DK3688141T3 - Ex-vivo-model af inflammeret menneskehud samt dens anvendelser til screening af antiinflammatoriske forbindelser - Google Patents
Ex-vivo-model af inflammeret menneskehud samt dens anvendelser til screening af antiinflammatoriske forbindelser Download PDFInfo
- Publication number
- DK3688141T3 DK3688141T3 DK18780025.5T DK18780025T DK3688141T3 DK 3688141 T3 DK3688141 T3 DK 3688141T3 DK 18780025 T DK18780025 T DK 18780025T DK 3688141 T3 DK3688141 T3 DK 3688141T3
- Authority
- DK
- Denmark
- Prior art keywords
- inflammed
- applications
- human skin
- vivo model
- inflammatory compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2301—Interleukin-1 (IL-1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2323—Interleukin-23 (IL-23)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1771020A FR3071508B1 (fr) | 2017-09-26 | 2017-09-26 | Modele ex vivo de peau humaine inflammee et ses utilisations pour le criblage de composes anti-inflammatoires |
| PCT/EP2018/000448 WO2019063122A1 (fr) | 2017-09-26 | 2018-09-25 | Modele ex vivo de peau humaine inflammee et ses utilisations pour le criblage de composes anti-inflammatoires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3688141T3 true DK3688141T3 (da) | 2022-12-12 |
Family
ID=60302404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18780025.5T DK3688141T3 (da) | 2017-09-26 | 2018-09-25 | Ex-vivo-model af inflammeret menneskehud samt dens anvendelser til screening af antiinflammatoriske forbindelser |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12071648B2 (da) |
| EP (1) | EP3688141B1 (da) |
| JP (1) | JP7199427B2 (da) |
| KR (1) | KR102665807B1 (da) |
| CA (1) | CA3075899A1 (da) |
| DK (1) | DK3688141T3 (da) |
| ES (1) | ES2933121T3 (da) |
| FR (1) | FR3071508B1 (da) |
| SG (1) | SG11202011454TA (da) |
| WO (1) | WO2019063122A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020235617A1 (en) | 2019-03-12 | 2021-11-04 | Epm (Ip), Inc. | Cannabinoid acid ester compositions and uses thereof |
| JP2020180068A (ja) * | 2019-04-25 | 2020-11-05 | 日本コルマー株式会社 | 真皮線維芽細胞による表皮の炎症反応制御を応用した抗炎症剤の評価方法 |
| EP3940058A1 (en) | 2020-07-16 | 2022-01-19 | Genoskin | Microfluidic system to control perfusion, diffusion and collection of molecules over long periods in an ex-vivo skin model |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100927135B1 (ko) * | 2007-11-06 | 2009-11-18 | 한국화학연구원 | 고농축액 아그로박테리움과 진공 처리를 통한 식물형질전환 효율을 향상시키는 방법 |
| ATE509095T1 (de) | 2008-05-28 | 2011-05-15 | Symrise Ag | Menschliches ex-vivo-hautmodell |
| FR2990106B1 (fr) * | 2012-05-03 | 2014-05-09 | Genoskin | Systeme permettant la maintenance en survie et le transport de biospsies de peau et ses applications |
| EP2885637B1 (en) | 2012-08-15 | 2016-11-30 | The Procter & Gamble Company | Use of human ex vivo skin model in a method of identifying modulators of skin inflammation |
| EP2925364A1 (en) * | 2012-11-30 | 2015-10-07 | Leo Pharma A/S | A method of inhibiting the expression of il-22 in activated t-cells |
| WO2014182655A1 (en) * | 2013-05-06 | 2014-11-13 | Stiefel Laboratories, Inc. | Assay for screening a compound for the ability to modulate proinflammatory cytokine production in human skin |
-
2017
- 2017-09-26 FR FR1771020A patent/FR3071508B1/fr active Active
-
2018
- 2018-09-25 ES ES18780025T patent/ES2933121T3/es active Active
- 2018-09-25 JP JP2020516700A patent/JP7199427B2/ja active Active
- 2018-09-25 CA CA3075899A patent/CA3075899A1/fr active Pending
- 2018-09-25 US US16/650,492 patent/US12071648B2/en active Active
- 2018-09-25 KR KR1020207012237A patent/KR102665807B1/ko active IP Right Grant
- 2018-09-25 DK DK18780025.5T patent/DK3688141T3/da active
- 2018-09-25 SG SG11202011454TA patent/SG11202011454TA/en unknown
- 2018-09-25 WO PCT/EP2018/000448 patent/WO2019063122A1/fr unknown
- 2018-09-25 EP EP18780025.5A patent/EP3688141B1/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP7199427B2 (ja) | 2023-01-05 |
| WO2019063122A1 (fr) | 2019-04-04 |
| FR3071508A1 (fr) | 2019-03-29 |
| ES2933121T3 (es) | 2023-02-02 |
| US20200347429A1 (en) | 2020-11-05 |
| US12071648B2 (en) | 2024-08-27 |
| SG11202011454TA (en) | 2020-12-30 |
| CA3075899A1 (fr) | 2019-04-04 |
| EP3688141A1 (fr) | 2020-08-05 |
| FR3071508B1 (fr) | 2022-07-29 |
| EP3688141B1 (fr) | 2022-11-09 |
| KR20200057765A (ko) | 2020-05-26 |
| KR102665807B1 (ko) | 2024-05-14 |
| JP2020535402A (ja) | 2020-12-03 |
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