CN110167624B - 核-壳微针装置及其用途 - Google Patents

核-壳微针装置及其用途 Download PDF

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Publication number
CN110167624B
CN110167624B CN201780081305.1A CN201780081305A CN110167624B CN 110167624 B CN110167624 B CN 110167624B CN 201780081305 A CN201780081305 A CN 201780081305A CN 110167624 B CN110167624 B CN 110167624B
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China
Prior art keywords
peroxide
insulin
glucose
pva
microneedle
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Expired - Fee Related
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CN201780081305.1A
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Chinese (zh)
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CN110167624A (zh
Inventor
顾震
J·王
叶彦奇
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North Carolina State University
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North Carolina State University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6955—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a plaster, a bandage, a dressing or a patch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03004—Glucose oxidase (1.1.3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01006—Catalase (1.11.1.6)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
CN201780081305.1A 2016-12-05 2017-12-05 核-壳微针装置及其用途 Expired - Fee Related CN110167624B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662430260P 2016-12-05 2016-12-05
US62/430,260 2016-12-05
PCT/US2017/064723 WO2018106696A1 (en) 2016-12-05 2017-12-05 Core-shell microneedle devices and uses thereof

Publications (2)

Publication Number Publication Date
CN110167624A CN110167624A (zh) 2019-08-23
CN110167624B true CN110167624B (zh) 2021-11-19

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US (2) US11697007B2 (https=)
EP (2) EP3548135B1 (https=)
JP (1) JP7232526B2 (https=)
CN (1) CN110167624B (https=)
CA (1) CA3045882A1 (https=)
DK (1) DK3548135T3 (https=)
WO (1) WO2018106696A1 (https=)

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DK3548135T3 (da) * 2016-12-05 2021-11-22 Univ North Carolina State Kerne-skal-mikronålsindretninger og anvendelser deraf
US12109032B1 (en) 2017-03-11 2024-10-08 Biolinq Incorporated Methods for achieving an isolated electrical interface between an anterior surface of a microneedle structure and a posterior surface of a support structure
US12599337B1 (en) 2017-08-08 2026-04-14 Biolinq Incorporated Method and system for confirmation of microneedle-based analyte-selective sensor insertion into viable tissue via electrical interrogation
WO2019143293A1 (en) * 2018-01-16 2019-07-25 Nanyang Technological University Self-implantable micro-drug-reservoirs for localized and controlled ocular drug delivery
US11724941B2 (en) 2018-02-15 2023-08-15 North Carolina State University Synthesis of micron and nanoscale carbon spheres and structures using hydrothemal carbonization
US20210145984A1 (en) * 2018-04-13 2021-05-20 North Carolina State University Ros-responsive microneedle patch for acne vulgaris treatment
JP2021533934A (ja) 2018-08-24 2021-12-09 ノース カロライナ ステート ユニバーシティNorth Carolina State University 閉ループインスリン送達用のグルコース応答性マトリックスを備えたマイクロニードルアレイパッチ
WO2020041694A1 (en) * 2018-08-24 2020-02-27 North Carolina State University Stem cell microneedle patch for treating heart diseases
EP3852721A4 (en) * 2018-09-20 2022-06-29 Singapore Health Services Pte Ltd Conductive microneedle patch for active agent delivery
CN109675185A (zh) * 2019-01-02 2019-04-26 浙江大学 一种苯硼酸水凝胶基糖敏微针贴及其制备方法
JP2021153914A (ja) * 2020-03-27 2021-10-07 国立大学法人 東京医科歯科大学 薬剤送達デバイスおよびその製造方法
JP2023523952A (ja) 2020-04-28 2023-06-08 ティコナ・エルエルシー マイクロニードルアセンブリ
KR102740788B1 (ko) * 2020-07-02 2024-12-09 연세대학교 산학협력단 멀티 레이어 마이크로니들 구조체 및 이의 제조 방법
GB2631618B (en) 2020-07-29 2025-05-14 Biolinq Incorporated Continuous analyte monitoring system with microneedle array
CN118001218B (zh) * 2022-11-08 2026-03-06 沈阳药科大学 一种血糖响应型释药可视化长效微针及其制备方法
CN115998850A (zh) * 2022-12-26 2023-04-25 中山大学 一种尿酸响应性水凝胶微针及其制备方法
CN120857905A (zh) 2023-02-02 2025-10-28 比奥林公司 用于改善基于微针的连续分析物监测系统的传感器灵敏度的方法
WO2024167986A2 (en) * 2023-02-10 2024-08-15 Alj Creative Works, Llc Programmable drug-device microneedle system for the treament of diabetes, obesity, and associated conditions
CN117088903B (zh) * 2023-08-15 2026-03-17 河南师范大学 苯硼酸基两性离子表面活性剂的制备方法及其合成pH响应二聚体分子的应用
CN117159443B (zh) * 2023-10-19 2024-04-19 暨南大学 原位超分子凝胶微针贴片及其制备方法和应用

Citations (4)

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WO2009040548A1 (en) * 2007-09-28 2009-04-02 The Queen's University Of Belfast Delivery device and method
CN102281897A (zh) * 2008-10-31 2011-12-14 T·S·顾巴 通过机械破坏表皮进行痘病毒载体的疫苗接种
WO2016172320A1 (en) * 2015-04-21 2016-10-27 North Carolina State University Office Of Technology Transfer Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites
WO2016172554A1 (en) * 2015-04-23 2016-10-27 Carnegie Mellon University Biosensor tattoos and uses therefor for biomarker monitoring

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CN110198730B (zh) 2016-12-05 2023-10-03 北卡罗莱纳州立大学 H2o2响应性纳米粒子及其用途
DK3548135T3 (da) * 2016-12-05 2021-11-22 Univ North Carolina State Kerne-skal-mikronålsindretninger og anvendelser deraf

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009040548A1 (en) * 2007-09-28 2009-04-02 The Queen's University Of Belfast Delivery device and method
CN102281897A (zh) * 2008-10-31 2011-12-14 T·S·顾巴 通过机械破坏表皮进行痘病毒载体的疫苗接种
WO2016172320A1 (en) * 2015-04-21 2016-10-27 North Carolina State University Office Of Technology Transfer Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites
WO2016172554A1 (en) * 2015-04-23 2016-10-27 Carnegie Mellon University Biosensor tattoos and uses therefor for biomarker monitoring

Also Published As

Publication number Publication date
EP3548135A1 (en) 2019-10-09
DK3548135T3 (da) 2021-11-22
EP3799865A1 (en) 2021-04-07
EP3548135A4 (en) 2020-07-29
WO2018106696A1 (en) 2018-06-14
EP3548135B1 (en) 2021-10-13
CA3045882A1 (en) 2018-06-14
US11697007B2 (en) 2023-07-11
JP2020512283A (ja) 2020-04-23
JP7232526B2 (ja) 2023-03-03
US20230364402A1 (en) 2023-11-16
EP3799865B1 (en) 2022-06-15
US20190351206A1 (en) 2019-11-21
CN110167624A (zh) 2019-08-23

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Granted publication date: 20211119