DK3461812T3 - N-(5-(biphen-4-ylmethyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase - Google Patents
N-(5-(biphen-4-ylmethyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase Download PDFInfo
- Publication number
- DK3461812T3 DK3461812T3 DK18191316.1T DK18191316T DK3461812T3 DK 3461812 T3 DK3461812 T3 DK 3461812T3 DK 18191316 T DK18191316 T DK 18191316T DK 3461812 T3 DK3461812 T3 DK 3461812T3
- Authority
- DK
- Denmark
- Prior art keywords
- ylmethyloxy
- biphen
- pentyl
- inhibitors
- substituted imino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14162104 | 2014-03-27 | ||
| EP15719845.8A EP3122726B1 (en) | 2014-03-27 | 2015-03-23 | N-(5-((aryl or heteroaryl)methyloxy)pentyl)-substituted iminosugars as inhibitors of glucosylceramide synthase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3461812T3 true DK3461812T3 (da) | 2021-12-20 |
Family
ID=50424020
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18191316.1T DK3461812T3 (da) | 2014-03-27 | 2015-03-23 | N-(5-(biphen-4-ylmethyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase |
| DK15719845.8T DK3122726T3 (da) | 2014-03-27 | 2015-03-23 | N-(5-((Aryl eller heteroaryl)methyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15719845.8T DK3122726T3 (da) | 2014-03-27 | 2015-03-23 | N-(5-((Aryl eller heteroaryl)methyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10189784B2 (da) |
| EP (2) | EP3461812B1 (da) |
| DK (2) | DK3461812T3 (da) |
| ES (2) | ES2895490T3 (da) |
| WO (1) | WO2015147639A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180185368A1 (en) | 2014-11-06 | 2018-07-05 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
| ES2958391T3 (es) | 2014-11-06 | 2024-02-08 | Bial R&D Invest S A | Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos |
| PT3215511T (pt) | 2014-11-06 | 2024-05-22 | Bial R&D Invest S A | Pirazolo(1,5-a)pirimidinas substituídas e a sua utilização no tratamento de distúrbios médicos |
| WO2017176961A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| KR20180133461A (ko) | 2016-04-06 | 2018-12-14 | 리소소말 테라퓨틱스 인크. | 피라졸로[1,5-a]피리미디닐 카르복스아미드 화합물 및 의학적 장애의 치료에서의 그의 용도 |
| EP3440081A4 (en) | 2016-04-06 | 2019-09-18 | Lysosomal Therapeutics Inc. | PYRROLO [1,2-A] PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| WO2017192841A1 (en) * | 2016-05-04 | 2017-11-09 | Lysosomal Therapeutics Inc. | Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds |
| AU2017261291C1 (en) | 2016-05-05 | 2022-05-26 | Bial - R&D Investments, S.A. | Substituted imidazo[1,2-b]pyridazines, substituted imidazo[1,5-b]pyridazines, related compounds, and their use in the treatment of medical disorders |
| EP3452455A4 (en) | 2016-05-05 | 2019-11-13 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMDAZO [1,2-] PYRIDINES, SUBSTITUTED IMIDAZO [1,2-] PYRAZINES, RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF ILLNESSES |
| EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
| EP3966199A4 (en) * | 2019-05-10 | 2023-02-01 | Alectos Therapeutics Inc. | NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF |
| EP4142878B1 (en) | 2020-04-28 | 2024-06-26 | The Regents of The University of Michigan | Pyridine inhibitors of glucosylceramide synthase and therapeutic methods using the same |
| KR20230008827A (ko) * | 2020-05-07 | 2023-01-16 | 알렉토스 테라퓨틱스 인크. | 비-리소좀 글루코실세라미다아제 억제제 및 이의 용도 |
| EP3978474A1 (en) * | 2020-10-02 | 2022-04-06 | Azafaros B.V. | Crystalline forms of a pharmaceutical compound |
| EP4209215A1 (en) | 2022-01-10 | 2023-07-12 | Azafaros B.V. | Treatment of gm2 gangliosidosis |
| WO2023131720A1 (en) | 2022-01-10 | 2023-07-13 | Azafaros B.V. | Treatment of gm2 gangliosidosis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU732552B2 (en) * | 1996-07-15 | 2001-04-26 | Genzyme Corporation | Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors |
| EP1528056A1 (en) | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
-
2015
- 2015-03-23 DK DK18191316.1T patent/DK3461812T3/da active
- 2015-03-23 EP EP18191316.1A patent/EP3461812B1/en active Active
- 2015-03-23 DK DK15719845.8T patent/DK3122726T3/da active
- 2015-03-23 US US15/129,815 patent/US10189784B2/en active Active
- 2015-03-23 EP EP15719845.8A patent/EP3122726B1/en active Active
- 2015-03-23 WO PCT/NL2015/050188 patent/WO2015147639A1/en active Application Filing
- 2015-03-23 ES ES18191316T patent/ES2895490T3/es active Active
- 2015-03-23 ES ES15719845.8T patent/ES2687843T3/es active Active
-
2019
- 2019-01-07 US US16/241,705 patent/US10590082B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2895490T3 (es) | 2022-02-21 |
| EP3122726A1 (en) | 2017-02-01 |
| US10189784B2 (en) | 2019-01-29 |
| US20170226058A1 (en) | 2017-08-10 |
| EP3461812A1 (en) | 2019-04-03 |
| DK3122726T3 (da) | 2018-10-08 |
| EP3461812B1 (en) | 2021-10-13 |
| EP3122726B1 (en) | 2018-08-29 |
| US10590082B2 (en) | 2020-03-17 |
| WO2015147639A1 (en) | 2015-10-01 |
| ES2687843T3 (es) | 2018-10-29 |
| US20190144388A1 (en) | 2019-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3461812T3 (da) | N-(5-(biphen-4-ylmethyloxy)pentyl)-substituerede iminosukre som inhibitorer af glucosylceramidsyntase | |
| DK3442980T3 (da) | Heterocykliske forbindelser som ret-kinase-hæmmere | |
| DK3704120T3 (da) | Heterocykliske forbindelser som prmt5-inhibitorer | |
| DK3371190T3 (da) | Heterocykliske forbindelser som pi3k-gamma-inhibitorer | |
| DK3164130T3 (da) | Heteroaryle forbindelser anvendelige som inhibatorer af sumo-aktiverende enzym | |
| DK3298002T3 (da) | Heterocykliske amider som kinasehæmmere | |
| DK3464272T3 (da) | Nye heterocykliske derivater som SHP2-inhibitorer | |
| DK3377488T3 (da) | Heterocykliske forbindelser som immunomodulatorer | |
| DK3371171T3 (da) | Inhibitorer af RET | |
| DK3556752T3 (da) | N-((het)arylmethyl)-heteroaryl-carboxamidforbindelser som plasmakallikreininhibitorer | |
| DK3472167T3 (da) | Heterocykliske forbindelser som immunomodulatorer | |
| DK3377059T3 (da) | Hæmmere af cxcr2 | |
| DK3102576T3 (da) | Dihydropyrrolopyridininhibitorer af ror-gamma | |
| DK3302448T3 (da) | Erstattede heterocyclylafledninger som cdk-inhibitore | |
| DK3461821T3 (da) | Indolcarboxamidforbindelser, der er brugbar som kinasehæmmere | |
| DK3342771T3 (da) | Heterocykliske amider som kinaseinhibitorer | |
| DK2782570T3 (da) | Heterocykliske hæmmere af glutaminase | |
| DK3105226T3 (da) | Cyclopropylaminer som lsd1-inhibitorer | |
| DK3164380T3 (da) | Hæmmere af lysinspecifik demethylase-1 | |
| DK3527263T3 (da) | Bipyrazolderivater som jak-inhibitorer | |
| DK3356345T3 (da) | Heteroaryl-derivater som sepiapterin-reduktase-inhibitorer | |
| DK3323814T3 (da) | (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepan-2-carboxamider som dipeptidylpeptidase i-hæmmere | |
| DK2920168T3 (da) | Heterocykliske glutaminase-inhibitorer | |
| DK3160952T3 (da) | Histone demethylase inhibitors | |
| DK3054936T3 (da) | 4-((2-hydroxy-3-methoxybenzyl)amino) benzensulfonamid derivater som 12-lipoxygenase inhibitorer |