DK3461812T3 - N-(5-(biphen-4-ylmethyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase - Google Patents
N-(5-(biphen-4-ylmethyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase Download PDFInfo
- Publication number
- DK3461812T3 DK3461812T3 DK18191316.1T DK18191316T DK3461812T3 DK 3461812 T3 DK3461812 T3 DK 3461812T3 DK 18191316 T DK18191316 T DK 18191316T DK 3461812 T3 DK3461812 T3 DK 3461812T3
- Authority
- DK
- Denmark
- Prior art keywords
- ylmethyloxy
- biphen
- pentyl
- inhibitors
- substituted imino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14162104 | 2014-03-27 | ||
| EP15719845.8A EP3122726B1 (en) | 2014-03-27 | 2015-03-23 | N-(5-((aryl or heteroaryl)methyloxy)pentyl)-substituted iminosugars as inhibitors of glucosylceramide synthase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3461812T3 true DK3461812T3 (da) | 2021-12-20 |
Family
ID=50424020
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15719845.8T DK3122726T3 (da) | 2014-03-27 | 2015-03-23 | N-(5-((Aryl eller heteroaryl)methyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase |
| DK18191316.1T DK3461812T3 (da) | 2014-03-27 | 2015-03-23 | N-(5-(biphen-4-ylmethyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15719845.8T DK3122726T3 (da) | 2014-03-27 | 2015-03-23 | N-(5-((Aryl eller heteroaryl)methyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10189784B2 (da) |
| EP (2) | EP3122726B1 (da) |
| DK (2) | DK3122726T3 (da) |
| ES (2) | ES2687843T3 (da) |
| WO (1) | WO2015147639A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170333435A1 (en) | 2014-11-06 | 2017-11-23 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| US20180185368A1 (en) | 2014-11-06 | 2018-07-05 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
| KR102662215B1 (ko) | 2014-11-06 | 2024-05-02 | 비알 - 알&디 인베스트먼츠, 에스.에이. | 치환된 피라졸로(1,5-a)피리미딘 및 의학적 장애의 치료에서의 그의 용도 |
| MX2018012207A (es) | 2016-04-06 | 2019-03-28 | Lysosomal Therapeutics Inc | Compuestos de pirrol[1,2-a]pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos. |
| MX2018012211A (es) | 2016-04-06 | 2019-03-28 | Lysosomal Therapeutics Inc | Compuestos de pirazol[1,5-a]pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos. |
| MX2018012208A (es) | 2016-04-06 | 2019-03-28 | Lysosomal Therapeutics Inc | Compuestos a base de imidazo [1,5-a] pirimidinil carboxamida y su uso en el tratamiento de trastornos médicos. |
| EP3452045A1 (en) * | 2016-05-04 | 2019-03-13 | Lysosomal Therapeutics Inc. | Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds |
| SG11201809693SA (en) | 2016-05-05 | 2018-11-29 | Lysosomal Therapeutics Inc | SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| WO2017192931A1 (en) | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
| BR112021011564A2 (pt) | 2018-12-17 | 2021-08-31 | Vertex Pharmaceuticals Incorporated | Inibidores de apol1 e métodos de uso dos mesmos |
| US20220213058A1 (en) * | 2019-05-10 | 2022-07-07 | Alectos Therapeutics Inc. | Non-lysosomal glucosylceramidase inhibitors and uses thereof |
| WO2021221953A1 (en) | 2020-04-28 | 2021-11-04 | The Regents Of The University Of Michigan | Pyridine inhibitors of glucosylceramide synthase and therapeutic methods using the same |
| MX2022013954A (es) * | 2020-05-07 | 2022-11-30 | Alectos Therapeutics Inc | Inhibidores de glucosilceramidasa no lisosomal y los usos de los mismos. |
| EP3978474A1 (en) * | 2020-10-02 | 2022-04-06 | Azafaros B.V. | Crystalline forms of a pharmaceutical compound |
| EP4209215A1 (en) | 2022-01-10 | 2023-07-12 | Azafaros B.V. | Treatment of gm2 gangliosidosis |
| IL314212A (en) | 2022-01-10 | 2024-09-01 | Azafaros B V | Treatment of GM2 gangliosidosis |
| WO2024179491A1 (en) | 2023-03-02 | 2024-09-06 | Ono Pharmaceutical Co., Ltd. | Gba1 and gcs dual modulator |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU732552B2 (en) * | 1996-07-15 | 2001-04-26 | Genzyme Corporation | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
| EP1528056A1 (en) | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
-
2015
- 2015-03-23 EP EP15719845.8A patent/EP3122726B1/en active Active
- 2015-03-23 EP EP18191316.1A patent/EP3461812B1/en active Active
- 2015-03-23 ES ES15719845.8T patent/ES2687843T3/es active Active
- 2015-03-23 WO PCT/NL2015/050188 patent/WO2015147639A1/en active Application Filing
- 2015-03-23 DK DK15719845.8T patent/DK3122726T3/da active
- 2015-03-23 ES ES18191316T patent/ES2895490T3/es active Active
- 2015-03-23 DK DK18191316.1T patent/DK3461812T3/da active
- 2015-03-23 US US15/129,815 patent/US10189784B2/en active Active
-
2019
- 2019-01-07 US US16/241,705 patent/US10590082B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2895490T3 (es) | 2022-02-21 |
| US10189784B2 (en) | 2019-01-29 |
| EP3461812A1 (en) | 2019-04-03 |
| EP3461812B1 (en) | 2021-10-13 |
| US10590082B2 (en) | 2020-03-17 |
| ES2687843T3 (es) | 2018-10-29 |
| DK3122726T3 (da) | 2018-10-08 |
| EP3122726B1 (en) | 2018-08-29 |
| WO2015147639A1 (en) | 2015-10-01 |
| US20170226058A1 (en) | 2017-08-10 |
| US20190144388A1 (en) | 2019-05-16 |
| EP3122726A1 (en) | 2017-02-01 |
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