DK3538161T3 - Fremgangsmåder til flerdosissyntese af [F-18]FDDNP til kliniske indstillinger - Google Patents
Fremgangsmåder til flerdosissyntese af [F-18]FDDNP til kliniske indstillinger Download PDFInfo
- Publication number
- DK3538161T3 DK3538161T3 DK17869521.9T DK17869521T DK3538161T3 DK 3538161 T3 DK3538161 T3 DK 3538161T3 DK 17869521 T DK17869521 T DK 17869521T DK 3538161 T3 DK3538161 T3 DK 3538161T3
- Authority
- DK
- Denmark
- Prior art keywords
- fddnp
- multidose
- synthesis
- methods
- clinical settings
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/34—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662419286P | 2016-11-08 | 2016-11-08 | |
| PCT/US2017/060637 WO2018089491A1 (en) | 2016-11-08 | 2017-11-08 | Methods for multi-dose synthesis of [f-18]fddnp for clinical settings |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3538161T3 true DK3538161T3 (da) | 2022-09-05 |
Family
ID=62066003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17869521.9T DK3538161T3 (da) | 2016-11-08 | 2017-11-08 | Fremgangsmåder til flerdosissyntese af [F-18]FDDNP til kliniske indstillinger |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10377701B2 (da) |
| EP (1) | EP3538161B1 (da) |
| JP (1) | JP2019534284A (da) |
| CN (1) | CN109922837A (da) |
| AU (1) | AU2017356943A1 (da) |
| BR (1) | BR112019009036A2 (da) |
| DK (1) | DK3538161T3 (da) |
| ES (1) | ES2929277T3 (da) |
| WO (1) | WO2018089491A1 (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115521276B (zh) * | 2022-11-24 | 2023-03-10 | 中山大学附属第一医院 | 一种f-18标记的羟基呋喃手性纯衍生物及其制备方法和应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5510522A (en) | 1995-02-22 | 1996-04-23 | Regents Of The University Of California | Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- 18 F!fluoro-1-dopa |
| US5861503A (en) | 1997-04-30 | 1999-01-19 | The Regents Of The University Of California | Process for producing 8-fluoropurines |
| JPH11295494A (ja) * | 1998-04-08 | 1999-10-29 | Nippon Meji Physics Kk | ［ｆ−１８］−フッ化物イオンの製造方法 |
| US6274119B1 (en) | 1998-08-20 | 2001-08-14 | The Regents Of The Univ. Of California | Methods for labeling β-amyloid plaques and neurofibrillary tangles |
| US7329401B2 (en) | 2002-04-15 | 2008-02-12 | The Regents Of The University Of California | Cyclooxygenase-2 selective agents useful as imaging probes and related methods |
| MXPA05011189A (es) * | 2003-04-17 | 2006-05-25 | Gen Hospital Corp | Metodo para monitorear el flujo sanguineo y la captacion metabolica en el tejido con acido alcanoico radiomarcado. |
| JP2007504283A (ja) | 2003-05-20 | 2007-03-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | β−アミロイド斑に作用物質を結合させる方法 |
| US20070218002A1 (en) | 2004-05-07 | 2007-09-20 | Barrio Jorge R | Method for Detecting Alzheimer's Disease and other Forms of Dementia, and Measuring Their Progression |
| EP1841959B1 (en) * | 2004-12-01 | 2012-05-09 | United Technologies Corporation | Balanced turbine rotor fan blade for a tip turbine engine |
| KR100789847B1 (ko) * | 2004-12-15 | 2007-12-28 | (주)퓨쳐켐 | 알코올 용매하에서 유기플루오로 화합물의 제조방법 |
| US8845999B2 (en) | 2005-05-23 | 2014-09-30 | The Regents Of The University Of California | Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease |
| EP1940543B1 (en) | 2005-09-29 | 2012-03-07 | Siemens Medical Solutions USA, Inc. | Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography |
| AU2007207228A1 (en) * | 2006-01-23 | 2007-07-26 | Between Lizenz Gmbh | Electrolyte containing phosphonic acid |
| CA2706017A1 (en) | 2007-03-30 | 2008-10-09 | Jorge R. Barrio | In vivo imaging of sulfotransferases |
| WO2010008522A2 (en) | 2008-07-14 | 2010-01-21 | The Regents Of The University Of California | Nucleophilic fluorination of aromatic compounds |
| TWI359673B (en) * | 2008-07-17 | 2012-03-11 | Atomic Energy Council | Automatic process for synthesizing f-18-fddnp |
| WO2010021719A1 (en) | 2008-08-19 | 2010-02-25 | The Regents Of The University Of California | Modular radiochemistry synthesis system |
| PL2381967T3 (pl) * | 2008-12-31 | 2017-06-30 | Avid Radiopharmaceuticals, Inc. | Synteza styrylopirydyn radioznakowanych 18F z prekursorów tosylanowych i ich stabilne kompozycje farmaceutyczne |
| US8742139B2 (en) | 2009-04-08 | 2014-06-03 | The Regents Of The University Of California | No-carrier-added nucleophilic [F-18] fluorination of aromatic compounds |
| KR101051084B1 (ko) * | 2009-09-14 | 2011-07-21 | 서울대학교산학협력단 | [１８ｆ]폴리프라이드의 개선된 제조방법 |
| TW201201846A (en) * | 2010-02-08 | 2012-01-16 | Bayer Schering Pharma Ag | Iodo precursor for a PET imaging agent of amyloid plaques |
| US10639608B2 (en) | 2010-04-08 | 2020-05-05 | Siemens Medical Solutions Usa, Inc. | System, device and method for preparing tracers and transferring materials during radiosynthesis |
| JP6245981B2 (ja) * | 2010-04-08 | 2017-12-13 | シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッドＳｉｅｍｅｎｓ Ｍｅｄｉｃａｌ Ｓｏｌｕｔｉｏｎｓ ＵＳＡ，Ｉｎｃ． | 含水有機溶媒中の１８ｆ−標識化トレーサーの合成 |
| EA022897B1 (ru) * | 2010-06-04 | 2016-03-31 | Пирамаль Имэджинг Са | СПОСОБ ПОЛУЧЕНИЯ F-18 МЕЧЕНЫХ Аβ ЛИГАНДОВ |
| KR20140006783A (ko) * | 2010-09-09 | 2014-01-16 | 피라말 이미징 에스에이 | 친핵성 ［18ｆ］플루오린화에 적합한 ［18ｆ］플루오라이드의 신속한 제조 방법 |
| US20150367005A1 (en) * | 2014-06-19 | 2015-12-24 | The Regents Of The University Of Michigan | Method of synthesizing fluorine-18 labeled radiopharmaceuticals in ethanol and water |
-
2017
- 2017-11-08 WO PCT/US2017/060637 patent/WO2018089491A1/en unknown
- 2017-11-08 AU AU2017356943A patent/AU2017356943A1/en active Pending
- 2017-11-08 CN CN201780068732.6A patent/CN109922837A/zh active Pending
- 2017-11-08 ES ES17869521T patent/ES2929277T3/es active Active
- 2017-11-08 EP EP17869521.9A patent/EP3538161B1/en active Active
- 2017-11-08 US US15/807,306 patent/US10377701B2/en active Active
- 2017-11-08 DK DK17869521.9T patent/DK3538161T3/da active
- 2017-11-08 BR BR112019009036A patent/BR112019009036A2/pt unknown
- 2017-11-08 JP JP2019522575A patent/JP2019534284A/ja active Pending
-
2019
- 2019-06-28 US US16/457,322 patent/US10626083B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3538161B1 (en) | 2022-07-27 |
| JP2019534284A (ja) | 2019-11-28 |
| ES2929277T3 (es) | 2022-11-28 |
| US20180127355A1 (en) | 2018-05-10 |
| US20190322616A1 (en) | 2019-10-24 |
| CN109922837A (zh) | 2019-06-21 |
| US10626083B2 (en) | 2020-04-21 |
| EP3538161A4 (en) | 2020-05-13 |
| WO2018089491A1 (en) | 2018-05-17 |
| AU2017356943A1 (en) | 2019-05-16 |
| EP3538161A1 (en) | 2019-09-18 |
| US10377701B2 (en) | 2019-08-13 |
| BR112019009036A2 (pt) | 2019-07-16 |
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