DK3957744T5 - Reagenser og fremgangsmåder til molekylær stregkodning af enkeltcellenukleinsyrer - Google Patents
Reagenser og fremgangsmåder til molekylær stregkodning af enkeltcellenukleinsyrer Download PDFInfo
- Publication number
- DK3957744T5 DK3957744T5 DK21168174.7T DK21168174T DK3957744T5 DK 3957744 T5 DK3957744 T5 DK 3957744T5 DK 21168174 T DK21168174 T DK 21168174T DK 3957744 T5 DK3957744 T5 DK 3957744T5
- Authority
- DK
- Denmark
- Prior art keywords
- reagents
- methods
- nucleic acids
- single cell
- cell nucleic
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/149—Particles, e.g. beads
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/185—Nucleic acid dedicated to use as a hidden marker/bar code, e.g. inclusion of nucleic acids to mark art objects or animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/50—Detection characterised by immobilisation to a surface
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1622222.6A GB201622222D0 (en) | 2016-12-23 | 2016-12-23 | Reagents and methods for molecular barcoding of nucleic acids of single cells |
EP17817859.6A EP3559267B1 (en) | 2016-12-23 | 2017-12-19 | Method for molecular barcoding of nucleic acids of single cells |
Publications (2)
Publication Number | Publication Date |
---|---|
DK3957744T3 DK3957744T3 (da) | 2023-09-18 |
DK3957744T5 true DK3957744T5 (da) | 2024-07-15 |
Family
ID=58360450
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK21168174.7T DK3957744T5 (da) | 2016-12-23 | 2017-12-19 | Reagenser og fremgangsmåder til molekylær stregkodning af enkeltcellenukleinsyrer |
DK17817859.6T DK3559267T3 (da) | 2016-12-23 | 2017-12-19 | Fremgangsmåde til molekylær stregkodning af nukleinsyrer i enkeltceller |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17817859.6T DK3559267T3 (da) | 2016-12-23 | 2017-12-19 | Fremgangsmåde til molekylær stregkodning af nukleinsyrer i enkeltceller |
Country Status (8)
Country | Link |
---|---|
US (2) | US12084714B2 (da) |
EP (3) | EP4265723A3 (da) |
DK (2) | DK3957744T5 (da) |
ES (2) | ES2880394T3 (da) |
GB (1) | GB201622222D0 (da) |
HR (1) | HRP20211078T1 (da) |
SI (1) | SI3559267T1 (da) |
WO (1) | WO2018115852A1 (da) |
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US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
GB2513024B (en) | 2012-02-27 | 2016-08-31 | Cellular Res Inc | A clonal amplification method |
GB2525104B (en) | 2013-08-28 | 2016-09-28 | Cellular Res Inc | Massively Parallel Single Cell Nucleic Acid Analysis |
CN113249297A (zh) | 2014-05-28 | 2021-08-13 | 儿童医院医疗中心 | 用于经由定向分化将前体细胞转化为胃组织的方法和系统 |
EP3207123A1 (en) | 2014-10-17 | 2017-08-23 | Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
WO2016138496A1 (en) | 2015-02-27 | 2016-09-01 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
US11535882B2 (en) | 2015-03-30 | 2022-12-27 | Becton, Dickinson And Company | Methods and compositions for combinatorial barcoding |
WO2016172373A1 (en) | 2015-04-23 | 2016-10-27 | Cellular Research, Inc. | Methods and compositions for whole transcriptome amplification |
EP3347465B1 (en) | 2015-09-11 | 2019-06-26 | Cellular Research, Inc. | Methods and compositions for nucleic acid library normalization |
US11066650B2 (en) | 2016-05-05 | 2021-07-20 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
CA3034924A1 (en) | 2016-09-26 | 2018-03-29 | Cellular Research, Inc. | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
US11767515B2 (en) | 2016-12-05 | 2023-09-26 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
GB201622222D0 (en) * | 2016-12-23 | 2017-02-08 | Cs Genetics Ltd | Reagents and methods for molecular barcoding of nucleic acids of single cells |
US11319583B2 (en) | 2017-02-01 | 2022-05-03 | Becton, Dickinson And Company | Selective amplification using blocking oligonucleotides |
AU2018281745B2 (en) | 2017-06-05 | 2022-05-19 | Becton, Dickinson And Company | Sample indexing for single cells |
WO2019213237A1 (en) | 2018-05-03 | 2019-11-07 | Becton, Dickinson And Company | Molecular barcoding on opposite transcript ends |
US11773441B2 (en) | 2018-05-03 | 2023-10-03 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
WO2020072380A1 (en) | 2018-10-01 | 2020-04-09 | Cellular Research, Inc. | Determining 5' transcript sequences |
US11932849B2 (en) | 2018-11-08 | 2024-03-19 | Becton, Dickinson And Company | Whole transcriptome analysis of single cells using random priming |
CN113195717A (zh) | 2018-12-13 | 2021-07-30 | 贝克顿迪金森公司 | 单细胞全转录组分析中的选择性延伸 |
ES2945227T3 (es) | 2019-01-23 | 2023-06-29 | Becton Dickinson Co | Oligonucleótidos asociados con anticuerpos |
US12071617B2 (en) | 2019-02-14 | 2024-08-27 | Becton, Dickinson And Company | Hybrid targeted and whole transcriptome amplification |
CN114144521A (zh) * | 2019-05-31 | 2022-03-04 | 儿童医院医学中心 | 基于聚合物的细胞标记、条形码化和组装 |
GB201909325D0 (en) | 2019-06-28 | 2019-08-14 | Cs Genetics Ltd | Reagents and methods for analysis for microparticles |
CN114051534A (zh) | 2019-07-22 | 2022-02-15 | 贝克顿迪金森公司 | 单细胞染色质免疫沉淀测序测定 |
JP7522189B2 (ja) | 2019-11-08 | 2024-07-24 | ベクトン・ディキンソン・アンド・カンパニー | 免疫レパートリーシーケンシングのための完全長v(d)j情報を得るためのランダムプライミングの使用 |
EP4090763A1 (en) | 2020-01-13 | 2022-11-23 | Becton Dickinson and Company | Methods and compositions for quantitation of proteins and rna |
CN112280829B (zh) * | 2020-04-07 | 2023-12-26 | 南方科技大学 | 一种试剂盒、样本标记方法、单细胞测序方法 |
EP4150118A1 (en) | 2020-05-14 | 2023-03-22 | Becton Dickinson and Company | Primers for immune repertoire profiling |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
EP4247967A1 (en) | 2020-11-20 | 2023-09-27 | Becton, Dickinson and Company | Profiling of highly expressed and lowly expressed proteins |
EP4355898A1 (en) | 2021-06-18 | 2024-04-24 | CS Genetics Limited | Reagents and methods for molecular barcoding |
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US20060040286A1 (en) | 2001-03-28 | 2006-02-23 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
US20070111204A1 (en) | 2003-06-27 | 2007-05-17 | Kathleen Delgrosso | Methods for detecting nucleic acid variations |
US20050064435A1 (en) | 2003-09-24 | 2005-03-24 | Xing Su | Programmable molecular barcodes |
CN102482668A (zh) | 2009-08-20 | 2012-05-30 | 群体遗传学科技有限公司 | 分子内核酸重排的组合物和方法 |
EP2623613B8 (en) | 2010-09-21 | 2016-09-07 | Population Genetics Technologies Ltd. | Increasing confidence of allele calls with molecular counting |
US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
US9150852B2 (en) * | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
DK3246416T3 (da) | 2011-04-15 | 2024-09-02 | Univ Johns Hopkins | Sikkert sekventeringssystem |
EP2753715A4 (en) | 2011-09-09 | 2015-05-20 | Univ Leland Stanford Junior | METHODS FOR OBTAINING A SEQUENCE |
US20140378345A1 (en) | 2012-08-14 | 2014-12-25 | 10X Technologies, Inc. | Compositions and methods for sample processing |
CN107090491A (zh) | 2012-11-05 | 2017-08-25 | 鲁比康基因组学公司 | 条形编码核酸 |
JP6093436B2 (ja) | 2013-03-12 | 2017-03-08 | 株式会社日立製作所 | 遺伝子定量・配列解析用2次元セルアレイデバイスおよび装置 |
US9328382B2 (en) | 2013-03-15 | 2016-05-03 | Complete Genomics, Inc. | Multiple tagging of individual long DNA fragments |
WO2015073693A1 (en) | 2013-11-15 | 2015-05-21 | The Regents Of The University Of California | Duplicating dna with contiguity barcodes for genome and epigenome sequencing |
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EP3146046B1 (en) | 2014-05-23 | 2020-03-11 | Digenomix Corporation | Haploidome determination by digitized transposons |
EP3161160B1 (en) * | 2014-06-26 | 2021-10-13 | 10X Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
US20180320241A1 (en) | 2014-12-19 | 2018-11-08 | Roche Sequencing Solutions, Inc. | Methods for identifying multiple epitopes in selected sub-populations of cells |
US20180284125A1 (en) | 2015-03-11 | 2018-10-04 | The Broad Institute, Inc. | Proteomic analysis with nucleic acid identifiers |
US11535882B2 (en) | 2015-03-30 | 2022-12-27 | Becton, Dickinson And Company | Methods and compositions for combinatorial barcoding |
WO2016168351A1 (en) * | 2015-04-15 | 2016-10-20 | The Board Of Trustees Of The Leland Stanford Junior University | Robust quantification of single molecules in next-generation sequencing using non-random combinatorial oligonucleotide barcodes |
AU2016248995B2 (en) | 2015-04-17 | 2022-04-28 | President And Fellows Of Harvard College | Barcoding systems and methods for gene sequencing and other applications |
GB2539675B (en) * | 2015-06-23 | 2017-11-22 | Cs Genetics Ltd | Libraries of multimeric barcoding reagents and kits thereof for labelling nucleic acids for sequencing |
US9768159B2 (en) * | 2015-08-19 | 2017-09-19 | Texas Instruments Incorporated | Electrostatic discharge protection device for high voltage |
US11156611B2 (en) * | 2015-09-24 | 2021-10-26 | Abvitro Llc | Single cell characterization using affinity-oligonucleotide conjugates and vessel barcoded polynucleotides |
EP3359683A1 (en) | 2015-10-05 | 2018-08-15 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | A novel method for the preparation of bar-coded primer sets |
US10011872B1 (en) * | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
GB201622222D0 (en) | 2016-12-23 | 2017-02-08 | Cs Genetics Ltd | Reagents and methods for molecular barcoding of nucleic acids of single cells |
SG11201910195WA (en) | 2017-05-05 | 2019-11-28 | Scipio Bioscience | Methods for trapping and barcoding discrete biological units in hydrogel |
-
2016
- 2016-12-23 GB GBGB1622222.6A patent/GB201622222D0/en not_active Ceased
-
2017
- 2017-12-19 EP EP23181491.4A patent/EP4265723A3/en active Pending
- 2017-12-19 ES ES17817859T patent/ES2880394T3/es active Active
- 2017-12-19 DK DK21168174.7T patent/DK3957744T5/da active
- 2017-12-19 EP EP17817859.6A patent/EP3559267B1/en active Active
- 2017-12-19 WO PCT/GB2017/053816 patent/WO2018115852A1/en unknown
- 2017-12-19 SI SI201730847T patent/SI3559267T1/sl unknown
- 2017-12-19 EP EP21168174.7A patent/EP3957744B1/en active Active
- 2017-12-19 ES ES21168174T patent/ES2955997T3/es active Active
- 2017-12-19 DK DK17817859.6T patent/DK3559267T3/da active
- 2017-12-19 US US16/471,941 patent/US12084714B2/en active Active
-
2021
- 2021-07-06 HR HRP20211078TT patent/HRP20211078T1/hr unknown
-
2023
- 2023-03-17 US US18/185,904 patent/US11845924B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3559267B1 (en) | 2021-04-14 |
US11845924B1 (en) | 2023-12-19 |
US12084714B2 (en) | 2024-09-10 |
DK3559267T3 (da) | 2021-07-12 |
EP3957744A1 (en) | 2022-02-23 |
GB201622222D0 (en) | 2017-02-08 |
WO2018115852A1 (en) | 2018-06-28 |
EP3957744B1 (en) | 2023-06-28 |
HRP20211078T1 (hr) | 2021-10-01 |
US20190316182A1 (en) | 2019-10-17 |
EP3559267A1 (en) | 2019-10-30 |
EP4265723A3 (en) | 2024-01-10 |
SI3559267T1 (sl) | 2021-08-31 |
ES2955997T3 (es) | 2023-12-11 |
EP4265723A2 (en) | 2023-10-25 |
ES2880394T3 (es) | 2021-11-24 |
DK3957744T3 (da) | 2023-09-18 |
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