DK3320338T3 - Barrierefunktionsmålinger - Google Patents
Barrierefunktionsmålinger Download PDFInfo
- Publication number
- DK3320338T3 DK3320338T3 DK16750529.6T DK16750529T DK3320338T3 DK 3320338 T3 DK3320338 T3 DK 3320338T3 DK 16750529 T DK16750529 T DK 16750529T DK 3320338 T3 DK3320338 T3 DK 3320338T3
- Authority
- DK
- Denmark
- Prior art keywords
- barrier function
- function measurements
- measurements
- barrier
- function
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5032—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on intercellular interactions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Plasma & Fusion (AREA)
- Electrochemistry (AREA)
- Dispersion Chemistry (AREA)
- Computer Hardware Design (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL2015130A NL2015130B1 (en) | 2015-07-09 | 2015-07-09 | Barrier function measurements. |
PCT/NL2016/050502 WO2017007325A1 (en) | 2015-07-09 | 2016-07-08 | Barrier function measurements |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3320338T3 true DK3320338T3 (da) | 2020-11-30 |
Family
ID=55077575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16750529.6T DK3320338T3 (da) | 2015-07-09 | 2016-07-08 | Barrierefunktionsmålinger |
Country Status (12)
Country | Link |
---|---|
US (1) | US11662342B2 (da) |
EP (1) | EP3320338B1 (da) |
JP (1) | JP6838749B2 (da) |
KR (1) | KR102579749B1 (da) |
CN (1) | CN108027366B (da) |
AU (1) | AU2016291078B2 (da) |
BR (1) | BR112018000452A2 (da) |
CA (1) | CA2991876A1 (da) |
DK (1) | DK3320338T3 (da) |
NL (1) | NL2015130B1 (da) |
RU (1) | RU2752085C2 (da) |
WO (1) | WO2017007325A1 (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL2020518B1 (en) | 2018-03-02 | 2019-09-12 | Mimetas B V | Device and method for performing electrical measurements |
WO2020195458A1 (ja) | 2019-03-28 | 2020-10-01 | 富士フイルム株式会社 | 測定装置、測定装置の作動プログラム及び測定方法 |
CN110793735B (zh) * | 2019-11-08 | 2021-02-26 | 湖南科技大学 | 一种液态危险化学品泄漏模拟试验装置 |
NL2024202B1 (en) | 2019-11-08 | 2021-07-20 | Mimetas B V | Microfluidic cell culture system |
JP2022061818A (ja) | 2020-10-07 | 2022-04-19 | ウシオ電機株式会社 | マイクロ流体デバイス及びマイクロ流体デバイスの使用方法 |
JP2023119434A (ja) | 2022-02-16 | 2023-08-28 | ウシオ電機株式会社 | マイクロ流体デバイス及びマイクロ流体デバイスの使用方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4829000A (en) | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
US4761381A (en) | 1985-09-18 | 1988-08-02 | Miles Inc. | Volume metering capillary gap device for applying a liquid sample onto a reactive surface |
US6156270A (en) | 1992-05-21 | 2000-12-05 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
US6429025B1 (en) * | 1996-06-28 | 2002-08-06 | Caliper Technologies Corp. | High-throughput screening assay systems in microscale fluidic devices |
US6601613B2 (en) | 1998-10-13 | 2003-08-05 | Biomicro Systems, Inc. | Fluid circuit components based upon passive fluid dynamics |
US6637463B1 (en) | 1998-10-13 | 2003-10-28 | Biomicro Systems, Inc. | Multi-channel microfluidic system design with balanced fluid flow distribution |
AU2023800A (en) * | 1998-11-10 | 2000-05-29 | Digital Gene Technologies, Inc. | Novel dnas and polypeptides |
US8231845B2 (en) | 2000-10-25 | 2012-07-31 | Steag Microparts | Structures for uniform capillary flow |
EP1843849A2 (en) | 2005-01-12 | 2007-10-17 | Inverness Medical Switzerland GmbH | A method of producing a microfluidic device and microfluidic devices |
EP1891201A4 (en) * | 2005-05-18 | 2011-11-09 | Cornell Res Foundation Inc | PHARMACOKINETICS-BASED CULTURAL SYSTEM WITH BIOLOGICAL BARRIERS |
US7312047B2 (en) * | 2005-05-24 | 2007-12-25 | University Of Southampton | Screening assay for improvement of epithelial barrier function |
US20070280856A1 (en) | 2006-06-02 | 2007-12-06 | Applera Corporation | Devices and Methods for Controlling Bubble Formation in Microfluidic Devices |
ES2486321T3 (es) * | 2010-06-18 | 2014-08-18 | Xiberscience Gmbh | Péptidos como agentes activos para estabilizar barreras biológicas |
WO2012118799A2 (en) * | 2011-02-28 | 2012-09-07 | President And Fellows Of Harvard College | Cell culture system |
GB201103917D0 (en) | 2011-03-08 | 2011-04-20 | Univ Leiden | Apparatus for and methods of processing liquids or liquid based substances |
WO2013086329A1 (en) * | 2011-12-08 | 2013-06-13 | Research Triangle Institute | Human emulated response with microfluidic enhanced systems |
JP2015509382A (ja) * | 2012-03-07 | 2015-03-30 | チルドレンズ メディカル センター コーポレーション | 組織構築体およびその使用 |
US9513280B2 (en) * | 2012-08-28 | 2016-12-06 | University Of Utah Research Foundation | Microfluidic biological barrier model and associated method |
US9588106B2 (en) * | 2012-09-05 | 2017-03-07 | The University Of Chicago | Methods and compositions for measuring cell permeability |
GB2505706A (en) | 2012-09-10 | 2014-03-12 | Univ Leiden | Apparatus comprising meniscus alignment barriers |
US20140363883A1 (en) * | 2013-06-11 | 2014-12-11 | BellBrook Labs | Device for cell culture and direct imaging |
CN104031878A (zh) * | 2014-05-16 | 2014-09-10 | 浙江大学 | 通过lps刺激建立的大鼠及猪肠道上皮细胞的综合模型 |
-
2015
- 2015-07-09 NL NL2015130A patent/NL2015130B1/en not_active IP Right Cessation
-
2016
- 2016-07-08 KR KR1020187004106A patent/KR102579749B1/ko active IP Right Grant
- 2016-07-08 CN CN201680052551.XA patent/CN108027366B/zh active Active
- 2016-07-08 CA CA2991876A patent/CA2991876A1/en active Pending
- 2016-07-08 BR BR112018000452A patent/BR112018000452A2/pt not_active IP Right Cessation
- 2016-07-08 RU RU2017146805A patent/RU2752085C2/ru active
- 2016-07-08 WO PCT/NL2016/050502 patent/WO2017007325A1/en active Application Filing
- 2016-07-08 US US15/741,076 patent/US11662342B2/en active Active
- 2016-07-08 JP JP2018521170A patent/JP6838749B2/ja active Active
- 2016-07-08 AU AU2016291078A patent/AU2016291078B2/en active Active
- 2016-07-08 DK DK16750529.6T patent/DK3320338T3/da active
- 2016-07-08 EP EP16750529.6A patent/EP3320338B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2017007325A1 (en) | 2017-01-12 |
JP2018522586A (ja) | 2018-08-16 |
EP3320338B1 (en) | 2020-11-11 |
CN108027366B (zh) | 2021-06-08 |
NL2015130B1 (en) | 2017-02-01 |
CN108027366A (zh) | 2018-05-11 |
RU2752085C2 (ru) | 2021-07-22 |
RU2017146805A (ru) | 2019-08-09 |
US20180196035A1 (en) | 2018-07-12 |
BR112018000452A2 (pt) | 2018-09-11 |
KR20180028503A (ko) | 2018-03-16 |
AU2016291078B2 (en) | 2021-10-07 |
AU2016291078A1 (en) | 2018-02-01 |
EP3320338A1 (en) | 2018-05-16 |
JP6838749B2 (ja) | 2021-03-03 |
RU2017146805A3 (da) | 2019-10-24 |
KR102579749B1 (ko) | 2023-09-15 |
US11662342B2 (en) | 2023-05-30 |
CA2991876A1 (en) | 2017-01-12 |
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