinolines and process for preparing same
ZA734895B (en) * 1972-07-20 1974-06-26 Du Pont Analgesigs and/or narcotic antagonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK152732B (da) * 1977-04-04 1988-05-02 Hoffmann La Roche Fremgangsmaade til fremstilling af imidazodiazepinderivater

Also Published As

Publication number Publication date
FR2283681A1 (fr) 1976-04-02
JPS5154572A (en) 1976-05-13
FI752516A (xx) 1976-03-10
DD123190A5 (xx) 1976-12-05
IE41898B1 (en) 1980-04-23
LU73348A1 (xx) 1976-08-13
IE41898L (en) 1976-03-09
NL7510617A (nl) 1976-03-11
DE2539907A1 (de) 1976-03-25
AR208562A1 (es) 1977-02-15
ES440830A1 (es) 1977-07-01
US4150135A (en) 1979-04-17
AU503631B2 (en) 1979-09-13
NO753062L (xx) 1976-03-10
BE833212A (fr) 1976-03-09
SU682126A3 (ru) 1979-08-25
IL48061A (en) 1979-09-30
ES456168A1 (es) 1978-08-01
AU8460875A (en) 1977-03-17
IL48061A0 (en) 1975-11-25
FR2309536B1 (xx) 1979-07-27
GB1484431A (en) 1977-09-01
FR2309536A1 (fr) 1976-11-26
SE7509022L (sv) 1976-03-10

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Legal Events

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ATS Application withdrawn