DK35684A - Antitumor-midler - Google Patents

Antitumor-midler Download PDF

Info

Publication number
DK35684A
DK35684A DK35684A DK35684A DK35684A DK 35684 A DK35684 A DK 35684A DK 35684 A DK35684 A DK 35684A DK 35684 A DK35684 A DK 35684A DK 35684 A DK35684 A DK 35684A
Authority
DK
Denmark
Prior art keywords
rebeccamycin
antitumor agents
atcc
fermentation
methyl
Prior art date
Application number
DK35684A
Other languages
English (en)
Other versions
DK160429B (da
DK35684D0 (da
DK160429C (da
Inventor
Jr Donald Edward Nettleton
James Allen Bush
William Turnbull Bradner
Terence William Doyle
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DK35684D0 publication Critical patent/DK35684D0/da
Publication of DK35684A publication Critical patent/DK35684A/da
Publication of DK160429B publication Critical patent/DK160429B/da
Application granted granted Critical
Publication of DK160429C publication Critical patent/DK160429C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK035684A 1983-01-28 1984-01-26 N-heterocyclisk glycosid med antitumorvirkning, fremstilling deraf samt farmaceutisk praeparat indeholdende glycosidet DK160429C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46181783 1983-01-28
US06/461,817 US4487925A (en) 1983-01-28 1983-01-28 Rebeccamycin and process for its preparation

Publications (4)

Publication Number Publication Date
DK35684D0 DK35684D0 (da) 1984-01-26
DK35684A true DK35684A (da) 1984-07-29
DK160429B DK160429B (da) 1991-03-11
DK160429C DK160429C (da) 1991-08-19

Family

ID=23834041

Family Applications (1)

Application Number Title Priority Date Filing Date
DK035684A DK160429C (da) 1983-01-28 1984-01-26 N-heterocyclisk glycosid med antitumorvirkning, fremstilling deraf samt farmaceutisk praeparat indeholdende glycosidet

Country Status (15)

Country Link
US (1) US4487925A (da)
EP (1) EP0115350B1 (da)
JP (1) JPS59141597A (da)
KR (1) KR910002856B1 (da)
AT (1) ATE36540T1 (da)
AU (1) AU564256B2 (da)
CA (1) CA1220149A (da)
DE (1) DE3473459D1 (da)
DK (1) DK160429C (da)
ES (1) ES8607396A1 (da)
FI (1) FI77264C (da)
GR (1) GR81748B (da)
IE (1) IE56651B1 (da)
PT (1) PT78019B (da)
ZA (1) ZA84582B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567143A (en) * 1984-09-04 1986-01-28 Bristol-Myers Company Process for preparing 4'-deschlororebeccamycin
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
US4743594A (en) * 1984-09-17 1988-05-10 Schering Corporation Antibiotic, antitumor compounds and their use
US4764510A (en) * 1986-04-11 1988-08-16 Eli Lilly And Company Antibiotic A42125 and process for its production
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
US4808613A (en) * 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Rebeccamycin analogs, their production and pharmaceutical compositions containing them
CA2037596C (en) * 1990-03-06 1995-07-18 Kin Sing Lam Rebeccamycin analog by bromide precursor feeding
US5158938A (en) * 1990-03-06 1992-10-27 Bristol-Myers Squibb Company Rebeccamycin
US5344823A (en) * 1990-03-06 1994-09-06 Bristol-Myers Squibb Company Antitumor antibiotic BMY-41219
US5478813A (en) * 1990-05-11 1995-12-26 Banyu Pharmaceutical Co., Ltd. Antitumor substance BE-13793C derivatives
WO1993018766A1 (en) * 1992-03-20 1993-09-30 The Wellcome Foundation Limited Further indole derivatives with antiviral activity
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6653290B2 (en) * 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
EE200300456A (et) 2001-03-22 2004-02-16 Bristol-Myers Squibb Company Indolopürrolokarbasoolide topoisomeraas I selektiivsed tsütotoksilised suhkruderivaadid ning nende kasutamine
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
FR2956934B1 (fr) 2010-02-26 2012-09-28 Blink E Procede et dispositif d'emission/reception de signaux electromagnetiques recus/emis sur une ou plusieurs premieres bandes de frequences.
FR2990315B1 (fr) 2012-05-04 2014-06-13 Blink E Procede de transmission d'informations entre une unite emettrice et une unite receptrice

Also Published As

Publication number Publication date
FI840301A0 (fi) 1984-01-25
ES529170A0 (es) 1986-05-16
DK160429B (da) 1991-03-11
US4487925A (en) 1984-12-11
DK35684D0 (da) 1984-01-26
AU2372084A (en) 1984-08-02
IE56651B1 (en) 1991-10-23
FI840301L (fi) 1984-07-29
CA1220149A (en) 1987-04-07
DK160429C (da) 1991-08-19
KR840007257A (ko) 1984-12-06
FI77264C (fi) 1989-02-10
KR910002856B1 (ko) 1991-05-06
PT78019B (en) 1986-06-18
EP0115350B1 (en) 1988-08-17
IE840201L (en) 1984-07-28
ES8607396A1 (es) 1986-05-16
DE3473459D1 (en) 1988-09-22
ATE36540T1 (de) 1988-09-15
AU564256B2 (en) 1987-08-06
GR81748B (da) 1984-12-12
JPS59141597A (ja) 1984-08-14
ZA84582B (en) 1984-09-26
PT78019A (en) 1984-02-01
JPH0452280B2 (da) 1992-08-21
EP0115350A3 (en) 1985-09-18
FI77264B (fi) 1988-10-31
EP0115350A2 (en) 1984-08-08

Similar Documents

Publication Publication Date Title
DK35684A (da) Antitumor-midler
GR930300130T1 (en) Modified ribozymes
DK0751959T3 (da) Modificerede polypeptider med forøget biologisk aktivitet
ES8606289A1 (es) Un procedimiento para la preparacion de piridazinaminas.
MY102693A (en) Antiviral nucleosides
GB1510925A (en) Chromogenic enzyme substrates
ES8706443A1 (es) Un procedimiento para preparar una solucion parenteral de activador de plasminogeno de tejido (t-pa)
FI860285A0 (fi) 6-tioxantinderivat.
YU47886B (sh) Postupak za dobijanje novih sojeva s. avermitilis
SE7704194L (sv) Antibiotiska foreningar
SE8502135D0 (sv) 4'-deschlororebeccamycin and process for its preparation
SG18792G (en) Drug preparations of reduced toxicity
JPS5665822A (en) Interferon stabilizing agent
AU6311386A (en) Appetite moderating and anti-gastritis conposition
AU558614B2 (en) Modified microorganism to produce interferon like activity
ES8707553A1 (es) Procedimiento para la obtencion de un peptido.
ES8609728A1 (es) Una composicion de conjugado de enzima estabilizado
NO913118D0 (no) T-pa pro stabilisering.
AU685022B2 (en) Native type II GAP, methods for purifying various GAPs and uses of GAPs to diagnose cancer
ES2013025A6 (es) Un metodo para preparar 24r-escimnol.
AU8640091A (en) Human interferon-gamma4-134, functional equivalents thereof and methods of using and compositions employing these materials
IE39496B1 (en) 5"-amino-4,5"-dideoxy/ambutyrosin a
AU6816787A (en) (Gem-heterocyclodimethanamine-N,N') platinum complexes
JPS5524150A (en) Anti-malignant-tumor agent
IL86824A (en) Antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin to 4'-deoxy-13(s)-dihydro-4'-iododoxorubicin

Legal Events

Date Code Title Description
PBP Patent lapsed