DK3573630T3 - Forebyggelse og behandling af skader eller sygdom i knogler og brusk - Google Patents

Forebyggelse og behandling af skader eller sygdom i knogler og brusk Download PDF

Info

Publication number
DK3573630T3
DK3573630T3 DK18703531.6T DK18703531T DK3573630T3 DK 3573630 T3 DK3573630 T3 DK 3573630T3 DK 18703531 T DK18703531 T DK 18703531T DK 3573630 T3 DK3573630 T3 DK 3573630T3
Authority
DK
Denmark
Prior art keywords
cartilage
bones
disease
prevention
damage
Prior art date
Application number
DK18703531.6T
Other languages
English (en)
Inventor
Christina Uvebrant
Jan Talts
Åkerlund Evy Lundgren
Original Assignee
Xintela Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xintela Ab filed Critical Xintela Ab
Application granted granted Critical
Publication of DK3573630T3 publication Critical patent/DK3573630T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Botany (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
DK18703531.6T 2017-01-27 2018-01-29 Forebyggelse og behandling af skader eller sygdom i knogler og brusk DK3573630T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762451372P 2017-01-27 2017-01-27
PCT/EP2018/052104 WO2018138322A1 (en) 2017-01-27 2018-01-29 Prevention and treatment of bone and cartilage damage or disease

Publications (1)

Publication Number Publication Date
DK3573630T3 true DK3573630T3 (da) 2021-06-07

Family

ID=61168072

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18703531.6T DK3573630T3 (da) 2017-01-27 2018-01-29 Forebyggelse og behandling af skader eller sygdom i knogler og brusk

Country Status (17)

Country Link
US (2) US11517593B2 (da)
EP (2) EP3573630B1 (da)
JP (1) JP7210829B2 (da)
KR (1) KR102580320B1 (da)
CN (1) CN110234329A (da)
AU (1) AU2018211504B2 (da)
BR (1) BR112019013508A2 (da)
CA (1) CA3050099C (da)
DK (1) DK3573630T3 (da)
ES (1) ES2870776T3 (da)
IL (1) IL266772B (da)
LT (1) LT3573630T (da)
MX (1) MX2019008872A (da)
PL (1) PL3573630T3 (da)
PT (1) PT3573630T (da)
SG (1) SG11201904535VA (da)
WO (1) WO2018138322A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019025888A2 (pt) 2017-06-07 2020-06-30 Regeneron Pharmaceuticals, Inc. polinucleotídeo que codifica uma proteína terapêutica multidomínio, vetor de terapia gênica, proteína terapêutica multidomínio recombinante, método de expressão, métodos para reduzir o acúmulo de glicogênio em um tecido em um paciente em necessidade, para reduzir o acúmulo de glicogênio em um tecido em um paciente em necessidade epara tratar a deficiência enzimática em um paciente em necessidade e/ou tolerar o paciente à enzima para a qual é deficiente, anticorpo anti-cd63 ou fragmento de ligação a antígeno, e, composição farmacêutica
WO2019157224A1 (en) 2018-02-07 2019-08-15 Regeneron Pharmaceuticals, Inc. Methods and compositions for therapeutic protein delivery
WO2021092199A1 (en) * 2019-11-08 2021-05-14 Kansas State University Research Foundation Isolation, preservation, and expansion of canine umbilical cord mesenchymal stromal cells
CN112941021A (zh) * 2020-03-13 2021-06-11 深圳市第二人民医院(深圳市转化医学研究院) 一种骨关节炎关节液来源的间充质干细胞的培养方法
JP2023524150A (ja) 2020-05-07 2023-06-08 シンテラ エービー 呼吸器疾患治療のための幹細胞
CN113667635A (zh) * 2020-05-14 2021-11-19 梦芊科技知识产权有限公司 无异源培养基及使用其扩增间充质干细胞的方法
CN112430269B (zh) * 2021-01-28 2021-04-20 中赛干细胞基因工程有限公司 一种促进脐带血干细胞成骨分化的组合物及其应用
BR112023023975A2 (pt) 2021-05-20 2024-01-30 Xintela Ab Composição, método para regeneração da pele, uso de uma composição cosmética, e, método para tratar um defeito de pele
CN114540298A (zh) * 2022-03-25 2022-05-27 北京瑷格干细胞科技有限公司 一种干细胞无血清培养基及其制备方法
WO2024077116A1 (en) * 2022-10-05 2024-04-11 Brim Biotechnology, Inc. Compositions comprising pedf-derived short peptides and mesenchymal stem cells for bone/cartilage regeneration
CN115651076B (zh) * 2022-12-09 2023-09-29 北京大学口腔医学院 人骨髓间充质干细胞来源凋亡囊泡的表面标志物及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2353061T5 (es) * 2000-04-25 2014-04-07 Osiris Therapeutics, Inc. Reparación de articulaciones utilizando células madre mesenquimatosas
AU2003239016B2 (en) * 2002-06-14 2007-09-20 Xintela Ab Marker for stem cells and its use
SE0301087D0 (sv) * 2003-04-14 2003-04-14 Cartela Ab New monoclonal antibody
EP1996698A1 (en) * 2006-03-01 2008-12-03 Cartela R&D AB Expansion and differentiation of mesenchymal stem cells
EP2097106A2 (en) 2006-12-15 2009-09-09 Xintela AB (SE) Novel uses and methods
CN101835479A (zh) * 2007-07-25 2010-09-15 佰欧益有限公司 多系祖细胞分化为软骨细胞

Also Published As

Publication number Publication date
EP3919064A1 (en) 2021-12-08
SG11201904535VA (en) 2019-08-27
LT3573630T (lt) 2021-05-25
KR102580320B1 (ko) 2023-09-19
PT3573630T (pt) 2021-05-06
CN110234329A (zh) 2019-09-13
IL266772A (en) 2019-07-31
PL3573630T3 (pl) 2021-09-13
KR20190107686A (ko) 2019-09-20
BR112019013508A2 (pt) 2020-01-07
EP3573630B1 (en) 2021-03-17
JP7210829B2 (ja) 2023-01-24
EP3573630A1 (en) 2019-12-04
IL266772B (en) 2022-04-01
US11517593B2 (en) 2022-12-06
MX2019008872A (es) 2019-09-18
ES2870776T3 (es) 2021-10-27
JP2020505916A (ja) 2020-02-27
US20230128397A1 (en) 2023-04-27
US20200038449A1 (en) 2020-02-06
CA3050099A1 (en) 2018-08-02
AU2018211504A1 (en) 2019-07-04
WO2018138322A1 (en) 2018-08-02
AU2018211504B2 (en) 2022-08-18
CA3050099C (en) 2024-04-16

Similar Documents

Publication Publication Date Title
DK3573630T3 (da) Forebyggelse og behandling af skader eller sygdom i knogler og brusk
DK3661954T3 (da) Interleukin-21-muteiner og fremgangsmåder til behandling
HK1247838A1 (zh) 骨質疏鬆症的治療
DK3328317T3 (da) Tilbagetrækning og/eller understøttelse af periurethralt væv
DK3872085T3 (da) Stam-virussekvenser og anvendelser heraf
DK3149019T3 (da) Cholan-derivater til anvendelse ved behandling og/eller forebyggelse af FXR- og TGR5/GPBAR1-formidlede sygdomme
DK3377637T3 (da) Sammensætninger til anvendelse i fremgangsmåder til behandling af sår, lidelser og sygdomme i huden
DK3842429T3 (da) Heterocykliske inhibitorer af ERK1 og ERK2 og anvendelse deraf i behandling af cancer
DK3474996T3 (da) Tågeapparat og anvendelsesmåde
DK3432899T3 (da) Anvendelse af probiotika ved behandling og/eller forebyggelse af psoriasis
ES2970509T3 (es) Composición y métodos para prevenir lesión por radiación y fomentar la regeneración tisular
DK3294142T3 (da) System og fremgangsmåde af biologiske vævsstrukturer
DK3558280T3 (da) Forebyggelse og behandling af migræne
DK3294345T3 (da) Tpp1-formuleringer og fremgangsmåder til behandling af cln2-sygdom
DK3722291T3 (da) Indolinonforbindelser og deres anvendelse i behandlingen af fibrotiske sygdomme
DK3174559T3 (da) Radiomærkede antistoffragmenter til anvendelse inden for forebyggelsen og/eller behandlingen af cancer
DK3212247T3 (da) Kirurgiske implantater til erstatning af brystvorte og areola eller beskadiget epidermis
DK3287078T3 (da) Fremgangsmåde til behandling af morfologi- og elasticitetsinformation af væv og elasticitetsdetekteringsindretning
DK3364915T3 (da) Medicinsk indretning til registrering og/eller stimulering af væv
DK3352752T3 (da) Påvisning og behandling af væksthormonmangel
DK3478310T3 (da) Sammensætninger, som er anvendelige inden for forebyggelsen og/eller behandlingen af osteoartikulær inflammation og smerte samt bruskskade
DK3444010T3 (da) Pklr-inhibering i behandlingen af nafld og hcc
DK3177599T3 (da) Fumarat-analoger og anvendelser heraf ved behandling af en autoimmun sygdom eller en inflammatorisk sygdom
DK3373922T3 (da) Sammensætninger og fremgangsmåder til anvendelse i behandlingen af homocystinuri
DK3721889T3 (da) Butyribacter intestini til anvendelse til forebyggelse og/eller behandling af inflammatorisk tarmsygdom