DK335083A - Fremgangsmaade til fremstilling af imidazobenzodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Fremgangsmaade til fremstilling af imidazobenzodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf Download PDF

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Publication number
DK335083A
DK335083A DK335083A DK335083A DK335083A DK 335083 A DK335083 A DK 335083A DK 335083 A DK335083 A DK 335083A DK 335083 A DK335083 A DK 335083A DK 335083 A DK335083 A DK 335083A
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DK
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Prior art keywords
lower alkyl
optionally substituted
imidazobenzodiazepines
acid addition
addition salts
Prior art date
Application number
DK335083A
Other languages
Danish (da)
English (en)
Other versions
DK335083D0 (da
Inventor
Walter Hunkeler
Emilio Kyburz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK335083D0 publication Critical patent/DK335083D0/da
Publication of DK335083A publication Critical patent/DK335083A/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/121,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/141,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/241,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26Two oxygen atoms, e.g. isatoic anhydride
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/38Oxygen atoms in positions 2 and 3, e.g. isatin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyrrole Compounds (AREA)
DK335083A 1982-07-21 1983-07-20 Fremgangsmaade til fremstilling af imidazobenzodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf DK335083A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH446082 1982-07-21

Publications (2)

Publication Number Publication Date
DK335083D0 DK335083D0 (da) 1983-07-20
DK335083A true DK335083A (da) 1984-01-22

Family

ID=4276529

Family Applications (1)

Application Number Title Priority Date Filing Date
DK335083A DK335083A (da) 1982-07-21 1983-07-20 Fremgangsmaade til fremstilling af imidazobenzodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (25)

Country Link
US (1) US4489003A (hu)
EP (1) EP0100906B1 (hu)
JP (1) JPS5933286A (hu)
KR (1) KR840005836A (hu)
AT (1) ATE27160T1 (hu)
AU (1) AU560286B2 (hu)
BR (1) BR8303898A (hu)
CA (1) CA1202969A (hu)
CS (1) CS246063B2 (hu)
CU (1) CU21554A3 (hu)
DE (1) DE3371516D1 (hu)
DK (1) DK335083A (hu)
ES (4) ES524280A0 (hu)
FI (1) FI832654A (hu)
GR (1) GR79322B (hu)
HU (1) HU189719B (hu)
IE (1) IE56121B1 (hu)
IL (1) IL69242A (hu)
MC (1) MC1528A1 (hu)
NO (1) NO832633L (hu)
NZ (1) NZ204912A (hu)
PH (1) PH18980A (hu)
PT (1) PT77063B (hu)
ZA (1) ZA835147B (hu)
ZW (1) ZW14383A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ210850A (en) * 1984-01-19 1988-10-28 Hoffmann La Roche Imidazodiazepine derivatives and pharmaceutical compositions
CA1259612A (en) * 1985-02-28 1989-09-19 Emilio Kyburz Imidazodiazepine derivatives
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
GB8720414D0 (en) * 1987-08-28 1987-10-07 Roussel Lab Ltd Chemical compounds
CA2015336A1 (en) * 1989-05-19 1990-11-19 F. Hoffmann-La Roche Ag Imidazodiazepines for the treatment of neurological symptoms
IE910939A1 (en) * 1990-04-13 1991-10-23 Neurosearch As Use of benzodiazepine compounds
GB9911152D0 (en) * 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
US7595395B2 (en) * 2005-05-16 2009-09-29 Wisys Technology Foundation Gabaergic agents to treat memory deficits
CN103288834B (zh) 2006-07-10 2015-07-15 Paion英国有限公司 短效苯并二氮杂*盐及其多晶型
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
EP2190435B1 (en) 2007-08-20 2018-05-30 Evotec International GmbH Treatment of sleep disorders
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
EP4069369A4 (en) * 2019-12-06 2024-02-14 Schrödinger, Inc. CYCLIC COMPOUNDS AND METHODS OF USE THEREOF

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
CA1184175A (en) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
US4352817A (en) * 1981-02-27 1982-10-05 Hoffmann-La Roche Inc. Imidazo-diazepines and their use
CA1173441A (en) * 1981-02-27 1984-08-28 Hoffmann-La Roche Limited Imidazodiazepines
CA1185602A (en) * 1981-02-27 1985-04-16 Emilio Kyburz Imidazodiazepines

Also Published As

Publication number Publication date
CS541983A2 (en) 1985-12-16
ES530672A0 (es) 1985-05-16
FI832654A (fi) 1984-01-22
PT77063A (en) 1983-08-01
NZ204912A (en) 1986-10-08
IE831696L (en) 1984-01-21
IL69242A (en) 1986-09-30
EP0100906B1 (de) 1987-05-13
ES8505179A1 (es) 1985-05-16
FI832654A0 (fi) 1983-07-21
NO832633L (no) 1984-01-23
CA1202969A (en) 1986-04-08
ES8505180A1 (es) 1985-05-16
ES530671A0 (es) 1985-05-16
CS246063B2 (en) 1986-10-16
CU21554A3 (en) 1987-06-09
HU189719B (en) 1986-07-28
IL69242A0 (en) 1983-11-30
EP0100906A2 (de) 1984-02-22
IE56121B1 (en) 1991-04-24
AU1688883A (en) 1984-01-26
GR79322B (hu) 1984-10-22
BR8303898A (pt) 1984-04-10
JPS5933286A (ja) 1984-02-23
KR840005836A (ko) 1984-11-19
PH18980A (en) 1985-11-29
ZA835147B (en) 1984-03-28
ES530673A0 (es) 1985-05-01
DE3371516D1 (de) 1987-06-19
US4489003A (en) 1984-12-18
AU560286B2 (en) 1987-04-02
ES8504805A1 (es) 1985-05-01
MC1528A1 (fr) 1984-04-13
ATE27160T1 (de) 1987-05-15
EP0100906A3 (en) 1984-08-22
ES8500945A1 (es) 1984-11-16
DK335083D0 (da) 1983-07-20
PT77063B (en) 1986-07-15
ZW14383A1 (en) 1985-01-23
ES524280A0 (es) 1984-11-16

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
AHB Application shelved due to non-payment