DK3886858T3 - Forbindelser til behandling af øjensygdomme forbundet med for megen vaskularisering - Google Patents
Forbindelser til behandling af øjensygdomme forbundet med for megen vaskularisering Download PDFInfo
- Publication number
- DK3886858T3 DK3886858T3 DK20838435.4T DK20838435T DK3886858T3 DK 3886858 T3 DK3886858 T3 DK 3886858T3 DK 20838435 T DK20838435 T DK 20838435T DK 3886858 T3 DK3886858 T3 DK 3886858T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- treatment
- diseases associated
- eye diseases
- excessive vascularization
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19218062 | 2019-12-19 | ||
| EP20156158 | 2020-02-07 | ||
| PCT/EP2020/086993 WO2021123142A1 (en) | 2019-12-19 | 2020-12-18 | Compounds for treatment of eye diseases associated with excessive vascularisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3886858T3 true DK3886858T3 (da) | 2022-08-22 |
Family
ID=74141502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK20838435.4T DK3886858T3 (da) | 2019-12-19 | 2020-12-18 | Forbindelser til behandling af øjensygdomme forbundet med for megen vaskularisering |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11478465B2 (https=) |
| EP (2) | EP3886858B1 (https=) |
| JP (1) | JP7730816B2 (https=) |
| KR (1) | KR20220118419A (https=) |
| CN (1) | CN114845718B (https=) |
| AU (1) | AU2020408179B2 (https=) |
| BR (1) | BR112022009192A2 (https=) |
| CA (1) | CA3157394A1 (https=) |
| DK (1) | DK3886858T3 (https=) |
| ES (1) | ES2921360T3 (https=) |
| IL (1) | IL293469B2 (https=) |
| MX (1) | MX2022006439A (https=) |
| PL (1) | PL3886858T3 (https=) |
| WO (1) | WO2021123142A1 (https=) |
| ZA (1) | ZA202204939B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3886946A1 (en) | 2019-06-05 | 2021-10-06 | Regeneron Pharmaceuticals, Inc. | Devices and methods for precision dose delivery |
| KR20220118419A (ko) * | 2019-12-19 | 2022-08-25 | 액티브 바이오테크 에이비 | 과도한 혈관신생과 관련된 안구 질병의 치료를 위한 화합물 |
| PL4312986T3 (pl) | 2021-04-01 | 2025-02-17 | Active Biotech Ab | Preparat lakwinimodu do stosowania do oczu |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
| AU2024306742A1 (en) * | 2023-06-28 | 2025-12-04 | Active Biotech Ab | Quinoline carboxamides for use in the treatment of mpn |
| CN117256554A (zh) * | 2023-09-08 | 2023-12-22 | 益诺思生物技术南通有限公司 | 一种c57bl/6j小鼠新生血管型眼病模型及其构建方法 |
| KR102925647B1 (ko) * | 2023-10-13 | 2026-02-11 | 재단법인 대구경북첨단의료산업진흥재단 | 안질환 치료제 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077851A (en) | 1998-04-27 | 2000-06-20 | Active Biotech Ab | Quinoline derivatives |
| SE9801474D0 (sv) | 1998-04-27 | 1998-04-27 | Active Biotech Ab | Quinoline Derivatives |
| US6875869B2 (en) | 2002-06-12 | 2005-04-05 | Active Biotech Ab | Process for the manufacture of quinoline derivatives |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| WO2008124828A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating vascular disruption disorders |
| WO2010070449A2 (en) | 2008-12-17 | 2010-06-24 | Actavis Group Ptc Ehf | Highly pure laquinimod or a pharmaceutically acceptable salt thereof |
| WO2012006538A1 (en) * | 2010-07-09 | 2012-01-12 | Teva Pharmaceutical Industries Ltd. | Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
| EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
| EP2527344A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases |
| EP2537517A1 (en) * | 2011-06-22 | 2012-12-26 | Active Biotech AB | Deuterium-enriched 4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide |
| IN2014MN00333A (https=) | 2011-07-28 | 2015-09-25 | Teva Pharma | |
| US20150111833A1 (en) * | 2012-04-20 | 2015-04-23 | Howard University | Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease |
| EP2849762A4 (en) | 2012-05-16 | 2016-02-24 | Aadigen Llc | MULTI-TARGET MODULATION FOR TREATING FIBROSIS AND INFLAMMATORY DISORDERS |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| MX373894B (es) * | 2012-11-08 | 2020-07-09 | Clearside Biomedical Inc | Métodos y dispositivos para el tratamiento de trastornos oculares en sujetos humanos. |
| CN109432073A (zh) | 2013-01-08 | 2019-03-08 | 帕萨罗杰卡有限公司 | Mgbg在制备治疗或预防进行性ms及其进展的药物中的用途 |
| EP3019526A1 (en) * | 2013-07-11 | 2016-05-18 | Novartis AG | Use of a vegf antagonist in treating chorioretinal neovascular and permeability disorders in paediatric patients |
| WO2015060812A1 (en) | 2013-10-21 | 2015-04-30 | Howard University | Treating ocular disease with efflux transporter inhibitors |
| EP3068395A4 (en) | 2013-11-15 | 2017-07-12 | Teva Pharmaceutical Industries Ltd. | Treatment of glaucoma using laquinimod |
| CA2933900A1 (en) * | 2013-12-20 | 2015-06-25 | Georgia Tech Research Corporation | Formulations and methods for targeted ocular delivery of therapeutic agents |
| WO2017120355A1 (en) | 2016-01-06 | 2017-07-13 | Teva Pharmaceutical Industries Ltd. | Dihydroquinolines and uses thereof |
| CA3010862A1 (en) | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Methods and devices for treating posterior ocular disorderswith aflibercept and other biologics |
| JP2020528082A (ja) * | 2017-07-17 | 2020-09-17 | ロイズマン,キース | 加齢黄斑変性と他の眼疾患の治療用の細胞透過性ペプチドを使用する治療薬の局所送達 |
| MX2020006460A (es) | 2017-12-22 | 2020-11-06 | Chemocentryx Inc | Compuestos de anillo 5,5 fusionado sustituido con diarilo como inhibidores de c5ar. |
| WO2019126424A1 (en) | 2017-12-22 | 2019-06-27 | Chemocentryx, Inc. | DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS |
| BR112020019822A2 (pt) | 2018-04-02 | 2021-03-16 | Chemocentryx, Inc. | Profármacos de antagonistas bicíclicos fundidos de c5ar |
| KR20220118419A (ko) * | 2019-12-19 | 2022-08-25 | 액티브 바이오테크 에이비 | 과도한 혈관신생과 관련된 안구 질병의 치료를 위한 화합물 |
-
2020
- 2020-12-18 KR KR1020227019983A patent/KR20220118419A/ko active Pending
- 2020-12-18 MX MX2022006439A patent/MX2022006439A/es unknown
- 2020-12-18 ES ES20838435T patent/ES2921360T3/es active Active
- 2020-12-18 AU AU2020408179A patent/AU2020408179B2/en active Active
- 2020-12-18 EP EP20838435.4A patent/EP3886858B1/en active Active
- 2020-12-18 WO PCT/EP2020/086993 patent/WO2021123142A1/en not_active Ceased
- 2020-12-18 IL IL293469A patent/IL293469B2/en unknown
- 2020-12-18 CA CA3157394A patent/CA3157394A1/en active Pending
- 2020-12-18 JP JP2022535637A patent/JP7730816B2/ja active Active
- 2020-12-18 DK DK20838435.4T patent/DK3886858T3/da active
- 2020-12-18 CN CN202080087752.XA patent/CN114845718B/zh active Active
- 2020-12-18 EP EP22167643.0A patent/EP4094765A1/en not_active Withdrawn
- 2020-12-18 PL PL20838435.4T patent/PL3886858T3/pl unknown
- 2020-12-18 BR BR112022009192A patent/BR112022009192A2/pt unknown
-
2021
- 2021-07-02 US US17/366,979 patent/US11478465B2/en active Active
-
2022
- 2022-05-05 ZA ZA2022/04939A patent/ZA202204939B/en unknown
- 2022-09-07 US US17/939,109 patent/US12208091B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PL3886858T3 (pl) | 2022-08-29 |
| EP3886858B1 (en) | 2022-05-11 |
| ZA202204939B (en) | 2023-12-20 |
| US12208091B2 (en) | 2025-01-28 |
| EP4094765A1 (en) | 2022-11-30 |
| ES2921360T3 (es) | 2022-08-24 |
| CN114845718A (zh) | 2022-08-02 |
| KR20220118419A (ko) | 2022-08-25 |
| IL293469A (en) | 2022-08-01 |
| CN114845718B (zh) | 2025-05-16 |
| CA3157394A1 (en) | 2021-06-24 |
| MX2022006439A (es) | 2022-07-19 |
| WO2021123142A1 (en) | 2021-06-24 |
| BR112022009192A2 (pt) | 2022-07-26 |
| EP3886858A1 (en) | 2021-10-06 |
| US20230066364A1 (en) | 2023-03-02 |
| US20210322400A1 (en) | 2021-10-21 |
| AU2020408179A1 (en) | 2022-06-30 |
| JP7730816B2 (ja) | 2025-08-28 |
| IL293469B1 (en) | 2023-12-01 |
| JP2023509336A (ja) | 2023-03-08 |
| US11478465B2 (en) | 2022-10-25 |
| AU2020408179B2 (en) | 2025-04-10 |
| IL293469B2 (en) | 2024-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3886858T3 (da) | Forbindelser til behandling af øjensygdomme forbundet med for megen vaskularisering | |
| DK3743070T3 (da) | Forbindelser til behandling af kinaseafhængige lidelser | |
| IL281773A (en) | Ophthalmic composition for treatment of dry eye disease | |
| DK3728271T3 (da) | Makrocykliske forbindelser til behandling af sygdomme | |
| IL271046A (en) | Compounds for treating huntington's disease | |
| DK3681500T3 (da) | Anvendelse af pilocarpinhydrochlorid til behandling af presbyopi | |
| DK3668509T3 (da) | Fremgangsmåde til behandling af amyotrofisk lateralsklerose med pridopidin | |
| DK3399962T3 (da) | Oftalmisk sammensætning til behandling af tør øjensygdom | |
| DK3240538T3 (da) | Anvendelse af masitinib til behandling af en underpopulation af patienter med amyotrofisk lateralsklerose | |
| DK3865484T3 (da) | Pde9-hæmmer med imidazopyrazinon-rygrad til behandling af perifere sygdomme | |
| DK3498278T3 (da) | Forbindelser til behandling af sygdomme relateret til DUX4-ekspression | |
| IL286340A (en) | Topical formulations for treatment of peripheral neuropathies | |
| DK3548061T3 (da) | Behandling af neurologiske sygdomme | |
| IL281244A (en) | Combination therapy for the treatment of liver disease | |
| DK3097085T3 (da) | Benzoxazinonderivater til behandling af hudsygdomme | |
| DK3773558T3 (da) | Kombinationsbehandling af artritisk sygdom | |
| IL282330A (en) | Therapeutic compounds | |
| DK3612208T5 (da) | Coversin til behandlingen af autoimmune sygdomme med blisterdannelse | |
| DK3210973T3 (da) | Heteroarylforbindelser til behandling af oftalmiske sygdomme | |
| DK3439661T3 (da) | Fremgangsmåder til behandling af øjenlidelser | |
| DK3578562T3 (da) | L-valinatamidbenzoxaborolderivater til behandling af parasitiske sygdomme | |
| DK3833746T5 (da) | Mini-gde til behandlingen af glykogenlagringssygdom iii | |
| IL282700A (en) | Heterocyclic compounds for the treatment of epilepsy | |
| DK3373931T3 (da) | Heterocykliske forbindelser til behandling af sygdom | |
| DK3897595T3 (da) | Nutraceutisk ophthalmisk sammensætning til behandlingen af retinale pathologier med en neovaskulær komponent |