DK3548135T3 - Kerne-skal-mikronålsindretninger og anvendelser deraf - Google Patents

Kerne-skal-mikronålsindretninger og anvendelser deraf Download PDF

Info

Publication number
DK3548135T3
DK3548135T3 DK17879565.4T DK17879565T DK3548135T3 DK 3548135 T3 DK3548135 T3 DK 3548135T3 DK 17879565 T DK17879565 T DK 17879565T DK 3548135 T3 DK3548135 T3 DK 3548135T3
Authority
DK
Denmark
Prior art keywords
core
needle devices
shell micro
micro
shell
Prior art date
Application number
DK17879565.4T
Other languages
Danish (da)
English (en)
Inventor
Zhen Gu
Yanqi Ye
Jinqiang Wang
Original Assignee
Univ North Carolina State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina State filed Critical Univ North Carolina State
Application granted granted Critical
Publication of DK3548135T3 publication Critical patent/DK3548135T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728Hyaluronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44Oxidoreductases (1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6955Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a plaster, a bandage, a dressing or a patch
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061Methods for using microneedles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03004Glucose oxidase (1.1.3.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y111/00Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01Peroxidases (1.11.1)
    • C12Y111/01006Catalase (1.11.1.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
DK17879565.4T 2016-12-05 2017-12-05 Kerne-skal-mikronålsindretninger og anvendelser deraf DK3548135T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662430260P 2016-12-05 2016-12-05
PCT/US2017/064723 WO2018106696A1 (en) 2016-12-05 2017-12-05 Core-shell microneedle devices and uses thereof

Publications (1)

Publication Number Publication Date
DK3548135T3 true DK3548135T3 (da) 2021-11-22

Family

ID=62491316

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17879565.4T DK3548135T3 (da) 2016-12-05 2017-12-05 Kerne-skal-mikronålsindretninger og anvendelser deraf

Country Status (7)

Country Link
US (2) US11697007B2 (https=)
EP (2) EP3548135B1 (https=)
JP (1) JP7232526B2 (https=)
CN (1) CN110167624B (https=)
CA (1) CA3045882A1 (https=)
DK (1) DK3548135T3 (https=)
WO (1) WO2018106696A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3548135T3 (da) * 2016-12-05 2021-11-22 Univ North Carolina State Kerne-skal-mikronålsindretninger og anvendelser deraf
US12109032B1 (en) 2017-03-11 2024-10-08 Biolinq Incorporated Methods for achieving an isolated electrical interface between an anterior surface of a microneedle structure and a posterior surface of a support structure
US12599337B1 (en) 2017-08-08 2026-04-14 Biolinq Incorporated Method and system for confirmation of microneedle-based analyte-selective sensor insertion into viable tissue via electrical interrogation
WO2019143293A1 (en) * 2018-01-16 2019-07-25 Nanyang Technological University Self-implantable micro-drug-reservoirs for localized and controlled ocular drug delivery
US11724941B2 (en) 2018-02-15 2023-08-15 North Carolina State University Synthesis of micron and nanoscale carbon spheres and structures using hydrothemal carbonization
US20210145984A1 (en) * 2018-04-13 2021-05-20 North Carolina State University Ros-responsive microneedle patch for acne vulgaris treatment
JP2021533934A (ja) 2018-08-24 2021-12-09 ノース カロライナ ステート ユニバーシティNorth Carolina State University 閉ループインスリン送達用のグルコース応答性マトリックスを備えたマイクロニードルアレイパッチ
WO2020041694A1 (en) * 2018-08-24 2020-02-27 North Carolina State University Stem cell microneedle patch for treating heart diseases
EP3852721A4 (en) * 2018-09-20 2022-06-29 Singapore Health Services Pte Ltd Conductive microneedle patch for active agent delivery
CN109675185A (zh) * 2019-01-02 2019-04-26 浙江大学 一种苯硼酸水凝胶基糖敏微针贴及其制备方法
JP2021153914A (ja) * 2020-03-27 2021-10-07 国立大学法人 東京医科歯科大学 薬剤送達デバイスおよびその製造方法
JP2023523952A (ja) 2020-04-28 2023-06-08 ティコナ・エルエルシー マイクロニードルアセンブリ
KR102740788B1 (ko) * 2020-07-02 2024-12-09 연세대학교 산학협력단 멀티 레이어 마이크로니들 구조체 및 이의 제조 방법
GB2631618B (en) 2020-07-29 2025-05-14 Biolinq Incorporated Continuous analyte monitoring system with microneedle array
CN118001218B (zh) * 2022-11-08 2026-03-06 沈阳药科大学 一种血糖响应型释药可视化长效微针及其制备方法
CN115998850A (zh) * 2022-12-26 2023-04-25 中山大学 一种尿酸响应性水凝胶微针及其制备方法
CN120857905A (zh) 2023-02-02 2025-10-28 比奥林公司 用于改善基于微针的连续分析物监测系统的传感器灵敏度的方法
WO2024167986A2 (en) * 2023-02-10 2024-08-15 Alj Creative Works, Llc Programmable drug-device microneedle system for the treament of diabetes, obesity, and associated conditions
CN117088903B (zh) * 2023-08-15 2026-03-17 河南师范大学 苯硼酸基两性离子表面活性剂的制备方法及其合成pH响应二聚体分子的应用
CN117159443B (zh) * 2023-10-19 2024-04-19 暨南大学 原位超分子凝胶微针贴片及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1469903A2 (en) * 2001-09-28 2004-10-27 BioValve Technologies, Inc. Microneedle with membrane
EP1453860A2 (en) 2001-12-02 2004-09-08 Novo Nordisk A/S Novel glucose-dependant insulins
US9549746B2 (en) 2007-09-28 2017-01-24 The Queen's University Of Belfast Delivery device and method
EP2234644B1 (en) 2008-01-04 2013-07-31 Biodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
WO2010050913A1 (en) 2008-10-31 2010-05-06 The Brigham And Women's Hospital, Inc. Vaccination with poxvirus vectors via mechanical epidermal disruption
WO2013123492A2 (en) 2012-02-17 2013-08-22 Massachusetts Institute Of Technology Glucose-responsive microgels for closed loop insulin delivery
US20150352777A1 (en) * 2013-01-18 2015-12-10 The University Of North Carolina At Chapel Hill High-throughput manufacturing of microneedles
US20160067190A1 (en) 2013-04-30 2016-03-10 The Children's Medical Center Corporation Injectable nano-network gels for diabetes treatment
US10987039B2 (en) 2014-12-03 2021-04-27 Stmicroelectronics S.R.L. Microneedle array device and method of making
TN2017000439A1 (en) 2015-04-21 2019-04-12 Univ North Carolina State Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites
WO2016172554A1 (en) 2015-04-23 2016-10-27 Carnegie Mellon University Biosensor tattoos and uses therefor for biomarker monitoring
CN110167537A (zh) 2016-11-07 2019-08-23 北卡罗来纳州立大学 用于增强葡萄糖反应性胰岛素的递送的装有双敏感囊泡的贴剂
CN110198730B (zh) 2016-12-05 2023-10-03 北卡罗莱纳州立大学 H2o2响应性纳米粒子及其用途
DK3548135T3 (da) * 2016-12-05 2021-11-22 Univ North Carolina State Kerne-skal-mikronålsindretninger og anvendelser deraf

Also Published As

Publication number Publication date
EP3548135A1 (en) 2019-10-09
EP3799865A1 (en) 2021-04-07
EP3548135A4 (en) 2020-07-29
CN110167624B (zh) 2021-11-19
WO2018106696A1 (en) 2018-06-14
EP3548135B1 (en) 2021-10-13
CA3045882A1 (en) 2018-06-14
US11697007B2 (en) 2023-07-11
JP2020512283A (ja) 2020-04-23
JP7232526B2 (ja) 2023-03-03
US20230364402A1 (en) 2023-11-16
EP3799865B1 (en) 2022-06-15
US20190351206A1 (en) 2019-11-21
CN110167624A (zh) 2019-08-23

Similar Documents

Publication Publication Date Title
DK3548135T3 (da) Kerne-skal-mikronålsindretninger og anvendelser deraf
IL293377A (en) Hsd17b13 variants and uses thereof
DK3625263T3 (da) Anti-galectin- 9-antistoffer og anvendelser deraf
DK3448386T3 (da) Isoquinolin-3-ylcarboxamider og fremstilling og anvendelse deraf
DK3383916T3 (da) Anti-CD73-antistoffer og anvendelser deraf
DK3485010T3 (da) Bacillus cibi-dnase-varianter og anvendelser deraf
DK3610005T3 (da) Peptidligase og anvendelse deraf
DK3283106T3 (da) Terapeutiske antistoffer og anvendelser deraf
DK3668512T3 (da) Pyruvatkinasemodulatorer og anvendelse deraf
DK3365368T3 (da) Tgfbeta1-bindende immunoglobuliner og anvendelse deraf
DK3516160T3 (da) Brøndanordning og tilhørende fremgangsmåder
DK3322804T3 (da) Nuklease-uafhængigt målrettet genredigeringsplatform og anvendelser deraf
DK3452463T3 (da) Amidsubstituerede pyridinyltriazolderivater og anvendelser deraf
DK3368534T3 (da) Valbenazin-ditosylat og polymorfer deraf
DK3354282T3 (da) Glycan-terapeutiske midler og relaterede fremgangsmåder deraf
EP3464374C0 (en) BAFF-R ANTIBODIES AND USES THEREOF
DK3559227T3 (da) Proteasevarianter og anvendelser deraf
EP3597500A4 (en) DRIVING ASSISTANCE DEVICE AND PROCEDURE
DK3532499T3 (da) ANTI-IL-33-antistoffer og anvendelser deraf
DK3402821T5 (da) Psma-bindende antistof og anvendelser deraf
DK3596125T3 (da) Anti-PAR2-antistoffer og anvendelser deraf
DK3484865T3 (da) Somatostatinmodulatorer og anvendelser deraf
EP3499437A4 (en) COMMERCIAL IMPROVEMENT ASSISTANCE DEVICE AND COMMERCIAL IMPROVEMENT ASSISTANCE METHOD
DK3128005T3 (da) Sirp-alfa-variantkonstruktioner og anvendelser deraf
DK3209773T3 (da) Prolintolerante tripeptidylpeptidaser og anvendelser deraf