FR2309536A1 - Nouvelles 1,3 diceto-1,2,3,4,4a,5,6,7-octahydroisoquinoleines, leur preparation et leur utilisation - Google Patents

Nouvelles 1,3 diceto-1,2,3,4,4a,5,6,7-octahydroisoquinoleines, leur preparation et leur utilisation

Info

Publication number
FR2309536A1
FR2309536A1 FR7616802A FR7616802A FR2309536A1 FR 2309536 A1 FR2309536 A1 FR 2309536A1 FR 7616802 A FR7616802 A FR 7616802A FR 7616802 A FR7616802 A FR 7616802A FR 2309536 A1 FR2309536 A1 FR 2309536A1
Authority
FR
France
Prior art keywords
octahydroisoquinoleins
diceto
news
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7616802A
Other languages
English (en)
Other versions
FR2309536B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of FR2309536A1 publication Critical patent/FR2309536A1/fr
Application granted granted Critical
Publication of FR2309536B1 publication Critical patent/FR2309536B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
FR7616802A 1974-09-09 1976-06-03 Nouvelles 1,3 diceto-1,2,3,4,4a,5,6,7-octahydroisoquinoleines, leur preparation et leur utilisation Granted FR2309536A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50430274A 1974-09-09 1974-09-09
US59946175A 1975-08-01 1975-08-01

Publications (2)

Publication Number Publication Date
FR2309536A1 true FR2309536A1 (fr) 1976-11-26
FR2309536B1 FR2309536B1 (fr) 1979-07-27

Family

ID=27054787

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7527562A Withdrawn FR2283681A1 (fr) 1974-09-09 1975-09-09 Composes analgesiques
FR7616802A Granted FR2309536A1 (fr) 1974-09-09 1976-06-03 Nouvelles 1,3 diceto-1,2,3,4,4a,5,6,7-octahydroisoquinoleines, leur preparation et leur utilisation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7527562A Withdrawn FR2283681A1 (fr) 1974-09-09 1975-09-09 Composes analgesiques

Country Status (19)

Country Link
US (1) US4150135A (fr)
JP (1) JPS5154572A (fr)
AR (1) AR208562A1 (fr)
AU (1) AU503631B2 (fr)
BE (1) BE833212A (fr)
DD (1) DD123190A5 (fr)
DE (1) DE2539907A1 (fr)
DK (1) DK401575A (fr)
ES (2) ES440830A1 (fr)
FI (1) FI752516A (fr)
FR (2) FR2283681A1 (fr)
GB (1) GB1484431A (fr)
IE (1) IE41898B1 (fr)
IL (1) IL48061A (fr)
LU (1) LU73348A1 (fr)
NL (1) NL7510617A (fr)
NO (1) NO753062L (fr)
SE (1) SE7509022L (fr)
SU (1) SU682126A3 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419517A (en) * 1973-06-01 1983-12-06 E. I. Du Pont De Nemours & Co. 4a-Aryl-trans-decahydroisoquinolines
US4219652A (en) * 1975-09-30 1980-08-26 Eli Lilly And Company N-Methyl and N-phenethyl-cis-decahydroisoquinolines
US4301290A (en) * 1975-12-16 1981-11-17 Sandoz Ltd. Organic compounds
DE2636684C3 (de) * 1976-08-14 1980-06-19 Merck Patent Gmbh, 6100 Darmstadt Phenylcyclohexanderivate und ihre Verwendung in flüssigkristallinen Dielektrika
DE2702598C2 (de) * 1977-01-22 1984-10-25 Merck Patent Gmbh, 6100 Darmstadt Cyclohexylcyclohexane und diese enthaltende Dielektrika
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
US4289882A (en) 1978-04-26 1981-09-15 The United States Of America As Represented By The Department Of Health & Human Services 4A-Aryl-decahydroisoquinolines
JPS57122041A (en) * 1981-01-21 1982-07-29 Suntory Ltd Phenylclohexane derivative
US4349677A (en) * 1981-11-09 1982-09-14 Morton-Norwich Products, Inc. 3,4-Dihydro-3,4-isoquinolinedione 4-oxime
US4421916A (en) * 1981-12-28 1983-12-20 E. I. Du Pont De Nemours & Co. Intermediates for octahydrobenzofuro[3,2-e]isoquinolines
US4537963A (en) * 1981-12-28 1985-08-27 E. I. Du Pont De Nemours And Company Intermediates for octahydrobenzofuro[3,2-E]isoquinolines
US4579952A (en) * 1981-12-28 1986-04-01 E. I. Du Pont De Nemours And Company Intermediates for octahydrobenzofuro[3,2-e]isoquinolines
IT1307327B1 (it) * 1995-09-12 2001-10-30 Smithkline Beecham Spa Derivati idroisochinolinici sostituiti
CN105473554B (zh) 2013-07-10 2019-08-13 沃泰克斯药物股份有限公司 作为离子通道调节剂的稠合的哌啶酰胺类

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2740788A (en) * 1956-04-03 J-hydroxy-n-propargyl-morphinanes
DE1670694B2 (de) 1966-05-05 1976-07-22 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von tetrahydroisochinolinen
US3546227A (en) * 1966-12-01 1970-12-08 Sandoz Ag 2,3-dihydro-1h-benz(d,e)isoquinoline carboxamidines
US3666763A (en) * 1970-01-06 1972-05-30 Hoffmann La Roche 4-phenyl isoquinolines and process for preparing same
AT330179B (de) * 1972-07-20 1976-06-25 Du Pont Verfahren zur herstellung von neuen 4a-aryl- transdecahydroisochinolinderivaten sowie deren optischen isomeren

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Also Published As

Publication number Publication date
IE41898L (en) 1976-03-09
AU503631B2 (en) 1979-09-13
JPS5154572A (en) 1976-05-13
IL48061A0 (en) 1975-11-25
ES440830A1 (es) 1977-07-01
LU73348A1 (fr) 1976-08-13
AU8460875A (en) 1977-03-17
DE2539907A1 (de) 1976-03-25
ES456168A1 (es) 1978-08-01
FR2309536B1 (fr) 1979-07-27
GB1484431A (en) 1977-09-01
NL7510617A (nl) 1976-03-11
NO753062L (fr) 1976-03-10
BE833212A (fr) 1976-03-09
AR208562A1 (es) 1977-02-15
FR2283681A1 (fr) 1976-04-02
IL48061A (en) 1979-09-30
SU682126A3 (ru) 1979-08-25
US4150135A (en) 1979-04-17
SE7509022L (sv) 1976-03-10
DD123190A5 (fr) 1976-12-05
FI752516A (fr) 1976-03-10
IE41898B1 (en) 1980-04-23
DK401575A (da) 1976-03-10

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Legal Events

Date Code Title Description
ST Notification of lapse