DK3720279T3 - Mus med et modificeret immunoglobulin-Lambda-letkæde og anvendelser deraf - Google Patents

Mus med et modificeret immunoglobulin-Lambda-letkæde og anvendelser deraf Download PDF

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Publication number
DK3720279T3
DK3720279T3 DK18821945.5T DK18821945T DK3720279T3 DK 3720279 T3 DK3720279 T3 DK 3720279T3 DK 18821945 T DK18821945 T DK 18821945T DK 3720279 T3 DK3720279 T3 DK 3720279T3
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DK
Denmark
Prior art keywords
mice
light chain
lambda light
modified immunoglobulin
immunoglobulin lambda
Prior art date
Application number
DK18821945.5T
Other languages
Danish (da)
English (en)
Inventor
Andrew J Murphy
Lynn Macdonald
Chunguang Guo
John Mcwhirter
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
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Publication of DK3720279T3 publication Critical patent/DK3720279T3/da

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1264—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal nucleotidyl transferase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK18821945.5T 2017-12-05 2018-12-04 Mus med et modificeret immunoglobulin-Lambda-letkæde og anvendelser deraf DK3720279T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762594944P 2017-12-05 2017-12-05
US201762594946P 2017-12-05 2017-12-05
US201762609241P 2017-12-21 2017-12-21
US201762609251P 2017-12-21 2017-12-21
PCT/US2018/063841 WO2019113065A1 (en) 2017-12-05 2018-12-04 Non-human animals having an engineered immunoglobulin lambda light chain and uses thereof

Publications (1)

Publication Number Publication Date
DK3720279T3 true DK3720279T3 (da) 2022-10-24

Family

ID=64734263

Family Applications (2)

Application Number Title Priority Date Filing Date
DK22188627.8T DK4140297T3 (da) 2017-12-05 2018-12-04 Mus med en konstrueret immunglobulin-lambda-letkæde og anvendelser deraf
DK18821945.5T DK3720279T3 (da) 2017-12-05 2018-12-04 Mus med et modificeret immunoglobulin-Lambda-letkæde og anvendelser deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK22188627.8T DK4140297T3 (da) 2017-12-05 2018-12-04 Mus med en konstrueret immunglobulin-lambda-letkæde og anvendelser deraf

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US (3) US11051498B2 (enExample)
EP (3) EP3720279B1 (enExample)
JP (2) JP7430636B2 (enExample)
KR (2) KR102760506B1 (enExample)
CN (2) CN116058333A (enExample)
AU (2) AU2018381316B2 (enExample)
BR (1) BR112020011184A2 (enExample)
CA (1) CA3084049A1 (enExample)
DK (2) DK4140297T3 (enExample)
ES (2) ES3035461T3 (enExample)
FI (1) FI4140297T3 (enExample)
HR (2) HRP20250920T1 (enExample)
HU (2) HUE060608T2 (enExample)
IL (2) IL274797B2 (enExample)
LT (2) LT3720279T (enExample)
MX (2) MX2020005830A (enExample)
PL (2) PL4140297T3 (enExample)
PT (2) PT3720279T (enExample)
RS (2) RS63772B1 (enExample)
SG (1) SG11202003044SA (enExample)
SI (2) SI4140297T1 (enExample)
SM (2) SMT202500277T1 (enExample)
TW (2) TWI827567B (enExample)
WO (1) WO2019113065A1 (enExample)

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EP2958937B1 (en) 2013-02-22 2018-08-15 Regeneron Pharmaceuticals, Inc. Mice expressing humanized major histocompatibility complex
US10813346B2 (en) 2015-12-03 2020-10-27 Trianni, Inc. Enhanced immunoglobulin diversity
PT3720279T (pt) 2017-12-05 2022-10-06 Regeneron Pharma Ratinhos tendo uma cadeia leve lambda de imunoglobulina manipulada e seus usos
IL318469A (en) 2018-06-14 2025-03-01 Regeneron Pharma Non-human animals capable of reorganizing transgenic DH-DH, and their uses
AU2020226865A1 (en) 2019-02-22 2021-07-29 Regeneron Pharmaceuticals, Inc. Rodents having genetically modified sodium channels and methods of use thereof
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CN114763558B (zh) * 2021-01-14 2024-02-20 上海泰槿生物技术有限公司 重组基因组、非人哺乳动物细胞及其产生方法和用途
AU2022249328A1 (en) * 2021-03-31 2023-09-21 Regeneron Pharmaceuticals, Inc. Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire
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PT3720279T (pt) 2017-12-05 2022-10-06 Regeneron Pharma Ratinhos tendo uma cadeia leve lambda de imunoglobulina manipulada e seus usos

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Publication number Publication date
CN116058333A (zh) 2023-05-05
CN111432635A (zh) 2020-07-17
ES3035461T3 (en) 2025-09-03
AU2025204547A1 (en) 2025-07-10
IL318197A (en) 2025-03-01
PT3720279T (pt) 2022-10-06
US12356967B2 (en) 2025-07-15
HUE060608T2 (hu) 2023-03-28
AU2018381316A1 (en) 2020-04-23
MX2024004496A (es) 2024-05-08
TWI827567B (zh) 2024-01-01
HRP20221459T1 (hr) 2023-01-20
DK4140297T3 (da) 2025-06-23
US11051498B2 (en) 2021-07-06
HRP20250920T1 (hr) 2025-09-26
EP3720279A1 (en) 2020-10-14
US20190223418A1 (en) 2019-07-25
PL4140297T3 (pl) 2025-08-25
SI4140297T1 (sl) 2025-08-29
PL3720279T3 (pl) 2023-01-16
ES2928995T3 (es) 2022-11-24
LT4140297T (lt) 2025-07-25
SMT202200448T1 (it) 2023-01-13
RS63772B1 (sr) 2022-12-30
KR20250022220A (ko) 2025-02-14
EP4140297B1 (en) 2025-05-21
WO2019113065A1 (en) 2019-06-13
KR102760506B1 (ko) 2025-02-04
CA3084049A1 (en) 2019-06-13
HUE071852T2 (hu) 2025-09-28
IL274797B1 (en) 2025-02-01
KR20200093570A (ko) 2020-08-05
SG11202003044SA (en) 2020-04-29
RU2020118699A (ru) 2022-01-10
EP4596688A2 (en) 2025-08-06
RU2020118699A3 (enExample) 2022-04-07
IL274797A (en) 2020-07-30
LT3720279T (lt) 2022-10-25
US20210292439A1 (en) 2021-09-23
US20210345591A1 (en) 2021-11-11
PT4140297T (pt) 2025-07-09
SI3720279T1 (sl) 2022-11-30
EP3720279B1 (en) 2022-09-21
EP4140297A1 (en) 2023-03-01
TW201938019A (zh) 2019-10-01
JP2024036440A (ja) 2024-03-15
TW202438676A (zh) 2024-10-01
IL274797B2 (en) 2025-06-01
FI4140297T3 (fi) 2025-07-10
BR112020011184A2 (pt) 2020-11-17
MX2020005830A (es) 2020-08-20
AU2018381316B2 (en) 2025-06-26
EP4596688A3 (en) 2025-11-12
CN111432635B (zh) 2022-10-21
JP7765514B2 (ja) 2025-11-06
JP2021505141A (ja) 2021-02-18
JP7430636B2 (ja) 2024-02-13
SMT202500277T1 (it) 2025-09-12
RS67058B1 (sr) 2025-08-29

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