DK3886917T3 - Kobbernanoklynger, sammensætning omfattende samme og behandling af neurodegenerative sygdomme - Google Patents

Kobbernanoklynger, sammensætning omfattende samme og behandling af neurodegenerative sygdomme Download PDF

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Publication number
DK3886917T3
DK3886917T3 DK19910313.6T DK19910313T DK3886917T3 DK 3886917 T3 DK3886917 T3 DK 3886917T3 DK 19910313 T DK19910313 T DK 19910313T DK 3886917 T3 DK3886917 T3 DK 3886917T3
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Prior art keywords
neurodegenerated
diseases
treatment
same
copper nanocluster
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DK19910313.6T
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English (en)
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Taolei Sun
Baisong Chang
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Wuhan Vast Conduct Science Found Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/785Polymers containing nitrogen
    • A61K31/787Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01GCOMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G3/00Compounds of copper
    • C01G3/006Compounds containing, besides copper, two or more other elements, with the exception of oxygen or hydrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/34Copper; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • AHUMAN NECESSITIES
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545Heterocyclic compounds
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    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
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    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B22F1/00Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
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    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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    • G01N33/521Single-layer analytical elements
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    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
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    • B22F1/10Metallic powder containing lubricating or binding agents; Metallic powder containing organic material
    • B22F1/102Metallic powder coated with organic material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
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DK19910313.6T 2019-01-16 2019-06-28 Kobbernanoklynger, sammensætning omfattende samme og behandling af neurodegenerative sygdomme DK3886917T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2019/071901 WO2020147029A1 (en) 2019-01-16 2019-01-16 Copper nanoclusters, thymine-modified hyaluronic acid and poly (copper nanoclusters), method for preparing the same, and application thereof
PCT/CN2019/093451 WO2020147267A1 (en) 2019-01-16 2019-06-28 Copper nanoclusters, composition comprising the same, and treatment of neurodegenerative diseases

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DK3886917T3 true DK3886917T3 (da) 2023-11-20

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DK19910313.6T DK3886917T3 (da) 2019-01-16 2019-06-28 Kobbernanoklynger, sammensætning omfattende samme og behandling af neurodegenerative sygdomme
DK19909903.7T DK3886868T3 (da) 2019-01-16 2019-06-28 Kobbernanoklynger, sammensætning, der omfatter samme, og behandling af multipel sklerose

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US (3) US20210379101A1 (da)
EP (4) EP3886918A4 (da)
JP (3) JP7372978B2 (da)
CN (2) CN113271952B (da)
AU (4) AU2019423049C1 (da)
DK (2) DK3886917T3 (da)
ES (2) ES2963534T3 (da)
FI (2) FI3886917T3 (da)
HU (1) HUE064709T2 (da)
PT (1) PT3886917T (da)
WO (3) WO2020147029A1 (da)

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CN109939243B (zh) * 2019-01-16 2022-03-15 武汉广行科学研究有限公司 铜团簇、胸腺嘧啶修饰的透明质酸和多聚铜团簇、其制备方法和应用
AU2019423049C1 (en) * 2019-01-16 2023-08-31 Shenzhen Profound View Pharmaceutical Technology Co., Ltd. Copper nanoclusters, thymine-modified hyaluronic acid and poly (copper nanoclusters), method for preparing the same, and application thereof
JP2024512585A (ja) * 2021-03-23 2024-03-19 武漢広行科学研究有限公司 リガンド結合硫化亜鉛ナノ粒子、その製造方法、およびその治療のための使用
CN113713860B (zh) * 2021-09-14 2023-02-28 东南大学 一种催化发光的铜簇纳米酶及其制备方法和应用
CN115960607B (zh) * 2022-09-15 2024-05-28 西南交通大学 四环素检测材料及其制备方法以及四环素的检测方法

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US20070209950A1 (en) 2006-02-10 2007-09-13 Althaus John S Methods and devices for the detection and measurement of free metals in fluids and methods for diagnosing metal-related diseases and for determining pharmacologic dosing regimens
CN102554217B (zh) * 2012-02-24 2014-12-17 河南大学 一种水溶性纳米铜及其制备方法
GB201302427D0 (en) * 2013-02-12 2013-03-27 Midatech Ltd Nanoparticle delivery compositions
CA2930290C (en) * 2013-11-11 2023-02-28 Collaborative Medicinal Development, Llc Metal complexes and methods of treatment
CN104458050A (zh) * 2014-11-27 2015-03-25 江南大学 一种用于活细胞温度监测的荧光铜纳米簇
CN105834444A (zh) * 2016-03-22 2016-08-10 大连理工大学 一种以胸腺嘧啶为模板合成荧光铜纳米簇的方法
JP2019533636A (ja) * 2016-08-05 2019-11-21 深▲セン▼深見医薬科技有限公司Shenzhen Profound−View Pharma Tech Co., Ltd. AuC含有物質、並びにその製造方法及びその使用
EP3545948B1 (en) 2016-11-28 2021-08-11 Shenzhen Profound-View Pharma Tech Co., Ltd. Use of gold cluster or gold cluster-containing substance in preparation of drug for preventing and/or treating glaucoma
US10806754B2 (en) * 2017-03-21 2020-10-20 Auburn University Engineered metal nanoparticles and methods thereof
CN106975373A (zh) * 2017-04-14 2017-07-25 浙江大学 Dna修饰的金属有机框架物薄膜及其制备方法和应用
CN108358814B (zh) 2018-02-09 2020-05-22 许昌学院 一种基于水杨酰腙衍生物的aie荧光探针及其制备方法、应用
AU2019423049C1 (en) * 2019-01-16 2023-08-31 Shenzhen Profound View Pharmaceutical Technology Co., Ltd. Copper nanoclusters, thymine-modified hyaluronic acid and poly (copper nanoclusters), method for preparing the same, and application thereof
CN109939243B (zh) * 2019-01-16 2022-03-15 武汉广行科学研究有限公司 铜团簇、胸腺嘧啶修饰的透明质酸和多聚铜团簇、其制备方法和应用

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JP7301980B2 (ja) 2023-07-03
JP2022522988A (ja) 2022-04-21
AU2019423049B2 (en) 2022-12-22
AU2019423109A1 (en) 2021-07-22
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EP3886918A1 (en) 2021-10-06
CN113271952A (zh) 2021-08-17
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JP7301981B2 (ja) 2023-07-03
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EP3886868B1 (en) 2023-08-09
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PT3886917T (pt) 2023-11-29
AU2019423049A1 (en) 2021-07-22
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