DK3532057T3 - Prodrugs af kallikreininhibitorer - Google Patents

Prodrugs af kallikreininhibitorer Download PDF

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Publication number
DK3532057T3
DK3532057T3 DK17864949.7T DK17864949T DK3532057T3 DK 3532057 T3 DK3532057 T3 DK 3532057T3 DK 17864949 T DK17864949 T DK 17864949T DK 3532057 T3 DK3532057 T3 DK 3532057T3
Authority
DK
Denmark
Prior art keywords
production
kallikrein inhibitors
kallikrein
inhibitors
Prior art date
Application number
DK17864949.7T
Other languages
English (en)
Inventor
Pravin L Kotian
Yarlagadda S Babu
V Satish Kumar
Venkat R Chintareddy
Weihe Zhang
Lakshminarayana Vogeti
Original Assignee
Biocryst Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc
Application granted granted Critical
Publication of DK3532057T3 publication Critical patent/DK3532057T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK17864949.7T 2016-10-31 2017-10-27 Prodrugs af kallikreininhibitorer DK3532057T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662415202P 2016-10-31 2016-10-31
PCT/US2017/058685 WO2018081513A1 (en) 2016-10-31 2017-10-27 Prodrugs of kallikrein inhibitors

Publications (1)

Publication Number Publication Date
DK3532057T3 true DK3532057T3 (da) 2023-02-20

Family

ID=62025466

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17864949.7T DK3532057T3 (da) 2016-10-31 2017-10-27 Prodrugs af kallikreininhibitorer

Country Status (10)

Country Link
US (2) US10759759B2 (da)
EP (1) EP3532057B1 (da)
JP (1) JP7128181B2 (da)
AU (1) AU2017348305B2 (da)
CA (1) CA3041058A1 (da)
DK (1) DK3532057T3 (da)
ES (1) ES2942285T3 (da)
IL (1) IL266223B2 (da)
MA (1) MA46642A (da)
WO (1) WO2018081513A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3532057T3 (da) 2016-10-31 2023-02-20 Biocryst Pharm Inc Prodrugs af kallikreininhibitorer
JP7486615B2 (ja) 2020-06-12 2024-05-17 アピカル モレキュラー バイオテック カンパニー リミテッド 非アルコール性脂肪性肝疾患および非アルコール性脂肪性肝炎を治療するためのプテロスチルベンアミノ酸含有炭酸塩の新規類縁体

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LU86084A1 (fr) 1985-09-20 1987-04-02 Faco Sa Apparei de massage electrique
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WO1990013332A1 (en) 1989-05-11 1990-11-15 Cedars-Sinai Medical Center Stent with sustained drug delivery
DE69110787T2 (de) 1990-02-28 1996-04-04 Medtronic, Inc., Minneapolis, Minn. Intraluminale prothese mit wirkstoffeluierung.
US5419760A (en) 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
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WO2004002985A1 (en) 2002-06-27 2004-01-08 Lg Life Sciences Ltd. Peptidic thrombin inhibitor compound
US6770729B2 (en) 2002-09-30 2004-08-03 Medtronic Minimed, Inc. Polymer compositions containing bioactive agents and methods for their use
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DK2070536T3 (da) 2006-10-06 2012-04-10 Toyama Chemical Co Ltd Farmaceutisk sammensætning med et phenylamidin-derivat og fremgangsmåde til anvendelse af den farmaceutiske sammensætning i kombination med et antifungalt middel
KR20100026641A (ko) 2008-09-01 2010-03-10 동아제약주식회사 신규한 벤즈아미드 유도체 화합물 및 그의 제조방법
WO2012137225A1 (en) 2011-04-08 2012-10-11 Sphaera Pharma Pvt. Ltd Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds
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EP3243511B1 (en) 2012-12-21 2019-03-20 ratiopharm GmbH Prodrugs of monomethylfumarate (mmf)
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DK3532057T3 (da) 2016-10-31 2023-02-20 Biocryst Pharm Inc Prodrugs af kallikreininhibitorer

Also Published As

Publication number Publication date
AU2017348305A1 (en) 2019-05-30
ES2942285T3 (es) 2023-05-31
US20190382344A1 (en) 2019-12-19
US10759759B2 (en) 2020-09-01
WO2018081513A1 (en) 2018-05-03
CA3041058A1 (en) 2018-05-03
IL266223B2 (en) 2024-04-01
EP3532057B1 (en) 2022-12-21
JP7128181B2 (ja) 2022-08-30
EP3532057A4 (en) 2020-07-01
AU2017348305B2 (en) 2022-04-21
MA46642A (fr) 2021-04-21
EP3532057A1 (en) 2019-09-04
IL266223B1 (en) 2023-12-01
US20210198204A1 (en) 2021-07-01
IL266223A (en) 2019-06-30
US11618731B2 (en) 2023-04-04
JP2019535688A (ja) 2019-12-12

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